D. Curiel

J. Contreras, D. Curiel, D. Eckhoff, 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Analysis of Cell-Specific Promoters for Viral Gene Therapy Targeted at the Vascular Endothelium

A. Dominiczak, M. Brosnan, D. Curiel, 2001, Hypertension.

Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells

P. Fisher, P. Dent, D. Curiel, 2007, Molecular Cancer Therapeutics.

Efficient Genome Editing Achieved via Plug-and-Play Adenovirus Piggyback Transport of Cas9/gRNA Complex on Viral Capsid Surface

D. Curiel, I. Dmitriev, E. Kashentseva, 2022, ACS nano.

Vector Strategies to Actualize B Cell–Based Gene Therapies

D. Curiel, J. Voss, P. Boucher, 2021, The Journal of Immunology.

A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting

D. Brough, D. Curiel, I. Dmitriev, 2020, Journal of Virology.

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

D. Curiel, Bin Liu, A. Hemminki, 2003, Cancer research.

Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.

R. Crystal, D. Curiel, M. Brantly, 1989, The Journal of laboratory and clinical medicine.

Selective transduction of murine myelomonocytic leukemia cells (WEHI-3B) with regular and RGD-adenoviral vectors.

D. Curiel, J. Gómez-Navarro, F. Garcia-sanchez, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Pro‐apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer

D. Curiel, J. Xiang, R. Alvarez, 2000, The journal of gene medicine.

Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and −

P. Fisher, S. Spiegel, P. Dent, 2010 .

Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity.

D. Curiel, M. Barnes, R. Alvarez, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

GENE THERAPY AND OVARIAN CANCER: A REVIEW

D. Curiel, M. Barnes, R. Alvarez, 1997, Obstetrics and gynecology.

Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.

J. Grill, D. Curiel, H. Haisma, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

CYTOPROTECTION OF PANCREATIC ISLETS BEFORE AND SOON AFTER TRANSPLANTATION BY GENE TRANSFER OF THE ANTI-APOPTOTIC Bcl-2 GENE1

J. Contreras, D. Curiel, D. Eckhoff, 2001, Transplantation.

Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement.

J. Contreras, D. Curiel, J. Thomas, 2001, Surgery.

Efficient Gene Transfer to Dispersed Human Pancreatic Islet Cells In Vitro Using Adenovirus-Polylysine/DNA Complexes or Polycationic Liposomes

D. Curiel, N. Welsh, K. Buschard, 1996, Diabetes.

Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosis.

D. Curiel, J. Grim, R. Alvarez, 1996, Cancer gene therapy.

Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen-presenting cells

Z. Wang, D. Curiel, Pingar Yang, 1998, Nature Biotechnology.

An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations.

P. Fisher, P. Dent, D. Curiel, 2010, Virology.

A system for the propagation of adenoviral vectors with genetically modified receptor specificities

C. Miller, D. Curiel, I. Dmitriev, 1999, Nature Biotechnology.

Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis

D. Curiel, 2001 .

Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers.

R. Alemany, D. Curiel, M. Yamamoto, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Inclusion of the murine IgGκ signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine.

D. Curiel, A. Moreno, I. Dmitriev, 2018, Vaccine.

Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation

D. Curiel, H. Hsu, A. Zajac, 2005, Gene Therapy.

Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines.

D. Curiel, F. Loechel, G. Siegal, 1994, Gene therapy.

Strategies to Adapt Adenoviral Vectors for Targeted Delivery

D. Curiel, 1999, Annals of the New York Academy of Sciences.

The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses.

R. Alemany, D. Curiel, Kaori Suzuki, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivo.

Ann Marie O'Neill, D. Curiel, T. D. de Gruijl, 2009, Vaccine.

Targeting Mcl-1 for the therapy of cancer

P. Fisher, John Calvin Reed, P. Dent, 2011, Expert opinion on investigational drugs.

A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration1

J. Mcghee, S. Shizukuishi, D. Curiel, 2008, The Journal of Immunology.

Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264----Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion.

R. Crystal, D. Curiel, M. Courtney, 1989, The Journal of biological chemistry.

Gene therapy for management of lupus: Correction of Fas and Fas ligand-induced apoptosis in murine disease — therapeutic rationale and strategies

D. Curiel, H. Hsu, J. Mountz, 2000 .

Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression

J. Contreras, D. Curiel, J. Mountz, 1998, Journal of Virology.

Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients.

D. Curiel, A. Lobuglio, T. Strong, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

High‐Efficiency Gene Transfer Mediated by Adenovirus‐Polylysine‐DNA Complexes

D. Curiel, 1994 .

Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector

D. Curiel, C. Rancourt, Minghui Wang, 1997, Nature Biotechnology.

Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession.

D. Curiel, H. Hsu, Pingar Yang, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

An allogeneic hybrid-cell fusion vaccine against canine mammary cancer.

D. Curiel, Erin E. Thacker, P. DeInnocentes, 2008, Veterinary immunology and immunopathology.

Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody.

S. Seaman, D. Curiel, I. Dmitriev, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Acquired and innate resistance to the cancer-specific apoptosis-inducing Cytokine, mda-7/IL-24: Not insurmountable therapeutic problems

P. Fisher, P. Dent, D. Curiel, 2008, Cancer biology & therapy.

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a ‘magic bullet’ for cancer therapy?

P. Fisher, P. Dent, D. Curiel, 2007, Expert opinion on biological therapy.

Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma.

P. Fisher, P. Dent, D. Curiel, 2004, Gynecologic oncology.

Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy

D. Curiel, J. Lam, M. Barnes, 2004, Gene Therapy.

Gene therapy for ovarian carcinoma.

D. Curiel, C. Rancourt, M. Wang, 1998, Seminars in oncology.

Gene therapy: ovarian carcinoma as the paradigm.

D. Curiel, R. Alvarez, G. Siegal, 1998, American journal of clinical pathology.

Cancer vaccine strategies get bigger and better

D. Curiel, T. D. Gruijl, 1999, Nature Medicine.

A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo.

D. Curiel, A. Lobuglio, M. J. Pike, 1995, Nucleic acids research.

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

P. Fisher, S. Spiegel, P. Dent, 2011, Molecular Pharmacology.

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

P. Fisher, P. Dent, A. Yacoub, 2008, Molecular Cancer Therapeutics.

Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Pharmacology.

Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.

D. Curiel, K. Scanlon, G. Cabrera, 1995, Cancer research.

Cancer Gene Therapy

D. Curiel, Masato Yamamoto, M. Yamamoto, 2005, Technology in cancer research & treatment.

Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice

S. Zeissig, D. Curiel, Minghui Wang, 2012, Hepatology.

Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer

Raymond D. Harris, D. Curiel, A. Hemminki, 2009, Clinical Cancer Research.

Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene.

E. Krenning, D. Curiel, A. Hemminki, 2004, Cancer biotherapy & radiopharmaceuticals.

The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.

W. Vandertop, M. Lamfers, J. Grill, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors

C. Meijer, P. Snijders, E. Bloemena, 2001, Cancer Gene Therapy.

Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM

D. Curiel, H. Haisma, H. Pinedo, 1999, Gene Therapy.

Targeting strategies for cancer radiotherapy.

M. Mayo, L. Chappell, M. Brechbiel, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine.

D. Curiel, T. D. de Gruijl, T. Tüting, 2011, Vaccine.

Therapeutics , Targets , and Chemical Biology Potent Antitumor Immunity Generated by a CD 40-Targeted Adenoviral Vaccine

L. Boon, D. Curiel, R. Scheper, 2011 .

Immune response to a carcinoembryonic antigen polynucleotide vaccine.

J. Schlom, D. Curiel, F. Loechel, 1994, Cancer research.

Circumventing Recombination Events Encountered with Production of a Clinical-Grade Adenoviral Vector with a Double-Expression Cassette

Raymond D. Harris, D. Curiel, Minghui Wang, 2006, Molecular Pharmacology.

Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells

D. Curiel, J. Thomas, I. Dmitriev, 2002, Gene Therapy.

Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.

W. Travis, R. Crystal, C. Vogelmeier, 1989, The Journal of biological chemistry.

Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing alpha 1-antitrypsin.

R. Crystal, D. Curiel, M. Brantly, 1989, The Journal of clinical investigation.

Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele

R. Crystal, C. Vogelmeier, D. Curiel, 1990, Molecular and cellular biology.

Characterization of the intracellular mechanism causing the alpha-1-antitrypsin Nullgranite falls deficiency state.

R. Crystal, D. Curiel, M. Brantly, 1989, The American review of respiratory disease.

Tumor-busting viruses.

D. Nettelbeck, D. Curiel, 2003, Scientific American.

Ribonuclease A cleavage combined with the polymerase chain reaction for detection of the Z mutation of the alpha-1-antitrypsin gene.

R. Crystal, D. Curiel, H. Takahashi, 1989, American journal of respiratory cell and molecular biology.

Rapid Publication

D. Curiel, G. Siegal, Ming-Hai Wang, 2003 .

CD40‐targeted adenoviral cancer vaccines: the long and winding road to the clinic

D. Curiel, L. Timares, R. Scheper, 2012, The journal of gene medicine.

Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-avidity Melanoma-reactive Cytotoxic T Cells by a CD40-targeted Adenovirus

D. Curiel, T. D. de Gruijl, E. Hooijberg, 2010, Journal of immunotherapy.

In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model

D. Curiel, P. Reynolds, M. Everts, 2005, The journal of gene medicine.

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

D. Curiel, T. D. de Gruijl, G. Ossenkoppele, 2003, British Journal of Cancer.

CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.

D. Curiel, T. D. de Gruijl, H. Haisma, 2003, Vaccine.

Prolonged Maturation and Enhanced Transduction of Dendritic Cells Migrated from Human Skin Explants After In Situ Delivery of CD40-Targeted Adenoviral Vectors1

D. Curiel, T. D. de Gruijl, J. Buter, 2002, The Journal of Immunology.

Delivery of CD40-Targeted Adenoviral from Human Skin Explants After In Situ Transduction of Dendritic Cells Migrated Prolonged Maturation and Enhanced

Herbert, D. Curiel, J. Buter, 2002 .

Characterization of the sequence of the normal alpha-1-antitrypsin M3 allele and function of the M3 protein.

R. Crystal, C. Vogelmeier, D. Curiel, 1989, American journal of respiratory cell and molecular biology.

Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase.

R. Crystal, D. Curiel, M. Casolaro, 1988, The American review of respiratory disease.

A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism

D. Curiel, D. Chaplin, J. Deshane, 2012, Gene Therapy.

Efficient Gene Transduction by RGB‐fiber Modified Recombinant Adenovirus into Dendritic Cells

D. Curiel, H. Wakasugi, Y. Heike, 2001, Japanese journal of cancer research : Gann.

Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha‐1 antitrypsin levels

J. Arbeit, D. Curiel, A. Annan, 2016, The journal of gene medicine.

Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene.

J. Contreras, D. Curiel, J. Thomas, 1999, Annals of surgery.

Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.

D. Curiel, C. Vasu, M. Holterman, 2006, Virus research.

Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.

D. Curiel, C. Vasu, M. Holterman, 2004, Virology.

A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial.

Martin R. Johnson, D. Curiel, M. Wang, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Rapid Targeted Tumor Killing via an Intracellular Antibody against erbB-2

D. Curiel, M. Wang, R. Alvarez, 2022 .

High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.

D. Curiel, C. Rancourt, M. Wang, 1998, Gynecologic oncology.

Strategy for achieving selective killing of carcinomas.

D. Curiel, P. Hu, E. Sorscher, 1994, Gene therapy.

A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity.

D. Curiel, F. Loechel, A. Lobuglio, 1995, Gene therapy.

Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications.

D. Curiel, A. Hemminki, M. Wang, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Conditionally Replicative Adenovirus for Prostate Cancer Therapy

D. Curiel, 1999 .

Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver.

D. Curiel, J. Mountz, C. Edwards, 1998, Human gene therapy.

Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation.

J. Contreras, D. Curiel, J. Thomas, 1999, Transplantation.

Intracellular expression of a single-chain antibody directed against human papillomavirus type 16 E7 oncoprotein achieves targeted antineoplastic effects.

D. Curiel, C. Rancourt, J. Grim, 1998, Cancer research.

In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin.

D. Curiel, H. Hsu, Pingar Yang, 2006, Human gene therapy.

Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells.

J. Fiveash, D. Curiel, W. Grizzle, 2004, International journal of radiation oncology, biology, physics.

Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma.

A. Rivera, D. Curiel, Yabing Chen, 2006, International journal of oncology.

Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement

D. Curiel, K. Takayama, Masato Yamamoto, 2003, Journal of Gastrointestinal Surgery.

Fluorescently tagged canine adenovirus via modification with protein IX-enhanced green fluorescent protein.

D. Curiel, G. Siegal, L. Le, 2005, The Journal of general virology.

An ovine adenovirus vector lacks transforming ability in cells that are transformed by AD5 E1A/B sequences.

D. Curiel, T. Dobner, M. Nevels, 2000, Virology.

Overcoming multi‐drug resistance using an intracellular anti‐MDR1 sFv

T. Tsuruo, N. Saijo, K. Kasono, 2001, International journal of cancer.

Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain.

D. Curiel, I. Dmitriev, E. Kashentseva, 2002, Cancer research.

erbB-2 knockout employing an intracellular single-chain antibody (sFv) accomplishes specific toxicity in erbB-2-expressing lung cancer cells.

D. Curiel, J. Grim, A. Lieber, 1996, American journal of respiratory cell and molecular biology.

Combination Therapy with Conditionally Replicating Adenovirus and Replication Defective Adenovirus

D. Carbone, S. Nadaf, K. Yanagisawa, 2004, Cancer Research.

A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine

D. Curiel, Monica Cabrera-Mora, A. Moreno, 2016, PloS one.

Adenoviral/retroviral vector chimeras: a novel strategy to achieve high‐efficiency stable transduction in vivo

D. Curiel, C. Rancourt, G. Bilbao, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Advances in adenoviral vectors for cancer gene therapy

J. Contreras, D. Curiel, G. Bilbao, 1997 .

Receptor-mediated gene delivery employing lectin-binding specificity.

D. Curiel, E. Wagner, R. Batra, 1994, Gene therapy.

An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer.

D. Curiel, J. Xiang, M. Barnes, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors

D. Curiel, W. Grizzle, D. Buchsbaum, 1999, Cancer Gene Therapy.

Enhanced in vivo gene delivery to human ovarian cancer xenografts utilizing a tropism-modified adenovirus vector

D. Curiel, D. Buchsbaum, B. Rogers, 1998 .

Approaches to enhance cancer radiotherapy employing gene transfer methods.

D. Raben, D. Curiel, D. Buchsbaum, 1996, Gene therapy.

Receptor-mediated gene transfer to airway epithelial cells in primary culture.

D. Curiel, E. Wagner, P. Hu, 1993, American journal of respiratory cell and molecular biology.

High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes.

P. Hu, M. Cotten, D. Curiel, 1992, Human gene therapy.

HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach

P. Stewart, D. Curiel, Hongju Wu, 2010, PloS one.

Lysis of dysplastic but not normal oral keratinocytes and tissue-engineered epithelia with conditionally replicating adenoviruses.

D. Curiel, A. Hills, K. Gaballah, 2007, Cancer research.

Detection of Coxsackie–Adenovirus Receptor (CAR) Immunoreactivity in Ovarian Tumors of Epithelial Derivation

D. Curiel, R. Alvarez, G. Siegal, 1999 .

Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter.

D. Curiel, M. Everts, H. Herschman, 2007, Cancer research.

Endothelial cell vehicles for delivery of cytotoxic genes as a gene therapy approach for carcinoma of the ovary.

D. Curiel, C. Rancourt, M. Wang, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapy.

D. Curiel, M. Wang, R. Alvarez, 1997, Gynecologic oncology.

Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins

Ann Marie O'Neill, D. Curiel, Erin E. Thacker, 2011, Cancer biology & therapy.

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism

D. Curiel, V. Krasnykh, J. Douglas, 1996, Journal of virology.

Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.

P. Fisher, K. Shah, P. Dent, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate system.

Sam C. Noureddini, D. Curiel, T. D. de Gruijl, 2005, Molecular pharmaceutics.

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.

D. Curiel, R. Desmond, A. Hemminki, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.

P. Fisher, P. Dent, A. Yacoub, 2010, Cytokine & growth factor reviews.

Derivation of a Triple Mosaic Adenovirus for Cancer Gene Therapy

D. Curiel, Hongju Wu, Q. Matthews, 2009, PloS one.

Targeting ofAdenovirus via Genetic Modification of the Viral Capsid Combined with aProteinBridge

D. Curiel, V. Krasnykh, G. Mikheeva, 2003, Journal of Virology.

Activation of Adenovirus Early Promoters and Lytic Phase in Differentiated Strata of Organotypic Cultures of Human Keratinocytes

T. R. Broker, C. Balagué, D. Curiel, 2003, Journal of Virology.

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

J. Minna, S. Piantadosi, D. Carbone, 1990, Oncogene.

The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv

D. Curiel, J. Grim, R. Alvarez, 1998, Journal of Molecular Medicine.

Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection

T. Curiel, D. Curiel, W. Zou, 2001, European journal of immunology.

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

Adenovirally mediated gene transfer of functional human tissue-type plasminogen activator to murine lungs.

D. Curiel, M. Olman, K. E. Rivera, 1998, American journal of respiratory cell and molecular biology.

Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene.

J. Contreras, D. Curiel, J. Thomas, 1999, Transplantation proceedings.

Chimeric viral vectors--the best of both worlds?

D. Curiel, M. Feng, P. Reynolds, 1999, Molecular medicine today.

Toward a new generation of conditionally replicating adenoviruses: pairing tumor selectivity with maximal oncolysis.

D. Curiel, F. Kruyt, 2002, Human gene therapy.

Addition of a short peptide ligand to the adenovirus fiber protein.

D. Curiel, J. Engler, S. I. Michael, 1995, Gene therapy.

Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice.

D. Curiel, H. Hsu, Pingar Yang, 2000, The Journal of clinical investigation.

Promotion of incisional wound repair by human mesenchymal stem cell transplantation

A. Rivera, D. Curiel, L. Chow, 2009, Experimental dermatology.

Targeted adenoviral vectors for cancer gene therapy.

D. Curiel, G. Bilbao, J. Gómez-Navarro, 1998, Advances in experimental medicine and biology.

Gene therapy: science fiction or reality?

D. Curiel, M. Preuss, 2007, Southern medical journal.

Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells

M. Halks-Miller, D. Curiel, M. Kashani-Sabet, 2000, Gene Therapy.

Evaluation of tissue‐specific promoters in carcinomas of the cervix uteri

D. Nettelbeck, D. Curiel, A. Hemminki, 2004, The journal of gene medicine.

Transcriptional targeting of tumors with a novel tumor-specific survivin promoter

B. Liu, D. Nettelbeck, A. Rivera, 2004, Cancer Gene Therapy.

Selectivity of TAG-72-targeted adenovirus gene transfer to primary ovarian carcinoma cells versus autologous mesothelial cells in vitro.

C. Miller, D. Curiel, M. Barnes, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Scavenger receptor A: a new route for adenovirus 5.

S. Gordon, A. Plüddemann, D. Curiel, 2009, Molecular pharmaceutics.

Cell cycle arrest and apoptosis induced by SART-1 gene transduction.

D. Curiel, H. Wakasugi, Y. Heike, 2005, Anticancer research.

Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system.

J. Contreras, D. Curiel, J. Mountz, 1999, Transplantation proceedings.

Viral Vectors for Cancer Gene Therapy

D. Curiel, J. Douglas, J. T. Douglas, 2005 .

Section Review Oncologic, Endocrine & Metabolic: Gene therapy for cancer therapeutics

D. Curiel, G. Bilbao, 1996 .

Cellular vehicles for cancer gene therapy: current status and future potential.

D. Curiel, L. Pereboeva, 2004, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.

Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human Dendritic Cells: Implications for Clinical Efficacy

D. Curiel, H. Wodrich, E. Kremer, 2007, Journal of Virology.

Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein.

M. Mondelli, D. Curiel, S. Dash, 2002, Journal of hepatology.

Genetically engineered intracellular single-chain antibodies in gene therapy

J. Contreras, D. Curiel, G. Bilbao, 2002, Molecular biotechnology.

Rhesus monocyte-derived dendritic cells modified to over-express TGF-&bgr;1 exhibit potent veto activity1

D. Curiel, C. Asiedu, S. Dong, 2002, Transplantation.

Special Section: Spirituality/Medicine Interface Project Gene Therapy: Science Fiction or Reality?

D. Curiel, M. Preuss, 2007 .

Intracellular expression of the anti-erbB-2 sFv N29 fails to accomplish efficient target modulation.

D. Curiel, J. Grim, R. Alvarez, 1998, Biochemical and biophysical research communications.

Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.

W. Vandertop, M. Lamfers, B. Geoerger, 2002, Cancer research.

Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies

R. Vernhout, A. Kleijn, M. Lamfers, 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

Convection enhanced delivery of the oncolytic adenovirus Delta24-RGD in patients with recurrent GBM: A phase I clinical trial including correlative studies

A. Kleijn, M. Lamfers, F. Lang, 2022 .

Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo versus in vitro models.

M. Lamfers, D. Curiel, Hongju Wu, 2007, Neuro-oncology.

The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma.

M. Lamfers, A. Rivera, D. Curiel, 2006, Journal of neurosurgery.

Oncolytic Virotherapy of Meningiomas in Vitro with Replication-competent Adenovirus

W. Vandertop, M. Lamfers, P. Sminia, 2005, Neurosurgery.

A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

M. Rots, J. Contreras, D. Curiel, 2004, Clinical Cancer Research.

EXPERIMENTAL STUDIES

W. Vandertop, M. Lamfers, P. Sminia, 2004 .

Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor

D. Curiel, W. Grizzle, Sanjay Kumar, 2005, Cancer Gene Therapy.

Targeted Vectors for Cancer Gene Therapy

D. Curiel, J. Gómez-Navarro, 2002 .

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Raymond D. Harris, D. Curiel, W. Grizzle, 2010, Clinical Cancer Research.

Adenoviral-mediated suicide gene therapy for ovarian cancer.

D. Curiel, Minghui Wang, M. Barnes, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents

M. Rots, J. Contreras, J. Mathis, 2006, Cancer Gene Therapy.

Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA

G. Giaccone, D. Curiel, F. Kruyt, 2004, Cancer Gene Therapy.

New generation adenoviral vectors improve gene transfer by coxsackie and adenoviral receptor-independent cell entry.

D. Curiel, P. Reynolds, 2002, Kidney international.

Efficient gene transfer to human endothelial cells using DNA complexed to adenovirus particles.

D. Curiel, P. Hu, C. Edgell, 1998, BioTechniques.

Trans complementation of an E1A-deleted adenovirus with codelivered E1A sequences to make recombinant adenoviral producer cells.

D. Curiel, J. Engler, K. Goldsmith, 1994, Human gene therapy.

Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor.

D. Curiel, P. Reynolds, T. Muramatsu, 2002, Journal of pediatric surgery.

Phase Ia Trial of a Polynucleotide Anti-Tumor Immunization to Human Carcinoembryonic Antigen in Patients with Metastatic Colorectal Cancer. University of Alabama at Birmingham, Birmingham, Alabama

D. Curiel, Principal Investigator Robert M. Conry, Co-Investigators Albert F. LoBuglio, 1996 .

Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma

D. Nettelbeck, D. Curiel, M. Yamamoto, 2003, Melanoma research.

Eradication of therapy-resistant human prostate tumors using a cancer terminator virus.

P. Fisher, P. Dent, D. Curiel, 2007, Cancer research.

Modified Adenoviruses for Gene Therapy

D. Curiel, A. Hemminki, J. Glasgow, 2003 .

A Genetically Retargeted Adenoviral Vector Enhances Viral Transduction in Esophageal Carcinoma Cell Lines and Primary Cultured Esophageal Resection Specimens

C. Buskens, P. Bosma, D. Curiel, 2003, Annals of surgery.

YB-1 Relocates to the Nucleus in Adenovirus-infected Cells and Facilitates Viral Replication by Inducing E2 Gene Expression through the E2 Late Promoter*

M. Dietel, D. Curiel, M. Dobbelstein, 2002, The Journal of Biological Chemistry.

A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene.

D. Curiel, K. Takayama, Minghui Wang, 2002, Molecular cancer therapeutics.

The Presence of the Adenovirus E 3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses 1

R. Alemany, D. Curiel, Kaori Suzuki, 2002 .

Second International Symposium On Genetic Anticancer Agents

B. Wollenberg, D. Curiel, H. Haisma, 2001, Cancer Gene Therapy.

An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma.

D. Curiel, J. Xiang, J. Gómez-Navarro, 2003, International journal of radiation oncology, biology, physics.

Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector.

T. Curiel, D. Curiel, T. D. de Gruijl, 1999, Journal of immunology.

CD40-Targeted Adenoviral Vector High-Efficiency Gene Transfer by a Maturation of Dendritic Cells Accompanies

T. Curiel, D. Curiel, H. Pinedo, 1999 .

Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids

D. Curiel, A. Hemminki, A. Kanerva, 2003, Cancer Gene Therapy.

Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors

D. Curiel, P. Reynolds, M. Everts, 2005, Gene Therapy.

Overexpression of adenovirus-encoded transgenes from the cytomegalovirus immediate early promoter in irradiated tumor cells.

D. Tang, D. Carbone, C. Chang, 1997, Human gene therapy.

Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo.

D. Nettelbeck, A. Rivera, D. Curiel, 2004, Virology.

Gene therapy for cancer.

D. Curiel, J. Gómez-Navarro, J. Douglas, 1999, European journal of cancer.

Derivation of a Myeloid Cell-Binding Adenovirus for Gene Therapy of Inflammation

D. Curiel, E. Abraham, S. Gerson, 2012, PloS one.

Tailoring vectors through DNA shuffling

D. Curiel, 2000, Nature Genetics.

Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob

D. Curiel, M. Asaka, S. Ohnami, 2007, Gene Therapy.

Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease

M. Heise, D. Curiel, I. Dmitriev, 2019, Front. Immunol..

Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor.

D. Curiel, N. Nishimoto, N. Yoshio-Hoshino, 2007, Cancer research.

Incorporation of Porcine Adenovirus 4 Fiber Protein Enhances Infectivity of Adenovirus Vector on Dendritic Cells: Implications for Immune-Mediated Cancer Therapy

D. Mutch, M. Colonna, D. Curiel, 2014, PloS one.

An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression.

D. Curiel, A. Hemminki, T. Chaudhuri, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Considerations and challenges for the achievement of targeted gene delivery

D. Curiel, 1999, Gene Therapy.

Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.

D. Curiel, M. Everts, Masato Yamamoto, 2009, Cancer research.

Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus

D. Curiel, S. Ponnazhagan, L. Pereboeva, 2007, Gene Therapy.

Ectodomain of Coxsackievirus and Adenovirus Receptor Genetically Fused to Epidermal Growth Factor Mediates Adenovirus Targeting to Epidermal Growth Factor Receptor-Positive Cells

D. Curiel, I. Dmitriev, V. Krasnykh, 2000, Journal of Virology.

A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: the safety profile of ad5/3-Δ24 in advance of a phase I clinical trial in ovarian cancer patients.

Raymond D. Harris, T. Rudge, D. Curiel, 2011, Human gene therapy.

Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule.

B. Liu, R. Alemany, D. Curiel, 2001, Cancer research.

Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.

D. Curiel, J. Bergelson, V. Krasnykh, 2001, Cancer research.

Rhabdomyosarcoma Cells Limits Adenovirus Gene Transfer and Oncolysis for Human Expression of the Coxsackievirus-Adenovirus Receptor That Fiber Knob Modifications Overcome Low , Heterogeneous Updated

D. Curiel, J. Bergelson, V. Krasnykh, 2001 .

Advances in Brief Targeting Oncolytic Adenoviral Agents to the Epidermal Growth Factor Pathway with a Secretory Fusion Molecule 1

B. Liu, R. Alemany, D. Curiel, 2001 .

Safety and Immunogenicity of a DNA Vaccine Encoding Carcinoembryonic Antigen and Hepatitis B Surface Antigen in Colorectal Carcinoma Patients 1

D. Curiel, A. Lobuglio, T. Strong, 2002 .

Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector

D. Curiel, I. Dmitriev, P. Reynolds, 1999, Gene Therapy.

A new targeting approach for breast cancer gene therapy using the heparanase promoter.

D. Curiel, P. Reynolds, T. Schöndorf, 2006, Cancer letters.

Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system

J. Mathis, A. Rivera, D. Curiel, 2005, Cancer biology & therapy.

Molecular conjugate-mediated gene transfer in renal transplantation.

J. Thompson, D. Curiel, A. Diethelm, 1996, Transplantation proceedings.

Molecular conjugate-mediated gene transfer into isolated human kidneys.

J. Thompson, D. Curiel, A. Diethelm, 1996, Transplantation.

Mutations in dominant and recessive oncogenes, and the expression of opioid and nicotine receptors in the pathogenesis of lung cancer

S. Steinberg, J. Minna, A. Gazdar, 1991 .

A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens

D. Curiel, Monica Cabrera-Mora, A. Moreno, 2016, The Journal of Immunology.

Chapter two--Adenovirus strategies for tissue-specific targeting.

D. Curiel, M. Beatty, 2012, Advances in cancer research.

Polynucleotide-mediated immunization therapy of cancer.

D. Curiel, A. Lobuglio, R. Conry, 1996, Seminars in oncology.

Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody.

D. Curiel, J. Grim, R. Alvarez, 1995, Gynecologic oncology.

Selected strategies to augment polynucleotide immunization.

D. Curiel, N. Yang, G. Widera, 1996, Gene therapy.

Targeted gene therapy for ovarian cancer.

D. Curiel, R. Alvarez, R. Rocconi, 2005, Current gene therapy.

Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern.

R. Crystal, D. Curiel, M. Brantly, 1990, American journal of human genetics.

Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562

M. Hagiwara, K. Kasono, D. Curiel, 2000, Cancer Gene Therapy.

A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology

D. Curiel, L. Aulisa, Ernst Wagner, 2022, Viruses.

Targeting Tumor Neoangiogenesis via Targeted Adenoviral Vector to Achieve Effective Cancer Gene Therapy for Disseminated Neoplastic Disease

D. Curiel, I. Dmitriev, E. Kashentseva, 2020, Molecular Cancer Therapeutics.

Monitoring of biodistribution and persistence of conditionally replicative adenovirus in a murine model of ovarian cancer using capsid-incorporated mCherry and expression of human somatostatin receptor subtype 2 gene.

S. Achilefu, D. Curiel, R. Alvarez, 2014, Molecular imaging.

Retargeting of gene expression using endothelium specific hexon modified adenoviral vector.

J. Arbeit, D. Curiel, W. Grizzle, 2013, Virology.

Substitution of Adenovirus Serotype 3 Hexon onto a Serotype 5 Oncolytic Adenovirus Reduces Factor X Binding, Decreases Liver Tropism, and Improves Antitumor Efficacy

J. Mathis, A. Rivera, D. Curiel, 2010, Molecular Cancer Therapeutics.

Genetic Targeting of an Adenovirus Vector via Replacement of the Fiber Protein with the Phage T4 Fibritin

D. Curiel, V. Krasnykh, G. Mikheeva, 2001, Journal of Virology.

Targeted adenoviral vectors for cancer gene therapy (Review).

D. Curiel, J. Douglas, 1997, International journal of oncology.

Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors.

D. Curiel, M. Kim, L. A. Sumerel, 2001, Cancer research.

Combined cytosine deaminase expression, 5-fluorocytoiine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells

M. Mayo, D. Curiel, S. Vickers, 1998, Journal of Gastrointestinal Surgery.

Strategies to enhance transductional efficiency of adenoviral‐based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds

A. Rivera, D. Curiel, L. Le, 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder

J. Lupski, W. Dobyns, D. Curiel, 2022, American journal of human genetics.

Structure and uncoating of immature adenovirus Running title: Structure of immature adenovirus

S. J. Flint, S. Scheres, D. Curiel, 2009 .

H1 histone and nucleosome repeat length alterations associated with the in vitro differentiation of murine embryonal carcinoma cells to extra-embryonic endoderm.

E. Linney, D. Curiel, R. Oshima, 1980, Journal of supramolecular structure.

Engineering regulatory elements for conditionally-replicative adeno-viruses.

D. Curiel, Y. Haviv, 2003, Current gene therapy.

Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus.

D. Curiel, H. Li, Y. Haviv, 2001, Cancer research.

Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor

D. Curiel, M. Beatty, 2013, Cancer Gene Therapy.

Towards Gene Therapy of Postoperative Adhesions: Fiber and Transcriptional Modifications Enhance Adenovirus Targeting towards Human Adhesion Cells

D. Curiel, G. Saed, M. Diamond, 2013, Gynecologic and Obstetric Investigation.

Adenovirus type 5 fiber knob binds to MHC class I α2 domain at the surface of human epithelial and B lymphoblastoid cells

D. Curiel, L. Karayan, J. Tournier, 1997, The EMBO journal.

Efficient transfection of primary cells in a canine hemophilia B model using adenovirus-polylysine-DNA complexes.

D. Curiel, P. Hu, K. High, 1994, Human gene therapy.

Long‐term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9

David T. Curiel, Wayne M. Yokoyama, D. Curiel, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Adeno-associated virus for cancer gene therapy.

D. Curiel, R. Alvarez, G. Siegal, 2001, Cancer research.

Adeno-associated Virus for Cancer Gene Therapy 1

D. Curiel, R. Alvarez, G. Siegal, 2001 .

Journal of Ovarian Research reviewer acknowledgement 2015

D. Curiel, B. Tsang, S. Kakar, 2016, Journal of Ovarian Research.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

D. Fremont, M. Diamond, H. Feldmann, 2021, bioRxiv.

Productive Replication of Human Adenovirus Type 5 in Canine Cells

D. Curiel, G. Siegal, L. Le, 2005, Journal of Virology.

Corneal avascularity is due to soluble VEGF receptor-1

J. Martin Collinson, Eiji Sakurai, Tushar Suthar, 2006, Nature.

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

D. Curiel, P. Boucher, Reka Lorincz, 2021, NPJ vaccines.

IN VIVO QUANTITATIVE NON-INVASIVE BIOLUMINESCENCE IMAGING OF INTRAHEPATIC TRANSPLANTED ISLETS.

J. Contreras, D. Curiel, D. Eckhoff, 2004 .

Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling.

D. Curiel, Masato Yamamoto, I. Dmitriev, 2006, Journal of the National Cancer Institute.

Oncolytic adenoviruses – selective retargeting to tumor cells

J. Mathis, D. Curiel, M. Stoff-Khalili, 2005, Oncogene.

Structure and uncoating of immature adenovirus.

Roberto Marabini, Sjors H W Scheres, S. J. Flint, 2009, Journal of molecular biology.

Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses

D. Curiel, L. Pereboeva, S. Komarova, 2006, Molecular Cancer Therapeutics.

Gene therapy for carcinoma of the breast

D. Curiel, P. Dall, M. Stoff-Khalili, 2006, Cancer Gene Therapy.

Gene therapy for ovarian cancer: progress and potential.

D. Curiel, R. Alvarez, T. Kirby, 2003, Hematology/oncology clinics of North America.

Cellular Vehicles for Cancer Gene Therapy

D. Curiel, L. Pereboeva, 2012, BioDrugs.

Gene therapy in the treatment of human cancer

P. Fisher, P. Dent, D. Curiel, 2017 .

Gene therapy strategies for carcinoma of the breast

D. Curiel, J. Ruppert, G. Bilbao, 1997, Breast Cancer Research and Treatment.

University of Groningen Ovarian cancer gene therapy

D. Curiel, R. Alvarez, H. Haisma, 2017 .

Ovarian cancer gene therapy strategies

Manjula., D. Curiel, Kataram, 2005 .

Gene therapy for cancer.

D. Curiel, J. Gómez-Navarro, J. Douglas, 1999, European journal of cancer.

Advances in cancer gene therapy

J. Contreras, D. Curiel, G. Bilbao, 1999 .

Gene therapy for cancer.

D. Curiel, J. Gómez-Navarro, J. Douglas, 1999, European journal of cancer.

The era of gene therapy: from preclinical development to clinical application.

D. Curiel, C. Berkland, N. Alhakamy, 2021, Drug discovery today.

Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.

Paul Dent, P. Fisher, P. Dent, 2009, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Adenovirus a pouvoir infectant renforce et a replication conditionnelle, et applications de celui-ci

R. Alemany, D. Curiel, I. Dmitriev, 2000 .

A Genetically Modified Adenoviral Vector with a Phage Display-Derived Peptide Incorporated into Fiber Fibritin Chimera Prolongs Survival in Experimental Glioma.

Atique U. Ahmed, Jacob S. Young, D. Curiel, 2015, Human gene therapy.

Selective Transduction of Mature DC in Human Skin and Lymph Nodes by CD80/CD86-targeted Fiber-modified Adenovirus-5/3

D. Curiel, T. D. de Gruijl, M. Everts, 2009, Journal of immunotherapy.

Correction to: “Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment”

John D. Roberts, P. Fisher, P. Dent, 2016, Molecular Pharmacology.

Oligonucleotide Uptake and Delivery in Tissue Culture Cells

D. Curiel, Donald M Miller, N. Vigneswaran, 1999 .

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

K. Zatloukal, M. Cotten, D. Curiel, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

K Zatloukal, K Mechtler, K. Zatloukal, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

M. Cotten, D. Curiel, E. Wagner, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Gene therapy for radioprotection

D. Curiel, W. Everett, David T. Curiel, 2015, Cancer Gene Therapy.

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Lisa E. Gralinski, Shamus P. Keeler, D. Fremont, 2020, Cell.

Conditional gene targeting for cancer gene therapy.

D. Curiel, Y. Haviv, 2001, Advanced drug delivery reviews.

Efficient delivery of triplex forming oligonucleotides to tumor cells by adenovirus-polylysine complexes.

C. Miller, D. Curiel, N. Vigneswaran, 1996, Gene therapy.

A Novel CDC25B Promoter–Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models

O. Podhajcer, D. Curiel, M. Gidekel, 2015, Clinical Cancer Research.

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

PI3K: a rational target for ovarian cancer therapy?

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

C. James, D. Curiel, C. Horbinski, 2020, bioRxiv.

Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma

D. Curiel, G. Siegal, Bruce F. Smith, 2006, Laboratory Investigation.

Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

C. James, D. Curiel, C. Horbinski, 2020, Clinical Cancer Research.

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB.

C. Ferran, F. Bach, D. Curiel, 1999, The Journal of clinical investigation.

A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer.

Raymond D. Harris, Karan P. Singh, D. Curiel, 2013, Gynecologic oncology.

Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer

D. Curiel, P. Goedegebuure, R. González-Pastor, 2020, Cancer Gene Therapy.

The NIH Somatic Cell Genome Editing program

David R. Liu, Benjamin S. Freedman, Daniel G. Anderson, 2021, Nature.

Resistance/Signaling Pathways

P. Fisher, P. Dent, D. Curiel, 2007 .

Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy.

D. Curiel, C. Rancourt, M. Wang, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Composition et methodes d'obtention de cellules productrices de virus de recombinaison isogeniques

D. Curiel, R. Garver, 1995 .

Gene therapy approaches for inherited and acquired lung diseases.

D. Curiel, J. Pilewski, S. Albelda, 1996, American journal of respiratory cell and molecular biology.

Antigen Targeting to Dendritic Cells for Cancer Immunotherapy

D. Curiel, T. D. Gruijl, D. Oosterhoff, 2013 .

An Insertion Mutation Rendering the al -Antitrypsin Gene Incapable of Producing al -Antitrypsin

R. Crystal, D. Curiel, M. Brantly, 1989 .

A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice.

O. Podhajcer, A. Rivera, D. Curiel, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Radiation-induced cell signaling: inside-out and outside-in

P. Fisher, P. Dent, K. Valerie, 2007, Molecular Cancer Therapeutics.

Contemporary Cancer Research

W. Grody, D. Curiel, R. Nagle, 2005 .

Nonhuman primate models in type 1 diabetes research.

J. Contreras, D. Curiel, D. Eckhoff, 2004, ILAR journal.

Substitution of the adenovirus serotype 5 knob with a serotype 3 knob enhances multiple steps in virus replication.

D. Curiel, V. Krasnykh, J. Blackwell, 2003, Cancer research.

Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells.

D. Curiel, M. Carpenter, D. Buchsbaum, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Interleukin‐6 induces both cell growth and VEGF production in malignant mesotheliomas

D. Curiel, K. Takayama, N. Nishimoto, 2006, International journal of cancer.

Procedes et composition de creation de cellules syngeniques productrices de virus recombines

D. Curiel, R. Garver, 1996 .

Improved anti-tumor therapy based upon infectivity-enhanced adenoviral delivery of RNA interference in ovarian carcinoma cell lines.

A. Rivera, D. Curiel, Minghui Wang, 2008, Gynecologic oncology.

Targeted combinatorial therapy of non‐small cell lung carcinoma using a GST‐fusion protein of full‐length or truncated MDA‐7/IL‐24 with Tarceva

P. Fisher, J. Settleman, P. Dent, 2008, Journal of cellular physiology.

Administration of a conditionally replicative oncolytic canine adenovirus in normal dogs.

H. J. Baker, D. Curiel, G. Siegal, 2006, Cancer biotherapy & radiopharmaceuticals.

Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells

D. Curiel, M. Yamamoto, T. Kishimoto, 2006, Cancer Gene Therapy.

Transduction of Brain Dopamine Neurons by Adenoviral Vectors Is Modulated by CAR Expression: Rationale for Tropism Modified Vectors in PD Gene Therapy

D. Standaert, D. Curiel, J. Glasgow, 2010, PloS one.

Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid

R. Ruigrok, D. Curiel, G. Schoehn, 2008, Journal of Virology.

Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer.

C. Miller, M. Mayo, D. Raben, 1998, Cancer Research.

Evolving gene therapy approaches for osteosarcoma using viral vectors: review.

M. Lamfers, D. Curiel, G. Siegal, 2007, Bone.

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer

D. Curiel, I. Dmitriev, A. El-Shemi, 2016, Journal of Ovarian Research.

Adenoviral vectors for in vivo delivery of CRISPR-Cas gene editors.

D. Curiel, X. Cui, Paul Boucher, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Cell vehicle targeting strategies

D. Curiel, L. Pereboeva, Justin C. Roth, 2008, Gene Therapy.

Rational design of viral vectors based on rigorous analysis of capsid structures.

D. Curiel, D T Curiel, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

An adenovirus serotype 5 vector with fibers derived from ovine atadenovirus demonstrates CAR-independent tropism and unique biodistribution in mice.

D. Curiel, Masaharu Nakayama, Boglárka Banizs, 2006, Virology.

Transductional targeting of adenovirus vectors for gene therapy

D. Curiel, M. Everts, J. Glasgow, 2006, Cancer Gene Therapy.

Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas.

D. Curiel, A. Al-Hendy, V. Rajaratnam, 2013, Human reproduction.

Capsid-Incorporation Strategy To Display Antigens for an Alternative Adenoviral Vector Vaccine Approach.

D. Curiel, A. Moreno, Claudia A J van Winkel, 2018, Molecular pharmaceutics.

Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor.

D. Curiel, Minghui Wang, H. Ugai, 2007, Journal of molecular biology.

Targeting Mesothelioma Using an Infectivity Enhanced Survivin-Conditionally Replicative Adenoviruses

D. Curiel, P. Reynolds, K. Takayama, 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Complementation of a human adenovirus early region 4 deletion mutant in 293 cells using adenovirus-polylysine-DNA complexes.

M. Kay, D. Curiel, A. Scaria, 1995, Gene therapy.

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.

P. Fisher, John Calvin Reed, P. Dent, 2010, Cancer research.

Transcriptional targeting for ovarian cancer gene therapy.

D. Nettelbeck, D. Curiel, A. Hemminki, 2001, Gynecologic oncology.

REVIEW Transcriptional Targeting for Ovarian Cancer Gene Therapy

D. Nettelbeck, D. Curiel, A. Hemminki, 2001 .

Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma

J. Mathis, A. Rivera, D. Curiel, 2007, Breast Cancer Research and Treatment.

Gene therapy for meningioma: improved gene delivery with targeted adenoviruses.

W. Vandertop, M. Lamfers, J. Grill, 2002, Journal of neurosurgery.

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate.

K., Andrew, L. Soroceanu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging.

D. Curiel, P. Reynolds, M. Wang, 2001, Cancer research.

Targeted gene transfer to human hematopoietic progenitor cell lines through the c-kit receptor.

D. Curiel, J. Keller, P. Schwarzenberger, 1996, Blood.

Evaluation of tumor-specific promoter activities in melanoma

D. Nettelbeck, A. Rivera, D. Curiel, 2005, Gene Therapy.

A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect.

D. Curiel, A. Starzinski-Powitz, M. Wang, 2010, Human reproduction.

Oncolytic adenoviruses targeted to cancer stem cells

D. Curiel, J. Short, 2009, Molecular Cancer Therapeutics.

Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene

J. Contreras, D. Curiel, G. Bilbao, 1999, Journal of Virology.

Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinoma.

D. Nettelbeck, D. Curiel, D. Nettelbeck, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

D. Fremont, M. Diamond, H. Feldmann, 2021, Cell Reports Medicine.

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

T. Curiel, Lieping Chen, D. Curiel, 2003, Nature Medicine.

Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway.

D. Curiel, S. I. Michael, 1994, Gene therapy.

Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity.

D. Curiel, W. Grizzle, M. Wang, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC).

P. Fisher, D. Curiel, I. Dmitriev, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus

D. Curiel, H. Hsu, J. Mountz, 2001, Gene Therapy.

Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene.

E. Jaffee, D. Raben, D. Curiel, 1997, Annals of surgery.

Targeted adenovirus vectors

D. Curiel, 2004 .

Synthetic Biology Approaches for Engineering Next-Generation Adenoviral Gene Therapies.

D. Curiel, L. Collins, 2021, ACS nano.

Ionizing radiation enhances adenoviral vector expressing mda‐7/IL‐24‐mediated apoptosis in human ovarian cancer

P. Fisher, P. Dent, D. Curiel, 2006, Journal of cellular physiology.

Enhanced Prostate Cancer Gene Transfer and Therapy Using a Novel Serotype Chimera Cancer Terminator Virus (Ad.5/3‐CTV)

P. Fisher, John Calvin Reed, P. Dent, 2013, Journal of cellular physiology.

An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites.

D. Curiel, J. Xiang, A. Hemminki, 2001, Gynecologic oncology.

Genetic Incorporation of Human Metallothionein into the Adenovirus Protein IX for Non-Invasive SPECT Imaging

J. Mathis, D. Curiel, Y. Odaka, 2011, PloS one.

Noninvasive Monitoring of mRFP1- and mCherry-Labeled Oncolytic Adenoviruses in an Orthotopic Breast Cancer Model by Spectral Imaging

D. Curiel, L. McNally, A. Borovjagin, 2010, Molecular imaging.

Evaluation of adenovirus capsid labeling versus transgene expression

D. Curiel, Minghui Wang, Q. Matthews, 2010, Virology Journal.

Novel Infectivity-Enhanced Oncolytic Adenovirus with a Capsid-Incorporated Dual-Imaging Moiety for Monitoring Virotherapy in Ovarian Cancer

A. Rivera, D. Curiel, R. Alvarez, 2009, Molecular imaging.

Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach

A. Rivera, D. Curiel, H. Hsu, 2008, Virology Journal.

Genetic Incorporation of a Herpes Simplex Virus Type 1 Thymidine Kinase and Firefly Luciferase Fusion into the Adenovirus Protein IX for Functional Display on the Virion

J. Mathis, D. Curiel, Hongju Wu, 2006, Molecular imaging.

Targeted and shielded adenovectors for cancer therapy

D. Curiel, Jian Chen, J. Mountz, 2006, Cancer Immunology, Immunotherapy.

Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation

D. Curiel, Hongju Wu, I. Dmitriev, 2005, Journal of Virology.

Fluorescently labeled adenovirus with pIX-EGFP for vector detection.

D. Curiel, M. Everts, Masato Yamamoto, 2004, Molecular imaging.

Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon

D. Curiel, Hongju Wu, Minghui Wang, 2002, Journal of Virology.

Human Papillomavirus E6E7-Mediated Adenovirus Cell Killing: Selectivity of Mutant Adenovirus Replication in Organotypic Cultures of Human Keratinocytes

C. Balagué, R. Alemany, D. Curiel, 2001, Journal of Virology.

Replicative adenoviruses for cancer therapy

C. Balagué, R. Alemany, D. Curiel, 2000, Nature Biotechnology.

Reovirus sigma1 fiber incorporated into adenovirus serotype 5 enhances infectivity via a CAR-independent pathway.

D. Curiel, C. Luongo, L. Pereboeva, 2005, Biochemical and biophysical research communications.

An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism.

D. Curiel, A. Hemminki, G. Siegal, 2004, Virology.

Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor

D. Curiel, Minghui Wang, R. Alvarez, 2004, Clinical Cancer Research.

Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus.

B. Liu, D. Curiel, A. Hemminki, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Mucopolysaccharidoses type I gene therapy

D. Curiel, P. Dickson, Sarah Hurt, 2021, Journal of Inherited Metabolic Disease.

Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9

David T. Curiel, D. Curiel, Lyudmila Kaliberova, 2018, Gene Therapy.

CryoEM Visualization of an Adenovirus Capsid-Incorporated HIV Antigen

P. Stewart, D. Curiel, I. Dmitriev, 2012, PloS one.

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy

D. Brough, D. Fremont, M. Diamond, 2019, Cell reports.

Species D Human Adenovirus Type 9 Exhibits Better Virus-Spread Ability for Antitumor Efficacy among Alternative Serotypes

D. Curiel, J. Uchino, H. Ugai, 2014, PloS one.

Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas

Jennifer A. Clark, P. Fisher, N. Turro, 2007, Proceedings of the National Academy of Sciences.

In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer

L. Soroceanu, D. Curiel, G. Bilbao, 1997, Nature Biotechnology.

Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan

M. Kuroki, D. Curiel, Y. Nakanishi, 2008, Cancer Gene Therapy.

Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer

A. Dietz, D. Mutch, D. Curiel, 2017, PloS one.

Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds

J. Mathis, A. Rivera, D. Curiel, 2007, Journal of Molecular Medicine.

Infectivity enhanced, hTERT promoter-based conditionally replicative adenoviruses are useful for SCLC treatment

D. Curiel, Y. Nakanishi, K. Takayama, 2005, Cancer Gene Therapy.

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells

P. Fisher, P. Dent, A. Yacoub, 2004, Cancer biology & therapy.

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

D. Fremont, M. Diamond, G. Alter, 2021, bioRxiv.

Transport across a polarized monolayer of Caco-2 cells by transferrin receptor-mediated adenovirus transcytosis.

A. Rivera, D. Curiel, Minghui Wang, 2004, Virology.

Discovery stitution of Adenovirus Serotype 3 Hexon onto a Serotype ncolytic Adenovirus Reduces Factor X Binding , Decreases Ther r Tropism , and Improves Antitumor Efficacy

A. Rivera, D. Curiel, Hongju Wu, 2010 .

Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma

J. Grill, D. Curiel, H. Haisma, 2002, The journal of gene medicine.

Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human Somatostatin Receptor Subtype 2 Gene

S. Achilefu, D. Curiel, R. Alvarez, 2014, Molecular imaging.

mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.

P. Fisher, P. Dent, S. Grant, 2006, Pharmacology & therapeutics.

Receptor-Mediated Gene Delivery Employing Adenovirus-Polylysine-DNA Complexes

D. Curiel, 1994 .

Serum and ascites neutralizing antibodies in ovarian cancer patients treated with intraperitoneal adenoviral gene therapy.

D. Curiel, R. Desmond, A. Hemminki, 2002, Human gene therapy.

In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.

B. Liu, D. Curiel, R. Desmond, 2002, Journal of the National Cancer Institute.

Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells.

D. Nettelbeck, D. Curiel, R. Desmond, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Delta-24 Increases the Expression and Activity of Topoisomerase I and Enhances the Antiglioma Effect of Irinotecan

W. Yung, F. McCormick, F. Lang, 2006, Clinical Cancer Research.

An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles.

Mark H Ellisman, Vaibhav Saini, Guy Perkins, 2008, Small.

dendritic cell migration A role for multidrug resistance protein 4 (MRP4; ABCC4) in human

D. Curiel, J. Gillet, G. Scheffer, 2013 .

A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.

D. Curiel, T. D. de Gruijl, G. Jansen, 2008, Blood.

Cloning and characterization of an α1-antitrypsin like gene 12 kb downstream of the genuine α1-antitrypsin gene

R. Crystal, D. Curiel, R. Frants, 1988 .

A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice.

D. Curiel, A. Moreno, I. Dmitriev, 2017, Vaccine.

Development of an adenovirus vector vaccine platform for targeting dendritic cells

J. Arbeit, T. Fleming, W. Gillanders, 2017, Cancer Gene Therapy.

Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control

J. Mathis, A. Rivera, D. Curiel, 2008, Breast Cancer Research and Treatment.

Minting a new class of Polo-like-kinase inhibitors

P. Fisher, P. Dent, S. Grant, 2009, Cancer biology & therapy.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

Lisa E. Gralinski, Shamus P. Keeler, D. Fremont, 2020, bioRxiv.

Transcription Initiation Activity of Adenovirus Left-End Sequence in Adenovirus Vectors with E1 Deleted

R. Alemany, D. Curiel, K. Takayama, 2003, Journal of Virology.

A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism.

M. Rots, D. Curiel, P. Reynolds, 2003, Virology.

mda-7/IL-24, A Novel Cancer Selective Apoptosis Inducing Cytokine Gene: From the Laboratory into the Clinic

Paul Dent, Elizabeth A Grimm, P. Fisher, 2003, Cancer biology & therapy.

Toward gene therapy of uterine fibroids: targeting modified adenovirus to human leiomyoma cells.

D. Curiel, F. Hamada, A. Al-Hendy, 2008, Human reproduction.

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

D. Curiel, T. D. de Gruijl, I. Dmitriev, 2018, Vaccines.

A Multi Targeting Conditionally Replicating Adenovirus Displays Enhanced Oncolysis while Maintaining Expression of Immunotherapeutic Agents

D. Curiel, H. Ugai, G. Gillespie, 2015, PloS one.

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

D. Curiel, R. Desmond, A. Hemminki, 2004, International journal of cancer.

Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway.

G. Fuller, T. Liu, W. Yung, 2003, Journal of the National Cancer Institute.

Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

The development of MDA-7/IL-24 as a cancer therapeutic.

P. Fisher, P. Dent, A. Yacoub, 2010, Pharmacology & therapeutics.

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer biology & therapy.

Cisplatin Enhances Protein Kinase R-Like Endoplasmic Reticulum Kinase- and CD95-Dependent Melanoma Differentiation-Associated Gene-7/Interleukin-24–Induced Killing in Ovarian Carcinoma Cells

P. Fisher, P. Dent, A. Yacoub, 2010, Molecular Pharmacology.

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

P. Fisher, S. Spiegel, P. Dent, 2009, Molecular Cancer Therapeutics.

Cisplatin enhances PERK- and CD95-dependent MDA-7/IL-24-induced killing in ovarian carcinoma cells

P. Fisher, P. Dent, A. Yacoub, 2009 .

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.

P. Fisher, N. Senzer, J. Nemunaitis, 2007, Toxicology and applied pharmacology.

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

S. Inoue, P. Fisher, R. Ramesh, 2007, International journal of oncology.

The potential of virus-based gene therapies for treatment of metastatic kidney cancer

P. Fisher, P. Dent, D. Curiel, 2011, Expert review of anticancer therapy.

Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors.

D. Curiel, S. Naito, A. Hemminki, 2002, Cancer research.

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)

P. Fisher, P. Dent, D. Curiel, 2011, Autophagy.

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

Z. Su, P. Fisher, P. Dent, 2010, Cancer Gene Therapy.

Characterization of infectivity of knob-modified adenoviral vectors in glioma

P. Fisher, M. Lamfers, P. Dent, 2008, Cancer biology & therapy.

A cancer terminator virus eradicates both primary and distant human melanomas

Z. Su, P. Fisher, P. Dent, 2008, Cancer Gene Therapy.

Searching for a cure: Gene therapy for glioblastoma

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

P. Fisher, S. Spiegel, P. Dent, 2008, Molecular Pharmacology.

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

O. Podhajcer, D. Curiel, I. Dmitriev, 2019, Journal of Ovarian Research.

Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells

P. Fisher, P. Dent, D. Curiel, 2010, The Prostate.

Applications of viruses for cancer therapy

P. Fisher, D. Curiel, 2012 .

Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

R. Kratzke, D. Curiel, J. Rubins, 2000, Cancer Gene Therapy.

Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo

D. Curiel, P. Reynolds, W. Grizzle, 2001, Nature Biotechnology.

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs

D. Curiel, D. Buchsbaum, W. Arafat, 2017, Clinical and Translational Medicine.

In vivo gene transfer to the human biliary tract.

J. Thompson, D. Curiel, S. Vickers, 1996, Gene therapy.

A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo.

D. Curiel, P. Reynolds, W. Grizzle, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

SEREX analysis for tumor antigen identification in a mouse model of adenocarcinoma

T. Hampton, D. Curiel, A. Lobuglio, 2000, Cancer Gene Therapy.

Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.

S. Baldus, D. Curiel, G. Bauerschmitz, 2011, Gynecologic oncology.

Advancements in adenoviral based virotherapy for ovarian cancer.

D. Curiel, R. Alvarez, K. Matthews, 2009, Advanced drug delivery reviews.

Development of an optimized conditionally replicative adenoviral agent for ovarian cancer.

P. Fisher, D. Curiel, Hongju Wu, 1992, International journal of oncology.

Identifying the safety profile of a novel infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-RGD, in anticipation of a phase I trial for recurrent ovarian cancer.

Raymond D. Harris, D. Curiel, Minghui Wang, 2007, American journal of obstetrics and gynecology.

Targeting lung cancer using an infectivity enhanced CXCR4-CRAd.

R. Cerfolio, A. Rivera, D. Curiel, 2007, Lung cancer.

Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses for pan-carcinoma application

D. Curiel, P. Reynolds, Y. Nakanishi, 2007, Cancer Gene Therapy.

Replicating Viruses for Brain Tumor Treatment

W. Yung, F. Lang, D. Curiel, 2006 .

Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based upon CAR-Independent Tropism

P. Stewart, J. Mathis, D. Curiel, 2006, Clinical Cancer Research.

A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.

D. Nettelbeck, D. Curiel, A. Hemminki, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypic cultures.

D. Nettelbeck, A. Rivera, D. Curiel, 2004, Molecular cancer therapeutics.

Intracellular Antibody-Mediated Knockout of the ErbB-2 Oncoprotein as a Cancer Gene Therapy Approach

D. Curiel, 1998 .

Targeted tumor cytotoxicity mediated by intracellular single-chain anti-oncogene antibodies.

D. Curiel, 1997, Advances in pharmacology.

Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor

D. Curiel, L. Pereboeva, S. Komarova, 2010, Journal of ovarian research.

Researchof mesenchymal stem cells to ovarian tumors via an artificial receptor

D. Curiel, R. Alvarez, L. Pereboeva, 2010 .

Localization of the N-terminus of minor coat protein IIIa in the adenovirus capsid.

Roberto Marabini, D. Curiel, R. Marabini, 2008, Journal of molecular biology.

Fiber-mosaic adenovirus as a novel approach to design genetically modified adenoviral vectors.

D. Curiel, P. Mahasreshti, L. Pereboeva, 2004, Virus research.

HSV-1 virions engineered for specific binding to cell surface receptors.

P. Grandi, X. Breakefield, D. Curiel, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism

D. Nettelbeck, A. Rivera, D. Curiel, 2003, Cancer biology & therapy.

Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob

M. Rots, D. Curiel, I. Dmitriev, 2003, Cancer Gene Therapy.

The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells.

David T. Curiel, Joanne T. Douglas, Myunghee Kim, 2002, European journal of cancer.

Phage Display of Adenovirus Type 5 Fiber Knob as a Tool for Specific Ligand Selection and Validation

D. Curiel, L. Pereboeva, A. Pereboev, 2001, Journal of Virology.

Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.

G F Pierce, G P Siegal, D. Curiel, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Targeting adenoviral infection with basic fibroblast growth factor enhances gene delivery to vascular endothelial and smooth muscle cells

C. Miller, D. Curiel, P. Reynolds, 1998 .

Targeted Adenoviral Vector Demonstrates Enhanced Efficacy for In Vivo Gene Therapy of Uterine Leiomyoma

D. Curiel, M. Diamond, A. Al-Hendy, 2016, Reproductive Sciences.

Chapter 8 Selective transduction of mature DC in human skin and lymph nodes by CD 80 / CD 86-targeted fiber-modified Adenovirus-5 / 3

Scheper, D. Curiel, T. D. Gruijl, 2011 .

A P Rep Gyn

Raymond D. Harris, D. Curiel, W. Grizzle, 2010 .

Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX.

D. Curiel, Hongju Wu, Q. Matthews, 2008, Virology.

Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model.

K. Bland, T. Thompson, D. Curiel, 2008, American journal of surgery.

Fiber-modified adenoviruses for targeted gene therapy.

D. Curiel, Hongju Wu, 2008, Methods in molecular biology.

Enhanced Gene Delivery to Human Primary Endothelial Cells Using Tropism-Modified Adenovirus Vectors.

D. Curiel, M. Everts, Hongju Wu, 2008, The open gene therapy journal.

Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neck.

E. Rosenthal, J. Mathis, A. Rivera, 2007, International journal of oncology.

Targeting adenovirus to CD80 and CD86 receptors increases gene transfer efficiency to malignant glioma cells.

A. Rivera, D. Curiel, I. Ulasov, 2007, Journal of neurosurgery.

Treatment of ovarian cancer with a novel dual targeted conditionally replicative adenovirus (CRAd).

A. Rivera, D. Curiel, Minghui Wang, 2007, Gynecologic oncology.

Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer

A. Rivera, D. Curiel, D. Eckhoff, 2007, International journal of cancer.

Tumor Targeting-Retargeted Adenovirus

D. Curiel, Masato Yamamoto, 2007 .

Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo.

A. Rivera, D. Curiel, Minghui Wang, 2005, International journal of oncology.

PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles

K. Berg, D. Curiel, G. Mælandsmo, 2005, Cancer Gene Therapy.

Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery.

B. Liu, D. Curiel, A. Hemminki, 2005, Gynecologic oncology.

A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types

M. Rots, D. Curiel, I. Dmitriev, 2004 .

Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cells.

D. Curiel, B. Tillman, Bryan W. Tillman, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

The development of conditionally replicative adenoviruses for cancer therapy.

D. Curiel, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector.

K. Kasono, D. Curiel, I. Dmitriev, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

A phase I study of recombinant adenovirus vector-mediated delivery of an anti-erbB-2 single-chain (sFv) antibody gene for previously treated ovarian and extraovarian cancer patients.

D. Curiel, R. Alvarez, 1997, Human gene therapy.

A Strategy for Adenovirus Vector Targeting with a Secreted Single Chain Antibody

D. Curiel, V. Krasnykh, G. Mikheeva, 2009, PloS one.

Generation and selection of targeted adenoviruses embodying optimized vector properties.

Sam C. Noureddini, D. Curiel, J. Douglas, 2006, Virus research.

Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy.

Vladimir P Zharov, V. Zharov, D. Curiel, 2005, Nanomedicine : nanotechnology, biology, and medicine.

Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors.

M. Rots, D. Curiel, H. Haisma, 2003, Journal of controlled release : official journal of the Controlled Release Society.

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

P. Fisher, P. Dent, D. Curiel, 2007, Clinical Cancer Research.

Adeno-Associated Virus Type 2-Mediated Transduction of Human Monocyte-Derived Dendritic Cells: Implications for Ex Vivo Immunotherapy

D. Curiel, S. Ponnazhagan, D. Shaw, 2001, Journal of Virology.

Adenovirus-mediated gene delivery to dendritic cells.

D. Curiel, V. Krasnykh, L. Timares, 2004, Methods in molecular biology.

Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to the melanoma microenvironment.

O. Podhajcer, D. Curiel, Y. Chernajovsky, 2013, The Journal of investigative dermatology.

Retargeting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma.

C. Miller, D. Curiel, P. Reynolds, 1999, Archives of otolaryngology--head & neck surgery.

Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.

D. Curiel, G. Pierce, J. Doukas, 1999, Cancer research.

Fiber-Modified Adenovirus for Central Nervous System Parkinson’s Disease Gene Therapy

D. Standaert, D. Curiel, A. Harms, 2014, Viruses.

Antineoplastic effect of anti-erbB-2 intrabody is not correlated with scFv affinity for its target

D. Curiel, J. Xiang, R. Alvarez, 2000, Cancer Gene Therapy.

Targeting of adenoviral vectors through a bispecific single-chain antibody

J. Grill, D. Curiel, H. Haisma, 2000, Cancer Gene Therapy.

In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector.

D. Curiel, J. Heaney, Z. Lu, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice.

D. Curiel, W. Grizzle, V. Krasnykh, 2002, Radiology.

Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver

D. Curiel, H. Hsu, Pingar Yang, 2002, Journal of Virology.

Improving adenoviral vectors for cancer gene therapy

J. Contreras, D. Curiel, G. Bilbao, 1998 .

Fluorescently Labeled Adenovirus with pIX-EGFP for Vector Detection

D. Curiel, M. Everts, Masato Yamamoto, 2004 .

Vector Targeting for Therapeutic Gene Delivery

David T. Curiel, Joanne T. Douglas, D. Curiel, 2002 .

Vector Targeting for Therapeutic Gene Delivery: Curiel/Therapeutic Gene Delivery

D. Curiel, J. Douglas, J. T. Douglas, 2002 .

AFiber-ModifiedMesothelin Promoter ^ Based Conditionally Replicating Adenovirus forTreatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008 .

Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology

D. Mutch, D. Curiel, I. Dmitriev, 2016, Scientific Reports.

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology

D. Mutch, D. Curiel, I. Dmitriev, 2016, Scientific Reports.

Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

D. Curiel, M. Lesniak, K. Aboody, 2018, Molecular therapy oncolytics.

Transferrinfection: A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

K. Zatloukal, M. Cotten, P. Steinlein, 1992, Annals of the New York Academy of Sciences.

Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy.

Vladimir P Zharov, Vaibhav Saini, Guy Perkins, 2006, Nano letters.

Crystallographic Structure of Porcine Adenovirus Type 4 Fiber Head and Galectin Domains

D. Curiel, R. Kahn, G. Fox, 2010, Journal of Virology.

Converting nonhuman primate dendritic cells into potent antigen-specific cellular immunosuppressants by genetic modification

D. Curiel, C. Asiedu, A. Hutchings, 2002, Immunologic research.

Icodextrin enhances survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy.

A. Rivera, D. Curiel, Minghui Wang, 2006, Gynecologic oncology.

Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α–induced apoptosis of human synovial fibroblasts

D. Curiel, Pingar Yang, J. Mountz, 2000 .

Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single‐chain diabody (scDb) adapter that binds to fiber knob and HMWMAA

R. Kontermann, D. Nettelbeck, A. Rivera, 2004, International journal of cancer.

Gene therapy for renal cancer.

D. Curiel, Y. Haviv, 2008, Contributions to nephrology.

Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation.

J. Contreras, D. Curiel, C. Ricordi, 1999, Surgery.

Construction and Radiolabeling of Adenovirus Variants that Incorporate Human Metallothionein into Protein IX for Analysis of Biodistribution

J. Mathis, D. Curiel, B. Rogers, 2014, Molecular imaging.

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008, Clinical Cancer Research.

Adenovirus‐mediated p16 gene transfer prevents drug‐induced cell death through G1 arrest in human glioma cells

K. Kurisu, N. Saijo, D. Curiel, 1998 .

Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells.

K. Kurisu, N. Saijo, D. Curiel, 1998, International journal of cancer.

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.

Atique U. Ahmed, R. Stupp, M. Tate, 2021, The Lancet. Oncology.

Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts.

D. Curiel, J. Mountz, T. Zhou, 2000, Arthritis and rheumatism.

Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion.

J. Mathis, D. Curiel, L. Le, 2005, Virology.

25. Genetic Incorporation of HSV-1 Thymidine Kinase into the Adenovirus Protein IX for Functional Display on the Virion

J. Mathis, D. Curiel, L. Le, 2005 .

Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus.

D. Curiel, G. Bauerschmitz, M. Breidenbach, 2010, Fertility and sterility.

Gene therapy for the treatment of cancer.

D. Curiel, D. Buchsbaum, David T. Curiel, 2001, Cancer biotherapy & radiopharmaceuticals.

Advances in Alpha-1 Antitrypsin Gene Therapy.

D. Curiel, Reka Lorincz, 2020, American journal of respiratory cell and molecular biology.

Synthetic Biology Design as a Paradigm Shift toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies

D. Curiel, S. Ponnazhagan, L. Collins, 2023, ACS synthetic biology.

Adenoviral vector infection of the human exocrine pancreas.

J. Thompson, D. Curiel, D. Eckhoff, 1997, Archives of surgery.

Retargeting Adenovirus for Cancer Gene Therapy

D. Curiel, Erin E. Thacker, 2010 .

A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow.

R. Hockett, D. Curiel, M. Kim, 1997, Human gene therapy.

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

P. Fisher, P. Dent, A. Yacoub, 2010, Anti-cancer drugs.

Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells.

T. Curiel, M. Cotten, D. Curiel, 1994, Virology.

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

S. Leppla, D. Curiel, M. Debatis, 2016, Clinical and Vaccine Immunology.

Modulation of viability and maturation of human monocyte‐derived dendritic cells by oncolytic adenoviruses

D. Nettelbeck, D. Curiel, G. Schuler, 2008, International journal of cancer.

MEK1/2 inhibition promotes Taxotere® lethality in mammary tumors in vivo

P. Fisher, P. Dent, M. Hagan, 2006, Cancer biology & therapy.

The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

D. Curiel, M. Everts, Minghui Wang, 2005, Leukemia & lymphoma.

Molecular Cancer Therapeutics (Models & Technologies) 1 Targeting tumor neoangiogenesis via targeted adenoviral vector to achieve 2 effective cancer gene therapy for disseminated neoplastic disease

D. Curiel, I. Dmitriev, E. Kashentseva, 2019 .

CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter

J. Mathis, A. Rivera, D. Curiel, 2016, Oncolytic virotherapy.

9 intracellular single-chain antibodies for gene therapy.

D. Curiel, G. Bilbao, J. Gómez-Navarro, 2000, Methods in molecular medicine.

Virotherapy using a novel chimeric oncolytic adenovirus prolongs survival in a human pancreatic cancer xenograft model.

Q. Chu, J. Mathis, Benjamin D. L. Li, 2012, Surgery.

Gene therapy strategies for novel cancer therapeutics.

D. Curiel, M. Rosenfeld, 1996, Current opinion in oncology.

The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy

B. Liu, A. Rivera, D. Curiel, 2003, The journal of gene medicine.

Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system

J. Mathis, A. Rivera, D. Curiel, 2005, Breast Cancer Research.

MDA‐7/IL‐24 regulates proliferation, invasion and tumor cell radiosensitivity: A new cancer therapy?

Paul Dent, P. Fisher, P. Dent, 2005, Journal of cellular biochemistry.

An ex vivo human model system to evaluate specificity of replicating and non‐replicating gene therapy agents

M. Rots, P. Olinga, G. Groothuis, 2006, The journal of gene medicine.

A One Health overview, facilitating advances in comparative medicine and translational research

Dongsheng Duan, Ubadah Sabbagh, James P. Calvet, 2016, Clinical and Translational Medicine.

Nonreplicating DNA viral vectors for suicide gene therapy: the adenoviral vectors.

D. Curiel, Masato Yamamoto, 2004, Methods in molecular medicine.

Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus

D. Curiel, D. Buchsbaum, S. Kaliberov, 2014, Cancer Gene Therapy.

Transcriptional targeting in renal cancer cell lines via the human CXCR4 promoter.

D. Curiel, W. V. van Houdt, Y. Haviv, 2004, Molecular cancer therapeutics.

Multiple Treatment Cycles of Neural Stem Cell Delivered Oncolytic Adenovirus for the Treatment of Glioblastoma

D. Curiel, M. Lesniak, T. Synold, 2021, Cancers.

E1A RNA transcripts amplify adenovirus-mediated tumor reduction.

D. Curiel, G. Bilbao, K. Goldsmith, 1996, Gene therapy.

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.

D. Curiel, T. Ellenberger, I. Dmitriev, 2015, Cell reports.

Lipid- and adenoviral-mediated gene transfer into AIDS-Kaposi's sarcoma cell lines.

K. Barnhart, D. Curiel, J. Campain, 1998, Cancer gene therapy.

Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene.

D. Raben, D. Curiel, W. Grizzle, 1996, Gene therapy.

Adenovirus facilitation of molecular conjugate-mediated gene transfer.

D. Curiel, 1993, Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale.

Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma

D. Curiel, M. Wang, G. Siegal, 1996, Journal of Molecular Medicine.

In Vitro and In Vivo Efficacy of a Stroma-Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer

O. Podhajcer, D. Curiel, A. N. Nicola Candia, 2023, International journal of molecular sciences.

Dendritic Cell Based PSMA Immunotherapy for Prostate Cancer Using a CD40-Targeted Adenovirus Vector

J. Mathis, D. Curiel, I. Kovesdi, 2012, PloS one.

Gene therapy for carcinoma of the breast: Genetic ablation strategies

D. Curiel, 1999, Breast Cancer Research.

6 Strategies to Adapt Adenoviral Vectors for Gene Therapy Applications: Targeting and Integration

D. Curiel, P. Reynolds, 1999 .

Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells.

D. Curiel, Essam-Eldin R Othman, A. Al-Hendy, 2008, American journal of obstetrics and gynecology.

Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors.

D. Curiel, M. Kim, R. Benjamin, 1994, Cancer gene therapy.

CYTOPROTECTION OF RHESUS MONKEY PANCREATIC ISLETS (PI) BEFORE AND AFTER TRANSPLANTATION (TX) BY GENE TRANSFER OF THE ANTI‐APOPTOTIC BCL‐2 GENE.: Abstract# 6

J. Contreras, D. Curiel, D. Eckhoff, 2000 .

A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters

M. Diamond, D. Curiel, I. Dmitriev, 2023, bioRxiv.

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway.

D. Curiel, C. Huang, E. Wagner, 1993, The Journal of biological chemistry.

Radiosensitization mediated by a transfected anti-erbB-2 single-chain antibody in vitro and in vivo.

M. Mayo, D. Curiel, W. Grizzle, 1998, International journal of radiation oncology, biology, physics.

Tumor localization of a radiolabeled bombesin analogue in mice bearing human ovarian tumors induced to express the gastrin‐releasing peptide receptor by an adenoviral vector

D. Curiel, D. Buchsbaum, B. Rogers, 1997, Cancer.

Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo.

M. Mayo, D. Raben, D. Curiel, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Intracellular Single Chain Antibodies — Methods for Derivation and Employment

J. Contreras, D. Curiel, G. Bilbao, 2001 .

c Chemical Sensitizers and Protectors RADIOSENSITIZATION MEDIATED BY A TRANSFECTED ANTI-ERBB-2 SINGLE-CHAIN ANTIBODY IN VITRO AND IN VIVO

D. Curiel, W. Grizzle, J. Buchsbaum, 1998 .

The flt-1 promoter for transcriptional targeting of teratocarcinoma.

D. Nettelbeck, D. Curiel, P. Reynolds, 2002, Cancer research.

Phenotypic knock-out of the latent membrane protein 1 of Epstein–Barr virus by an intracellular single-chain antibody

T. Curiel, K. Kasono, D. Curiel, 1998, Gene Therapy.

Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome.

A. Hamvas, D. Curiel, D. Wegner, 2016, American journal of respiratory cell and molecular biology.

Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors

P. Bosma, D. Curiel, P. Reynolds, 2001, Gene Therapy.

The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context

M. Rots, D. Curiel, W. M. Gommans, 2006, Cancer Gene Therapy.

Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses.

C. Balagué, R. Alemany, D. Curiel, 1999, Experimental cell research.

328. An Orthotopic Murine Model of Advanced Breast Cancer for Imaging and Comparison of Targeting Moieties

S. Goodison, D. Curiel, P. Laakkonen, 2005 .

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Raymond D. Harris, D. Curiel, W. Grizzle, 2010, Clinical Cancer Research.

Targeted eradication of ErbB-2 over-expressing tumor cells employing expression of an intracellular antibody directed against the ErbB-2 oncoprotein

D. Curiel, F. Loechel, J. Grim, 1995 .

From gene therapy to virotherapy for ovarian cancer.

D. Curiel, P. Dall, M. Stoff-Khalili, 2004, Minerva ginecologica.

Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment

John D. Roberts, P. Fisher, P. Dent, 2007, Molecular Pharmacology.

Insulin-like Growth Factor-binding Protein-7 (IGFBP7); A Promising Gene Therapeutic for Hepatocellular Carcinoma (HCC).

P. Fisher, D. Curiel, I. Dmitriev, 2013, Molecular Therapy.

Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells

D. Nettelbeck, A. Rivera, D. Curiel, 2004, Gene Therapy.

Conditionally replicative adenoviral vectors for cancer gene therapy.

D. Curiel, J. Gómez-Navarro, 2000, The Lancet. Oncology.

Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®)

Ashutosh Kumar Singh, M. Diamond, D. Curiel, 2023, NPJ vaccines.

Adenovirus Vector Expressing Stx1/Stx2-Neutralizing Agent Protects Piglets Infected with Escherichia coli O157:H7 against Fatal Systemic Intoxication

S. Tzipori, D. Curiel, M. Debatis, 2014, Infection and Immunity.

Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.

P. Fisher, P. Dent, A. Yacoub, 2010, Cancer research.

Searching for a cure: Gene therapy for glioblastoma

P. Fisher, K. Shah, P. Dent, 2008, Cancer biology & therapy.

Dendritic Cell Migration a Role for Multidrug Resistance Protein 4 (mrp4; Abcc4) in Human

D. Curiel, J. Gillet, G. Scheffer, 2008 .

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

P. Fisher, P. Dent, D. Curiel, 2008, Clinical Cancer Research.

Current issues and future directions of oncolytic adenoviruses.

D. Curiel, Masato Yamamoto, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Ovarian cancer gene therapy strategies

Manjula., D. Curiel, Kataram, 2005 .

Cancer Gene Therapy

D. Curiel, Masato Yamamoto, 2005, Technology in cancer research & treatment.

Gene Therapy: Delivery Targeting

D. Curiel, M. Beatty, J. Glasgow, 2007 .

Joanne, C. Miller, D. Raben, 1998, Cancer research.

The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses.

Q. Chu, J. Mathis, Benjamin D. L. Li, 2010, The Journal of surgical research.

ASSOCIATION FOR ACADEMIC SURGERY The Utility of a Tissue Slice Model System to Determine Breast Cancer Infectivity by Oncolytic Adenoviruses 1

Q. Chu, J. Mathis, Benjamin D. L. Li, 2010 .

EVALUATION OF FIVE CONDITIONALLY REPLICATIVE ADENOVIRUSES FOR OVARIAN CANCER THERAPY

D. Curiel, A. Hemminki, A. Kanerva, 2004, International Journal of Gynecologic Cancer.

A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma

D. Curiel, A. Hemminki, A. Kanerva, 2004, Gene Therapy.

Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon

D. Curiel, Hongju Wu, Minghui Wang, 2002, Journal of Virology.

Targeted enzymes for molecular chemotherapy

D. Curiel, H. Haisma, H. Pinedo, 2000 .

Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus.

D. Curiel, G. Bauerschmitz, M. Breidenbach, 2010, Fertility and sterility.

Selective Transduction of Mature DC in Human Skin and Lymph Nodes by CD80/CD86-targeted Fiber-modified Adenovirus-5/3

D. Curiel, T. D. de Gruijl, M. Everts, 2009, Journal of immunotherapy.

Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.

S. Baldus, D. Curiel, G. Bauerschmitz, 2011, Gynecologic oncology.

Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine.

L. Boon, D. Curiel, T. D. de Gruijl, 2011, Cancer research.

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

P. Fisher, John Calvin Reed, P. Dent, 2011, Proceedings of the National Academy of Sciences.

Enhancing Adenoviral-Mediated Gene Transfer and Expression to Endometrial Cells

D. Curiel, A. Al-Hendy, Essam-Edin R Othman, 2016, Reproductive Sciences.

Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession.

D. Curiel, H. Hsu, Pingar Yang, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.