D. Germain

发表

Raheleh Hatami Survival KLF 6-SV 1 Drives Breast Cancer Metastasis and Is Associated with Poor

J. Foekens, A. Sieuwerts, M. Look, 2013 .

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy

D. Germain, D. Frank, 2007, Clinical Cancer Research.

Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response

D. Germain, E. Jenkins, Mrittika Chattopadhyay, 2021, Frontiers in Cell and Developmental Biology.

Targeting the ubiquitin-proteasome pathway in cancer therapy.

D. Germain, S. Waxman, Y. Ishii, 2007, Anti-cancer agents in medicinal chemistry.

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions.

D. Germain, P. Hart, M. Bonini, 2016, Trends in biochemical sciences.

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2

D. Germain, A. Villanueva, Elizabeth M. Slocum, 2019, Breast Cancer Research.

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.

E. Alnemri, D. Germain, A. Zervos, 2014, Biochimica et biophysica acta.

Doxycycline promotes proteasome fitness in the central nervous system

D. Germain, M. O'Connell, E. Jenkins, 2021, Scientific reports.

Doxycycline promotes proteasome fitness in the central nervous system

D. Germain, M. O'Connell, G. Manfredi, 2021, Scientific Reports.

Ubiquitin‐dependent and ‐independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseases

D. Germain, 2008, Molecular microbiology.

Mitohormesis, UPRmt, and the complexity of mitochondrial DNA landscapes in cancer.

D. Germain, T. C. Kenny, Maria Gomez, 2019, Cancer research.

Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration

D. Germain, Maria Gomez, 2019, Molecular and Cellular Neuroscience.

Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53

D. Germain, Y. Hoshida, K. Adelson, 2017, Clinical Cancer Research.

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi*

J. Schulz, R. Krüger, D. Germain, 2008, Journal of Biological Chemistry.

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPRmt)

D. Germain, T. C. Kenny, Timothy C Kenny, 2017, Front. Cell Dev. Biol..

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

D. Germain, G. Manfredi, T. C. Kenny, 2017, Front. Oncol..

Retinoic Acid-mediated Growth Arrest Requires Ubiquitylation and Degradation of the F-box Protein Skp2*

E. Musgrove, D. Germain, J. Hendley, 2001, The Journal of Biological Chemistry.

Ubiquitination of Free Cyclin D1 Is Independent of Phosphorylation on Threonine 286*

D. Germain, J. Hendley, A. Russell, 2000, The Journal of Biological Chemistry.

Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer

D. Germain, M. Thompson, J. Hendley, 1999, Oncogene.

SOD2 to SOD1 Switch in Breast Cancer*

B. Evans, L. Papa, D. Germain, 2014, The Journal of Biological Chemistry.

Sex specific activation of the ER&agr; axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS

D. Germain, S. Burstein, G. Manfredi, 2017, Human molecular genetics.

Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trial

B. Ramaswamy, C. Shapiro, J. Sparano, 2015, npj Breast Cancer.

Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer subtype determination according to age?

D. Germain, E. Jenkins, Mrittika Chattopadhyay, 2021, Aging and cancer.

Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclins

D. Germain, J. Hendley, A. Russell, 1999, Oncogene.

Skp2B attenuates p53 function by inhibiting prohibitin

J. Manfredi, D. Germain, L. Resnick-Silverman, 2010, EMBO reports.

Protein Response SirT 3 Regulates the Mitochondrial Unfolded

L. Papa, D. Germain, Luena Papa, 2014 .

SirT3 Regulates the Mitochondrial Unfolded Protein Response

L. Papa, D. Germain, Luena Papa, 2013, Molecular and Cellular Biology.

A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT

D. Germain, B. Schulman, S. Ganiatsas, 2001, Oncogene.

Estrogen carcinogenesis in breast cancer.

D. Germain, 2011, Endocrinology and metabolism clinics of North America.

Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.

T. Sakai, D. Germain, A. Nishikawa, 2008, Oncology reports.

Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer

D. Germain, S. Radke, Andreja Pirkmaier, 2005, Oncogene.

Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer

K. Eliceiri, S. Jaffer, C. Oxvig, 2016, EMBO molecular medicine.

Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responses

D. Germain, D. Sia, E. Jenkins, 2022, Aging cell.

Mitochondrial dysfunction in breast cancer

L. Papa, D. Germain, A. Riar, 2015 .

Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.

D. Germain, S. Waxman, D. Frank, 2006, Journal of the National Cancer Institute.

From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3

D. Germain, T. C. Kenny, Timothy C Kenny, 2017, Journal of Bioenergetics and Biomembranes.

Sirtuins and the Estrogen Receptor as Regulators of the Mammalian Mitochondrial UPR in Cancer and Aging.

D. Germain, 2016, Advances in cancer research.

Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis

D. Germain, H. Chander, A. Craig, 2014, Breast Cancer Research.

Raloxifene is a Female-specific Proteostasis Therapeutic in the Spinal Cord

D. Germain, G. Casalena, E. Jenkins, 2020, Endocrinology.

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

L. Papa, D. Germain, Luena Papa, 2011, Journal of Cell Science.

Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma

D. Germain, S. Ganiatsas, P. Waring, 2003, Oncogene.

Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1

S. Friedman, D. Germain, G. Narla, 2004, Cancer Research.

SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferation.

D. Germain, E. Jenkins, T. C. Kenny, 2019, Oncogene.

Abstract 5314: An oncogenic splice variant of the KLF6 tumor suppressor gene is associated with poor survival and is a potent driver of breast cancer metastasis

J. Foekens, A. Sieuwerts, Raheleh Hatami, 2012 .

Collagen and PAPP-A in the Etiology of Postpartum Breast Cancer

D. Germain, Elizabeth Slocum, 2019, Hormones and Cancer.

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

S. Friedman, M. Czaja, D. Germain, 2018, Nature Communications.

Cyclin-Dependent Kinase Inhibition by the KLF 6 Tumor Suppressor Protein through Interaction with Cyclin D 1

S. Friedman, D. Germain, G. Narla, 2004 .

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival

J. Foekens, A. Sieuwerts, M. Look, 2013, Science Translational Medicine.

DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.

B. Futcher, D. Germain, J. Hendley, 1997, Journal of cell science.

The portrait of liver cancer is shaped by mitochondrial genetics.

E. Guccione, D. Germain, J. Enríquez, 2022, Cell reports.

Skp2B Stimulates Mammary Gland Development by Inhibiting REA, the Repressor of the Estrogen Receptor

D. Germain, Z. Pan, H. Chander, 2007, Molecular and Cellular Biology.

The Multi-Faced Role of PAPP-A in Post-Partum Breast Cancer: IGF-Signaling is Only the Beginning

D. Germain, E. Jenkins, Samantha O. Brown, 2020, Journal of Mammary Gland Biology and Neoplasia.

SOD1, an unexpected novel target for cancer therapy

L. Papa, D. Germain, G. Manfredi, 2014, Genes & cancer.

Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3.

D. Germain, S. Waxman, Y. Ishii, 2008, Cancer research.

Skp2B Overexpression Alters a Prohibitin-p53 Axis and the Transcription of PAPP-A, the Protease of Insulin-Like Growth Factor Binding Protein 4

J. Manfredi, D. Germain, L. Resnick-Silverman, 2011, PloS one.

Mitohormesis Primes Tumor Invasion and Metastasis

D. Germain, A. Villanueva, A. Craig, 2019, Cell reports.

Mitohormesis Primes Tumor Invasion and Metastasis

D. Germain, A. Villanueva, A. Craig, 2019, Cell reports.

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

K. Eliceiri, T. LaFramboise, L. Papa, 2017, Oncogene.

Postpartum Involution and Cancer: An Opportunity for Targeted Breast Cancer Prevention and Treatments?

D. Germain, V. Borges, T. Lyons, 2020, Cancer Research.

Can THEM6 targeting stop resistance to prostate cancer treatment?

D. Germain, Mrittika Chattopadhyay, 2022, EMBO molecular medicine.

Skp2 and Skp2B team up against Rb and p53

D. Germain, 2011, Cell Division.

An acetyltransferase-independent function of Eso1 regulates centromere cohesion

D. Germain, O. Jabado, Claudia Tapia-Alveal, 2016, Molecular biology of the cell.

Bortezomib Enhances the Efficacy of Fulvestrant by Amplifying the Aggregation of the Estrogen Receptor, Which Leads to a Proapoptotic Unfolded Protein Response

L. Papa, D. Germain, S. Waxman, 2011, Clinical Cancer Research.

Hormonal modulation in the treatment of breast cancer.

D. Germain, K. Adelson, G. Raptis, 2011, Endocrinology and metabolism clinics of North America.

Proteasome mapping reveals sexual dimorphism in tissue‐specific sensitivity to protein aggregations

D. Germain, G. Casalena, E. Jenkins, 2020, EMBO reports.

Mitochondrial UPR in Cancer

D. Germain, 2016 .

Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide.

D. Germain, K. Yuen, J. Hendley, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2

D. Germain, A. Villanueva, A. Craig, 2019, Breast Cancer Research.

OT3-01-01: Randomized Phase II Study of Fulvestrant Versus Fulvestrant Plus Bortezomib in Postmenopausal Women with Estrogen Receptor (ER) Positive, Aromatase-Inhibitor (AI) Resistant Metastatic Breast Cancer (MBC): New York Cancer Consortium Trial P8457.

J. Sparano, D. Germain, K. Adelson, 2011 .

Cancer Therapy: Preclinical Bortezomib Enhances the Efficacy of Fulvestrant by Amplifying the Aggregation of the Estrogen Receptor, Which Leads to a Proapoptotic Unfolded Protein Response

D. Germain, S. Waxman, J. Aguirre-Ghiso, 2011 .

Correction for Papa and Germain, “SirT3 Regulates a Novel Arm of the Mitochondrial Unfolded Protein Response”

D. Germain, Luena Papa, 2017, Molecular and Cellular Biology.

Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3.

D. Germain, S. Waxman, Y. Ishii, 2008, Cancer research.