J. Haugh

发表

Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts*

Chang Shin Park, I. Schneider, J. Haugh, 2003, Journal of Biological Chemistry.

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (erk) Signaling Network * □ S Experimental Procedures Data-driven Modeling of Feedback Regulating Erk Signaling Data-driven Modeling of Feedback Regulating Erk Signaling Data-driven Modeling of Fee

Murat Cirit, Jason M Haugh, Chun-Chao Wang, 2022 .

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-γ1 Signaling Pathway*

Alan Wells, H. Steven Wiley, Douglas A. Lauffenburger, 1999, The Journal of Biological Chemistry.

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions.

D. Lauffenburger, A. Wells, J. Haugh, 2000, Biotechnology and bioengineering.

Deactivation of a negative regulator: a distinct signal transduction mechanism, pronounced in Akt signaling.

J. Haugh, Anisur Rahman, 2014, Biophysical journal.

Computational Models of Tandem Src Homology 2 Domain Interactions and Application to Phosphoinositide 3-Kinase*

Dipak Barua, James R. Faeder, Jason M. Haugh, 2008, Journal of Biological Chemistry.

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation.

Murat Cirit, Jason M Haugh, J. Haugh, 2012, The Biochemical journal.

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling.

Jason M Haugh, Ian C Schneider, I. Schneider, 2004, Journal of theoretical biology.

Analysis of reaction-diffusion systems with anomalous subdiffusion.

Jason M Haugh, J. Haugh, 2009, Biophysical journal.

Physical modulation of intracellular signaling processes by locational regulation.

D A Lauffenburger, D. Lauffenburger, J. Haugh, 1997, Biophysical journal.

Analysis of receptor internalization as a mechanism for modulating signal transduction.

D A Lauffenburger, D. Lauffenburger, J. Haugh, 1998, Journal of theoretical biology.

Signaling pathways that control cell migration: models and analysis

Erik S. Welf, J. Haugh, E. Welf, 2011, Wiley interdisciplinary reviews. Systems biology and medicine.

Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics.

Erik S. Welf, J. Haugh, E. Welf, 2012, Methods in cell biology.

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing.

J. Haugh, 2006, Biophysical journal.

Mechanisms of Gradient Sensing and Chemotaxis: Conserved Pathways, Diverse Regulation

Jason M Haugh, Ian C Schneider, I. Schneider, 2006, Cell cycle.

Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.

Erik S. Welf, Jason M Haugh, Erik S Welf, 2010, Biophysical journal.

Quantitative analysis of B-lymphocyte migration directed by CXCL13.

J. Haugh, J. Bear, Sreeja B. Asokan, 2016, Integrative biology : quantitative biosciences from nano to macro.

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TH2 Cell Line

Kristen K. Comfort, J. Haugh, 2008, Cellular and molecular bioengineering.

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration.

W. Reichert, J. Haugh, V. N. Vernekar, 2014, Colloids and surfaces. B, Biointerfaces.

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

Erik S. Welf, Adam T. Melvin, J. Haugh, 2012, The Journal of cell biology.

Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration.

J. Haugh, J. Bear, Scott A Baldwin, 2021, Biomicrofluidics.

Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring?

J. Haugh, 2012, Biophysical journal.

Lamellipodia are crucial for haptotactic sensing and response

B. Kuhlman, N. Sharpless, J. Haugh, 2016, Journal of Cell Science.

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts

J. Haugh, J. Bear, Heath E Johnson, 2015, The Journal of Cell Biology.

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

Adam T. Melvin, J. Haugh, K. Adler, 2013, PloS one.

Structure-based kinetic models of modular signaling protein function: focus on Shp2.

Dipak Barua, James R Faeder, Jason M Haugh, 2007, Biophysical journal.

A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

J. Haugh, J. Bear, Jamie L. Nosbisch, 2022, The Journal of biological chemistry.

Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Laura E. Edwards, J. Haugh, M. Cirit, 2014, Molecular systems biology.

Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies.

J. Genzer, Michael Weiger, J. Haugh, 2011, Biomacromolecules.

Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides

T. Meyer, J. Haugh, M. Teruel, 2000, The Journal of cell biology.

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly.

Jason M Haugh, Chang Shin Park, J. Haugh, 2006, The Biochemical journal.

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132

J. Haugh, M. Cirit, Kyle G. Grant, 2012, PloS one.

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase*

Murat Cirit, Jason M Haugh, Carla Mattos, 2010, The Journal of Biological Chemistry.

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

J. Haugh, M. Cirit, Chun-Chao Wang, 2009, Molecular systems biology.

Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk.

Jason M Haugh, Michael I Monine, J. Haugh, 2008, Biophysical journal.

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments.

Jason M Haugh, Ian C Schneider, I. Schneider, 2004, Biophysical journal.

Localization of receptor-mediated signal transduction pathways: the inside story.

Jason M Haugh, J. Haugh, 2002, Molecular interventions.

Data-driven, Mechanistic Modeling of Biochemical Reaction Networks

T. Elston, N. Hao, J. Haugh, 2016 .

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.

Jason M Haugh, Ian C Schneider, I. Schneider, 2004, Biophysical journal.

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

J. Haugh, A. Deiters, Wenyuan Zhou, 2020, The Journal of Biological Chemistry.

Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics.

D. Lauffenburger, J. Haugh, E. Fallon, 1998, Chemistry & biology.

Erratum to: Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

Erik S. Welf, J. Haugh, E. Welf, 2012, Cellular and molecular bioengineering.

Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

Erik S. Welf, J. Haugh, E. Welf, 2010 .

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet.

Jason M Haugh, James E Bear, J. Haugh, 2014, Current opinion in cell biology.

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

J. Haugh, J. Bear, Heath E Johnson, 2015, The Journal of cell biology.

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

Jason M. Haugh, I. Schneider, J. Haugh, 2005, The Journal of cell biology.

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity.

Jason M Haugh, Ian C Schneider, I. Schneider, 2005, Biophysical journal.

A unified model for signal transduction reactions in cellular membranes.

Jason M Haugh, J. Haugh, 2002, Biophysical journal.

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21 ras in Fibroblasts*

D. Lauffenburger, H. Wiley, J. Haugh, 1999, The Journal of Biological Chemistry.

Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks.

Laura E. Herring, J. Haugh, Kyle G. Grant, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Guidelines for visualizing and annotating rule-based models.

Bin Hu, Jin Yang, James R Faeder, 2011, Molecular bioSystems.

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

Murat Cirit, Jason M Haugh, Chun-Chao Wang, 2011, Molecular Systems Biology.

Linking morphodynamics and directional persistence of T lymphocyte migration

Erik S. Welf, Jason M Haugh, Erik S Welf, 2015, Journal of The Royal Society Interface.

Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling.

T. Meyer, J. Haugh, 2002, Journal of cell science.

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

J. Haugh, B. Rao, Karthik Tiruthani, 2019, Science Signaling.

Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.

J. Haugh, J. Bear, Anisur Rahman, 2014, Developmental cell.

Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties

J. Haugh, M. Monine, 2008, Cell adhesion & migration.

Mathematical Model of Human Growth Hormone (hGH)‐Stimulated Cell Proliferation Explains the Efficacy of hGH Variants as Receptor Agonists or Antagonists

J. Haugh, 2004, Biotechnology progress.

In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.

Erik S. Welf, Adam T. Melvin, D. Irvine, 2011, Biophysical journal.

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

John J Rhoden, Jason M Haugh, Chun-Chao Wang, 2009, Journal of Cell Science.

Cellular compartmentation effects in receptor-mediated signal transduction

Jason Michael Haugh, J. Haugh, 1999 .

A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

Dipak Barua, James R. Faeder, Jason M. Haugh, 2009, PLoS Comput. Biol..

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

J. Haugh, J. Bear, D. Kovar, 2015, Developmental cell.

Semi-autonomous wound invasion via matrix-deposited, haptotactic cues.

J. Haugh, Scott A Baldwin, 2023, Journal of theoretical biology.

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.

T. Elston, J. Haugh, J. Bear, 2017, Biophysical journal.

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation*

J. Haugh, Anisur Rahman, 2017, The Journal of Biological Chemistry.

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Timothy C Elston, Jason M Haugh, Jamie L Nosbisch, 2020, PLoS Comput. Biol..

JCB_201406102 1..13

J. Haugh, J. Bear, Heath E Johnson, 2015 .

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

Erik S. Welf, Colin K. Choi, Jason M. Haugh, 2010, PLoS Comput. Biol..

Lysophosphatidic acid provokes fibroblast chemotaxis through combinatorial regulation of myosin II

T. Svitkina, J. Sondek, J. Haugh, 2018 .

Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulations.

Jason M Haugh, Michael I Monine, J. Haugh, 2005, The Journal of chemical physics.

Quantitative Analysis of Phosphoinositide 3‐Kinase (PI3K) Signaling Using Live‐Cell Total Internal Reflection Fluorescence (TIRF) Microscopy

J. Haugh, Heath E Johnson, 2013, Current protocols in cell biology.

Mathematical Modelling of Biological Signaling Networks

J. Haugh, 2008 .

Are Filopodia Privileged Signaling Structures in Migrating Cells?

J. Haugh, Heath E Johnson, 2016, Biophysical journal.

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

Erik S. Welf, J. Haugh, E. Welf, 2013, Molecular biology of the cell.

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients.

Callie J. Miller, T. Elston, J. Haugh, 2019, Integrative biology : quantitative biosciences from nano to macro.

Quantitative models of signal transduction networks

J. Haugh, M. Cirit, 2011, Communicative & integrative biology.

Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology.

J. Haugh, 2007, Biophysical journal.

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.

D A Lauffenburger, D. Lauffenburger, H. Wiley, 1999, The Journal of biological chemistry.

Supplementary Figure Legends

Laura E. Edwards, J. Haugh, M. Cirit, 2022 .

Effectiveness factor for spatial gradient sensing in living cells

I. Schneider, J. Haugh, 2006 .

Lamellipodia are crucial for haptotactic sensing and response

B. Kuhlman, N. Sharpless, J. Haugh, 2016, Journal of Cell Science.

Molecular Machines in the Synapse: Overlapping Protein Sets Control Distinct Steps in Neurosecretion

M. Verhage, Evgeni Tsivtsivadze, J. Haugh, 2012, PLoS Comput. Biol..

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

Erik S. Welf, Adam T. Melvin, J. Haugh, 2012, The Journal of cell biology.

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

J. Haugh, J. Bear, D. Kovar, 2015, Developmental cell.

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network*

J. Haugh, M. Cirit, Chun-Chao Wang, 2010, The Journal of Biological Chemistry.

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts

J. Haugh, J. Bear, Heath E Johnson, 2015, The Journal of cell biology.

Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

Omer Dushek, Philip K. Maini, P. Anton van der Merwe, 2013, PLoS Comput. Biol..

Quantitative analysis of B-lymphocyte migration directed by CXCL13.

J. Haugh, J. Bear, Sreeja B. Asokan, 2016, Integrative biology : quantitative biosciences from nano to macro.

Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies.

J. Genzer, Michael Weiger, J. Haugh, 2011, Biomacromolecules.

Quantifying collective motion patterns in mesenchymal cell populations using topological data analysis and agent-based modeling.

John T. Nardini, J. Haugh, Kyle C. Nguyen, 2024, Mathematical biosciences.

Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Laura E. Edwards, J. Haugh, Michael B Goshe, 2014, Molecular systems biology.