S. Smale

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Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques

C. Peterson, M. Carey, S. Smale, 2000 .

Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

S. Smale, S. Plevy, J. H. Gemberling, 1997, Molecular and cellular biology.

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

J. Ragoussis, M. Bulyk, Trevor Siggers, 2011, Nature Immunology.

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

Matthias Merkenschlager, Simon S Guest, A. Fisher, 1997, Cell.

Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription.

A. O'Shea-Greenfield, S. Smale, 1992, Journal of Biological Chemistry.

The “initiator” as a transcription control element

D. Baltimore, S. Smale, 1989, Cell.

Hierarchies of NF-κB target-gene regulation

S. Smale, 2011, Nature Immunology.

Core promoters: active contributors to combinatorial gene regulation.

S. Smale, Stephen T. Smale, 2001, Genes & development.

The RNA polymerase II core promoter.

J. T. Kadonaga, S. Smale, 2003, Annual review of biochemistry.

MHC binding prediction with KernelRLSpan and its variations.

Hau-San Wong, Shuai Cheng Li, Yu Ting Wei, 2014, Journal of immunological methods.

Chromatin structure and gene regulation in the immune system.

A. Fisher, S. Smale, 2002, Annual review of immunology.

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

Matthias Merkenschlager, Neil Brockdorff, Jonathan Godwin, 2005, The Journal of experimental medicine.

Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis

Irving L. Weissman, E. Camilla Forsberg, I. Weissman, 2007, Proceedings of the National Academy of Sciences.

A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation

Brandon J Thomas, G. Barish, S. Smale, 2016, Cell.

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

Luis C. Santos, Brandon J Thomas, Xia Yang, 2019, bioRxiv.

Title Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Permalink

S. Frietze, O. Witte, S. Smale, 2013 .

Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters

R. Tjian, S. Smale, 1985 .

Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796))

K. Akashi, A. Fisher, S. Smale, 1998 .

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.

I. Weissman, K. Akashi, A. Fisher, 1998, Genes & development.

Transcriptional Control of Inflammatory

S. Akira, G. Natoli, T. Kawai, 2014 .

Divergence of transcriptional landscape occurs early in B cell activation

Alexander S. Garruss, Alexander S Garruss, M. Weirauch, 2015, Epigenetics & Chromatin.

A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3*

A. Smith, S. Smale, S. Schultz-Cherry, 2011, The Journal of Biological Chemistry.

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

M. Pellegrini, K. Plath, G. Bonora, 2018, BMC Genomics.

A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains.

S. Smale, B. Cobb, Deanna L Russell, 2002, Genes & development.

Selectivity of the NF- k B Response

S. Smale, R. Sen, 2010 .

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL

S. Frietze, O. Witte, S. Smale, 2017, The Journal of experimental medicine.

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator.

S. Smale, M. Merkenschlager, I. Garraway, 2001, Genes & development.

Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery

S. Smale, J. Groopman, S. Kim, 1991, Journal of virology.

Transcription of the lymphocyte-specific terminal deoxynucleotidyltransferase gene requires a specific core promoter structure.

S. Smale, I. Garraway, K. Semple, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.

K. Honda, T. Mizutani, H. Iba, 2015, The Journal of Biological Chemistry.

T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication

R. Tjian, S. Smale, 1986, Molecular and cellular biology.

Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K.

C. Turck, S. Smale, K. Hahm, 1993, Nucleic acids research.

Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells

G. Natoli, S. Smale, I. Barozzi, 2019, bioRxiv.

Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis

R. Tjian, S. Smale, M. Haltiner, 1986, Molecular and cellular biology.

C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages.

S. Smale, M. Bradley, Michelle N. Bradley, 2003, Molecular and cellular biology.

The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion.

Brandon J Thomas, S. Smale, 2016, Immunity.

Self‐Renewal of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells Is Regulated by Ikaros

I. Weissman, S. Smale, Y. Sontani, 2009, Stem cells.

Dignam and Roeder nuclear extract preparation.

C. Peterson, M. Carey, S. Smale, 2009, Cold Spring Harbor protocols.

Chloramphenicol acetyltransferase assay.

S. Smale, 2010, Cold Spring Harbor protocols.

Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression

L. Tran, P. Nelson, S. Smale, 2014, Molecular and Cellular Biology.

Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence

S. Smale, I. Garraway, B. Zenzie-Gregory, 1993 .

Calcium phosphate transfection of 3T3 fibroblasts.

S. Smale, 2010, Cold Spring Harbor protocols.

Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

D. Black, G. Natoli, S. Smale, 2012, Cell.

Transgenic Expression of Helios in B Lineage Cells Alters B Cell Properties and Promotes Lymphomagenesis1

M. Teitell, S. Smale, E. Montecino-Rodriguez, 2005, The Journal of Immunology.

LymphomagenesisCells Alters B Cell Properties and Promotes Transgenic Expression of Helios in B Lineage

M. Teitell, S. Smale, E. Montecino-Rodriguez, 2005 .

Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter.

A. Fisher, S. Smale, M. Merkenschlager, 1999 .

A potential role for Elf-1 in terminal transferase gene regulation

M. Roussel, C. Turck, S. Smale, 1996, Molecular and cellular biology.

Kinetics of mRNA nuclear export regulate innate immune response gene expression

Erin M. Wissink, D. Black, Y. Xing, 2022, Nature Communications.

Hematopoiesis flies high with Ikaros

S. Smale, K. Dorshkind, 2006, Nature Immunology.

Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression.

D. Black, S. Smale, Amy Pandya-Jones, 2013, RNA.

Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene

S. Smale, K. Hahm, P. Ernst, 1993, Molecular and cellular biology.

DNA sequence requirements for transcriptional initiator activity in mammalian cells.

S. Smale, S T Smale, R Javahery, 1994, Molecular and cellular biology.

PCR-mediated site-directed mutagenesis.

C. Peterson, M. Carey, S. Smale, 2013, Cold Spring Harbor protocols.

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.

B. Bloom, S. Smale, S. Plevy, 1999, Science.

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

S. Smale, M. Horwitz, J. C. de la Torre, 2016, PLoS pathogens.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Brandon J Thomas, S. Young, A. Lusis, 2018, Cell.

Chromatin contributions to the regulation of innate immunity.

G. Natoli, A. Tarakhovsky, S. Smale, 2014, Annual review of immunology.

Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm.

Jian Xu, Jian Xu, S. Smale, 2008, Cold Spring Harbor symposia on quantitative biology.

Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

I. Weissman, S. Morrison, S. Smale, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Dimer‐specific regulatory mechanisms within the NF‐κB family of transcription factors

S. Smale, 2012, Immunological reviews.

The primer extension assay.

C. Peterson, M. Carey, S. Smale, 2013, Cold Spring Harbor protocols.

Synthesis of 3-deoxy-3-fluoro-d-mannose and 4-deoxy-4- fluoro-d-mannose

S. Smale, S. Tafuri, J. R. Rasmussen, 1983 .

Direct recognition of initiator elements by a component of the transcription factor IID complex.

S. Smale, J. Kaufmann, J Kaufmann, 1994, Genes & development.

HIV-1 core promoter lacks a simple initiator element but contains a bipartite activator at the transcription start site.

P. Sheridan, K. Jones, S. Smale, 1993, The Journal of biological chemistry.

Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription.

A. O'Shea-Greenfield, S. Smale, S T Smale, 1992, The Journal of biological chemistry.

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

D. Baltimore, A. Berk, S. Smale, 1990, Proceedings of the National Academy of Sciences of the United States of America.

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes

S. Smale, N. Landau, K. Lo, 1991, Molecular and cellular biology.

SYNTHESIS OF 3-DEOXY-3-FLUORO-D-MANNOSE AND 4-DEOXY-4-FLUORO-D-MANNOSE

S. Smale, S. Tafuri, J. R. Rasmussen, 1983 .

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

S. Smale, P. Murray, 2012, Nature Immunology.

Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes.

S. Smale, S T Smale, 1997, Biochimica et biophysica acta.

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

T. Hibi, S. Smale, S. Plevy, 2011, The Journal of Immunology.

Assembly of silent chromatin during thymocyte development.

S. Smale, R. Sridharan, R. Su, 2005, Seminars in immunology.

Pioneer factors in embryonic stem cells and differentiation.

S. Smale, 2010, Current opinion in genetics & development.

C/EBPβ Regulation in Lipopolysaccharide-Stimulated Macrophages

S. Smale, Michelle N. Bradley, Liang Zhou, 2003, Molecular and Cellular Biology.

Core promoter specificities of the Sp1 and VP16 transcriptional activation domains

S. Smale, W. Navarre, K. H. Emami, 1995, Molecular and cellular biology.

Confirming the functional importance of a protein-DNA interaction.

C. Peterson, M. Carey, S. Smale, 2012, Cold Spring Harbor protocols.

Chromatin immunoprecipitation (ChIP).

C. Peterson, M. Carey, S. Smale, 2009, Cold Spring Harbor protocols.

Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation

S. Smale, V. Ramirez-Carrozzi, Caiyi C. Li, 2006, Nature Immunology.

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

Brandon J Thomas, A. Lusis, S. Smale, 2018, Nature Medicine.

Selective Transcription in Response to an Inflammatory Stimulus

S. Smale, 2010, Cell.

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

A. Hoffmann, Christine S Cheng, S. Smale, 2009, Cell.

Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ*

K. Honda, T. Mizutani, H. Iba, 2008, Journal of Biological Chemistry.

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.

S. Smale, A. Imbalzano, R. Sridharan, 2006, Genes & development.

Combinatorial regulation of transcription. I: General aspects of transcriptional control.

S. Smale, P. Ernst, Patricia Ernst, 1995, Immunity.

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.

Jian Xu, K. Plath, S. Smale, 2009, Genes & development.

Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells

I. Weissman, Jian Xu, S. Smale, 2007, Proceedings of the National Academy of Sciences.

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells

M. Pellegrini, K. Plath, G. Bonora, 2017, bioRxiv.

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor

S. Smale, H. Schjerven, Teresita L. Arenzana, 2015, Genes & development.

A role for Dicer in immune regulation

F. J. Livesey, A. Fisher, S. Smale, 2006, The Journal of experimental medicine.

Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells

K. Plath, S. Smale, R. Sridharan, 2022, Genes & development.

Transcriptional regulation in the innate immune system.

S. Smale, 2012, Current opinion in immunology.

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense

Brandon J Thomas, R. Spreafico, Kindra M Kelly-Scumpia, 2017, PLoS pathogens.

let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

J. Listgarten, M. Pellegrini, S. Smale, 2014, Stem cell reports.

Selectivity of the NF-{kappa}B response.

S. Smale, R. Sen, 2010, Cold Spring Harbor perspectives in biology.

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

A. Hoffmann, S. Saccani, G. Natoli, 2005, Genes & development.

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages.

A. Hoffmann, D. Baltimore, S. Smale, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.

P. Scumpia, S. Smale, K. Iwamoto, 2017, Immunity.

Brandon J Thomas, S. Smale, T. Kollmann, 2015, PloS one.

Transcriptional control of inflammatory responses.

G. Natoli, S. Smale, 2014, Cold Spring Harbor perspectives in biology.

Toward an understanding of the gene-specific and global logic of inducible gene transcription.

S. Smale, S. Plevy, Scott D. Pope, 2013, Cold Spring Harbor symposia on quantitative biology.

Differential regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

P. Farnham, S. Frietze, O. Witte, 2013, Nature Immunology.

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses

A. Aderem, K. Honda, T. Taniguchi, 2012, Nature Immunology.

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.

Ajit S. Divakaruni, P. Scumpia, R. Flavell, 2020, Cell metabolism.

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation.

E. Petretto, A. Fisher, S. Smale, 2013, Blood.

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

Ignacio A. Demarco, E. Bertolino, Harinder Singh, 2008, Nature Immunology.

Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes*

S. Smale, R. Sridharan, Rupa Sridharan, 2007, Journal of Biological Chemistry.

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

A. Fisher, S. Smale, H. Jumaa, 2007, Immunity.

Ikaros-family proteins: in search of molecular functions during lymphocyte development.

S. Smale, B. Cobb, Bradley S. Cobb, 2005, Current topics in microbiology and immunology.

Ikaros Family Members from the Agnathan Myxine glutinosa and the Urochordate Oikopleura dioica: Emergence of an Essential Transcription Factor for Adaptive Immunity 1

S. Smale, J. Hansen, Fabio Spada, 2003, The Journal of Immunology.

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.

A. Perkins, S. Smale, C. Goodnow, 2003, Immunity.

Selective dimerization of a C2H2 zinc finger subfamily.

D. Eisenberg, S. Smale, G. Kleiger, 2003, Molecular cell.

Selective Dimerization of a C 2 H 2 Zinc Finger

D. Eisenberg, S. Smale, G. Kleiger, 2003 .

Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding.

A. Fisher, S. Smale, G. Kleiger, 2000, Genes & development.

Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros

Liang Zhou, S. Smale, H. Schjerven, 2014, The Journal of Immunology.

Upstream of Ikaros.

S. Smale, M. Merkenschlager, D. Liberg, 2003, Trends in immunology.

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

C. Turck, S. Smale, K. Hahm, 1994, Molecular and cellular biology.

Generality of a functional initiator consensus sequence.

S. Smale, S T Smale, K Lo, 1996, Gene.

IKZF2 (IKAROS family zinc finger 2)

S. Smale, R. Sridharan, 2008 .

Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient.

S. Smale, 2022, Trends in immunology.

Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.

S. Smale, P. Ernst, Patricia Ernst, 1995, Immunity.

Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate

B. Ames, S. Smale, J. C. Baker, 1989 .

Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters

R. Tjian, S. Smale, 1985, Molecular and cellular biology.

Transcriptional regulation in the immune system: a status report.

S. Smale, 2014, Trends in immunology.

Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells

M. Pellegrini, S. Smale, David López, 2021, Stem cell reports.

Luciferase assay.

S. Smale, S. T. Smale, 2010, Cold Spring Harbor protocols.

Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.

K. Honda, T. Mizutani, H. Iba, 2008, The Journal of Biological Chemistry.

Inhibition of simian virus 40 DNA replication in vitro by poly(ADP-ribosyl)ated diadenosine tetraphosphate.

R. Tjian, B. Ames, S. Smale, 1987, The Journal of biological chemistry.

Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

R. Damoiseaux, P. Scumpia, S. Smale, 2020, Nature Immunology.

Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.

T. Taniguchi, S. Smale, J. Nishio, 2013, Biochemical and biophysical research communications.

Dynamic assembly of silent chromatin during thymocyte maturation

A. Fisher, S. Smale, M. Merkenschlager, 2004, Nature Genetics.

The establishment and maintenance of lymphocyte identity through gene silencing

S. Smale, 2003, Nature Immunology.

The RNase protection assay.

C. Peterson, M. Carey, S. Smale, 2013, Cold Spring Harbor protocols.

Towards a Mathematical Foundation of Immunology and Amino Acid Chains pdf

Hau-San Wong, Stephen Smale, Xin Guo, 2012, ArXiv.

Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2

G. Cheng, S. Smale, K. Reue, 2022, Acta Pharmaceutica Sinica B.

Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization.

S. Smale, S T Smale, A Jain, 1997, Genes & development.

Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence.

S. Smale, I. Garraway, S T Smale, 1993, Molecular and cellular biology.

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

A. Hoffmann, S. Smale, H. Liou, 2001, Nature Immunology.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy

Kindra M Kelly-Scumpia, P. Scumpia, S. Smale, 2017, Cell.

Introduction to the Peptide Binding Problem of Computational Immunology: New Results

Hau-San Wong, Stephen Smale, Xin Guo, 2014, Found. Comput. Math..

An Inducible Enhancer Required for Il12b Promoter Activity in an Insulated Chromatin Environment

Jian Xu, D. Tantin, S. Smale, 2007, Molecular and Cellular Biology.

Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway

S. Smale, Liang Zhou, Aaron A Nazarian, 2004, Molecular and Cellular Biology.

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

E. Wagner, P. Chakravarty, S. Smale, 2022, The Journal of Immunology.

Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription.

S. Smale, S. Plevy, A. Weinmann, 1999, Immunity.

Evaluation of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells with CD150

I. Weissman, Jian Xu, S. Smale, 2009, Stem cells.

Common Interaction Surfaces of the Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets

G. Cheng, S. Smale, V. Agarwal, 2003, Molecular and Cellular Biology.

Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID.

T. Burke, S. Smale, K. H. Emami, 1998, Nucleic acids research.

Initiator Recognition in a Primitive Eukaryote: IBP39, an Initiator-Binding Protein from Trichomonas vaginalis

S. Smale, Patricia J. Johnson, A. O. Lau, 2001, Molecular and Cellular Biology.

The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes.

S. Smale, I. Garraway, J. Kaufmann, 1998, Cold Spring Harbor Symposia on Quantitative Biology.

A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle.

S. Smale, 2003, Immunity.

Potassium permanganate probing of Pol II open complexes.

C. Peterson, M. Carey, S. Smale, 2010, Cold Spring Harbor protocols.

In vitro transcription using HeLa cell extracts and primer extension.

C. Peterson, M. Carey, S. Smale, 2009, Cold Spring Harbor protocols.

A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages1

S. Smale, S. Plevy, H. Brightbill, 2000, The Journal of Immunology.

IL-10 Promoter in Macrophages Lipopolysaccharide-Mediated Induction of A Prominent Role for Sp 1 During

S. Smale, S. Plevy, H. Brightbill, 2000 .

Regulation of human ribosomal RNA transcription.

R. Tjian, S. Smale, R. M. Learned, 1983, Proceedings of the National Academy of Sciences of the United States of America.

CIF, an essential cofactor for TFIID-dependent initiator function.

C. Verrijzer, S. Smale, J. Shao, 1996, Genes & development.

Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia.

S. Gordon, A. Plüddemann, S. Smale, 2010, Cell host & microbe.

CIF150, a Human Cofactor for Transcription Factor IID-Dependent Initiator Function

S. Smale, R. Müller, J. Kaufmann, 1998, Molecular and Cellular Biology.

S. Smale, D. Quon, P. J. Johnson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

DNA sequence requirements for transcriptional initiator activity in mammalian cells

S. Smale, B. Zenzie-Gregory, A. Khachi, 1994 .

A common ATP requirement for open complex formation and transcription at promoters containing initiator or TATA elements.

J. Gralla, S. Smale, Y. Jiang, 1993, The Journal of biological chemistry.

Prediction of residue-residue contacts from protein families using similarity kernels and least squares regularization

Shuai Cheng Li, Massimo Andreatta, Santiago Laplagne, 2013, 1311.1301.

Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs

S. Smale, Yajing Gao, S. Tevosian, 2022, Genes & development.

Designing an Enhancer Landscape

Jian Xu, S. Smale, 2012, Cell.

Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP.

R. Tjian, S. Smale, 1986, The Journal of biological chemistry.

A. O'Shea-Greenfield, S. Smale, B. Zenzie-Gregory, 1992, The Journal of biological chemistry.

Transfection by electroporation of RAW 264.7 macrophages.

S. Smale, 2010, Cold Spring Harbor protocols.

Purification of mediator from HeLa cell lines expressing a flag-tagged mediator subunit.

C. Peterson, M. Carey, S. Smale, 2010, Cold Spring Harbor protocols.

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

S. Smale, K. Hahm, P. Ernst, 1994 .

Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions.

M. Carey, S. Smale, 2007, CSH protocols.

Identifying cis-acting DNA elements within a control region.

C. Peterson, M. Carey, S. Smale, 2012, Cold Spring Harbor protocols.

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

Y. Kluger, R. Flavell, S. Smale, 2023, bioRxiv.

Protein complex binding to promoter DNA: immobilized template assay.

C. Peterson, M. Carey, S. Smale, 2010, Cold Spring Harbor protocols.

Nuclear run-on assay.

S. Smale, 2009, Cold Spring Harbor protocols.

Beta-galactosidase assay.

S. Smale, 2010, Cold Spring Harbor protocols.

Experimental strategies for cloning or identifying genes encoding DNA-binding proteins.

C. Peterson, M. Carey, S. Smale, 2012, Cold Spring Harbor protocols.

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.

Jian Xu, K. Plath, S. Smale, 2009, Genes & development.

Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.

P. Scumpia, S. Smale, K. Iwamoto, 2017, Immunity.

Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

D. Black, G. Natoli, S. Smale, 2012, Cell.

Rapid transcriptional reprogramming of the lipid biosynthesis genes in response to type I interferon

S. Smale, S. Bensinger, Ann-Jay Tong, 2016, The Journal of Immunology.

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation.

E. Petretto, A. Fisher, S. Smale, 2013, Blood.

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

N. Brockdorff, A. Fisher, S. Smale, 2005, The Journal of experimental medicine.

This information is current as Macrophages and Mucosal Immunity NFIL 3 Is a Regulator of IL-12 p 40 in Kashiwada and

T. Hibi, S. Smale, S. Plevy, 2011 .

Erratum for Garcia et al., Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression

L. Tran, P. Nelson, S. Smale, 2014, Molecular and Cellular Biology.

DNase I footprinting.

C. Peterson, M. Carey, S. Smale, 2013, Cold Spring Harbor protocols.

In vivo DNase I, MNase, and restriction enzyme footprinting via ligation-mediated polymerase chain reaction (LM-PCR).

C. Peterson, M. Carey, S. Smale, 2009, Cold Spring Harbor protocols.