A. Robles

A. Robles, C. Conti, I. Gimenez-Conti, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Deconstruction of p53 functions and regulation

V. Rotter, C. Prives, A. Robles, 2002, Oncogene.

Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability

Li Ding, Molly Brewer, Rui Zhao, 2020, Cell reports medicine.

A purine scaffold Hsp90 inhibitor destabilizes Bcl6 and has specific anti-tumor activity in Bcl6 dependent B-cell lymphomas

J. Walling, Karen L. Bunting, A. Melnick, 2009, Nature Medicine.

Comprehensive genomic analysis of circulating tumor DNA for patients with advanced non-small cell lung cancer.

A. Robles, Delphine Lissa, 2019, Annals of translational medicine.

Nitric oxide is a signaling molecule that regulates gene expression.

C. Harris, A. Robles, L. Hofseth, 2005, Methods in enzymology.

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

L. Ding, H. Rodriguez, A. Robles, 2019, Cell.

Overexpression of cyclin D1 in mouse skin carcinogenesis.

A. Robles, C. Conti, S. Fischer, 1993, Oncogene.

Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.

L. Liotta, Yusuke Nakamura, T. Katagiri, 2002, Cancer research.

Synchronized proliferation induced by 12-O-tetradecanoylphorbol-13-acetate treatment of mouse skin: an in vivo model for cell cycle regulation.

A. Robles, D. Johnson, C. Conti, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

A. Gemma, M. Seike, C. Harris, 2020, BMC Cancer.

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.

Y. Pommier, A. Robles, Z. Miao, 2007, Cancer research.

Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.

F. Larcher, J. Jorcano, A. Robles, 1996, Cancer research.

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Sara R. Savage, G. Getz, S. Carr, 2020, Cell.

Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma

G. Hostetter, G. Omenn, Hui Zhang, 2022, Clinical Proteomics.

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

F. Larcher, J. Jorcano, A. Robles, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Prenatal smoke exposure, DNA methylation and a link between DRD1 and lung cancer.

A. Robles, B. Ryan, 2019, International Journal of Epidemiology.

KRT81 miR-SNP rs3660 is associated with risk and survival of NSCLC.

A. Robles, B. Ryan, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer

R. Gibbs, B. Kim, J. Lei, 2022, Cancer discovery.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

C. Harris, E. Appella, T. Forshew, 2018, Nature Communications.

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

I. Jonassen, Yi-Ju Chen, Yih-Leong Chang, 2020, Cell.

Early overexpression of cyclin D1 protein in mouse skin carcinogenesis.

A. Robles, C. Conti, 1995, Carcinogenesis.

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer.

Jun Yokota, Takashi Kohno, E. Bowman, 2015, Cancer research.

rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer

C. Croce, E. Bowman, C. Harris, 2012, PloS one.

p53-mediated apoptosis is attenuated in Werner syndrome cells.

G. Schellenberg, C. Harris, A. Robles, 1999, Genes & development.

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

S. Miyano, J. Yokota, C. Harris, 2015, Carcinogenesis.

Proteogenomic and metabolomic characterization of human glioblastoma.

Joshua F. McMichael, Sneha P. Couvillion, Matthew A. Wyczalkowski, 2021, Cancer cell.

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Guo Ci Teo, Allison P. Heath, Marilyn M. Li, 2020, Cell.

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.

Deepak K. Singh, A. Schetter, C. Harris, 2017, Cell reports.

Optimal Targeting of HER 2 – PI 3 K Signaling in Breast Cancer : Mechanistic Insights and Clinical Implications

A. Schetter, S. Groshen, E. Bowman, 2013 .

A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

A. Schetter, P. Meltzer, M. Gorospe, 2020, eLife.

ras activity and cyclin D1 expression: An essential mechanism of mouse skin tumor development

A. Robles, C. Conti, M. Rodriguez-Puebla, 1999, Molecular carcinogenesis.

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.

R. Tennant, R. Weinberg, A. Robles, 1998, Genes & development.

The Expression of Four Genes as a Prognostic Classifier for Stage I Lung Adenocarcinoma in 12 Independent Cohorts

Jun Yokota, Takashi Kohno, Seiichi Takenoshita, 2014, Cancer Epidemiology, Biomarkers & Prevention.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

A. Børresen-Dale, P. Sætrom, B. Nielsen, 2016, Journal of Translational Medicine.

A proteogenomic portrait of lung squamous cell carcinoma

Dana R. Valley, Matthew A. Wyczalkowski, Ratna R. Thangudu, 2021, Cell.

Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.

C. Harris, A. Robles, 2017, Lung cancer.

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

C. Harris, M. Serrano, A. Robles, 2017, Cell Death and Differentiation.

Seeing the Forest through the Phylogenetic Tree.

J. Zenklusen, A. Robles, 2017, The New England journal of medicine.

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Guo Ci Teo, Meghan C. Burke, Jeffrey R. Whiteaker, 2020, Cell.

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

C. Harris, A. Robles, I. Horikawa, 2013, Oncogene.

Cigarette Smoke Mediates Epigenetic Repression of miR-217 During Esophageal Adenocarcinogenesis

S. Steinberg, D. Beer, E. Bowman, 2015, Oncogene.

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness.

Guo Ci Teo, Matthew A. Wyczalkowski, Ratna R. Thangudu, 2022, Cancer cell.

Laser Capture Microdissection and Microarray Expression Analysis of Lung Adenocarcinoma Reveals Tobacco Smoking-and Prognosis-related Molecular Profiles 1

L. Liotta, Yusuke Nakamura, T. Katagiri, 2002 .

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Leah E. Mechanic, C. Harris, A. Robles, 2004, Cancer Research.

p53-Mediated Oxidative Stress and Apoptosis

Shawn, S. Hilsenbeck, P. O’Connell, 2004 .

A Nucleolar Stress–Specific p53–miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network

J. Yokota, C. Harris, T. Kohno, 2018, EBioMedicine.

Clinical outcomes and correlates of TP53 mutations and cancer.

C. Harris, A. Robles, Curtis C Harris, 2010, Cold Spring Harbor perspectives in biology.

The p53 network in lung carcinogenesis

C. Harris, A. Robles, S. Linke, 2002, Oncogene.

A Two‐Gene Prognostic Classifier for Early‐Stage Lung Squamous Cell Carcinoma in Multiple Large‐Scale and Geographically Diverse Cohorts

A. Gemma, M. Seike, E. Bowman, 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers

David Petersen, Naoto Tsuchiya, Vidar Skaug, 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma.

Alexander R. Pico, Matthew A. Wyczalkowski, Sara R. Savage, 2021, Cancer cell.

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

A. Schetter, D. Lowy, Xi Liu, 2012, Cancer Research.

Molecular and Cellular Pathobiology Functional Interaction of Tumor Suppressor DLC 1 and Caveolin-1 in Cancer Cells

A. Schetter, D. Lowy, Xi Liu, 2012 .

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

M. Pittman, K. Kinzler, B. Vogelstein, 2016, Gastroenterology.

A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis

K. Kumamoto, A. Robles, M. Unoki, 2008, FEBS letters.

Interaction between the microbiome and TP53 in human lung cancer

Eric C. Polley, Paul S. Meltzer, James R. White, 2018, Genome Biology.

8-24-2018 Interaction between the microbiome and TP 53 in human lung cancer

Archana S Bhat, Sergey V. Balashov, Julia Oh, 2018 .

Clinical Outcomes of TP53 Mutations in Cancers.

C. Harris, J. Jen, A. Robles, 2016, Cold Spring Harbor perspectives in medicine.

Clinical Outcomes of TP 53 Mutations in Cancers

C. Harris, J. Jen, A. Robles, 2016 .

Functional Interaction of p53 and BLM DNA Helicase in Apoptosis*

Curtis C. Harris, Peng Hu, X. Wang, 2001, The Journal of Biological Chemistry.

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Guo Ci Teo, Matthew A. Wyczalkowski, Andy T. Kong, 2019, Cell.

MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer

E. Bowman, S. Ambs, A. Robles, 2012, International journal of cancer.

Epigenetic predictive biomarkers for response or outcome to platinum-based chemotherapy in non-small cell lung cancer, current state-of-art

A. Robles, U. Falkmer, O. Røe, 2018, The Pharmacogenomics Journal.

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Li Ding, Hongwen Zhu, Henry Rodriguez, 2019, Cell.

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Jane J. Sohn, A. Schetter, E. Bowman, 2012, PloS one.

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1

Jason I. Herschkowitz, C. Perou, A. Robles, 2008, Molecular Cancer.

Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma.

A. Schetter, E. Bowman, J. Yokota, 2013, Cancer research.

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

Weiliang Tang, Xin Wei Wang, Curtis C. Harris, 2014, Proceedings of the National Academy of Sciences.

p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.

X. Wang, C. Harris, A. Robles, 2004, Chest.

Epigenetic predictive biomarkers for response or outcome to platinum-based chemotherapy in non-small cell lung cancer, current state-of-art

A. Robles, U. Falkmer, O. Røe, 2018, The Pharmacogenomics Journal.

A primate-specific microRNA enters the lung cancer landscape

C. Harris, A. Robles, 2013, Proceedings of the National Academy of Sciences.

Microenvironmental modulation of asymmetric cell division in human lung cancer cells

Curtis C. Harris, Bríd M. Ryan, C. Harris, 2010, Proceedings of the National Academy of Sciences.

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.

C. Harris, R. Beyer, R. Monnat, 2016, Human molecular genetics.

Harnessing genetically engineered mouse models for preclinical testing.

A. Robles, L. Varticovski, 2008, Chemico-biological interactions.

A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells

D. Esposito, L. Wakefield, K. Flanders, 2014, Stem cell reports.

Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.

A. Robles, C. Conti, S. Y. Zhang, 1995, Carcinogenesis.

Liquid biopsy in early stage lung cancer.

A. Robles, M. Cañadas-Garre, M. Molina, 2016, Translational lung cancer research.

HOXA9 methylation and blood vessel invasion in FFPE tissues for prognostic stratification of stage I lung adenocarcinoma patients.

E. Bowman, C. Harris, A. Robles, 2018, Lung cancer.

Low frequency of codon 61 Ha‐ras mutations and lack of keratin 13 expression in 7,12‐dimethylbenz[a]‐anthracene—induced hamster skin tumors

T. Slaga, A. Robles, D. Roop, 1993, Molecular carcinogenesis.

Proteogenomic characterization of pancreatic ductal adenocarcinoma

Dana R. Valley, Matthew A. Wyczalkowski, Ratna R. Thangudu, 2021, Cell.

Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer

Julie Goodman, Meredith Yeager, Krista A. Zanetti, 2014, International journal of cancer.

A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood

E. Bowman, J. Jen, Ping Yang, 2014, Cancer Prevention Research.

The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.

John N Weinstein, Frank Staib, X. Wang, 2005, Cancer research.

Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer.

A. Robles, M. Cañadas-Garre, M. Molina, 2017, Mutation research.

APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

C. Harris, A. Robles, N. A. Bemmels, 2001, Cancer research.

Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

C. Harris, A. Robles, L. Hofseth, 2004, Cancer research.

Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death

X. Wang, C. Harris, A. Robles, 1999, Oncogene.

Studies Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classi fi er in Stage I Lung Adenocarcinoma

A. Schetter, E. Bowman, J. Yokota, 2013 .

Clinical Studies Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classi fi er in Stage I Lung Adenocarcinoma

A. Schetter, E. Bowman, J. Yokota, 2013 .

Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programs

C. Harris, R. Beyer, R. Monnat, 2015, bioRxiv.

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer.

A. Robles, M. Cañadas-Garre, M. Molina, 2017, Surgical oncology.

3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.

Krista A. Zanetti, S. Chanock, E. Bowman, 2012, Cancer research.

Interaction between the microbiome and TP53 in human lung cancer

Archana S Bhat, Sergey V. Balashov, Julia Oh, 2018, Genome Biology.

Microbiome-TP53 Gene Interaction in Human Lung Cancer

Archana S Bhat, Sergey V. Balashov, Julia Oh, 2018, bioRxiv.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

A. Melnick, Tony Taldone, A. Rodina, 2009, Proceedings of the National Academy of Sciences.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

C. Harris, E. Appella, T. Forshew, 2018, Nature Communications.

Prevention and Epidemiology 3 0-UTR and Functional Secretor Haplotypes in Mannose-Binding Lectin 2 Are Associated with Increased Colon Cancer Risk in African Americans

S. Chanock, E. Bowman, C. Harris, 2012 .

Lung Cancer Field Cancerization: Implications for Screening by Low-Dose Computed Tomography.

C. Harris, A. Robles, 2017, Journal of the National Cancer Institute.

Sputum-based DNA methylation biomarkers to guide lung cancer screening decisions.

A. Robles, Delphine Lissa, 2017, Journal of thoracic disease.

Methylation analyses in liquid biopsy.

A. Robles, Delphine Lissa, 2016, Translational lung cancer research.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

A. Børresen-Dale, P. Sætrom, B. Nielsen, 2016, Journal of Translational Medicine.

KRAS-LCS6 Genotype as a Prognostic Marker in Early-Stage CRC–Letter

C. Harris, A. Robles, B. Ryan, 2012, Clinical Cancer Research.

p53-Mediated Apoptosis and Genomic Instability Diseases

A. Robles, Curtis C. Harris, 2001 .

Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.

C. Harris, A. Robles, 2017, Lung cancer.

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

D. Lowy, Xi Liu, A. Robles, 2012, Cancer research.

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

M. Pittman, K. Kinzler, B. Vogelstein, 2016, Gastroenterology.

Abstract 922: Delta133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

C. Harris, M. Serrano, A. Robles, 2017 .