C. Sarkar

发表

Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”

D. Lauffenburger, B. Tidor, K. Lowenhaupt, 2002, Nature Biotechnology.

Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo.

D. Lauffenburger, C. Sarkar, Casim A. Sarkar, 2003, Molecular pharmacology.

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

Andreas Plückthun, Casim A Sarkar, Emmanuel Hermans, 2008, Proceedings of the National Academy of Sciences.

Tunable Signal Processing in Synthetic MAP Kinase Cascades

James J. Collins, Santhosh Palani, J. Collins, 2011, Cell.

Hematopoiesis and its disorders: a systems biology approach.

Marek Kimmel, Casim A Sarkar, Zakary L. Whichard, 2010, Blood.

Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.

S. Jung, William J Kelton, J. Andersen, 2013, ACS chemical biology.

Towards a Quantitative Understanding of Cell Identity.

C. Sarkar, Casim A. Sarkar, Zi Ye, 2018, Trends in cell biology.

Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanisms⃞

A. Plückthun, C. Sarkar, S. Kubetzko, 2005, Molecular Pharmacology.

Conceptual and methodological advances in cell-free directed evolution.

C. Sarkar, Igor Dodevski, Casim A. Sarkar, 2015, Current opinion in structural biology.

Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition

S. Corey, J. Maciejewski, C. Sarkar, 2014, Leukemia.

Toward Bioremediation of Methylmercury Using Silica Encapsulated Escherichia coli Harboring the mer Operon

Kelly G. Aukema, Stephen C. Heinsch, B. Al-Shayeb, 2016, PloS one.

Transient noise amplification and gene expression synchronization in a bistable mammalian cell-fate switch.

S. Palani, C. Sarkar, Casim A. Sarkar, 2012, Cell reports.

Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

C. Sarkar, Casim A. Sarkar, W. J. Errington, 2019, Proceedings of the National Academy of Sciences.

Engineering Signal Peptides for Enhanced Protein Secretion from Lactococcus lactis

C. Sarkar, Daphne T. W. Ng, 2012, Applied and Environmental Microbiology.

Nisin‐inducible secretion of a biologically active single‐chain insulin analog by Lactococcus lactis NZ9000

C. Sarkar, Daphne T. W. Ng, Casim A. Sarkar, 2011, Biotechnology and bioengineering.

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution.

A. Plückthun, C. Sarkar, C. Zahnd, 2010, Protein engineering, design & selection : PEDS.

MVsim is a toolset for quantifying and designing multivalent interactions

C. Sarkar, Casim A. Sarkar, W. J. Errington, 2022, Nature Communications.

Parsing the Effects of Binding, Signaling, and Trafficking on the Mitogenic Potencies of Granulocyte Colony‐Stimulating Factor Analogues

D. Lauffenburger, K. Lowenhaupt, C. Sarkar, 2003, Biotechnology progress.

Streamlined protocol for mRNA display.

C. Sarkar, Daphne T. W. Ng, Casim A. Sarkar, 2013, ACS combinatorial science.

Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch.

Santhosh Palani, Casim A Sarkar, S. Palani, 2008, Biophysical journal.

pH Dependence of structural stability of interleukin‐2 and granulocyte colony‐stimulating factor

D. Lauffenburger, D. Brems, C. Sarkar, 2003, Protein science : a publication of the Protein Society.

Lectures 7, 8 and 9: October 11, 13 and 18, 1999 Lecturer: Mona Singh Scribes: Ching Law and Casim A. Sarkar

C. Sarkar, 2007 .

Variable cellular decision-making behavior in a constant synthetic network topology

Casim A. Sarkar, Najaf A. Shah, C. Sarkar, 2019, BMC Bioinformatics.

NP-Sticky: a web server for optimizing DNA ligation with non-palindromic sticky ends.

C. Sarkar, Daphne T. W. Ng, Casim A. Sarkar, 2014, Journal of molecular biology.

Broad-Specificity mRNA–rRNA Complementarity in Efficient Protein Translation

Najaf A. Shah, C. Sarkar, Pamela A. Barendt, 2012, PLoS genetics.

Integrating Extrinsic and Intrinsic Cues into a Minimal Model of Lineage Commitment for Hematopoietic Progenitors

Santhosh Palani, Casim A. Sarkar, S. Palani, 2009, PLoS Comput. Biol..

Robust Network Topologies for Generating Switch-Like Cellular Responses

Casim A. Sarkar, Najaf A. Shah, C. Sarkar, 2011, PLoS Comput. Biol..

Trajectory-based energy landscapes of gene regulatory networks.

C. Sarkar, S. Azarin, Harish Venkatachalapathy, 2021, Biophysical journal.

Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue

Marshall J. Levesque, Najaf A. Shah, A. Raj, 2015, Journal of Cell Science.

Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue

Marshall J. Levesque, Najaf A. Shah, A. Raj, 2015, Journal of Cell Science.

Model-guided engineering of DNA sequences with predictable site-specific recombination rates

Samira M. Azarin, C. Sarkar, S. Azarin, 2021, Nature Communications.

Evidence for context-dependent complementarity of non-Shine-Dalgarno ribosome binding sites to Escherichia coli rRNA.

Najaf A. Shah, C. Sarkar, Pamela A. Barendt, 2013, ACS chemical biology.

Cell-free Display Systems For Protein Engineering

C. Sarkar, Casim A. Sarkar, Pamela A. Barendt, 2009 .

Selection and characterization of DARPins specific for the neurotensin receptor 1.

A. Plückthun, C. Sarkar, D. Ferrari, 2009, Protein engineering, design & selection : PEDS.

MVsim: a toolset for quantifying and designing multivalent interactions

C. Sarkar, Casim A. Sarkar, W. J. Errington, 2021, bioRxiv.

Antibody-lectin chimeras for glyco-immune checkpoint blockade

C. Bertozzi, C. Sarkar, J. Ravetch, 2022, bioRxiv.

Synthetic conversion of a graded receptor signal into a tunable, reversible switch

Santhosh Palani, Casim A Sarkar, S. Palani, 2011, Molecular systems biology.

Inertial effect of cell state velocity on the quiescence-proliferation fate decision in breast cancer

Eric Batchelor, C. Sarkar, S. Azarin, 2023, bioRxiv.

Engineering a Minimal Leucine-rich Repeat IgG-binding Module

C. Sarkar, A. Ohoka, Casim A. Sarkar, 2021, Applied Biochemistry and Biotechnology.

Analyzing and engineering cell signaling modules with synthetic biology.

Casim A Sarkar, C. Sarkar, Ellen C O'Shaughnessy, 2012, Current opinion in biotechnology.

Model-guided ligation strategy for optimal assembly of DNA libraries.

Daphne T W Ng, Casim A Sarkar, C. Sarkar, 2012, Protein engineering, design & selection : PEDS.