R. Contractor

发表

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

K. Flaherty, M. Herlyn, M. Soengas, 2007, Cancer research.

PML-RARα and AML1–ETO translocations are rarely associated with methylation of the RARβ2 promoter

J. Issa, M. Konopleva, M. Andreeff, 2006, Annals of Hematology.

Evidence of Gender- and Tissue-Specific Promoter Methylation and the Potential for Ethinylestradiol-Induced Changes in Japanese Medaka (Oryzias Latipes) Estrogen Receptor and Aromatase Genes

R. Contractor, K. Willett, C. Foran, 2004, Journal of toxicology and environmental health. Part A.

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.

M. Konopleva, Z. Estrov, D. Harris, 2005, Cancer research.

A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis

M. Konopleva, M. Andreeff, I. Samudio, 2005, Molecular Pharmacology.

PPARgamma-Active triterpenoid CDDO enhances ATRA-induced differentiation in APL

J. Issa, M. Konopleva, M. Andreeff, 2007, Cancer biology & therapy.

The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells

M. Konopleva, R. Contractor, S. Kurinna, 2005, Leukemia.

Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells.

M. Konopleva, M. Andreeff, M. Munsell, 2006, Blood.

Up-regulation of MDR 1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide ( FK 228 ) and ATRA in acute promyelocytic leukemia cells

M. Andreeff, M. Munsell, R. Contractor, 2006 .

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

John Calvin Reed, M. Konopleva, Z. Estrov, 2006, Cancer cell.

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.

K. Flaherty, M. Herlyn, K. Nathanson, 2008, Cancer research.

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels

K. Flaherty, M. Herlyn, K. Nathanson, 2007, British Journal of Cancer.

Bcl2 phosphorylation and active PKC α are associated with poor survival in AML

M. Konopleva, M. Andreeff, R. Contractor, 2006, Leukemia.

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

M. Herlyn, K. Nathanson, K. Smalley, 2008, Clinical Cancer Research.

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

M. Konopleva, Z. Estrov, D. Harris, 2008, Cancer research.

PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter.

J. Issa, M. Konopleva, M. Andreeff, 2006, Annals of hematology.

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells.

M. Konopleva, M. Andreeff, J. McCubrey, 2005, Cancer research.

Targeted therapy of AML new concepts.

G. Mills, E. Estey, John Calvin Reed, 2004, Annals of hematology.

Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1

D. Gold, M. Konopleva, M. Andreeff, 2007, Cell Death and Differentiation.

Histone Deacetylase Inhibitor Depsipeptide (FK228) Induces Apoptosis through Histone Acetylation and Upregulation of Annexin A1 in AML1-ETO Expressing Kasumi-1 Cells.

M. Konopleva, M. Andreeff, R. Contractor, 2004 .

Tumor Regression When Combined with Docetaxel ( ARRY-142886 ) Induces Growth Arrest in Melanoma Cells Signal-Regulated Kinase Kinase Inhibitor AZD 6244 The Mitogen-Activated Protein / Extracellular

M. Herlyn, K. Nathanson, K. Smalley, 2007 .

High Glucose Activates AKT Signaling and Induces Upregulation of Genes Encoding Glycolytic Enzymes Glut-1 and HK-2 in Acute Lymphocytic Leukemia.

M. Konopleva, M. Andreeff, H. Kantarjian, 2004 .

Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML.

M. Konopleva, M. Andreeff, R. Contractor, 2006, Leukemia.