Yun-ping Zhou

发表

Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets

B. Yandell, Chunsheng Zhang, E. Schadt, 2012, PLoS genetics.

Overexpression of Repressive cAMP Response Element Modulators in High Glucose and Fatty Acid-treated Rat Islets

A. Schweitzer, J. Blume, Yun-ping Zhou, 2003, Journal of Biological Chemistry.

Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.

K. Polonsky, Yun-ping Zhou, C. Yuan, 2002, Diabetes.

Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.

Margaret S. Wu, Yun-ping Zhou, A. Howard, 2018, ACS medicinal chemistry letters.

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

M. Reitman, J. Metzger, Yun-ping Zhou, 2011, Endocrinology.

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Yun-ping Zhou, J. Berger, N. Thornberry, 2008, Diabetes.

Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.

Margaret S. Wu, Yun-ping Zhou, A. Howard, 2012, ACS medicinal chemistry letters.

A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.

K. Polonsky, V. Bindokas, A. Fox, 2003, Metabolism: clinical and experimental.

Palmitate-Induced β-Cell Insensitivity to Glucose is Coupled to Decreased Pyruvate Dehydrogenase Activity and Enhanced Kinase Activity in Rat Pancreatic Islets

Yun-ping Zhou, V. Grill, 1995, Diabetes.

Defective Pancreatic β-Cell Glycolytic Signaling in Hepatocyte Nuclear Factor-1α-deficient Mice*

K. Polonsky, L. Philipson, M. Yaniv, 1998, The Journal of Biological Chemistry.

FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ.

Yun-ping Zhou, J. Berger, Yuli Chen, 2013, European journal of pharmacology.

Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets.

Yun-ping Zhou, J. Mancini, N. Thornberry, 2008, Biochemical pharmacology.

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Yun-ping Zhou, J. Berger, N. Thornberry, 2010, Bioorganic & medicinal chemistry letters.

Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.

Yun-ping Zhou, E. Sherer, A. Howard, 2014, ACS medicinal chemistry letters.

The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets

M. Jensen, C. Newgard, Yun-ping Zhou, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.

Margaret S. Wu, M. Reibarkh, Yun-ping Zhou, 2014, ACS medicinal chemistry letters.

Hepatic safety of the antifungal triazole agent posaconazole: characterization of adverse event reports in a manufacturer’s safety database

H. Waskin, W. Straus, Yun-ping Zhou, 2022, Expert opinion on drug safety.

Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists.

Yun-ping Zhou, E. Sherer, A. Howard, 2015, Bioorganic & medicinal chemistry letters.

Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

Yue Feng, Yun-ping Zhou, D. Moller, 2006, Diabetes.

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.

Margaret S. Wu, Rebecca T. Ruck, M. Reibarkh, 2012, ACS medicinal chemistry letters.

Identification of Glucose-Dependent Insulin Secretion Targets in Pancreatic β Cells by Combining Defined-Mechanism Compound Library Screening and siRNA Gene Silencing

Yun-ping Zhou, N. Thornberry, A. Howard, 2008, Journal of biomolecular screening.

Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice

B. Yandell, E. Schadt, M. Cleary, 2009, Mammalian Genome.

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.

Yun-ping Zhou, N. Thornberry, J. Mu, 2009, European journal of pharmacology.

Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion

E. Schadt, A. Attie, O. Ilkayeva, 2014, Diabetes.

A Fatty Acid—Induced Decrease in Pyruvate Dehydrogenase Activity Is an Important Determinant of β-Cell Dysfunction in the Obese Diabetic db/db Mouse

Yun-ping Zhou, P. Berggren, V. Grill, 1996, Diabetes.

Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets*

D. Macneil, M. Jensen, O. Ilkayeva, 2008, Journal of Biological Chemistry.

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.

Margaret S. Wu, M. Reibarkh, Yun-ping Zhou, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Margaret S. Wu, Yun-ping Zhou, E. Sherer, 2015, ACS medicinal chemistry letters.

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Jing Li, A. Attie, C. Newgard, 2015, Molecular endocrinology.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

Margaret S. Wu, J. Holst, J. Rehfeld, 2018, Molecular metabolism.

Matrix metalloproteinases contribute to insulin insufficiency in Zucker diabetic fatty rats.

A. Schweitzer, J. Blume, C. Burant, 2005, Diabetes.

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.

O. McManus, V. Garsky, Yun-ping Zhou, 2006, Diabetes.

A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat.

Yun-ping Zhou, Bei B. Zhang, Hiroki Takano, 2010, European journal of pharmacology.

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Yun-ping Zhou, V. Grill, Y. P. Zhou, 1995, The Journal of clinical endocrinology and metabolism.

Evaluation of Neural Tube Defects (NTDs) After Exposure to Raltegravir During Pregnancy

W. Straus, Yun-ping Zhou, W. Greaves, 2019, Journal of acquired immune deficiency syndromes.

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Yun-ping Zhou, V. Grill, Y. P. Zhou, 1994, The Journal of clinical investigation.

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

D. Hanahan, K. Polonsky, V. Bindokas, 2000, American journal of physiology. Endocrinology and metabolism.

Calpains play a role in insulin secretion and action.

N. Cox, K. Polonsky, C. Burant, 2001, Diabetes.

Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism.

Yun-ping Zhou, V. Grill, Z. Ling, 1996, Metabolism: clinical and experimental.