Y. Zhang

发表

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 1997, Journal of medicinal chemistry.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

R. S. Rogers, C. Koboldt, K. Seibert, 1997, Journal of medicinal chemistry.

Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 2000, Journal of medicinal chemistry.

Mediation of inflammation by cyclooxygenase-2.

K. Seibert, P. Isakson, W. Perkins, 1995, Agents and actions. Supplements.

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 1996, Journal of medicinal chemistry.

Cytokine Regulation of Eicosanoid Generation

K. Seibert, P. Isakson, J. Masferrer, 1994, Annals of the New York Academy of Sciences.

Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase.

J. Gierse, C. Koboldt, K. Seibert, 1995, Advances in prostaglandin, thromboxane, and leukotriene research.

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo

K. Seibert, P. Isakson, J. Masferrer, 1996, The Journal of experimental medicine.

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

K. Seibert, P. Isakson, W. Perkins, 1994, Proceedings of the National Academy of Sciences of the United States of America.

N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.

C. Koboldt, K. Seibert, Y. Zhang, 2000, Journal of medicinal chemistry.

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.

R. S. Rogers, C. Koboldt, K. Seibert, 2000, Journal of medicinal chemistry.

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.

C. Koboldt, K. Seibert, Y. Zhang, 1999, Bioorganic & medicinal chemistry letters.

Pharmacological analysis of cyclooxygenase-1 in inflammation.

C. Koboldt, K. Seibert, P. Isakson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.

K. Seibert, P. Isakson, Y. Zhang, 1997, The Journal of pharmacology and experimental therapeutics.

Distribution of COX-1 and COX-2 in normal and inflamed tissues.

K. Seibert, P. Isakson, J. Masferrer, 1997, Advances in experimental medicine and biology.

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.

C. Koboldt, K. Seibert, P. Isakson, 1996, Journal of medicinal chemistry.