H. Loetscher

发表

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

D. Banner, R. Gentz, A. D'arcy, 1993, Cell.

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

Anirvan Ghosh, Jens Niewoehner, Petra Rueger, 2014, Neuron.

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.

F. Barkhof, W. Klunk, L. Thurfjell, 2012, Archives of neurology.

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

D. Banner, H. Loetscher, W. Lesslauer, 1993, The Journal of biological chemistry.

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

Guido Steiner, Markus von Kienlin, Basil Künnecke, 2005, Neurobiology of Disease.

Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation.

H. Loetscher, W. Lesslauer, F. Mackay, 1994, Journal of immunology.

Plasmepsins I and II from the malarial parasite Plasmodium falciparum.

B. Dunn, J. Kay, H. Loetscher, 1998, Advances in experimental medicine and biology.

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.

H. Loetscher, U. Deuschle, C. Haass, 1998, Biochemistry.

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

W. Fiers, P. Vandenabeele, H. Loetscher, 1992, The Journal of experimental medicine.

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)*

F. Metzger, A. Hoeflich, H. Schoenfeld, 2011, The Journal of Biological Chemistry.

Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis.

H. Loetscher, W. Lesslauer, M. Sachdeva, 1992, The Journal of infectious diseases.

Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55

H. Loetscher, W. Lesslauer, D. Stueber, 1993, The Journal of experimental medicine.

Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors

B. Aggarwal, H. Loetscher, H. Gallati, 1995, Journal of cellular biochemistry.

Tumor Necrosis Factor c ~ ( TNF-c ~ )-induced Cell Adhesion to Human Endothelial Cells Is under Dominant Control of One TNT Receptor Type , TNF-R 55 By

H. Loetscher, W. Lesslauer, D. Stueber, 2003 .

A Human Tumor Necrosis Factor (TNF) c~ Mutant That Binds Exclusively to the p55 TNF Receptor Produces Toxicity in the Baboon By Kimberly

S. Calvano, L. Moldawer, S. Lowry, 2003 .

Tumor Necrosis Factor-cw Induces Activation of Coagulation and Fibrinolysis in Baboons Through an Exclusive Effect on the p 55 Receptor

Kimberly, J., S. Lowry, 2002 .

A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon

J. Vauthey, L. Moldawer, S. Lowry, 1996, The Journal of experimental medicine.

Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.

T. van der Poll, L. Moldawer, S. Lowry, 1996, Blood.

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram- negative sepsis

H. Loetscher, W. Lesslauer, J. Cohen, 1994, The Journal of experimental medicine.

A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon

S. Calvano, L. Moldawer, H. Loetscher, 1994, The Journal of experimental medicine.

Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

H. Loetscher, W. Lesslauer, T. Espevik, 1990, The Journal of experimental medicine.

Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.

R. Gentz, H. Loetscher, W. Lesslauer, 1992, Immunology.

Human Tumor Necrosis Factor a (TNF'a) Mutants with Exclusive Specificity for the 55-kDa or 75-kDa TNF' Receptors*

D. Banner, H. Loetscher, D. Stueber, 2001 .

In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite.

H. Loetscher, J. Paulson, F. Knoflach, 2010, European journal of pharmacology.

Region-specific permeability of the blood–brain barrier upon pericyte loss

L. Collin, H. Loetscher, P. Freskgård, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons.

T. van der Poll, L. Moldawer, S. Lowry, 1997, Journal of Infectious Diseases.

55-kd tumor necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-1 expression.

H. Loetscher, M. Brockhaus, J. Krutmann, 1991, The Journal of investigative dermatology.

Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.

H. Loetscher, W. Lesslauer, M. Brockhaus, 1990, The Journal of biological chemistry.

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

H. Schoenfeld, H. Loetscher, W. Lesslauer, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Comprehensive in vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu®) and oseltamivir active metabolite

H. Loetscher, M. Brockhaus, H. Jacobsen, 2008 .

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.

H. Loetscher, J. Benz, K. Baumann, 2012, Journal of Alzheimer's disease : JAD.

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

H. Tabuchi, R. Gentz, H. Loetscher, 1990, Cell.

Role of Caspase-3 Activation in Cerebral Ischemia-Induced Neurodegeneration in Adult and Neonatal Brain

K. Blomgren, J. Kemp, H. Loetscher, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

J. Kemp, H. Loetscher, R. Gill, 2001, Drug discovery today.

The Influence of Endoproteolytic Processing of Familial Alzheimer's Disease Presenilin 2 on Aβ42 Amyloid Peptide Formation*

H. Loetscher, M. Brockhaus, H. Jacobsen, 1999, The Journal of Biological Chemistry.

Presenilins Are Processed by Caspase-type Proteases*

H. Loetscher, U. Deuschle, C. Haass, 1997, The Journal of Biological Chemistry.

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

J. Kemp, J. Kew, G. Higgins, 2003, The Journal of Neuroscience.

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.

R. Gentz, H. Loetscher, W. Lesslauer, 1990, Cytokine.

Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis

F. Metzger, I. Torres-Aleman, H. Loetscher, 2006, Neurobiology of Aging.

Tumor Necrosis Factor-a Inhibits Stem Cell Factor-induced Proliferation of Human Bone Marrow Progenitor Cells In Vitro Role of p55 and p75 Tumor Necrosis Factor Receptors

E. Smeland, S. Jacobsen, H. Loetscher, 2022 .

Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.

H. Tabuchi, R. Gentz, M. Zulauf, 1991, The Journal of biological chemistry.

Human TNF mutants with selective activity on the p55 receptor

Jan Tavernier, Manfred Brockhaus, Peter Vandenabeele, 1993, Nature.

Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors.

E. Smeland, S. Jacobsen, H. Loetscher, 1994, Blood.

Cargo Delivery into the Brain by in vivo identified Transport Peptides

U. Certa, H. Loetscher, P. Freskgård, 2015, Scientific Reports.

Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors.

M. Zulauf, A. Lustig, H. Schoenfeld, 1991, The Journal of biological chemistry.

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor

H. Loetscher, T. Espevik, M. Brockhaus, 1990, The Journal of experimental medicine.

Expression of a transgenic T cell receptor beta chain enhances collagen- induced arthritis

H. Loetscher, H. Bluethmann, L. Mori, 1992, The Journal of experimental medicine.

Tumor necrosis factor: receptors and inhibitors.

H. Loetscher, W. Lesslauer, M. Steinmetz, 1991, Cancer cells.

Structure and membrane topology of the high-affinity receptor for human IFN-gamma: requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins.

H. Loetscher, M. Fountoulakis, L. Ozmen, 1989, Journal of immunology.

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

C. Betsholtz, L. Collin, H. Loetscher, 2016, Scientific Reports.

Two Distinct Tumor Necrosis Factor Receptors in Health and Disease

D. Banner, R. Gentz, H. Schoenfeld, 1993 .

PRODUCTION OF RECOMBINANT SOLUBLE HUMAN TNF RECEPTOR USING THE BACULOVIRUS-INSECT CELL EXPRESSION SYSTEM

R. Gentz, H. Loetscher, E. Schlaeger, 1992 .

A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers

C. Adessi, H. Loetscher, C. Czech, 2005, Journal of neurochemistry.

Expression and characterisation of plasmepsin I from Plasmodium falciparum.

U. Certa, B. Dunn, J. Kay, 1997, European journal of biochemistry.

Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.

R. Gentz, H. Loetscher, W. Lesslauer, 1992, Journal of immunology.

Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.

S. Calvano, L. Moldawer, S. Lowry, 1996, Journal of immunology.

Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

F. Metzger, M. Dietrich, I. Torres-Aleman, 2007, The Journal of Neuroscience.

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.

M. Citron, H. Loetscher, C. Haass, 1999, Biochemistry.

Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from Plasmodium falciparum

Robert G. Ridley, M. James, H. Loetscher, 1999, Nature Structural Biology.

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

W. Guba, A. Kuglstatter, A. Rufer, 2017, EBioMedicine.

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

J. Andersen, H. Loetscher, S. Nave, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.

U. Certa, J. Kay, A. D'arcy, 1998, Advances in experimental medicine and biology.

Tumor necrosis factor receptors-structure and function

H. Loetscher, W. Lesslauer, J. Rothe, 1992, Immunologic research.

Two Distinct Human TNF Receptors: Purification, Molecular Cloning and Expression

H. Tabuchi, R. Gentz, M. Zulauf, 1992 .

Caspase‐mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

S. Röhrig, N. Wittenburg, H. Loetscher, 1998, Neuroreport.

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram- negative sepsis

H. Loetscher, W. Lesslauer, D. Moyes, 1994, The Journal of experimental medicine.

Monoclonal Antibodies against Cytokine Receptors

H. Loetscher, M. Brockhaus, 1990 .

Crystallization and preliminary crystallographic analysis of a TNF-beta-55 kDa TNF receptor complex.

F. Winkler, D. Banner, R. Gentz, 1993, Journal of molecular biology.

Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)*

F. Metzger, A. Hoeflich, H. Schoenfeld, 2011, The Journal of Biological Chemistry.

Thermodynamic studies on the interaction of antibodies with beta-amyloid peptide.

H. Loetscher, W. Huber, M. Brockhaus, 2007, The journal of physical chemistry. B.

Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons.

L. Moldawer, H. Loetscher, W. Lesslauer, 1997, The Journal of infectious diseases.