D. Coombs

发表

Optimizing within-host viral fitness: infected cell lifespan and virion production rate.

A. Perelson, M. Gilchrist, D. Coombs, 2004, Journal of theoretical biology.

Asymptotic Analysis of First Passage Time Problems Inspired by Ecology

J. Tzou, M. Ward, D. Coombs, 2015, Bulletin of mathematical biology.

Estimating the impact of COVID-19 control measures using a Bayesian model of physical distancing

A. M. Edwards, D. Coombs, S. Iyaniwura, 2020, medRxiv.

Optimal viral production

A. Perelson, J. Percus, M. Gilchrist, 2003, Bulletin of mathematical biology.

Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everything

David L Buckeridge, Daniel Coombs, Nathaniel Hupert, 2011, BMC public health.

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

Daniel Coombs, Omer Dushek, Vincenzo Cerundolo, 2010, Immunity.

Analysis of peptide/MHC-induced TCR downregulation

Daniel Coombs, Clemens Utzny, C. Utzny, 2007, Cell Biochemistry and Biophysics.

Analysis of membrane-localized binding kinetics with FRAP

Raibatak Das, Daniel Coombs, Omer Dushek, 2008, European Biophysics Journal.

A Theoretical and Experimental Study of Competition Between Solution and Surface Receptors for Ligand in a Biacore Flow Cell

Daniel Coombs, Byron Goldstein, David G Myszka, 2006, Bulletin of mathematical biology.

Modeling Membrane Domains

D. Coombs, Raibatak Das, J. S. Morrison, 2011 .

Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens.

Daniel Coombs, M. Gilchrist, D. Coombs, 2007, Theoretical population biology.

Modeling Within-Host Evolution of HIV: Mutation, Competition and Strain Replacement

Daniel Coombs, M. Gilchrist, D. Coombs, 2007, Bulletin of mathematical biology.

Evolution of virulence: interdependence, constraints, and selection using nested models.

Daniel Coombs, M. Gilchrist, D. Coombs, 2006, Theoretical population biology.

Predicting the impact of clustered risk and testing behaviour patterns on the population-level effectiveness of pre-exposure prophylaxis against HIV among gay, bisexual and other men who have sex with men in Greater Vancouver, Canada.

D. Coombs, M. Gilbert, M. Irvine, 2020, Epidemics.

Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity.

D. Coombs, D. Woodsworth, Valentin Dunsing, 2015, Biophysical journal.

Effects of Intracellular Calcium and Actin Cytoskeleton on TCR Mobility Measured by Fluorescence Recovery

I. Caramalho, D. Coombs, S. Valitutti, 2008, PloS one.

An age-structured model of hiv infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells.

Daniel Coombs, Patrick W Nelson, Alan S Perelson, 2004, Mathematical biosciences and engineering : MBE.

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

S. Grinstein, M. Gold, D. Coombs, 2015, Nature Communications.

Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility

Joshua M. Scurll, M. Gold, D. Coombs, 2017, Scientific Reports.

Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic.

D. Coombs, R. Balshaw, M. Gilbert, 2019, Addiction.

Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing

Sean C. Anderson, A. M. Edwards, D. Coombs, 2020, PLoS Comput. Biol..

How much leeway is there to relax COVID-19 control measures?

A. M. Edwards, D. Coombs, S. Iyaniwura, 2020, Epidemics.

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.

J. Allard, D. Coombs, Omer Dushek, 2012, Biophysical journal.

T cell activation: kinetic proofreading, serial engagement and cell adhesion

B. Goldstein, D. Coombs, 2005 .

Activated TCRs remain marked for internalization after dissociation from pMHC

B. Goldstein, D. Coombs, C. Wofsy, 2002, Nature Immunology.

Regulatory vs. helper CD4+ T-cell ratios and the progression of HIV/AIDS disease

J. Dushoff, W. Ndifon, D. Coombs, 2014, bioRxiv.

The causes of individual variability in the length of time between human immunodeficiency virus ( HIV ) infection and the development of AIDS

J. Dushoff, W. Ndifon, D. Coombs, 2014 .

The role of mathematical modelling in aiding public health policy decision-making: A case study of the BC opioid overdose emergency.

D. Coombs, M. Gilbert, M. Irvine, 2019, The International journal on drug policy.

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control

J. Schiffer, A. Wald, L. Corey, 2019, bioRxiv.

Density gradient fractionation by piston displacement.

D. Coombs, 1975, Analytical biochemistry.

The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore

B. Goldstein, D. Coombs, C. Wofsy, 1999, Journal of molecular recognition : JMR.

Particle-Based Stochastic Reaction-Diffusion Models in Biology

D. Coombs, 2016 .

First among equals: Comment on "Redundancy principle and the role of extreme statistics in molecular and cellular biology" by Z. Schuss, K. Basnayake and D. Holcman.

D. Coombs, 2019, Physics of life reviews.

Asymptotic Analysis of First Passage Time Problems Inspired by Ecology

J. Tzou, M. Ward, D. Coombs, 2015, Bulletin of mathematical biology.

Stochastic Dynamics of the Latently Infected Cell Reservoir During HIV Infection

D. Coombs, S. Azoz, 2018, Bulletin of Mathematical Biology.

StormGraph: A graph-based algorithm for quantitative clustering analysis of diverse single-molecule localization microscopy data

Keng C. Chou, Daniel Coombs, Da Wei Zheng, 2019, bioRxiv.

A Hidden Markov Model for Single Particle Tracks Quantifies Dynamic Interactions between LFA-1 and the Actin Cytoskeleton

Raibatak Das, Christopher W. Cairo, Daniel Coombs, 2009, PLoS Comput. Biol..

Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition

Daniel Coombs, Catherine M. Byrne, Soren Gantt, 2018, PLoS Comput. Biol..

Stochastic Analysis of Pre- and Postexposure Prophylaxis against HIV Infection

Daniel Coombs, Jessica M. Conway, Bernhard P. Konrad, 2013, SIAM J. Appl. Math..

Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

M. Sliwkowski, F. Kabbinavar, D. Coombs, 1999, Oncogene.

Mechanical force regulates integrin turnover in Drosophila in vivo

D. Coombs, Raibatak Das, G. Tanentzapf, 2012, Nature Cell Biology.

Effects of the geometry of the immunological synapse on the delivery of effector molecules.

B. Goldstein, D. Coombs, 2004, Biophysical journal.

Symptomatic and Asymptomatic Transmission of SARS-CoV-2 in K-12 Schools, British Columbia, Canada April to June 2021

L. Mâsse, D. Coombs, P. Lavoie, 2022, Microbiology spectrum.

SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: a cross-sectional study

L. Mâsse, D. Coombs, M. Sadarangani, 2022, BMJ Open.

SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada

L. Mâsse, D. Coombs, M. Sadarangani, 2021, medRxiv.

Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor

M. Gold, D. Coombs, C. Roskelley, 2017, Journal of Cell Science.

Examining the dynamics of Epstein-Barr virus shedding in the tonsils and the impact of HIV-1 coinfection on daily saliva viral loads

J. Schiffer, A. Wald, L. Corey, 2021, PLoS Comput. Biol..

Modeling COVID-19 and Its Impacts on U.S. Immigration and Customs Enforcement (ICE) Detention Facilities, 2020

J. Rich, D. Coombs, F. Taxman, 2020, Journal of Urban Health.

In vivo regulation of integrin turnover by outside-in activation

D. Coombs, G. Tanentzapf, A. D. Herrera-Reyes, 2016, Journal of Cell Science.

Mathematical modeling of COVID-19 in British Columbia: An age-structured model with time-dependent contact rates

D. Coombs, M. Spencer, S. Iyaniwura, 2021, Epidemics.

On the duration of the period between exposure to HIV and detectable infection.

Bernhard P. Konrad, D. Coombs, G. Ogilvie, 2017, Epidemics.

Probability of a false-negative HIV antibody test result during the window period: a tool for pre- and post-test counselling

Bernhard P. Konrad, C. Archibald, T. Wong, 2015, International journal of STD & AIDS.

Conditions for eradicating hepatitis C in people who inject drugs: A fibrosis aware model of hepatitis C virus transmission.

D. Coombs, I. Rozada, V. Lima, 2016, Journal of theoretical biology.

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

Daniel Coombs, Byron Goldstein, B. Goldstein, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

Joshua M. Scurll, M. Gold, D. Coombs, 2018, bioRxiv.

In vivo quantitative analysis of Talin turnover in response to force

D. Coombs, Raibatak Das, G. Tanentzapf, 2015, Molecular biology of the cell.

Calculations show substantial serial engagement of T cell receptors.

B. Goldstein, D. Coombs, C. Wofsy, 2001, Biophysical journal.

Supplementary information for Activated TCRs remain marked for internalization after dissociation from pMHC

Daniel Coombs, Alexis M. Kalergis, Byron Goldstein, 2022 .

The space and time frames of T cell activation at the immunological synapse

Daniel Coombs, D. Coombs, L. Dupré, 2010, FEBS letters.

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters.

Daniel Coombs, Omer Dushek, D. Coombs, 2008, Biophysical journal.

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

Daniel Coombs, Omer Dushek, Tao Dong, 2011, Science Signaling.

A Review of Mathematical Models for T Cell Receptor Triggering and Antigen Discrimination

Daniel Coombs, Omer Dushek, P. Anton van der Merwe, 2011 .

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

Raibatak Das, Daniel Coombs, Omer Dushek, 2009, PLoS Comput. Biol..

Kinetic proofreading model.

Daniel Coombs, James R Faeder, Byron Goldstein, 2008, Advances in experimental medicine and biology.

Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs.

Daniel Coombs, Byron Goldstein, Micah Dembo, 2004, Biophysical journal.

Dynamic Regulation of CD45 Lateral Mobility by the Spectrin-Ankyrin Cytoskeleton of T Cells*

Raibatak Das, Christopher W. Cairo, Daniel Coombs, 2010, The Journal of Biological Chemistry.

A Biophysical Model of Cell Adhesion Mediated by Immunoadhesin Drugs and Antibodies

R. Gutenkunst, Michael Loran Dustin, B. Goldstein, 2010, PloS one.

Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study.

D. Coombs, R. Balshaw, T. Kerr, 2018, The Lancet. Public health.

Estimating naloxone need in the USA across fentanyl, heroin, and prescription opioid epidemics: a modelling study

Brandon D. L. Marshall, D. Coombs, M. Irvine, 2022, The Lancet. Public health.

Correction: The Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model

J. Montaner, A. Spaulding, C. Beckwith, 2015, PloS one.

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and cell activation

M. Gold, D. Coombs, Madison Bolger-Munro, 2018, bioRxiv.

Sustained Reduction in Sexual Behavior that May Pose a Risk of HIV Transmission Following Diagnosis During Early HIV Infection Among Gay Men in Vancouver, British Columbia

D. Coombs, R. Balshaw, M. Gilbert, 2018, AIDS and Behavior.

The Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model

J. Montaner, A. Spaulding, C. Beckwith, 2015, PloS one.

Competition among viruses at the within-and between-host scales

M. Gilchrist, D. Coombs, Colleen L. Ball, 2007 .

Diffusion analysis of single particle trajectories in a Bayesian nonparametrics framework

Daniel Coombs, Rebeca Cardim Falcao, D. Coombs, 2019, bioRxiv.

Diffusion on a Sphere with Localized Traps: Mean First Passage Time, Eigenvalue Asymptotics, and Fekete Points

Daniel Coombs, Michael J. Ward, Ronny Straube, 2009, SIAM J. Appl. Math..

Modeling Effect of a γ-Secretase Inhibitor on Amyloid-β Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism

Raibatak Das, Daniel Coombs, Leah Edelstein-Keshet, 2011, Bulletin of mathematical biology.

Microelastohydrodynamics of Swimming Organisms Near Solid Boundaries in Complex Fluids

D. Coombs, N. Balmforth, S. Pachmann, 2010 .

Under Consideration for Publication in the Siam J. Multiscale Analysis and Simulation Conditional Mean First Passage times to Small Traps in a 3-d Domain with a Sticky Boundary: Applications to T Cell Searching Behaviour in Lymph Nodes

Daniel Coombs, Michael J. Ward, Monica I. Delgado, 2022 .

Dynamics of travelling helicity fronts in bacterial flagella

D. Coombs, 2001 .

SARS-CoV-2 cross-sectional seroprevalence study among public school staff in Metro Vancouver after the first Omicron wave in British Columbia, Canada

L. Mâsse, D. Coombs, S. O’Brien, 2023, BMJ open.

Assessing the optimal virulence of malaria‐targeting mosquito pathogens: a mathematical study of engineered Metarhizium anisopliae

Bernhard P. Konrad, Anja C. Gumpinger, D. Coombs, 2014, Malaria Journal.

A novel Bayesian approach to predicting reductions in HIV incidence following increased testing interventions among gay, bisexual and other men who have sex with men in Vancouver, Canada

Bernhard P. Konrad, D. Coombs, R. Balshaw, 2018, Journal of The Royal Society Interface.

A Stochastic Model of Latently Infected Cell Reactivation and Viral Blip Generation in Treated HIV Patients

Daniel Coombs, Jessica M. Conway, D. Coombs, 2011, PLoS Comput. Biol..

Stochastic Dynamics of the Latently Infected Cell Reservoir During HIV Infection

D. Coombs, S. Azoz, 2018, Bulletin of mathematical biology.

Quantification and Modeling of Tripartite CD2-, CD58FC Chimera (Alefacept)-, and CD16-mediated Cell Adhesion*

Daniel Coombs, Byron Goldstein, Adrian Whitty, 2007, Journal of Biological Chemistry.

Improving parameter estimation for cell surface FRAP data.

D. Coombs, Omer Dushek, 2008, Journal of biochemical and biophysical methods.

SIR-Network Model and Its Application to Dengue Fever

Daniel Coombs, Lucas M. Stolerman, Stefanella Boatto, 2015, SIAM J. Appl. Math..

Importance of COVID-19 vaccine efficacy in older age groups

D. Coombs, M. Sadarangani, S. Iyaniwura, 2021, Vaccine.

Quantifying transmissibility of SARS-CoV-2 and impact of intervention within long-term healthcare facilities

A. M. Edwards, D. Coombs, S. Iyaniwura, 2022, Royal Society Open Science.

Quantifying transmissibility of COVID-19 and impact of intervention within long-term health care facilities

A. M. Edwards, D. Coombs, C. Colijn, 2021, medRxiv.

Periodic chirality transformations propagating on bacterial flagella.

G. Huber, D. Coombs, R. Goldstein, 2002, Physical review letters.

A Biophysical Model of Cell Adhesion Mediated by Immunoadhesin Drugs and Antibodies

R. Gutenkunst, Michael Loran Dustin, B. Goldstein, 2010, PloS one.

Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study.

D. Coombs, R. Balshaw, T. Kerr, 2018, Lancet Public Health.