I. Slaymaker

发表

Rationally engineered Cas9 nucleases with improved specificity

David A. Scott, Feng Zhang, Linyi Gao, 2015, Science.

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

A. Regev, E. Koonin, J. Joung, 2015, Cell.

Base editing: advances and therapeutic opportunities

Gene W. Yeo, Alexis C. Komor, I. Slaymaker, 2020, Nature Reviews Drug Discovery.

The 1.8-Å crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.

I. Slaymaker, Xiaojiang S. Chen, Yang Fu, 2014, Journal of molecular biology.

Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology

S. Forsburg, Z. Zhou, I. Slaymaker, 2013, Nucleic acids research.

Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28

Kira S. Makarova, Eugene V. Koonin, Feng Zhang, 2016, bioRxiv.

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.

O. Abudayyeh, J. Gootenberg, Feng Zhang, 2019, Cell reports.

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.

D. Boger, R. Stevens, B. Cravatt, 2008, Bioorganic & medicinal chemistry letters.

Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding

I. Slaymaker, Xiaojiang S. Chen, A. Brewster, 2010, BMC Molecular Biology.

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

Randall J. Platt, G. Feng, G. Crabtree, 2017, Cell reports.

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

Kira S. Makarova, Eugene V. Koonin, Yinqing Li, 2016, Cell.

Base editing: advances and therapeutic opportunities

Alexis C. Komor, I. Slaymaker, Elizabeth M Porto, 2020, Nature Reviews Drug Discovery.

Directed evolution of adenine base editors with increased activity and therapeutic application

Jonathan Yen, Nicole M. Gaudelli, Jason M. Gehrke, 2020, Nature Biotechnology.

Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation.

Nicole M. Gaudelli, Luis A. Barrera, M. Packer, 2021, The CRISPR journal.

Cas 13 b Is a Type VIB CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx 27 and Csx 28

Sergey A. Shmakov, E. Koonin, J. Gootenberg, 2017 .

Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28

Sergey A. Shmakov, E. Koonin, J. Gootenberg, 2016, bioRxiv.

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Eric S. Lander, Aviv Regev, Kira S. Makarova, 2016, Science.

Reconstitution of the L . shahii C 2 c 2 locus in Escherichia coli confers RNA-guided immunity

Makarova, Sergey A. Shmakov, E. Lander, 2016 .

Engineering Cas9 for human genome editing.

Nicole M. Gaudelli, I. Slaymaker, 2021, Current opinion in structural biology.

Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function

Nicole M. Gaudelli, M. Packer, I. Slaymaker, 2021, Blood.

MCM structure and mechanics: what we have learned from archaeal MCM.

I. Slaymaker, Xiaojiang S. Chen, 2012, Sub-cellular biochemistry.

Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

Nicole M. Gaudelli, Luis A. Barrera, M. Packer, 2020 .

CRISPR EVOLUTION C 2 c 2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Sergey A. Shmakov, A. Regev, E. Lander, 2016 .

CRISPR-Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling.

Remo Rohs, Wei Jiang, Rosa Di Felice, 2017, ACS chemical biology.

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.