Toshiharu Suzuki

发表

Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-κB–mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis

E. Zabarovsky, T. Tokino, A. Cheung, 2011, Proceedings of the National Academy of Sciences.

Crystallization of silicon films of submicron thickness by blue-multi-laser-diode annealing

J. D. Mugiraneza, Toshiharu Suzuki, T. Okada, 2012 .

Anomalous Increase in Resistivity of Boron-Doped Silicon Film after Solid Phase Crystallization

T. Noguchi, Toshiharu Suzuki, K. Kawai, 2009 .

Crystallinity Improvement of Small Grained Poly-Si Films by Excimer Laser Annealing for High Performance TFT's

T. Noguchi, Toshiharu Suzuki, H. Tsukamoto, 1991 .

Crystallization of Si Thin Film on Flexible Plastic Substrate by Blue Multi-Laser Diode Annealing

J. D. Mugiraneza, Toshiharu Suzuki, T. Okada, 2012 .

Constitutive Cleavage of the Single-Pass Transmembrane Protein Alcadeinα Prevents Aberrant Peripheral Retention of Kinesin-1

Toshiharu Suzuki, C. Maruta, Yuhki Saito, 2012, PloS one.

Endoplasmic Reticulum Stress-inducible Protein, Herp, Enhances Presenilin-mediated Generation of Amyloid β-Protein* 210

Yuuki Kawamura, B. de Strooper, M. Kawaichi, 2002, The Journal of Biological Chemistry.

Flat panel displays for ubiquitous product applications and related impurity doping technologies

Toshiharu Suzuki, Toshiharu Suzuki, 2006 .

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice*

S. Itohara, H. Gomi, T. Ikeda, 1997, The Journal of Biological Chemistry.

Conformational transitions of subunit epsilon in ATP synthase from thermophilic Bacillus PS3.

Masasuke Yoshida, Toshiharu Suzuki, Y. Kato-Yamada, 2010, Biophysical journal.

β-Amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray

Y. Kirino, Toshiharu Suzuki, N. Hirashima, 2001, Neuroscience Letters.

FE65 as a link between VLDLR and APP to regulate their trafficking and processing

Y. Suh, S. Dumanis, Toshiharu Suzuki, 2012, Molecular Neurodegeneration.

Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells

T. Kawai, Toshiharu Suzuki, T. Nakaya, 2009, The FEBS journal.

Regulation of FE65 Nuclear Translocation and Function by Amyloid β-Protein Precursor in Osmotically Stressed Cells*

T. Kawai, Toshiharu Suzuki, T. Nakaya, 2008, Journal of Biological Chemistry.

Role of APP phosphorylation in FE65‐dependent gene transactivation mediated by AICD

Toshiharu Suzuki, T. Nakaya, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Differential Roles of JIP Scaffold Proteins in the Modulation of Amyloid Precursor Protein Metabolism*

Y. Kirino, Toshiharu Suzuki, H. Taru, 2002, The Journal of Biological Chemistry.

Facilitation of Stress-induced Phosphorylation of β-Amyloid Precursor Protein Family Members by X11-like/Mint2 Protein*[boxs]

Toshiharu Suzuki, H. Taru, Hidenori Taru, 2004, Journal of Biological Chemistry.

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions*

Toshiharu Suzuki, T. Nakaya, 2008, Journal of Biological Chemistry.

Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.

T. Tokuda, H. Arai, Toshiharu Suzuki, 2014, Journal of Alzheimer's disease : JAD.

Production of multi-subunit complexes on liposome through an E. coli cell-free expression system.

Yutetsu Kuruma, Takuya Ueda, Toshiharu Suzuki, 2010, Methods in molecular biology.

The product of uncI gene in F1Fo-ATP synthase operon plays a chaperone-like role to assist c-ring assembly

Masasuke Yoshida, Toshiharu Suzuki, Y. Ozaki, 2007, Proceedings of the National Academy of Sciences.

Paul Greengard, Ph.D. (1925-2019)

S. Gandy, Toshiharu Suzuki, 2019, Alzheimer's & Dementia.

Alternative Processing of c-Secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer’s Disease: Evidence for c-Secretase Dysfunction

A. Fagan, D. Holtzman, T. Montine, 2011 .

Alternative processing of γ‐secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for γ‐secretase dysfunction

A. Fagan, D. Holtzman, T. Montine, 2011, Annals of neurology.

Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms

S. Small, M. Ehrlich, S. Gandy, 2009 .

Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction*

F. Fahrenholz, R. Martins, D. Hartmann, 2009, The Journal of Biological Chemistry.

Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

J. Buxbaum, S. Lovestone, T. Mustelin, 2007, Molecular Neurodegeneration.

X11 Proteins Regulate the Translocation of Amyloid β-Protein Precursor (APP) into Detergent-resistant Membrane and Suppress the Amyloidogenic Cleavage of APP by β-Site-cleaving Enzyme in Brain*

Y. Sano, S. Gandy, Toshiharu Suzuki, 2008, Journal of Biological Chemistry.

ATP-driven stepwise rotation of FoF1-ATP synthase.

Kazuhiko Kinosita, Masasuke Yoshida, Hiroshi Ueno, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Efficient ATP synthesis by thermophilic Bacillus FoF1-ATP synthase

Masasuke Yoshida, Toshiharu Suzuki, K. Kinosita, 2011, The FEBS journal.

Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease

Toshiharu Suzuki, M. Nakajima, Toru Tanaka, 2017, Nutritional neuroscience.

Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis.

Toshiharu Suzuki, T. Nakaya, Tohru Yamamoto, 2006, Journal of biochemistry.

Modulation of Amyloid Precursor Protein Cleavage by Cellular Sphingolipids*

K. Zou, Toshiharu Suzuki, M. Michikawa, 2004, Journal of Biological Chemistry.

The cytoplasmic region of the amyloid β‐protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin‐1

Toshiharu Suzuki, M. Kinjo, Akira Kitamura, 2018, FEBS letters.

SREC-II, a New Member of the Scavenger Receptor Type F Family, Trans-interacts with SREC-I through Its Extracellular Domain*

S. Tomita, Toshiharu Suzuki, H. Arai, 2002, The Journal of Biological Chemistry.

Roasted Coffee Reduces &bgr;‐Amyloid Production by Increasing Proteasomal &bgr;‐Secretase Degradation in Human Neuroblastoma SH‐SY5Y Cells

Toshiharu Suzuki, K. Kobata, M. Funakoshi-Tago, 2018, Molecular nutrition & food research.

Crystallization of Si Thin Film on Flexible Plastic Substrate by Blue Multi-Laser Diode Annealing

J. D. Mugiraneza, Toshiharu Suzuki, T. Okada, 2012 .

A Small Peptide Sequence is Sufficient for Initiating Kinesin‐1 Activation Through Part of TPR Region of KLC1

Toshiharu Suzuki, M. Kinjo, Tohru Yamamoto, 2012, Traffic.

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.

L. Meijer, K. Blennow, H. Zetterberg, 2018, Journal of Alzheimer's disease : JAD.

Specific Triazine Herbicides Induce Amyloid-β42 Production.

L. Meijer, K. Blennow, A. Covaci, 2016, Journal of Alzheimer's disease : JAD.

The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells

P. Greengard, A. Nairn, A. Czernik, 1997, Molecular medicine.

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like

Toshiharu Suzuki, T. Nakaya, Yuhki Saito, 2011, PloS one.

Molecular cloning of synaphins/complexins, cytosolic proteins involved in transmitter release, in the electric organ of an electric ray (Narke japonica)

T. Ishizuka, Y. Kirino, H. Saisu, 1997, Neuroscience Letters.

The Role of the βDELSEED-loop of ATP Synthase*

Toshiharu Suzuki, J. Weber, N. Mnatsakanyan, 2009, Journal of Biological Chemistry.

Regulatory Interplay between Proton Motive Force, ADP, Phosphate, and Subunit ϵ in Bacterial ATP Synthase*

Masasuke Yoshida, Toshiharu Suzuki, B. Feniouk, 2007, Journal of Biological Chemistry.

Probing conformations of the subunit of F 0F 1-ATP synthase in catalysis

Masasuke Yoshida, S. Tsunoda, Toshiharu Suzuki, 2006 .

Crystallization Behavior of Sputtered Amorphous Silicon Films by Blue-Multi-Laser-Diode Annealing

J. D. Mugiraneza, Toshiharu Suzuki, T. Okada, 2011 .

Microsoft Word-Takei (JBC_2014_599852 Re).docx

Toshiharu Suzuki, Norio Takei, T. Nakaya, 2014 .

Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer’s Amyloid Precursor Protein*

S. Tomita, Y. Kirino, S. Takeda, 1999, The Journal of Biological Chemistry.

The phototroph-specific β-hairpin structure of the γ subunit of FoF1-ATP synthase is important for efficient ATP synthesis of cyanobacteria

Toshiharu Suzuki, T. Hisabori, Keisuke Yoshida, 2021, The Journal of biological chemistry.

The 3 × 120° rotary mechanism of Paracoccus denitrificans F1-ATPase is different from that of the bacterial and mitochondrial F1-ATPases

H. Noji, Toshiharu Suzuki, D. G. McMillan, 2020, Proceedings of the National Academy of Sciences.

Identification of aqueous access residues of the sodium half channel in transmembrane helix 5 of the Fo-a subunit of Propionigenium modestum ATP synthase

Hiroki Sato, Toshiharu Suzuki, K. Shimabukuro, 2017, Biophysics and physicobiology.

Purification, characterization and reconstitution into membranes of the oligomeric c-subunit ring of thermophilic F(o)F(1)-ATP synthase expressed in Escherichia coli.

Masasuke Yoshida, I. Iwasaki, Toshiharu Suzuki, 2012, Protein expression and purification.

Suppression of oxidation-induced stacking fault generation in argon ambient annealing with controlled oxygen and the effect upon bulk defects

Toshiharu Suzuki, 2002 .

Enhanced amyloid-beta generation by gamma-secretase complex in DRM microdomains with reduced cholesterol levels

Toshiharu Suzuki, M. Nishimura, M. Morishima-kawashima, 2021 .

Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment.

Toshiharu Suzuki, A. Lin, M. Miura, 2005, The Journal of biological chemistry.

thermophilus.extreme thermophile, Thermus Pyrimidine biosynthesis genes (pyrE and pyrF)

Toshiharu Suzuki, T. Oshima, A. Yamagishi, 2013 .

Stabilization of intracellular trafficking and metabolism of amyloid β‐protein precursor and Alcadein β by apolipoprotein E

Toshiharu Suzuki, Saori Hata, Ayano Kimura, 2015, FEBS letters.

Expression and localization of X11 family proteins in neurons

Toshiharu Suzuki, Yuhki Saito, Saori Hata, 2016, Brain Research.

Regulation of X11L-dependent Amyloid Precursor Protein Metabolism by XB51, a Novel X11L-binding Protein*

S. Tomita, Y. Kirino, Toshiharu Suzuki, 2000, The Journal of Biological Chemistry.

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase

Toshiharu Suzuki, Yuhki Saito, Saori Hata, 2013, PloS one.

Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain.

Toshiharu Suzuki, T. Nakaya, M. Sakaitani, 2019, International journal of molecular medicine.

Chemical Conformation of the Essential Glutamate Site of the c-Ring within Thermophilic Bacillus FoF1-ATP Synthase Determined by Solid-State NMR Based on its Isolated c-Ring Structure.

Masasuke Yoshida, T. Ikegami, Toshiharu Suzuki, 2022, Journal of the American Chemical Society.

The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer βA4-amyloid precursor protein: Some technical notes

P. Greengard, J. Buxbaum, A. Nairn, 1992, Neurobiology of Aging.

Expression of mammalian mitochondrial F1‐ATPase in Escherichia coli depends on two chaperone factors, AF1 and AF2

Masasuke Yoshida, Toshiharu Suzuki, T. Hisabori, 2016, FEBS open bio.

Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex*

R. Roepman, M. Takeda, Toshiharu Suzuki, 2010, The Journal of Biological Chemistry.

Interaction of N-Terminal Acetyltransferase with the Cytoplasmic Domain of β-Amyloid Precursor Protein and Its Effect on Aβ Secretion

Y. Kirino, Toshiharu Suzuki, M. Asaumi, 2005 .

Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion.

Y. Kirino, Toshiharu Suzuki, M. Asaumi, 2005, Journal of biochemistry.

Aggregation in methanol and formation of molecular glasses for europium(III) N-acylaminocarboxylates: effects of alkyl chain length and head group.

Toshiharu Suzuki, Masako Kato, M. Harada, 2009, Dalton transactions.

Formation of molecular glasses and the aggregation in solutions for lanthanum(III), calcium(II), and yttrium(III) complexes of octanoyl-DL-alaninate.

Toshiharu Suzuki, R. Masuda, M. Harada, 2008, Dalton transactions.

Angular Correlation of Positron Annihilation Radiation from Single Crystals of Vanadium-Deuterium Alloys

Toshiharu Suzuki, M. Hasegawa, H. Asano, 1979 .

Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation

P. Greengard, A. Nairn, Y. Kirino, 1999, The Journal of Neuroscience.

Effect of annealing a silicon wafer in argon with a very low oxygen partial pressure

Toshiharu Suzuki, 2000 .

Elastic Anomalies and Special Mode Softening Preceding Martensitic Phase Transition in Au-Ag-Cd Alloys

Toshiharu Suzuki, M. Takano, Y. Matsuo, 1979 .

Composition and temperature dependence of orthorhombic distortion and volume in γ2-AuCd martensite

Toshiharu Suzuki, A. Nagasawa, N. Hashimoto, 1994 .

The stabilisation of step-quenched copper-zinc-aluminum martensite part II : Crystal structure and reordering

J. Humbeeck, Toshiharu Suzuki, L. Delaey, 1984 .

Magnetodielectric and magnetoelastic properties of spinel Mn3O4

Toshiharu Suzuki, T. Katsufuji, 2009 .

Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kappaB target genes protecting the macrophage from staurosporine-induced apoptosis.

Toshiharu Suzuki, T. Nakai, Y. Okinaka, 2006, Microbial pathogenesis.

Changes in the amount of sarcocystatin A, a new cysteine proteinase inhibitor, during the development of adult Sarcophaga peregrina

Toshiharu Suzuki, S. Natori, 1986 .

The Regulatory C-Terminal Domain of Subunit ε of FoF1 ATP Synthase Is Dispensable for Growth and Survival of Escherichia coli

Masasuke Yoshida, Toshiharu Suzuki, M. Berney, 2011, Journal of bacteriology.

UncI protein can mediate ring-assembly of c-subunits of FoF1-ATP synthase in vitro.

Yutetsu Kuruma, Takuya Ueda, Masasuke Yoshida, 2008, Biochemical and biophysical research communications.

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

G. Sobue, Toshiharu Suzuki, M. Katsuno, 2011, The Journal of Neuroscience.

Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease

L. Meijer, C. Rowe, R. Martins, 2019, Alzheimer's & dementia.

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

Masasuke Yoshida, H. Noji, Toshiharu Suzuki, 2013, Proceedings of the National Academy of Sciences.

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier

T. Tsunoda, T. Kudo, H. Kazui, 2014, Proceedings of the National Academy of Sciences.

I. Tooyama, Toshiharu Suzuki, M. Nishimura, 2012, Journal of neurochemistry.

Essential arginine residue of the F(o)-a subunit in F(o)F(1)-ATP synthase has a role to prevent the proton shortcut without c-ring rotation in the F(o) proton channel.

Masasuke Yoshida, Toshiharu Suzuki, N. Sone, 2010, The Biochemical journal.

PDZ Domain-dependent Suppression of NF-κB/p65-induced Aβ42 Production by a Neuron-specific X11-like Protein*

S. Tomita, Y. Kirino, Toshiharu Suzuki, 2000, The Journal of Biological Chemistry.

Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice

Toshiharu Suzuki, M. Michikawa, H. Kawashima, 2015, Brain Research.

RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans

Yishi Jin, Toshiharu Suzuki, Hidenori Taru, 2019, The Journal of Neuroscience.

Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein

D. Yanagisawa, I. Tooyama, Toshiharu Suzuki, 2020, Journal of Alzheimer's disease : JAD.

Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides

Toshiharu Suzuki, T. Nakaya, Keitarou Suzuki, 2007 .

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

Toshiharu Suzuki, T. Nakaya, Keitarou Suzuki, 2007, The Biochemical journal.

F0F1-ATPase/Synthase Is Geared to the Synthesis Mode by Conformational Rearrangement of ϵ Subunit in Response to Proton Motive Force and ADP/ATP Balance*

Masasuke Yoshida, Y. Shirakihara, R. Iino, 2003, Journal of Biological Chemistry.

The role of subunit epsilon in the catalysis and regulation of FOF1-ATP synthase.

Masasuke Yoshida, Toshiharu Suzuki, B. Feniouk, 2006, Biochimica et biophysica acta.

Significance of the ε subunit in the thiol modulation of chloroplast ATP synthase

Masasuke Yoshida, Toshiharu Suzuki, T. Hisabori, 2004 .

The Fermi surface of Hume-Rothery phases in Ag-Al and Cu-Ge alloys studied by a positron annihilation method

Toshiharu Suzuki, M. Hasegawa, S. Koike, 1982 .

Anomalous behaviour of electrical resistivity and elastic constants in quenched β (Au−Cd)+Cu alloys

Toshiharu Suzuki, Y. Matsuo, K. Miyata, 1988 .

A study of Fermi surfaces of the α-phase Cu-Ge and Cu-Si alloys by positron annihilation

Toshiharu Suzuki, M. Hasegawa, M. Hirabayashi, 1974 .

Positron Annihilation Study on the Fermi Surface of Cd–Mg Alloys

Toshiharu Suzuki, M. Hasegawa, S. Koike, 1979 .

The effect of aging in the β-phase on forward and reverse martensitic transformation temperatures in quenched Cu–Zn–Al alloys

Toshiharu Suzuki, K. Morita, 2006 .

Elimination of stacking‐fault formation in silicon by preoxidation annealing in N2/HCl/O2 mixtures

Toshiharu Suzuki, T. Hattori, 1978 .

Structure of a bacterial ATP synthase

J. Rubinstein, Toshiharu Suzuki, Hui Guo, 2018, bioRxiv.

Differential Transcription of the Fibroin and Sericin‐1 Genes in Cell‐Free Extracts 1

K. Matsuno, C. Hui, Toshiharu Suzuki, 1990 .

Fibroin Gene Transcription in the Embryonic Stages of the Silkworm, Bombyx mori

Toshiharu Suzuki, Yoshiaki Suzuki, S. Takiya, 1988 .

Axle-Less F1-ATPase Rotates in the Correct Direction

Masasuke Yoshida, Toshiharu Suzuki, H. Itoh, 2008, Science.

Structure of a thermophilic F1‐ATPase inhibited by an ε‐subunit: deeper insight into the ε‐inhibition mechanism

Masasuke Yoshida, Masayoshi Nakasako, Masasuke Yoshida, 2015, The FEBS journal.

Sulfolobus tokodaii sp. nov. (f. Sulfolobus sp. strain 7), a new member of the genus Sulfolobus isolated from Beppu Hot Springs, Japan

Toshio Iwasaki, Akihiko Yamagishi, Tairo Oshima, 2002, Extremophiles.

Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.

F. Rubio-Moscardo, J. Clarimón, M. Boada, 2014, Journal of Alzheimer's disease : JAD.

Membrane-Microdomain Localization of Amyloid β-Precursor Protein (APP) C-terminal Fragments Is Regulated by Phosphorylation of the Cytoplasmic Thr668 Residue*

Toshiharu Suzuki, J. Elliott, M. Nishimura, 2012, The Journal of Biological Chemistry.

Residue 668 Phosphorylation of the Cytoplasmic Thr C-terminal Fragments Is Regulated by-Precursor Protein ( APP ) β Amyloid Membrane-Microdomain Localization of Molecular Bases of Disease :

Toshiharu Suzuki, J. Elliott, M. Nishimura, 2012 .

Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α–deficient mice

T. Abe, Toshiharu Suzuki, Mayo Shigeta, 2020, The Journal of Biological Chemistry.

Alternative Selection of beta-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid beta-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the A beta Sequence

Toshiharu Suzuki, Saori Hata, Ayano Kimura, 2018 .

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence*

Toshiharu Suzuki, Saori Hata, Ayano Kimura, 2016, The Journal of Biological Chemistry.

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

R. Nitsch, Toshiharu Suzuki, U. Konietzko, 2004, Journal of Cell Science.

The presence of phosphate at a catalytic site suppresses the formation of the MgADP-inhibited form of F(1)-ATPase.

Masasuke Yoshida, E. Muneyuki, Toshiharu Suzuki, 2002, European journal of biochemistry.

Activity-dependent increase in &bgr;-amyloid precursor protein mRNA expression in neurons

Toshiharu Suzuki, M. Tsuda, M. Fukuchi, 2004, Neuroreport.

A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer’s β-Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the α-Site*

S. Tomita, Y. Kirino, Toshiharu Suzuki, 1998, The Journal of Biological Chemistry.

Cleavage of Alzheimer’s Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway

Yutaka Kirino, S. Tomita, Y. Kirino, 1998, The Journal of Biological Chemistry.

Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein

P. Greengard, J. Buxbaum, A. Nairn, 1992 .

Protein Phosphorylation Regulates Processing of the Alzheimer β/A4-Amyloid Precursor Protein

P. Greengard, J. Buxbaum, A. Nairn, 1992 .

Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice

D. Small, G. Jacobson, Toshiharu Suzuki, 2011, PloS one.

Coordinated Metabolism of Alcadein and Amyloid β-Protein Precursor Regulates FE65-dependent Gene Transactivation*

B. de Strooper, Toshiharu Suzuki, M. Nishimura, 2004, Journal of Biological Chemistry.

Novel Cadherin-related Membrane Proteins, Alcadeins, Enhance the X11-like Protein-mediated Stabilization of Amyloid β-Protein Precursor Metabolism*

S. Tomita, Y. Kirino, Toshiharu Suzuki, 2003, Journal of Biological Chemistry.

Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of β-Amyloid*

Y. Kirino, Toshiharu Suzuki, J. Elliott, 2001, The Journal of Biological Chemistry.

Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5

P. Greengard, A. Nairn, S. Itohara, 2000, Journal of neurochemistry.

Identification and expression of a novel gene in odour‐taste associative learning in the terrestrial slug

T Suzuki, S Kawahara, Y Kirino, 2001, Genes to cells : devoted to molecular & cellular mechanisms.

A new solution structure of ATP synthase subunit c from thermophilic Bacillus PS3, suggesting a local conformational change for H+-translocation.

Masasuke Yoshida, T. Ikegami, Toshiharu Suzuki, 2006, Journal of molecular biology.

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

Jordi Villà-Freixa, Mireia Coma, Gianni de Fabritiis, 2009, Brain : a journal of neurology.

Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model

Y. Sano, K. Zou, Toshiharu Suzuki, 2021, Scientific Reports.

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

Y. Sano, Toshiharu Suzuki, J. Aoki, 2020, bioRxiv.

Torque Generation and Utilization in Motor Enzyme F0F1-ATP Synthase

Masasuke Yoshida, Toshiharu Suzuki, K. Kinosita, 2011, The Journal of Biological Chemistry.

Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging

Toshiharu Suzuki, M. Michikawa, T. Saido, 2022, Neurobiology of Aging.

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels

Toshiharu Suzuki, M. Nishimura, S. Murayama, 2020 .

Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant membrane microdomains with reduced cholesterol levels.

Toshiharu Suzuki, M. Nishimura, S. Murayama, 2019, Human molecular genetics.

Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice.

Toshiharu Suzuki, M. Michikawa, H. Kawashima, 2015, Journal of Alzheimer's disease : JAD.

The novel cargo Alcadein induces vesicle association of kinesin‐1 motor components and activates axonal transport

Yu Ohsugi, Kenji Matsuno, Yuhki Saito, 2007, The EMBO journal.

Alzheimer's Disease as a Membrane‐Associated Enzymopathy of β‐Amyloid Precursor Protein (APP) Secretases

Toshiharu Suzuki, Yuhki Saito, Saori Hata, 2011 .

Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins

Toshiharu Suzuki, Hidenori Taru, 2020 .

Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins.

Toshiharu Suzuki, Hidenori Taru, 2009, Journal of Alzheimer's disease : JAD.

Prostaglandin E2 Stimulates the Production of Amyloid-β Peptides through Internalization of the EP4 Receptor*

S. Narumiya, Toshiharu Suzuki, Y. Sugimoto, 2009, The Journal of Biological Chemistry.

Involvement of Prostaglandin E2 in Production of Amyloid-β Peptides Both in Vitro and in Vivo*

S. Narumiya, Toshiharu Suzuki, Y. Sugimoto, 2007, Journal of Biological Chemistry.

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

Toshiharu Suzuki, M. Maeda, Norio Takei, 2010, Molecular Neurodegeneration.

Suppression of APP‐containing vesicle trafficking and production of β‐amyloid by AID/DHHC‐12 protein

Yuhki Saito, Takao Ishikawa, Toshiharu Suzuki, 2009, Journal of neurochemistry.

Vesicular Glutamate Transporters Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter

Toshiharu Suzuki, R. Jahn, G. Ahnert-Hilger, 2014, Neuron.

Chemomechanical coupling of human mitochondrial F1-ATPase motor.

Masasuke Yoshida, Masasuke Yoshida, Toshiharu Suzuki, 2014, Nature chemical biology.

Kinetic Equivalence of Transmembrane pH and Electrical Potential Differences in ATP Synthesis

Masasuke Yoshida, Toshiharu Suzuki, K. Kinosita, 2012, The Journal of Biological Chemistry.

Analysis of the open and closed conformations of the beta subunits in thermophilic F1-ATPase by solution NMR.

Masasuke Yoshida, Toshiharu Suzuki, H. Akutsu, 2010, Journal of molecular biology.

Neither Helix in the Coiled Coil Region of the Axle of F1-ATPase Plays a Significant Role in Torque Production

Masasuke Yoshida, Toshiharu Suzuki, H. Itoh, 2008, Biophysical journal.

Real-time Monitoring of Conformational Dynamics of the ϵ Subunit in F1-ATPase*

Masasuke Yoshida, R. Iino, Toshiharu Suzuki, 2005, Journal of Biological Chemistry.

Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus.

Toshiharu Suzuki, T. Oshima, A. Yamagishi, 2002, Protein engineering.

Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2

Yasushi Kishimoto, Yutaka Kirino, Ann Marie Craig, 2016, Neuron.

A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1*

K. Miyazawa, Toshiharu Suzuki, N. Kitamura, 2003, Journal of Biological Chemistry.

Interaction of Alzheimer's β-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signaling Cascade*

Y. Kirino, Toshiharu Suzuki, Y. Yagi, 2002, The Journal of Biological Chemistry.

Oxygen partial pressure dependence of suppressing oxidation-induced stacking fault generation in argon ambient annealing including oxygen and HCl

Toshiharu Suzuki, 2001 .

Relation between the suppression of the generation of stacking faults and the mechanism of silicon oxidation during annealing under argon containing oxygen

Toshiharu Suzuki, 2000 .

Escherichia coli phage‐shock protein A (PspA) binds to membrane phospholipids and repairs proton leakage of the damaged membranes

Masasuke Yoshida, Masasuke Yoshida, Toshiharu Suzuki, 2007, Molecular microbiology.

X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice

C. Homma, Y. Sano, S. Itohara, 2009, The Journal of Neuroscience.

Purification and Functional Reconstitution of a Seven-Subunit Mrp-Type Na+/H+ Antiporter

Toshiharu Suzuki, T. A. Krulwich, M. Morino, 2013, Journal of bacteriology.

Puriﬁcation and Functional Reconstitution of a Seven-Subunit Mrp-Type Na (cid:2) /H (cid:2) Antiporter

Toshiharu Suzuki, M. Morino, M. Ito, 2013 .

Antiporter + / H + of a Seven-Subunit Mrp-Type Na Purification and Functional Reconstitution

Toshiharu Suzuki, Terry, M. Morino, 2013 .

An immobilized cell system in polyurethane foam for the lipophilic micro-alga Prototheca zopfii

Toshiharu Suzuki, M. Ishida, Takahiro Suzuki, 1999 .

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

R. Dutzler, E. Pardon, J. Steyaert, 2017, Biochemistry.

Differential Transcription of the Fibroin and Sericin‐1 Genes in Cell‐Free Extracts 1

K. Matsuno, C. Hui, Toshiharu Suzuki, 1990, Development, growth & differentiation.

LHCf experiment: forward physics at LHC for cosmic rays study

A. Perrot, M. Haguenauer, A. Tricomi, 2016 .

Genes to Cells

Toshiharu Suzuki, T. Nakaya, Daiki Kawahara, 2021 .

Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.

Toshiharu Suzuki, M. Nishimura, S. Murayama, 2021, Journal of Alzheimer's disease : JAD.

Perfect chemomechanical coupling of FoF1-ATP synthase

Masasuke Yoshida, Toshiharu Suzuki, K. Kinosita, 2017, Proceedings of the National Academy of Sciences.

Simple mechanism whereby the F1-ATPase motor rotates with near-perfect chemomechanical energy conversion

Kazuhiko Kinosita, Masasuke Yoshida, Masasuke Yoshida, 2015, Proceedings of the National Academy of Sciences.

γ-Secretase activity is associated with Braak Senile Plaque stages.

Toshiharu Suzuki, K. Akazawa, Y. Ihara, 2020, The American journal of pathology.

Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo

A. Nairn, Toshiharu Suzuki, M. Kinjo, 2017, Molecular biology of the cell.

Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1

A. Nairn, Toshiharu Suzuki, M. Kinjo, 2017, Molecular biology of the cell.

IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper‐layer neurons

T. Abe, Toshiharu Suzuki, F. Matsuzaki, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Direct assignment of 13C solid-state NMR signals of TFoF1 ATP synthase subunit c-ring in lipid membranes and its implication for the ring structure

Masasuke Yoshida, Toshiharu Suzuki, T. Fujiwara, 2018, Journal of biomolecular NMR.

Physiological Mouse Brain Aβ Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP

Y. Sano, S. Itohara, S. Takeda, 2006, PloS one.

A giant liposome for single-molecule observation of conformational changes in membrane proteins.

Masasuke Yoshida, O. Orwar, Toshiharu Suzuki, 2009, Biochimica et biophysica acta.

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

R. Shigemoto, Toshiharu Suzuki, K. Imoto, 2012, Molecular Neurodegeneration.

Instructions for use Title Hyperpolarization-activated cyclic nucleotide gated channels : a potential molecular link between epileptic seizures andAβ generation in Alzheimer ' s disease

R. Shigemoto, Toshiharu Suzuki, K. Imoto, 2018 .

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

A. Nairn, Toshiharu Suzuki, M. Kinjo, 2014, Molecular biology of the cell.

F(0) of ATP synthase is a rotary proton channel. Obligatory coupling of proton translocation with rotation of c-subunit ring.

Masasuke Yoshida, Toshiharu Suzuki, H. Ueno, 2002, The Journal of biological chemistry.

Role of 14-3-3γ in FE65-dependent Gene Transactivation Mediated by the Amyloid β-Protein Precursor Cytoplasmic Fragment*

Toshiharu Suzuki, A. Lin, M. Miura, 2005, Journal of Biological Chemistry.

Suppression of Alzheimer’s Disease-Related Phenotypes by Geranylgeranylacetone in Mice

Toshiharu Suzuki, T. Mizushima, N. Yamakawa, 2013, PloS one.

Improvement of cognitive function in Alzheimer’s disease model mice by genetic and pharmacological inhibition of the EP4 receptor

S. Narumiya, Toshiharu Suzuki, Y. Sugimoto, 2012, Journal of neurochemistry.

Expression and characterization of the Drosophila X11‐like/Mint protein during neural development

S. Tomita, K. Matsuno, Toshiharu Suzuki, 2002, Journal of neurochemistry.

Enhanced Amyloidogenic Metabolism of the Amyloid β-Protein Precursor in the X11L-deficient Mouse Brain*

Y. Sano, S. Itohara, S. Tomita, 2006, Journal of Biological Chemistry.

Alcadein cleavages by APP α - and γ -secretases generate small peptides p3-Alcs indicating Alzheimer disease-related γ -secretase dysfunction

F. Fahrenholz, R. Martins, D. Hartmann, 2009 .

Regulation of APP by phosphorylation and protein interactions

Toshiharu Suzuki, T. Nakaya, 2008 .

X11 and X11‐like proteins regulate the level of extrasynaptic glutamate receptors

Toshiharu Suzuki, T. Nakaya, Yuhki Saito, 2018, Journal of neurochemistry.

Suppression of the caspase cleavage of β‐amyloid precursor protein by its cytoplasmic phosphorylation

Toshiharu Suzuki, K. Yoshikawa, Hidenori Taru, 2004, FEBS letters.

Influence of quenching on the martensitic transformation temperature in Au–47.5at.%Cd–Ag alloys

Toshiharu Suzuki, S. Nakamoto, 1999 .

Functional analysis of membranous Fo-a subunit of F1Fo-ATP synthase by in vitro protein synthesis.

Yutetsu Kuruma, Takuya Ueda, Masasuke Yoshida, 2012, The Biochemical journal.

Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system

S. Gandy, Toshiharu Suzuki, M. Maeda, 2011, Molecular Neurodegeneration.

Instructions for use Title Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer ' s disease patients : quantitative analysis of p 3-Alcα with a new ELISA system

S. Gandy, Toshiharu Suzuki, M. Maeda, 2016 .

Phosphorylation of the amino‐terminal region of X11L regulates its interaction with APP

A. Nairn, S. Tomita, S. Gandy, 2009, Journal of neurochemistry.

Mechanism of Alzheimer Amyloid β-Protein Precursor Localization to Membrane Lipid Rafts

Toshiharu Suzuki, Yuhki Saito, T. Matsushima, 2013 .

The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement

S. Dumanis, Toshiharu Suzuki, D. Pak, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease.

K. Kohara, Y. Tabara, T. Miki, 2012, Journal of Alzheimer's disease : JAD.

Cytoplasmic granule formation by FUS‐R495X is attributable to arginine methylation in all Gly‐rich, RGG1 and RGG2 domains

Toshiharu Suzuki, T. Nakaya, Daiki Kawahara, 2021, Genes to Cells.

ATP Photosynthetic vesicles for light-driven bioprocesses

Masasuke Yoshida, K. Hara, Toshiharu Suzuki, 2011, Biotechnology Letters.

Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

R. Edwards, Toshiharu Suzuki, Matthew M. McGregor, 2016, Neuron.

Active-site structure of the thermophilic Foc-subunit ring in membranes elucidated by solid-state NMR.

Masasuke Yoshida, I. Iwasaki, Toshiharu Suzuki, 2014, Biophysical journal.

The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm.

Toshiharu Suzuki, Yuhki Saito, Tohru Yamamoto, 2008, Experimental cell research.

XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.

Y. Kirino, R. Martins, Toshiharu Suzuki, 2003, The Biochemical journal.

A 127‐kDa Protein (UV‐DDB) Binds to the Cytoplasmic Domain of the Alzheimer's Amyloid Precursor Protein

P. Greengard, A. Nairn, S. Tomita, 1999, Journal of neurochemistry.

Novel Zinc-containing Ferredoxin Family in Thermoacidophilic Archaea*

Toshiharu Suzuki, T. Kon, T. Imai, 1997, The Journal of Biological Chemistry.

Cytoplasmic Fragment of Alcadein alpha Generated by Regulated Intramembrane Proteolysis Enhances Amyloid beta- Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage

Toshiharu Suzuki, Norio Takei, T. Nakaya, 2016 .

Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.

T. Asada, Toshiharu Suzuki, M. Maeda, 2014, Journal of Alzheimer's disease : JAD.

The Fermi Surfaces of Cu-Pd Alloys Studied by Positron Annihilation(Physics)

Toshiharu Suzuki, M. Hasegawa, M. Hirabayashi, 1977 .

Detection and Tracking Protein Molecules in Fluorescence Microscopic Video

Yaokai Feng, Seiichi Uchida, Yuki Saito, 2013, 2013 First International Symposium on Computing and Networking.

HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

M. Yoshida, Toshiharu Suzuki, Minoru Yoshida, 1996, The EMBO journal.

Control of bacteriophage T4 tail lysozyme activity during the infection process.

M. Rossmann, Toshiharu Suzuki, S. Kanamaru, 2005, Journal of molecular biology.

P1-453: APP metabolism in brain of Thr668 residue mutant mice

Toshiharu Suzuki, T. Nakaya, T. Matsushima, 2008, Alzheimer's & Dementia.

Developmental Regulation of Silk Gene Expression in Bombyx mori

K. Matsuno, C. Hui, Toshiharu Suzuki, 1990 .

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects

A. Fagan, D. Holtzman, R. Bateman, 2012, Molecular Neurodegeneration.

Membrane perturbation by the neurotoxic alzheimer amyloid fragment β25‐35 requires aggregation and β‐sheet formation

Y. Kirino, Toshiharu Suzuki, B. Kagan, 1998 .

Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons

Toshiharu Suzuki, Hirotaka Matsumoto, Naoya Gotoh, 2011, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease

Toshiharu Suzuki, M. Nakajima, Toru Tanaka, 2017, Nutritional neuroscience.

Stabilization of intracellular trafficking and metabolism of amyloid β‐protein precursor and Alcadein β by apolipoprotein E

Toshiharu Suzuki, Saori Hata, Ayano Kimura, 2015, FEBS letters.

Brain Aging as a Cause of Alzheimer’s Disease

Toshiharu Suzuki, T. Nakaya, Saori Hata, 2015 .

IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper‐layer neurons

T. Abe, Toshiharu Suzuki, F. Matsuzaki, 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins.

Toshiharu Suzuki, Hidenori Taru, 2009, Journal of Alzheimer's disease : JAD.

Role of gene flaFV on flagellar hook formation in Salmonella typhimurium

Toshiharu Suzuki, T. Suzuki, K. Kutsukake, 1979, Journal of bacteriology.

Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate

T. Arakawa, Toshiharu Suzuki, F. Matsuzaki, 2008, Brain Research.

Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of (cid:1) -Amyloid*

Y. Kirino, Toshiharu Suzuki, J. Elliott, 2001 .

Activation and Stiffness of the Inhibited States of F1-ATPase Probed by Single-molecule Manipulation

Masasuke Yoshida, R. Iino, Toshiharu Suzuki, 2010, The Journal of Biological Chemistry.

Formation of molecular glasses and the aggregation in solutions for lanthanum(III), calcium(II), and yttrium(III) complexes of octanoyl-DL-alaninate.

Toshiharu Suzuki, R. Masuda, H. Kurosu, 2008, Dalton transactions.

Angular Correlation of Photons from Positron Annihilation in Copper-Nickel Alloys

Toshiharu Suzuki, M. Hasegawa, M. Hirabayashi, 1974 .

Roles of the intramolecular regions of FE65 in its trans‐accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells

T. Kawai, Toshiharu Suzuki, T. Nakaya, 2010, FEBS letters.

Increased Levels of Plasma p3-Alc alpha 35, a Major Fragment of Alcadein alpha by gamma-Secretase Cleavage, in Alzheimer's Disease

Toshiharu, T. Asada, Toshiharu Suzuki, 2019 .

ATP Synthase that Lacks F0a-Subunit

Masasuke Yoshida, Toshiharu Suzuki, N. Sone, 2004, Journal of Biological Chemistry.