M. Irving

发表

X-ray diffraction studies of the contractile mechanism in single muscle fibres.

A. Stewart, G. Piazzesi, V. Lombardi, 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The myosin motor in muscle generates a smaller and slower working stroke at higher load

A. Stewart, G. Piazzesi, V. Lombardi, 2004, Nature.

Elastic distortion of myosin heads and repriming of the working stroke in muscle

G. Piazzesi, I. Dobbie, M. Irving, 1995, Nature.

Time‐lapse FRET microscopy using fluorescence anisotropy

S. Ameer-Beg, P. Barber, B. Vojnovic, 2010, Journal of microscopy.

Skeletal Muscle Performance Determined by Modulation of Number of Myosin Motors Rather Than Motor Force or Stroke Size

A. Stewart, G. Piazzesi, V. Lombardi, 2007, Cell.

Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction

M. Irving, R. E. Dale, Y. E. Goldman, 1999, Nature.

Conformation and dynamics of a rhodamine probe attached at two sites on a protein: implications for molecular structure determination in situ.

F. Fraternali, M. Irving, A. De Simone, 2008, Journal of the American Chemical Society.

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

Yin-Biao Sun, M. Irving, Xuemeng Zhang, 2017, eLife.

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

M. Irving, L. Fusi, E. Brunello, 2021, Proceedings of the National Academy of Sciences.

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle.

M. Irving, J. Kendrick‐Jones, J. Sleep, 1996, Biophysical journal.

Structural changes in troponin in response to Ca2+ and myosin binding to thin filaments during activation of skeletal muscle

Yin-Biao Sun, M. Irving, B. Brandmeier, 2006, Proceedings of the National Academy of Sciences.

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

Yin-Biao Sun, M. Irving, Xuemeng Zhang, 2017, The Journal of physiology.

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle

Yin-Biao Sun, M. Irving, T. Kampourakis, 2019, Proceedings of the National Academy of Sciences.

Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle.

N. Sizto, J. Maylie, M. Irving, 1990, Biophysical journal.

Molecular motor mechanics

M. Irving, 1988, Nature.

Birefringence as a probe of crossbridge orientation in demembranated muscle fibres.

M. Irving, M. Ferenczi, M. Peckham, 1988, Advances in experimental medicine and biology.

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

K. Campbell, M. Gautel, Yin-Biao Sun, 2020, The Journal of Biological Chemistry.

Toward protein structure in situ: comparison of two bifunctional rhodamine adducts of troponin C.

B. Sykes, Yin-Biao Sun, M. Irving, 2007, Biophysical journal.

Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments

M. Irving, L. Fusi, E. Brunello, 2022, The Journal of physiology.

In situ orientations of protein domains: troponin C in skeletal muscle fibers.

B. Sykes, P. Mercier, Yin-Biao Sun, 2003, Molecular cell.

Changes in the x-ray diffraction pattern from single, intact muscle fibers produced by rapid shortening and stretch.

G. Piazzesi, V. Lombardi, I. Dobbie, 1995, Biophysical journal.

In Vitro and in Situ Structure and Function of the Cardiac Troponin C Familial Hypertrophic Cardiomyopathy-Linked Mutation, L29Q

I. M. Robertson, B. Sykes, Yin-Biao Sun, 2014 .

Elastic bendingandactive tiltingofmyosinheads duringmusclecontraction

G. Piazzesi, V. Lombardi, I. Dobbie, 1998 .

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A

Yin-Biao Sun, M. Irving, T. Kampourakis, 2022, The Journal of biological chemistry.

The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation

M. Irving, L. Fusi, Zhe Huang, 2015, Biophysical journal.

Structural dynamics of troponin during activation of skeletal muscle

Yin-Biao Sun, M. Irving, L. Fusi, 2014, Proceedings of the National Academy of Sciences.

Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction.

Yin-Biao Sun, M. Irving, A. C. Knowles, 2012, Journal of molecular biology.

The NMR Structure of a Bifunctional Rhodamine Labeled N-domain of Troponin C inComplex with the Regulatory 'Switch' Peptide from Troponin I

B. Sykes, P. Mercier, M. Irving, 2003 .

NMR structure of a bifunctional rhodamine labeled N-domain of troponin C complexed with the regulatory "switch" peptide from troponin I: implications for in situ fluorescence studies in muscle fibers.

B. Sykes, P. Mercier, M. Irving, 2003, Biochemistry.

Model-independent analysis of the orientation of fluorescent probes with restricted mobility in muscle fibers.

M. Irving, R. Dale, Y. Goldman, 1999, Biophysical journal.

Steady-state fluorescence polarization studies of the orientation of myosin regulatory light chains in single skeletal muscle fibers using pure isomers of iodoacetamidotetramethylrhodamine.

M. Irving, J. Corrie, D. Trentham, 1998, Biophysical journal.

Fluorescence polarization transients from rhodamine isomers on the myosin regulatory light chain in skeletal muscle fibers.

M. Irving, J. Corrie, Y. Goldman, 1998, Biophysical journal.

Orientation changes in myosin regulatory light chains following photorelease of ATP in skinned muscle fibers.

M. Irving, Y. Goldman, N. Ling, 1996, Biophysical journal.

Actomyosin energy turnover declines while force remains constant during isometric muscle contraction

Yin-Biao Sun, M. Irving, Timothy G. West, 2004, The Journal of physiology.

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

Yin-Biao Sun, M. Irving, T. Kampourakis, 2016, Proceedings of the National Academy of Sciences.

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q

I. M. Robertson, B. Sykes, Yin-Biao Sun, 2015, Journal of molecular and cellular cardiology.

Calcium‐ and myosin‐dependent changes in troponin structure during activation of heart muscle

Malcolm Irving, Yin-Biao Sun, M. Irving, 2009, The Journal of physiology.

Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle

Malcolm Irving, Yale E. Goldman, M. Irving, 1995, Nature.

Birefringence changes associated with isometric contraction and rapid shortening steps in frog skeletal muscle fibres.

M. Irving, Malcolm Irving, 1993, The Journal of physiology.

Sarcomere‐length dependence of myosin filament structure in skeletal muscle fibres of the frog

G. Piazzesi, V. Lombardi, M. Reconditi, 2014, The Journal of physiology.

Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing

G. Piazzesi, V. Lombardi, T. Irving, 2021, The Journal of general physiology.

Myosin filament-based regulation of the dynamics of contraction in heart muscle

T. Narayanan, M. Irving, L. Fusi, 2020, Proceedings of the National Academy of Sciences.

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

M. Irving, L. Fusi, E. Brunello, 2016, Nature Communications.

Reversible Covalent Binding to Cardiac Troponin C by the Ca2+-Sensitizer Levosimendan.

I. M. Robertson, B. Sykes, Yin-Biao Sun, 2016, Biochemistry.

Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation

G. Piazzesi, V. Lombardi, T. Irving, 2019, The Journal of general physiology.

Orientation of the N- and C-Terminal Lobes of the Myosin Regulatory Light Chain in Cardiac Muscle

Yin-Biao Sun, M. Irving, T. Kampourakis, 2015, Biophysical journal.

Orientation of the N-terminal lobe of the myosin regulatory light chain in skeletal muscle fibers.

Yin-Biao Sun, M. Irving, D. Trentham, 2012, Biophysical journal.

Bifunctional rhodamine probes of Myosin regulatory light chain orientation in relaxed skeletal muscle fibers.

M. Irving, R. Ferguson, A. Brack, 2004, Biophysical journal.

Myosin crossbridge orientation in demembranated muscle fibres studied by birefringence and X-ray diffraction measurements.

M. Irving, M. Peckham, 1989, Journal of molecular biology.

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

M. Irving, T. Kampourakis, Saraswathi Ponnam, 2018, Journal of molecular and cellular cardiology.

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

M. Irving, T. Kampourakis, 2015, Journal of molecular and cellular cardiology.

IRVING gr AL . Mg and Ca Signals in Cut Muscle Fibers 587 similar to that used by Kovacs

N. Sizto, J. Maylie, M. Irving, 2003 .

Simultaneous monitoring of changes in magnesium and calcium concentrations in frog cut twitch fibers containing antipyrylazo III

N. Sizto, J. Maylie, M. Irving, 1989, The Journal of general physiology.

Comparison of arsenazo III optical signals in intact and cut frog twitch fibers

N. Sizto, J. Maylie, M. Irving, 1987, The Journal of general physiology.

Calcium signals recorded from cut frog twitch fibers containing antipyrylazo III

N. Sizto, J. Maylie, M. Irving, 1987, The Journal of general physiology.

Intrinsic optical and passive electrical properties of cut frog twitch fibers

N. Sizto, J. Maylie, M. Irving, 1987, The Journal of general physiology.

Calcium Signals Recorded from Cut Frog

N. Sizto, J. Maylie, M. Irving, 1987 .

Steady-state polarization from cylindrically symmetric fluorophores undergoing rapid restricted motion.

M. Irving, 1996, Biophysical journal.

Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

M. Irving, L. Fusi, E. Brunello, 2021, eLife.

Scanning total internal reflection fluorescence imaging

M. Parsons, A. M. Quirke, S. M. Ameer-Beg, 2006, SPIE BiOS.

Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog

I. M. Robertson, B. Sykes, Yin-Biao Sun, 2016, Journal of molecular and cellular cardiology.

Myosin head movements are synchronous with the elementary force-generating process in muscle

G. Piazzesi, V. Lombardi, M. Irving, 1992, Nature.

Myosin head movements are synchronous with the elementary force-generating process in muscle

Malcolm Irving, Vincenzo Lombardi, Michael A. Ferenczi, 1992, Nature.

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

G. Piazzesi, V. Lombardi, M. Reconditi, 2015, Nature.

Regulation of Contraction by the Thick Filaments in Skeletal Muscle.

M. Irving, 2017, Biophysical journal.

The structural basis of the increase in isometric force production with temperature in frog skeletal muscle

G. Piazzesi, V. Lombardi, M. Reconditi, 2005, The Journal of physiology.

The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actin.

G. Piazzesi, V. Lombardi, I. Dobbie, 1998, Biophysical journal.

Motion of myosin head domains during activation and force development in skeletal muscle

G. Piazzesi, V. Lombardi, M. Reconditi, 2011, Proceedings of the National Academy of Sciences.

Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ.

Brittney A. Klein, I. M. Robertson, B. Sykes, 2018, Biochemistry.

A high-content screening platform utilizing polarization anisotropy and FLIM microscopy

Klaus Suhling, Malcolm Irving, Paul Barber, 2008, SPIE BiOS.

Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

M. Gautel, Yin-Biao Sun, M. Irving, 2014, Proceedings of the National Academy of Sciences.

In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells

M. Irving, S. Ameer-Beg, E. Ehler, 2023, Proceedings of the National Academy of Sciences of the United States of America.

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

M. Irving, T. Kampourakis, 2021, Nature Communications.

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions

Yin-Biao Sun, M. Irving, T. Kampourakis, 2018, The Journal of Biological Chemistry.

The molecular basis of the steep force–calcium relation in heart muscle

Malcolm Irving, Yin-Biao Sun, M. Irving, 2010, Journal of molecular and cellular cardiology.

Changes in the Orientation of the Myosin Light Chain Domain (LCD) Associated with Thick Filament-Based Regulation of Skeletal Muscle

M. Irving, L. Fusi, Zhe Huang, 2014 .

Orientation changes of the myosin light chain domain during filament sliding in active and rigor muscle.

M. Irving, J. Corrie, R. Ferguson, 2002, Journal of molecular biology.

High‐energy phosphate metabolism and energy liberation associated with rapid shortening in frog skeletal muscle

E. Homsher, M. Irving, A. Wallner, 1981, The Journal of physiology.

Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components.

G. Piazzesi, V. Lombardi, M. Reconditi, 2019, Biophysical journal.

The contributions of filaments and cross‐bridges to sarcomere compliance in skeletal muscle

Malcolm Irving, Marco Linari, Gabriella Piazzesi, 2014, The Journal of physiology.

Structural changes in the myosin filament and cross‐bridges during active force development in single intact frog muscle fibres: stiffness and X‐ray diffraction measurements

G. Piazzesi, V. Lombardi, M. Reconditi, 2006, The Journal of physiology.

Structural changes in myosin motors and filaments during relaxation of skeletal muscle

G. Piazzesi, V. Lombardi, M. Reconditi, 2009, The Journal of physiology.

Structure‐Function Relation of the Myosin Motor in Striated Muscle

A. Stewart, G. Piazzesi, V. Lombardi, 2005, Annals of the New York Academy of Sciences.

Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin

G. Piazzesi, V. Lombardi, M. Reconditi, 2007, Proceedings of the National Academy of Sciences.

Effect of active shortening on the rate of ATP utilisation by rabbit psoas muscle fibres

M. Irving, K. Hilber, Y. Sun, 2001, The Journal of physiology.

Calcium signals recorded from cut frog twitch fibers containing tetramethylmurexide

N. Sizto, J. Maylie, M. Irving, 1987, The Journal of general physiology.

Motor proteins. Biomechanics goes quantum.

M. Irving, 1991, Nature.

Conformation of the myosin motor during force generation in skeletal muscle.

G. Piazzesi, V. Lombardi, I. Dobbie, 2000 .

Elastic bending and active tilting of myosin heads during muscle contraction

G. Piazzesi, V. Lombardi, I. Dobbie, 1998, Nature.

Myosin head movements during isometric contraction studied by X-ray diffraction of single frog muscle fibres.

G. Piazzesi, V. Lombardi, I. Dobbie, 1998, Advances in experimental medicine and biology.

Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle

G. Piazzesi, V. Lombardi, M. Reconditi, 2021, The Journal of general physiology.

Mechanism of force generation by myosin heads in skeletal muscle

G. Piazzesi, V. Lombardi, M. Reconditi, 2002, Nature.

Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers.

V Lombardi, M Irving, G Piazzesi, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Conformation of the myosin motor during force generation in skeletal muscle

G. Piazzesi, V. Lombardi, I. Dobbie, 2000, Nature Structural Biology.

Orientation changes of fluorescent probes at five sites on the myosin regulatory light chain during contraction of single skeletal muscle fibres.

M. Irving, S. Lowey, Y. Goldman, 1998, Journal of molecular biology.

The variation in shortening heat with sarcomere length in frog muscle.

E. Homsher, M. Irving, J. Lebacq, 1983, The Journal of physiology.

Transients of fluorescence polarization in skeletal muscle fibers labeled with rhodamine on the regulatory light chain.

M. Irving, Y. Goldman, C. Sabido-David, 1995, Biophysical journal.

4.11 Cell-Based Studies of the Molecular Mechanism of Muscle Contraction

M. Irving, 2012 .

Weak and strong crossbridges.

M. Irving, 1985, Nature.

Muscle contraction: Weak and strong crossbridges

M. Irving, 1985, Nature.

Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres

G. Piazzesi, V. Lombardi, I. Dobbie, 1999, The Journal of physiology.

Interference X-ray Diffraction from Single Muscle Cells Reveals the Molecular Basis of Muscle Braking

G. Piazzesi, V. Lombardi, M. Reconditi, 2011 .

On the working stroke elicited by steps in length and temperature.

G. Piazzesi, V. Lombardi, M. Irving, 1998, Advances in experimental medicine and biology.

Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation

T. Narayanan, M. Irving, L. Fusi, 2022, The Journal of general physiology.

THE ENERGETICS OF CONTRACTING MUSCLE AND ITS RELATION TO CROSSBRIDGE MECHANISMS

E. Homsher, M. Irving, 1981 .