G. O'neill

发表

The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

M. Percival, D. Riendeau, B. Kennedy, 1999, Bioorganic & medicinal chemistry letters.

Discovery of a receptor related to the galanin receptors

B. O'dowd, G. O'neill, S. George, 1999, FEBS letters.

Structure of the gene encoding the exoglucanase of Cellulomonas fimi.

G. O'neill, D. Kilburn, R. Miller, 1986, Gene.

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.

Cheryl A. Grice, G. O'neill, G. Simon, 2018, Journal of medicinal chemistry.

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

G. O'neill, C. Dufresne, D. Guay, 1995, Molecular pharmacology.

Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling

G. O'neill, M. Niphakis, Justin S Cisar, 2019, SLAS technology.

Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.

D. Slipetz, J. Tam, J. Mortimer, 2005, American journal of respiratory cell and molecular biology.

Expression and Secretion of a Cellulomonas fimi Exoglucanase in Saccharomyces cerevisiae

G. O'neill, N. Gilkes, N. Skipper, 1988, Applied and Environmental Microbiology.

Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

L. F. Kolakowski, G. O'neill, M. Abramovitz, 2000, The Journal of pharmacology and experimental therapeutics.

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

D. Riendeau, B. Kennedy, S. Charleson, 1997, Inflammation Research.

Suppression of Niacin‐induced Vasodilation with an Antagonist to Prostaglandin D2 Receptor Subtype 1

G. O'neill, F. Liu, I. de Lepeleire, 2007, Clinical pharmacology and therapeutics.

Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.

Y. Boie, R. Stocco, S. Kargman, 1999, European journal of pharmacology.

2,3-Diarylthiophenes as selective EP1 receptor antagonists.

D. Denis, S. Kargman, G. O'neill, 2005, Bioorganic & medicinal chemistry letters.

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.

Christopher M. Tan, D. Slipetz, H. Houshyar, 2008, American journal of respiratory cell and molecular biology.

Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.

C. Austin, J. Evans, S. Kargman, 2001, American journal of respiratory and critical care medicine.

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

M. Crackower, D. Denis, R. Stocco, 2011, Bioorganic & medicinal chemistry letters.

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

D. Denis, Y. Leblanc, G. O'neill, 2008, Bioorganic & medicinal chemistry letters.

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.

D. Denis, G. O'neill, Jennifer Wang, 2004, Bioorganic & medicinal chemistry letters.

Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa

G. O'neill, M. Desrosiers, D. Wright, 2004 .

Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice

D. Denis, G. O'neill, R. Breyer, 2001 .

Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.

T. Mcdonald, P. Whiting, M. Rigby, 1999, Genomics.

Selective inhibitors of COX-2.

J. Falgueyret, B. Kennedy, C. Chan, 1995, Agents and actions. Supplements.

Characterization of the human cysteinyl leukotriene CysLT1 receptor

Jilly F. Evans, C. Austin, B. Connolly, 1999, Nature.

Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3

L. F. Kolakowski, B. O'dowd, S. Kargman, 1998, Journal of neurochemistry.

Cloning of Cellulase Genes

G. O'neill, D. Kilburn, N. Gilkes, 1987 .

Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist

D. Slipetz, M. Crackower, D. Denis, 2011, Molecular Pharmacology.

Epitope-labeled Soluble Human Interleukin-5 (IL-5) Receptors

G. Sanyal, A. Ford-hutchinson, G. O'neill, 1995, The Journal of Biological Chemistry.

The C3a receptor antagonist SB 290157 has agonist activity.

A. Therien, S. Kargman, G. O'neill, 2005, Immunology letters.

Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms.

J. Evans, G. O'neill, G. Ng, 1999, Bioorganic & medicinal chemistry.

Cross-species comparison of 5-lipoxygenase-activating protein.

S. Charleson, J. Mancini, G. O'neill, 1992, Molecular pharmacology.

Pharmacokinetics, Pharmacodynamics, and Safety of a Prostaglandin D2 Receptor Antagonist

G. O'neill, F. Liu, H. Greenberg, 2008, Clinical pharmacology and therapeutics.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators

Cheryl A. Grice, G. O'neill, I. Fraser, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor

D. Denis, G. O'neill, C. Beaulieu, 2005, Molecular Pharmacology.

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

J. Chen, G. O'neill, Sheng-ping Wang, 2013, Journal of Lipid Research.

Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

D. Riendeau, P. Prasit, C. Brideau, 1997 .

Cytosolic phospholipase A2, cyclo-oxygenases and arachidonate in human stomach tumours.

S. Kargman, G. O'neill, P. Weech, 1997, European journal of cancer.

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP.

G. O'neill, K. Metters, F. Nantel, 2001, The Journal of allergy and clinical immunology.

A single-step purification of biologically active recombinant human interleukin-5 from a baculovirus expression system.

G. O'neill, P. Tagari, D. Nicholson, 1995, Protein expression and purification.

Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni.

A. Ford-hutchinson, G. O'neill, H. Abdel Baset, 1995, Molecular and biochemical parasitology.

Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1.

G. O'neill, F. Liu, J. Wagner, 2007, Clinical pharmacology and therapeutics.

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

J. Lacaille, R. Mckernan, G. O'neill, 2001, Molecular pharmacology.

The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels.

B. Chronwall, J. Lacaille, R. Robitaille, 2001, The Journal of pharmacology and experimental therapeutics.

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

R. Young, D. Denis, S. Kargman, 2007, Journal of medicinal chemistry.

A new series of selective COX-2 inhibitors : 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

P. Prasit, C. Brideau, C. Chan, 1997 .

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

J. Falgueyret, M. Percival, D. Riendeau, 1997, British journal of pharmacology.

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.

D. Riendeau, S. Charleson, J. Evans, 1996, Gastroenterology.

Overproduction from a cellulase gene with a high guanosine-plus-cytosine content in Escherichia coli

G. O'neill, D. Kilburn, R. Miller, 1986, Applied and environmental microbiology.

Secretion of Cellulomonas fimi exoglucanase by Escherichia coli.

G. O'neill, D. Kilburn, R. Miller, 1986, Gene.

Mutation of serine‐516 in human prostaglandin G/H synthase‐2 to methionine or aspirin acetylation of this residue stimulates 15‐R‐HETE synthesis

J. Mancini, G. O'neill, P. Vickers, 1994, FEBS letters.

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

H Perrier, R Gordon, M. Percival, 1999, The Journal of pharmacology and experimental therapeutics.

Transfer RNA involvement in chlorophyll biosynthesis.

D. Söll, G. O'neill, D. Jahn, 1991, Sub-cellular biochemistry.

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

A. Ford-hutchinson, G. O'neill, 1993, FEBS letters.

Characterization of the Human Cysteinyl Leukotriene 2 Receptor*

Jilly F. Evans, B. O'dowd, R. Stocco, 2000, The Journal of Biological Chemistry.

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

S Jothy, Jilly F. Evans, J. Evans, 1995, Cancer research.

b-Aminolevulinic Acid Dehydratase Deficiency Can Cause B-Aminolevulinate Auxotrophy in Escherichia coli

G. O'neill, G. Eggertsson, Dieter, 2003 .

delta-Aminolevulinic acid dehydratase deficiency can cause delta-aminolevulinate auxotrophy in Escherichia coli

D. Söll, G. O'neill, S. Thorbjarnardóttir, 1991, Journal of bacteriology.

Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.

D. Denis, G. O'neill, R. Zamboni, 2010, Bioorganic & medicinal chemistry letters.

Identification of an indole series of prostaglandin D2 receptor antagonists.

R. Young, D. Denis, C. Brideau, 2006, Bioorganic & medicinal chemistry letters.

Structure-Function Relationships in the Neuropeptide S Receptor

Christopher M. Tan, D. Slipetz, M. Crackower, 2006, Journal of Biological Chemistry.

Receptor for motilin identified in the human gastrointestinal system.

Jilly F. Evans, Ploeg, C. Austin, 1999, Science.

Investigation of human cyclooxygenase-2 glycosylation heterogeneity and protein expression in insect and mammalian cell expression systems.

P. Griffin, M. Percival, S. Kargman, 1997, Protein expression and purification.

Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs.

J. Falgueyret, D. Riendeau, J. Mancini, 1997, Molecular pharmacology.

Formation of the chlorophyll precursor delta-aminolevulinic acid in cyanobacteria requires aminoacylation of a tRNAGlu species

D. Söll, G. O'neill, D. Peterson, 1988, Journal of bacteriology.

Expression of the Synechocystis sp. strain PCC 6803 tRNA(Glu) gene provides tRNA for protein and chlorophyll biosynthesis

D. Söll, G. O'neill, 1990, Journal of bacteriology.

Strain PCC 6803 tRNAGlu Gene Provides tRNA for Protein and Chlorophyll Biosynthesis

G. O'neill, D. Soll, A. Schon, 2022 .

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.

G. O'neill, S. Wright, K. Metters, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2

G. O'neill, D. Nicholson, K. Metters, 2002, British journal of pharmacology.

Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity*

Jilly F. Evans, L. F. Kolakowski, T. Bonner, 1999, The Journal of Biological Chemistry.

Identification of Distinct Plasma Biomarker Signatures in Patients with Rapid and Slow Declining Forms of COPD

M. Leppert, V. Devanarayan, M. Crackower, 2011, COPD.

The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

P. Clark, Steve Rowland, D. Denis, 2010, Journal of medicinal chemistry.

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

J. Falgueyret, B. Kennedy, W. Cromlish, 1994, Molecular pharmacology.

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

D. Denis, Y. Leblanc, G. O'neill, 2009, Bioorganic & medicinal chemistry letters.

Comparative Analysis of the Effects of Antimuscarinic Agents on Bladder Functions in Both Nonhuman Primates and Rodents

G. O'neill, S. Alves, X. Tong, 2011, Journal of Pharmacology and Experimental Therapeutics.

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.

Jilly F. Evans, J. Falgueyret, D. Riendeau, 1996, Biochemical pharmacology.

Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety *

J. Falgueyret, D. Riendeau, J. Mancini, 1995, The Journal of Biological Chemistry.

Transfer RNA and the formation of the heme and chlorophyll precursor, 5-aminolevulinic acid.

D. Söll, G. O'neill, 1990, BioFactors.

Overproduction froma Cellulase Genewitha HighGuanosine-Plus- Cytosine Content inEscherichia coli

G. O'neill, D. Kilburn, R. Warren, 1986 .

The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs.

C. Bayly, J. Falgueyret, M. Percival, 1997, Molecular pharmacology.

Purification and characterization of Chlamydomonas reinhardtii chloroplast glutamyl-tRNA synthetase, a natural misacylating enzyme.

D. Söll, G. O'neill, D. Jahn, 1990, The Journal of biological chemistry.

Glutamate tRNA : involvement in protein synthesis and aminolevulinate formation in Chlamydomonas reinhardtii

D. Söll, G. O'neill, D. Jahn, 1992 .

Purification and characterization of recombinant human cyclooxygenase-2.

M. Percival, B. Kennedy, G. O'neill, 1994, Archives of biochemistry and biophysics.

Unusual structural organization of two cellulases from Cellulomonas fimi

G. O'neill, D. Kilburn, N. Gilkes, 1987 .

A New Series of Selective COX-2 Inhibitors: 5,6-Diarylthiazolo(3,2-b)( 1,2,4)triazoles.

P. Prasit, C. Brideau, C. Chan, 1997 .

Amino acid residues of 5-lipoxygenase-activating protein critical for the binding of leukotriene biosynthesis inhibitors.

M. Adam, S. Charleson, J. Mancini, 1993, Journal of lipid mediators.

Molecular Cloning and Functional Expression of aCaenorhabditis elegans Aminopeptidase Structurally Related to Mammalian Leukotriene A4 Hydrolases*

A. Ford-hutchinson, G. O'neill, A W Ford-Hutchinson, 1998, The Journal of Biological Chemistry.

Sequence conservation and region shuffling in an endoglucanase and an exoglucanase from Cellulomonas fimi

G. O'neill, D. Kilburn, N. Gilkes, 1986, Proteins.

delta-Aminolevulinic acid biosynthesis in Escherichia coli and Bacillus subtilis involves formation of glutamyl-tRNA.

D. Söll, G. O'neill, M. W. Chen, 1989, FEMS microbiology letters.