D. Nebert

D. Nebert, A. Puga, Baisakhi Raychaudhurl, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Analysis of Constitutive and TCDD-Inducible Expression of Genes in the [Ah] Battery

D. Nebert, V. Rapić, 1991 .

The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery.

D. Nebert, A. Puga, B. Raychaudhuri, 1990, Molecular endocrinology.

Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse.

D. Nebert, G. Lambert, Daniel W. Nebert, 1977, Teratology.

Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci.

D. Nebert, J. Robinson, N. Considine, 1974, The Journal of biological chemistry.

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

D. Nebert, J. Gielen, F. Goujon, 1972, Molecular pharmacology.

Evolution of the cytochrome P450 genes.

D. Nelson, D. Nebert, R. Feyereisen, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

21 – The Ah Locus: Genetic Regulation of the Enzymes which Metabolize Polycyclic Hydrocarbons and the Risk for Cancer

R. E. Kouri, D. Nebert, S. Atlas, 1978 .

Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

D. Nebert, M. Kuo, L. Teeter, 1991, DNA and cell biology.

Cellular Responses To Oxidative Stress

A. Fornace, D. Nebert, D. D. Petersen, 1990 .

Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins

D. Nebert, A. Puga, L. Ponomareva, 1999, Marine Biotechnology.

Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus.

D. Nebert, J. Gielen, J. van Cantfort, 1985, Biochemical pharmacology.

P450 gene nomenclature based on evolution.

D. Nelson, D. Nebert, 1991, Methods in enzymology.

Activation of transcription factors in zebrafish cell cultures by environmental pollutants.

D. Nebert, M. Carvan, L. Gedamu, 2000, Archives of biochemistry and biophysics.

Induction of immunotoxicity by polycyclic hydrocarbons: Role of the Ah locus

D. Taramelli, R. E. Kouri, D. Nebert, 1984, Archives of Toxicology.

Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.

D. Nebert, T. Dalton, Bin Wang, 2003, Biochemical and biophysical research communications.

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

D. Nebert, S. Sweitzer, P. Sinclair, 2001, Biochemical pharmacology.

Response of [Ah] battery genes to compounds that protect against menadione toxicity.

V. Vasiliou, D. Nebert, H. Shertzer, 1995, Biochemical pharmacology.

Association between susceptibility to dibenzanthracene‐induced fibrosarcoma formation and the Ah locus

D. Nebert, R. Lubet, Richard E. Kour, 1983, International journal of cancer.

Y. T. Chen, R. Tukey, D. Nebert, 1982, European journal of biochemistry.

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction

K. Ozato, D. Nebert, Y. Shirayoshi, 1989, Molecular and cellular biology.

The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA

R. Tukey, D. Nebert, M. Negishi, 1982, Cell.

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

D. Nebert, K. Kumaki, J. Shire, 1977, The Journal of biological chemistry.

P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics.

D. Nebert, F. Gonzalez, A. Jaiswal, 1986, Cold Spring Harbor symposia on quantitative biology.

Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450.

D. Nebert, P. Mackenzie, F. Gonzalez, 1984, Gene.

Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

D. Nebert, K. Kumaki, A. Niwa, 1975 .

Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.

D. Nebert, J. Robinson, Joseph R. Robinson, 1974, Molecular pharmacology.

Analysis of two benzo[a]pyrene‐resistant mutants of the mouse hepatoma Hepa‐1 P(1)450 gene via cDNA expression in yeast.

O. Hankinson, D. Nebert, S. Kimura, 1987, The EMBO journal.

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells.

D. Nebert, I. Owens, 1976, Biochemical pharmacology.

Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.

D. Nebert, H. Gelboin, 1968, The Journal of biological chemistry.

An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations.

N. Tuteja, D. Nebert, F. Gonzalez, 1986, Biochemical pharmacology.

Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.

N. Tuteja, D. Nebert, F. Gonzalez, 1985, Developmental biology.

Changes in cytochrome P-450 iron spin state as a function of castration, testosterone or estrogen treatment, vigorous exercise, or starvation.

D. Nebert, H. Kon, A. Rispin, 1984, Biochemical pharmacology.

Genetic Differences in Drug Metabolism: Proposed Relationship to Human Birth Defects

D. Nebert, 1983 .

Hepatic Drug-Metabolizing Enzymes during Embryonic and Fetal Development

D. Nebert, A. Okey, 1983 .

Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution.

D. Nebert, M. Negishi, 1982, Biochemical pharmacology.

Clinical pharmacology. Possible clinical importance of genetic differences in drug metabolism.

D. Nebert, 1981, British medical journal.

For Dioxin-induced Birth Defects, Mouse or Human CYP1A2 in Maternal Liver Protects whereas Mouse CYP1A1 and CYP1B1 Are Inconsequential*

D. Nebert, Nadine Dragin, T. Dalton, 2006, Journal of Biological Chemistry.

Dioxin increases reactive oxygen production in mouse liver mitochondria.

D. Nebert, T. Dalton, H. Shertzer, 2002, Toxicology and applied pharmacology.

Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.

D. Nebert, K. Setchell, A. Puga, 1999, Chemico-biological interactions.

Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways

D. Nebert, C. Serhan, C. Karp, 2013, The Journal of Immunology.

Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT).

D. Nebert, F. Carrier, A. Puga, 1994, Biochemical pharmacology.

Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.

D. Nebert, A. Puga, B. Raychaudhuri, 1990, DNA and cell biology.

Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures.

D. Nebert, R. Owens, 1990, Biochemical and biophysical research communications.

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

O. Hankinson, D. Nebert, H. Eisen, 1982, The Journal of biological chemistry.

Dioxin-inducible enhancer region upstream from the mouse P(1)450 gene and interaction with a heterologous SV40 promoter.

D. Nebert, F. Gonzalez, A. Jaiswal, 1986, DNA.

Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line.

B. Birren, O. Hankinson, D. Nebert, 1985, The Journal of biological chemistry.

Cytochrome P450 (CYP) Gene Superfamily

D. Nelson, D. Nebert, 2011 .

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

D. Nebert, I. Owens, 1975, Molecular pharmacology.

Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds

D. Nebert, 1979 .

Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a

V. Vasiliou, D. Nebert, A. Puga, 1993, Annals of the New York Academy of Sciences.

Glutathione defense mechanism in liver injury: insights from animal models.

Ying Chen, V. Vasiliou, D. Nebert, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse Chromosome 2

C. Kozak, D. Nebert, A. Puga, 2004, Mammalian Genome.

Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization.

D. Nebert, J. Jones, A. Dey, 1999, Biochemical pharmacology.

Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse.

D. Nebert, A. Dey, D. W. Nebert, 1998, Biochemical and biophysical research communications.

Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.

D. Nebert, H. Liang, R. McKinnon, 1997, Biochemical pharmacology.

Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450.

L. Enquist, D. Nebert, M. Negishi, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.

D. Nebert, A. Puga, D. D. Petersen, 1991, Pharmacogenetics.

The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation.

D. Nebert, H. Gelboin, 1970, Journal of Biological Chemistry.

The Ah receptor: binding specificity only for foreign chemicals?

O. Hankinson, D. Nebert, H. Eisen, 1984, Biochemical pharmacology.

Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions.

D W Nebert, D. Nebert, 1991, Molecular endocrinology.

Drug-Metabolizing Enzymes, Polymorphisms and Interindividual Response to Environmental Toxicants

D. Nebert, 2000, Clinical chemistry and laboratory medicine.

Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation.

D. Nebert, S. Kimura, J. C. Donovan, 1987, Journal of experimental pathology.

Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines.

D. Nebert, G. Bondy, A. Okey, 1980, The Journal of biological chemistry.

2,3,7,8-Tetrachlorodibenzo-p-dioxin: covalent binding of reactive metabolic intermediates principally to protein in vitro.

D. Nebert, T. Guenthner, J. Fysh, 1979, Pharmacology.

Genetic differences in microsomal electron transport: the Ah locus.

D. Nebert, 1978, Methods in enzymology.

Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene.

D. Nebert, J. Jones, 1989, DNA.

Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines.

D. Nebert, A. Jaiswal, Howard W. Eisen, 1985, Biochemical pharmacology.

Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance.

D. Nebert, Y. Sheen, L. Heilmann, 1988, DNA.

Association of fertility, fitness and longevity with the murine Ah locus among (C57BL/6N) (C3H/HeN) recombinant inbred lines.

D. Nebert, H. Eisen, D. D. Brown, 1984, Biology of reproduction.

Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture.

D. Nebert, T. Peterson, F. Gonzalez, 1986, Biochemical pharmacology.

Theophylline pharmacokinetics: comparison of Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice

D. Nebert, Nadine Dragin, T. Dalton, 2005, Pharmacogenetics and genomics.

Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence.

R. Tukey, D. Nebert, M. Negishi, 1981, The Journal of biological chemistry.

Human P3(450): cDNA and complete amino acid sequence.

D. Nebert, F. Gonzalez, A. Jaiswal, 1986, Nucleic acids research.

Evolution of the P450 gene superfamily.

D. Nebert, A. Puga, J. Owens, 1988, Progress in clinical and biological research.

Carcinogenic benzo(a)pyrene metabolites bound to DNA: metabolic formation by human cultured lymphocytes and by human liver microsomes.

A. Boobis, D. Nebert, S. Atlas, 1978, Pharmacology.

Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.

C. Vorhees, D. Nebert, T. Dalton, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

The 1986 Bernard B. Brodie award lecture. The genetic regulation of drug-metabolizing enzymes.

D. Nebert, 1988, Drug metabolism and disposition: the biological fate of chemicals.

CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

M. Makishima, D. Nebert, K. Yoshizato, 2009, Toxicology and applied pharmacology.

Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract.

D. Nebert, F. Gonzalez, Nadine Dragin, 2008, Free radical biology & medicine.

Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8].

D. Nebert, A. Jaiswal, 1986, Nucleic acids research.

Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer*

Allan B. Okey, Frank J. Gonzalez, D. Nebert, 2004, Journal of Biological Chemistry.

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1 Knockout Mouse Lines as a Paradigm

D. Nebert, Marina Gálvez-Peralta, Zhanquan Shi, 2013, Molecular Pharmacology.

Oral benzo[a]pyrene in Cyp1a1/1b1(–/–) double‐knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct

D. Nebert, Marina Gálvez-Peralta, Zhanquan Shi, 2013, International journal of cancer.

Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

V. Vasiliou, D. Nebert, F. Gonzalez, 2013, Biochemical and biophysical research communications.

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

V. Arlt, D. Phillips, D. Nebert, 2012, Toxicology and applied pharmacology.

Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor.

D. Nebert, H. Dong, Zhanquan Shi, 2008, Biochemical and biophysical research communications.

Role of Protein Kinase C-mediated Protein Phosphorylation in Mitochondrial Translocation of Mouse CYP1A1, Which Contains a Non-canonical Targeting Signal*

D. Nebert, V. R. Dasari, M. Robin, 2006, Journal of Biological Chemistry.

Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

D. Nebert, H. Dong, T. Dalton, 2006, Biochemical and biophysical research communications.

Role of host susceptibility to toxicity and cancer caused by pesticides: Cytochromes P450

D. Nebert, 2005, Journal of biochemical and molecular toxicology.

Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.

Andrew G Smith, D. Nebert, R. Davies, 2005, Biochemical and biophysical research communications.

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the "responsive" homozygote and heterozygote at the Ah locus.

D. Nebert, A. Poland, K. Kumaki, 1975, Archives of Biochemistry and Biophysics.

Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.

D. Nebert, G. Talaska, T. Dalton, 2002, Toxicology and applied pharmacology.

The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.

D. Nebert, S. W. Bigelow, 1986, Journal of biochemical toxicology.

NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.

D. Nebert, H. C. Chen, J. Robertson, 1986, Journal of Biological Chemistry.

DRUGS AND MICROSOMAL ENZYME FORMATION IN VIVO AND IN MAMMALIAN CELL CULTURE

D. Nebert, H. Gelboin, 1969 .

Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women.

D. Nebert, H. Gelboin, J. Winker, 1969, Cancer research.

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

D. Jerina, R. E. Kouri, D. Nebert, 1978, Cancer research.

Clinical importance of the cytochromes P450

D. Russell, D. Nebert, David W Russell, 2002, The Lancet.

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

D. Nebert, G. Talaska, T. Dalton, 2007, Carcinogenesis.

Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.

C. Kozak, D. Nebert, F. Gonzalez, 1990, DNA and cell biology.

Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.

D. Nebert, H. Gelboin, 1968, The Journal of biological chemistry.

Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis.

D. Nebert, H. Shertzer, Ying Chen, 2012, Chemical research in toxicology.

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Andrew G Smith, D. Nebert, P. Sinclair, 2004, Toxicology and applied pharmacology.

Measurements of the cytosolic Ah receptor among four strains of Drosophila melanogaster

D. Nebert, E. Vogel, J. Zijlstra, 1985, Archives of Toxicology.

IMPACT OF GENETICS AND GENETIC MONITORING ON PHARMACOLOGY STUDIES

D. Nebert, 1983 .

Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450.

D. Nebert, K. Kumaki, H. Shichi, 1978, Chemico-biological interactions.

Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus.

D. Nebert, I. Owens, N. Considine, 1973, Archives of biochemistry and biophysics.

Polycyclic hydrocarbon‐produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures

W. Benedict, D. Nebert, J. Gielen, 1972, International journal of cancer.

Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p,p'-DDT

D. Nebert, J. Gielen, 1971, Science.

ARYL HYDROCARBON HYDROXYLASE INDUCTION IN CELL CULTURE AS A FUNCTION OF GENE EXPRESSION GENE EXPRESSION

D. Nebert, L. Bausserman, D. W. Nebert, 1971, Annals of the New York Academy of Sciences.

Changes in aryl hydrocarbon hydroxylase activity and microsomal P450 during polycyclic hydrocarbon treatment of mammalian cells in culture.

D. Nebert, 1969, Biochemical and biophysical research communications.

Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays.

D. Nebert, A. Jaiswal, D. W. Nebert, 1987, Biochemical and biophysical research communications.

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

D. Nebert, F. Gonzalez, S. Kimura, 1985, The Journal of biological chemistry.

Pharmacogenetics in clinical pharmacology and toxicology.

P. Watkins, G. Tucker, L. Bertilsson, 1995, Canadian journal of physiology and pharmacology.

Lipid metabolism and body composition in Gclm(-/-) mice.

D. Nebert, E. Johansson, H. Shertzer, 2011, Toxicology and applied pharmacology.

Chapter 3 – Human Genetic Variation in the Enzymes of Detoxication

D. Nebert, 1980 .

The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.

D. Nebert, S. W. Bigelow, D. Nebert, 1982, Toxicology letters.

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake

D. Nebert, Marina Gálvez-Peralta, Fei Chen, 2016, Oncotarget.

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

M. J. Coon, M. Waterman, Y. Fujii‐Kuriyama, 1991, DNA and cell biology.

Possible Role of Cytochromes P450 in Lupus Erythematosus and Related Disorders

D. Nebert, R. Mckinnon, R. McKinnon, 1994, Lupus.

Genetic expression of aryl hydrocarbon hydroxylase induction. Genetic specificity resides in the fraction containing cytochromes P448 and P450.

M. J. Coon, D. Nebert, H. Strobel, 1973, The Journal of biological chemistry.

The Ah locus: aromatic hydrocarbon responsiveness... of mice and men.

D. Nebert, S. Atlas, 1978, Human genetics. Supplement.

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes

T. Yuen, C. Hunter, D. Nebert, 2013, Proceedings of the National Academy of Sciences.

Hemopexin and aryl hydrocarbon hydroxylase induction in the mouse and in cell culture.

D. Nebert, U. Müller‐Eberhard, I. Owens, 1978, Biochemical pharmacology.

Conflicts of Interests: Declarations for All

D. Nebert, 2004, Environmental health perspectives.

Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.

S. Thorgeirsson, A. Boobis, D. Nebert, 1977, The Journal of biological chemistry.

Dioxin causes a sustained oxidative stress response in the mouse.

D. Nebert, K. Dixon, A. Puga, 1998, Biochemical and biophysical research communications.

Drug metabolic enzymes in developmental toxicology.

D. Nebert, M. Miller, F. Guengerich, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

The AP-1 site and the cAMP- and serum response elements of the c-fos gene are constitutively occupied in vivo.

K. Ozato, D. Nebert, A. Dey, 1991, DNA and cell biology.

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

D. Nebert, J. Idle, F. Gonzalez, 2005, Chemical research in toxicology.

Evolutionary divergence and functions of the ADAM and ADAMTS gene families

Vasilis Vasiliou, C. Brocker, V. Vasiliou, 2009, Human Genomics.

Oral Cadmium in Mice Carrying 5 Versus 2 Copies of the Slc39a8 Gene

Bin Wang, D. Nebert, Zhiwei Liu, 2014, International journal of toxicology.

Structure of the mouse cytochrome P1-450 genomic gene.

Y. T. Chen, R. Tukey, D. Nebert, 1983, European journal of biochemistry.

Uroporphyria in mice: Thresholds for hepatic CYP1A2 and iron

D. Nebert, P. Sinclair, T. Dalton, 2002, Hepatology.

Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.

D. Nebert, F. Gonzalez, P. Sinclair, 2000, Archives of biochemistry and biophysics.

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

D. Nebert, P. Sinclair, T. Dalton, 2000, Toxicology and applied pharmacology.

Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution.

D. Nebert, M. Carvan, G. Stuart, 2002, Environmental Health Perspectives.

Elevated estrogen 16 alpha-hydroxylase activity: is this a genotoxic or nongenotoxic biomarker in human breast cancer risk?

D. Nebert, D. W. Nebert, 1993, Journal of the National Cancer Institute.

Drug metabolism. Growth signal pathways.

D. Nebert, 1990, Nature.

Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead.

D. Nebert, E. Vesell, 2004, European journal of pharmacology.

A Tribute to Elliot S. Vesell (1933–2018)

D. Nebert, 2018, Trends in Pharmacological Sciences.

Human Cytochrome P-450 (CYP) Genes

M. Ingelman-Sundberg, D. Nebert, S. Garte, 2001 .

Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family

V. Vasiliou, D. Nebert, D. Ross, 2006, Human Genomics.

ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition.

D. Nebert, Marina Gálvez-Peralta, Lei He, 2012, Metallomics : integrated biometal science.

Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA.

Y. T. Chen, D. Nebert, M. Negishi, 1982, DNA.

Sulfobetaine derivatives of bile acids: nondenaturing surfactants for membrane biochemistry.

D. Nebert, J. C. Osborne, L. Hjelmeland, 1983, Analytical biochemistry.

Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices.

D. Nebert, O. Pelkonen, C. Legraverend, 1979, Biochemical pharmacology.

Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.

A. Bairoch, V. Vasiliou, K. Tipton, 1999, Pharmacogenetics.

Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.

D. Nebert, 1981, Environmental health perspectives.

CHAPTER 7 – The Ah Receptor: Controlling Factor in the Induction of Drug-Metabolizing Enzymes by Certain Chemical Carcinogens and Other Environmental Pollutants

D. Nebert, A. Okey, H. Eisen, 1983 .

Human drug metabolism polymorphisms: use of recombinant DNA techniques.

D. Nebert, A. Jaiswal, 1987, Pharmacology & therapeutics.

Comparative EPR study on high-spin ferric porphine complexes and cytochrome P-450 having rhombic character.

D. Nebert, M. Sato, K. Kumaki, 1977, Biochimica et biophysica acta.

cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene.

D. Nebert, S. Kimura, 1986, Nucleic acids research.

Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9.

C. E. Hildebrand, C. Kozak, D. Nebert, 1985, Biochemical and biophysical research communications.

Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15.

C. E. Hildebrand, D. Nebert, O. Mcbride, 1985, Nucleic acids research.

Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone.

R. Tukey, D. Nebert, 1984, Biochemistry.

Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9.

R. Tukey, D. Nebert, P. Lalley, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney.

S. Thorgeirsson, A. Boobis, D. Nebert, 1975, Biochemical pharmacology.

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

D. Nebert, P. Sinclair, T. Dalton, 2003, Biochemical pharmacology.

Regulation ofMouseCYPIAJGeneExpression byDioxin: Requirement ofTwocis-Acting Elements during Induction

D. Nebert, 1989 .

Placing human gene families into their evolutionary context

Zheng Wang, J. Townsend, E. Bruford, 2022, Human Genomics.

Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5

C. Kozak, D. Krasnewich, D. Nebert, 1987, Somatic cell and molecular genetics.

Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.

M. Ingelman-Sundberg, T. Ogata, D. Nebert, 2009, Pharmacogenetics and genomics.

Cell-specific induction of mouse Cyp1a1 mRNA during development.

D. Nebert, H. Westphal, A. Dey, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

D. Nebert, Zhiwei Liu, Lei He, 2008, Molecular Pharmacology.

Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.

D. Nebert, Zhiwei Liu, Lei He, 2008, Biochemical and biophysical research communications.

From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions.

Ge Zhang, D. Nebert, E. Vesell, 2008, Drug metabolism reviews.

Pharmacogenetics: 65 candles on the cake

D. Nebert, 1997 .

Subcellular localization of membrane-bound aryl-hydrocarbon hydroxylase and NAD(P)H-dependent reductase activities in mouse liver.

D. Nebert, I. Kano, D. Nebert, 1980, European journal of biochemistry.

Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans”

R. E. Kouri, D. Nebert, R. Lubet, 1983 .

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

D. Nebert, P. Sinclair, T. Dalton, 1998, The Biochemical journal.

Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.

D. Nebert, O. Mcbride, F. Gonzalez, 1987, Journal of experimental pathology.

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Xiping Wang, C. Brocker, V. Vasiliou, 2012, Planta.

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

D. Nebert, Zhiwei Liu, Lei He, 2008, Molecular Pharmacology.

Variations in Aryl Hydrocarbon Hydroxylase Activities in Mitogen-Activated Human and Nonhuman Primate Lymphocytes

R. E. Kouri, D. Nebert, A. Levine, 1984, Toxicologic pathology.

Genetic Dissection of Complex Traits : Susceptibility to Environmental Agents IN THIS ISSUE

D. Nebert, M. Director, 2000 .

Spectral evidence for weak ligand in sixth position of hepatic microsomal cytochrome P-450 low spin ferric iron in vivo.

D. Nebert, K. Kumaki, 1978, Pharmacology.

Ontogenetic expression of regulatory and structural gene products associated with the Ah locus. Comparison of rat, mouse, rabbit and Sigmoden hispedis.

D. Nebert, A. Okey, G. F. Kahl, 1980, Developmental pharmacology and therapeutics.

Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene binding to several moieties in mouse liver cytosol.

D. Nebert, H. Eisen, R. Hannah, 1981, The Journal of biological chemistry.

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. I. Stimulation of enzyme activity in nonhepatic cells and in hepatic cells by phenobarbital, polycyclic hydrocarbons, and 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane.

D. Nebert, J. Gielen, 1971, Journal of Biological Chemistry.

Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals

D. Nebert, D. Knoell, Marina Gálvez-Peralta, 2014, International journal of toxicology.

Genetic Differences in Benzo[a]pyrene Carcinogenic Index in Vivo and in Mouse Cytochrome P1 450-Mediated Benzo[a]pyrene Metabolite Binding to DNA in Vitro

D. Jerina, A. Boobis, R. E. Kouri, 1977 .

The Ah locus and the metabolism of chemical carcinogens and other foreign compounds.

S. Thorgeirsson, D. Nebert, 1977, Advances in cancer research.

Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.

D. Nebert, F. Gonzalez, F. J. Gonzalez, 1990, Trends in genetics : TIG.

Human cytochromes P450 in health and disease

Walter L. Miller, D. Nebert, W. Miller, 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

The Ah locus, a multigene family necessary for survival in a chemically adverse environment: comparison with the immune system.

D. Nebert, M. Lang, M. Negishi, 1982, Advances in genetics.

Biological effects of the Sudan dyes. Role of the Ah cytosolic receptor.

R. E. Kouri, D. Nebert, R. Lubet, 1983, Biochemical pharmacology.

Hyperfine Structure in the EPR Spectrum of the Manganous Ion in Frozen Solutions

D. Nebert, B. T. Allen, 1964 .

Aryl hydrocarbon hydroxylase induction in cell culture as a function of gene expression.

D. Nebert, L. Bausserman, 1971, Annals of the New York Academy of Sciences.

Drug-metabolizing enzymes in ligand-modulated transcription.

D. Nebert, 1994, Biochemical pharmacology.

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

L. Maltais, H. Wain, D. Nelson, 2004, Pharmacogenetics.

P450 genes: structure, evolution, and regulation.

D W Nebert, D. Nebert, F. Gonzalez, 1987, Annual review of biochemistry.

Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity

D. Nebert, 1979, Molecular and Cellular Biochemistry.

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

D. Nebert, T. Dalton, 2006, Nature Reviews Cancer.

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.

D. Nebert, A. Jaiswal, R. Owens, 1989, Molecular endocrinology.

Cytochrome P450 gene expression and regulation

D. Nebert, F. Gonzalez, 1985 .

Microsomal aryl hydrocarbon hydroxylase in rat adrenal: regulation by ACTH but not by polycyclic hydrocarbons.

D. Nebert, T. Guenthner, R. Menard, 1979, Molecular pharmacology.

NADPH-cytochrome P-450 reductase: preferential inhibition by ellipticine and other type II compounds having little effect on NADPH-cytochrome c reductase.

D. Nebert, T. Guenthner, G. F. Kahl, 1980, Biochemical pharmacology.

ASSOCIATION ON TYPE I, TYPE II, AND REVERSE TYPE I DIFFERENCE SPECTRA WITH ABSOLUTE SPIN STATE OF CYTOCHROME P-450 IRON

D. Nebert, K. Kumaki, H. Kon, 1977 .

Genetic differences in the extent of aryl hydrocarbon hydroxylase induction in mouse fetal cell cultures.

D. Nebert, L. Bausserman, 1970, The Journal of biological chemistry.

Correlation of type I, type II, and reverse type I difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species.

D W Nebert, D. Nebert, M. Sato, 1978, The Journal of biological chemistry.

Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450.

D. Nebert, J. Gielen, F. Goujon, 1972, Molecular pharmacology.

A sensitive radiometric assay of aminopyrine N-demethylation.

D. Nebert, A. Poland, 1973, The Journal of pharmacology and experimental therapeutics.

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family

Vasilis Vasiliou, V. Vasiliou, D. Nebert, 2005, Human Genomics.

Manganese accumulation in the mouse ear following systemic exposure

D. Nebert, J. Caruso, M. Genter, 2008, Journal of biochemical and molecular toxicology.

Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse

D. Nebert, F. Gonzalez, C. Karp, 2008, Molecular Pharmacology.

Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse

D. Nebert, T. Dalton, Yi Yang, 2002, The Journal of Biological Chemistry.

The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.

M. Scally, D. Nebert, J. Goldstone, 2006, Developmental biology.

Genetically altered mice to evaluate glutathione homeostasis in health and disease.

D. Nebert, T. Dalton, H. Shertzer, 2004, Free radical biology & medicine.

Analysis of the glutathione S-transferase (GST) gene family

V. Vasiliou, D. Nebert, 2004, Human Genomics.

Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes.

D. Nebert, M. Lang, 1981, The Journal of biological chemistry.

Separation of acetanilide and its hydroxylated metabolites and quantitative determination of "acetanilide 4-hydroxylase activity" by high-pressure liquid chromatography.

D. Nebert, M. Negishi, T. Guenthner, 1979, Analytical biochemistry.

Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

D. Nebert, T. Guenthner, 1978, European journal of biochemistry.

Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice.

D. Nebert, S. Atlas, 1976, Archives of biochemistry and biophysics.

Tentative identification of benzo[a]pyrene metabolite-nucleoside complexes produced in vitro by mouse liver microsomes.

D. Jerina, A. Boobis, D. Nebert, 1978, Molecular pharmacology.

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

D. Nebert, A. Poland, A. Niwa, 1975, Journal of cellular physiology.

Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

R. E. Kouri, D. Nebert, S. Atlas, 1974, Life sciences.

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

D. Nebert, U. Meyer, F. Gonzalez, 1988, Nature.

Nomenclature for human CYP2D6 alleles.

M. Ingelman-Sundberg, V. Steen, J. Brockmöller, 1996, Pharmacogenetics.

The DNA binding of benzo[alpha]pyrene metabolites catalysed by rat lung microsomes in vitro and in isolated perfused rat lung.

D. Nebert, K. Vähäkangas, O. Pelkonen, 1979, Chemico-biological interactions.

Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.

A. Boobis, D. Nebert, O. Pelkonen, 1979, Biochemical pharmacology.

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

D. Nebert, G. Lambert, R. Levitt, 1977, Archives of Toxicology.

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.

D W Nebert, D. Nebert, 1989, Critical reviews in toxicology.

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism.

D. Nebert, S. Shum, N. M. Jensen, 1979, Teratology.

The in vitro metabolism and convalent binding of benzo[a]pyrene to DNA catalysed by trout liver microsomes.

D. Nebert, O. Pelkonen, J. Ahokas, 1979, Chemico-biological interactions.

Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease

Hongyu Zhao, E. Dermitzakis, E. Bruford, 2020, Human Genetics.

A MICROSOMAL DIFFERENCE BETWEEN NORMAL LIVER AND "MINIMAL-DEVIATION" HEPATOMA 5123 DETECTABLE BY ELECTRON SPIN RESONANCE.

D. Nebert, H. S. Mason, 1964, Biochimica et biophysica acta.

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

D. Nebert, O. Pelkonen, 1982, Pharmacological reviews.

Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon

D. Nebert, R. M. Friedman, 1973, Journal of virology.

Genetic differences in drug metabolism associated with ocular toxicity.

D. Nebert, H. Shichi, 1982, Environmental health perspectives.

Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

D. Nebert, 1997, American journal of human genetics.

The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.

G. Siest, D. Lancet, D. Nelson, 1991, DNA and cell biology.

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

C. Guillemette, J. Miners, D. Nebert, 2005, Pharmacogenetics and genomics.

Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders

E. Bruford, V. Vasiliou, D. Nebert, 2022, Human genomics.

Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance.

D. Nebert, R. Mckinnon, A. Puga, 1997, Critical reviews in toxicology.

Update on the olfactory receptor (OR) gene superfamily

Tsviya Olender, Doron Lancet, D. Lancet, 2008, Human Genomics.

Update of human and mouse forkhead box (FOX) gene families

Brian C. Jackson, V. Vasiliou, D. Nebert, 2010, Human Genomics.

Toward the evaluation of function in genetic variability: Characterizing human SNP frequencies and establishing BAC‐transgenic mice carrying the human CYP1A1_CYP1A2 locus

D. Nebert, R. Deka, T. Dalton, 2005, Human mutation.

Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA.

A. Boobis, D. Nebert, 1976, Advances in enzyme regulation.

Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.

D. Nebert, F. Carrier, A. Puga, 1992, DNA and cell biology.

Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology

J. Hickman, D. Nebert, T. Goldsworthy, 1997 .

Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology.

J. Hickman, D. Nebert, T. Goldsworthy, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

D. Nebert, O. Mcbride, U. Meyer, 1988, Genomics.

Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.

C. Kozak, D. Nebert, U. Meyer, 1987, DNA.

Comparison of the mouse P(1)450 gene and flanking sequences from a MOPC 41 plasmacytoma and normal liver.

D. Nebert, S. Kimura, 1985, DNA.

Genes encoding drug-metabolizing enzymes: possible role in human disease.

D. Nebert, D. Nebert, 1988, Basic life sciences.

SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside

D. Nebert, Zijuan Liu, 2019, Human Genomics.

From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions

Ge Zhang, D. Nebert, E. Vesell, 2008 .

Recommendations for locus‐specific databases and their curation

M. Vihinen, J. Beckmann, A. Brookes, 2008 .

Update of human and mouse matrix metalloproteinase families

Brian C. Jackson, V. Vasiliou, D. Nebert, 2010, Human Genomics.

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis.

D. Nebert, T. Dalton, Yi Yang, 2000, Biochemical pharmacology.

Genetic risk prediction: individualized variability in susceptibility to toxicants.

Ge Zhang, D. Nebert, E. Vesell, 2013, Annual review of pharmacology and toxicology.

In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes

C. Vorhees, D. Nebert, T. Schaefer, 2011, Environmental health perspectives.

Mouse Dioxin-Inducible Ahd4 Gene

V. Vasiliou, D. Nebert, A. Puga, 1996 .

Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology.

D W Nebert, D. Nebert, 2000, Pharmacogenetics.

Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes".

D. Nebert, 2006, American journal of physiology. Cell physiology.

The Y-box Motif Mediates Redox-dependent Transcriptional Activation in Mouse Cells (*)

D. Nebert, A. Puga, H. Shertzer, 1995, The Journal of Biological Chemistry.

Analysis and update of the human solute carrier (SLC) gene superfamily

D. Nebert, Konstandinos Vasiliou, Lei He, 2009, Human Genomics.

Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.

D. Eaton, D. Nebert, R. Tonge, 1998, Toxicology and applied pharmacology.

COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission

C. D. Dela Cruz, D. Thompson, V. Vasiliou, 2020, Human Genomics.

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.

E. Puffenberger, R. Hegele, S. Küry, 2015, American journal of human genetics.

In utero gene expression in the Slc39a8(neo/neo) knockdown mouse

Jingyuan Deng, D. Nebert, J. Chen, 2018, Scientific Reports.

Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone.

D. Nebert, P. Mackenzie, S. Haque, 1991, DNA and cell biology.

Identification of genetic differences in drug metabolism: Prediction of individual risk of toxicity or cancer

D. Nebert, 1991, Hepatology.

Role of genetics and drug metabolism in human cancer risk.

D. Nebert, 1991, Mutation research.

An investigation of genetic variation within a series of congenic strains of mice

D. Nebert, M. Festing, J. B. Greig, 1984, Laboratory animals.

Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.

V. Vasiliou, D. Nebert, T. Dalton, 2009, Free radical biology & medicine.

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.

D. Nebert, Wei Huang, D. Lu, 2006, The Journal of clinical investigation.

Transcription factors and cancer: an overview.

D. Nebert, 2002, Toxicology.

Genetics and functions of the retinoic acid pathway, with special emphasis on the eye

D. Thompson, V. Vasiliou, N. Katsanis, 2019, Human Genomics.

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”

E. Bruford, D. Thompson, V. Vasiliou, 2019, Human Genomics.

“Gene‐Swap Knock‐in” Cassette in Mice to Study Allelic Differences in Human Genes

D. Nebert, M. Carvan, G. Stuart, 2000, Annals of the New York Academy of Sciences.

Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.

W. Benedict, D. Nebert, N. Considine, 1973, Molecular pharmacology.

Statistical power of association using the extreme discordant phenotype design

Ge Zhang, Li Jin, R. Chakraborty, 2006, Pharmacogenetics and genomics.

Update of the human and mouse SERPIN gene superfamily

Mathew W. Wright, Vasilis Vasiliou, Brian C. Jackson, 2013, Human Genomics.

The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.

D. Nebert, M. Adesnik, A. Reiss, 1991, European journal of biochemistry.

Genetic mechanisms controlling the induction of polysubstrate monooxygenase (P-450) activities.

D. Nebert, M. Lang, A. Okey, 1981, Annual review of pharmacology and toxicology.

Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.

D. Nebert, Nadine Dragin, T. Dalton, 2007, American journal of physiology. Cell physiology.

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci.

M. J. Coon, M. Waterman, R. Estabrook, 1989, DNA.

Update on the aldehyde dehydrogenase gene (ALDH) superfamily

Brian C. Jackson, C. Brocker, D. Thompson, 2011, Human Genomics.

Oral benzo[a]pyrene‐induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype

C. Rubio, D. Nebert, Zhanquan Shi, 2010, International journal of cancer.

Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.

D. Nebert, Jian-yin Lin, Jiajun Shi, 2005, Metabolism: clinical and experimental.

The P450 gene superfamily: recommended nomenclature.

D W Nebert, M. J. Coon, R. Estabrook, 1987, DNA.

Perceptions of genetic research in three rural Appalachian Ohio communities

A. N. Fullenkamp, P. Succop, D. Nebert, 2012, Journal of Community Genetics.

Erratum to: Perceptions of genetic research in three rural Appalachian Ohio communities

A. N. Fullenkamp, P. Succop, D. Nebert, 2012, Journal of Community Genetics.

Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics.

D W Nebert, D. Nebert, D. W. Nebert, 2000, European journal of pharmacology.

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family Published, JLR Papers in Press, August 1, 2004. DOI 10.1194/jlr.E400002-JLR200

Lois J. Maltais, Alessandra Renieri, David A. Bernlohr, 2004, Journal of Lipid Research.

Xenobiotic-metabolizing Cytochromes P450 Convert Prostaglandin Endoperoxide to Hydroxyheptadecatrienoic Acid and the Mutagen, Malondialdehyde*

L. Marnett, D. Nebert, F. Guengerich, 2000, The Journal of Biological Chemistry.

Genetic control of carcinogen metabolism leading to individual differences in cancer risk

D. Nebert, 1978 .

A Case in Which a Second Gastrointestinal Lesion Was Masked by a Gastrostomy

D. Nebert, S. J. Goldberg, P. Gaal, 1966 .

Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity.

M. Weedon, D. Nebert, Lei He, 2002, Toxicology and applied pharmacology.

Growth signal pathways

D. Nebert, 1990, Nature.

Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse.

F. Oesch, J. Daly, W. Benedict, 1972, Molecular pharmacology.

Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids.

W. Benedict, D. Nebert, E. Thompson, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Hypoproteinemia and cystic fibrosis.

D. Nebert, D. D. Curtis, 1966, California medicine.

Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.

D. Nebert, T. Dalton, E. Johansson, 2007, Biochemical pharmacology.

Ecogenetics: From Ecology To Health

D. Nebert, M. Carvan, 1997, Toxicology and industrial health.

Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice.

C. Vorhees, D. Nebert, C. Curran, 2012, Neurotoxicology and teratology.

Inter-individual susceptibility to environmental toxicants--a current assessment.

D. Nebert, 2005, Toxicology and applied pharmacology.

Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.

D. Nebert, Lei He, T. Dalton, 2011, Biochemical and biophysical research communications.

Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica.

D. Nebert, R. Feyereisen, D. Farnsworth, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

D. Nebert, F. Carrier, A. Puga, 1992, Molecular and cellular biology.

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

D W Nebert, D. Nebert, O. Mcbride, 1988, The Journal of biological chemistry.

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

David H Phillips, Marie Stiborová, Eva Frei, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues.

M. Ingelman-Sundberg, D. Nebert, A. Daly, 1999, Drug metabolism reviews.

The Evolution of Drug Metabolism

D. Nebert, Daniel W. Nebert, M. Z. Dieter, 2000, Pharmacology.

The importance of genetics in the metabolism and fate of mutagens and promutagens

D. Nebert, 1982 .

Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.

M. Makishima, D. Nebert, K. Sakurai, 2014, Toxicology.

Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.

V. Vasiliou, D. Nebert, D. Orlicky, 2010, Journal of hepatology.

Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines.

V. Vasiliou, D. Nebert, H. Zhu, 1994, Carcinogenesis.

Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues

D. Nebert, F. Gonzalez, S. Kimura, 1986, Molecular and cellular biology.

Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene.

D. Nebert, J. Jones, Daniel W. Nebert, 1989, The International journal of biochemistry.

How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress.

D. Nebert, J. Duffy, D. Nebert, 1997, Biochemical pharmacology.

Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice.

V. Vasiliou, D. Nebert, S. Reuter, 1997, Biochemical and biophysical research communications.

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

D. Nebert, G. Bondy, A. Okey, 1979, The Journal of biological chemistry.

Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

D. Nebert, T. Guenthner, 1977, The Journal of biological chemistry.

4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice.

Mario Medvedovic, Glenn Talaska, M. Medvedovic, 2003, Journal of the National Cancer Institute.

Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

D. Nebert, Zhanquan Shi, T. Dalton, 2009, Molecular Pharmacology.

Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology*

D. Nebert, C. Karp, 2008, Journal of Biological Chemistry.

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.

D W Nebert, H. Li, S. Potter, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.

D. Nebert, F. Gonzalez, A. Jaiswal, 1985, Nucleic acids research.

Ecogenetics: genetic susceptibility to environmental adversity

D. Nebert, 2002 .

Ecogenetics: The Study of Gene–Environment Interactions

D. Nebert, A. Roe, 2001 .

Dioxin exposure is an environmental risk factor for ischemic heart disease

Bin Wang, Alvaro Puga, D. Nebert, 2007, Cardiovascular Toxicology.

Genetic aspects of toxicity during development.

S. Thorgeirsson, D. Nebert, G. Lambert, 1976, Environmental health perspectives.

Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily

Mathew W. Wright, Brian C. Jackson, D. Thompson, 2011, Human Genomics.

Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

Li Jin, Alexander A. Vinks, Magnus Ingelman-Sundberg, 2006, Pharmacogenetics and genomics.

Cyclophilin nomenclature problems, or, 'a visit from the sequence police'

V. Vasiliou, D. Nelson, D. Nebert, 2004, Human Genomics.

Aryl hydrocarbon hydroxylase induction by benzo[a]anthracene: regulatory gene localized to the distal portion of mouse chromosome 17.

C. Kozak, D. Nebert, J. Womack, 1984, Genetics.

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family

C. Brocker, V. Vasiliou, D. Nebert, 2010, Human Genomics.

Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors.

B. Edwards, R. E. Kouri, D. Nebert, 1984, Cancer research.

Effects of environmental chemicals on the genetic regulation of microsomal enzyme systems

D. Nebert, R. Levitt, J. Felton, 1977, Clinical pharmacology and therapeutics.

Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles.

M. Ingelman-Sundberg, D. Nebert, S. Garte, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.

D W Nebert, D. Nebert, A. Puga, 1996, DNA and cell biology.

Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability.

D. Nebert, S. Atlas, 1978, Seminars in oncology.

Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse.

D. Nebert, J. Gielen, F. Goujon, 1972, Nature: New biology.

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

D. Nebert, O. Mcbride, A. Bale, 1991, American journal of human genetics.

Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity

D. Nebert, 2004, Molecular and Cellular Biochemistry.

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements.

D. Nebert, E. Vesell, Lucia F. Jorge-Nebert, 2003, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

The Ah locus. A gene with possible importance in cancer predictability.

D. Nebert, 1980, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals.

D. Nebert, H. Kon, 1973, The Journal of biological chemistry.

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. 3. Effects of various sera, hormones, biogenic amines, and other endogenous compounds on the enzyme activity.

D. Nebert, J. Gielen, 1972, The Journal of biological chemistry.

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review

Eula Bingham, D. Nebert, G. Oakley, 2002, Genetics in Medicine.

Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically "nonresponsive" to other aromatic hydrocarbons.

D. Nebert, J. Robinson, E. Glover, 1974, The Journal of biological chemistry.

Improved drug therapy: triangulating phenomics with genomics and metabolomics

C. Brocker, V. Vasiliou, D. Nebert, 2014, Human Genomics.

Pharmacogenetics: an approach to understanding chemical and biologic aspects of cancer.

D. Nebert, 1980, Journal of the National Cancer Institute.

Update on human genome completion and annotations: Gene nomenclature

H. Wain, D. Nebert, Daniel W Nebert, 2003, Human Genomics.

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

D W Nebert, D. Nebert, T. Dalton, 2000, Biochemical and biophysical research communications.

Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.

D. Nebert, M. Negishi, M. Genter, 1998, The Journal of pharmacology and experimental therapeutics.

Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.

Mary Beth Genter, Alvaro Puga, D. Nebert, 2006, Biochemical and biophysical research communications.

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

D. Nebert, T. Dalton, Marian L Miller, 2004, Molecular pharmacology.

Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.

D. Warshawsky, D. Nebert, G. Talaska, 2001, Biochemical and biophysical research communications.

Covalent binding of diethylstilbestrol to dna catalyzed by hepatic and uterine microsomes. Abstr.

D. Nebert, A. Okey, 1979 .

What do animal experiments tell us that in vitro systems cannot? The Human Toxome Project.

M. Ingelman-Sundberg, D. Nebert, 2016, Regulatory toxicology and pharmacology : RTP.

Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature

A. Bairoch, V. Vasiliou, K. Tipton, 2009, Pharmacogenetics and genomics.

Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation.

D. Nebert, B. Copple, Hua Wang, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.

D. Nebert, Gangduo Wang, L. Roberts, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Single-nucleotide polymorphisms in the lipoprotein lipase gene associated with coronary heart disease in Chinese.

D. Nebert, Yi Hou, T. Li, 2002, European journal of pharmacology.

A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity DOI 10.1194/jlr.M200046-JLR200

D. Nebert, Yi Hou, Z. Su, 2002, Journal of Lipid Research.

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. II. Effects of actinomycin D and cycloheximide on induction processes by phenobarbital or polycyclic hydrocarbons.

D. Nebert, J. Gielen, 1971, The Journal of biological chemistry.

Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse.

D. Nebert, J. Gielen, 1972, Federation proceedings.

Genetic Differences in Enzymes which Metabolize Drugs, Chemical Carcinogens, and Other Environmental Pollutants

D. Nebert, M. Negishi, H. Eisen, 1983 .

Aryl Hydrocarbon Hydroxylase. Evidence of Receptors for Induction Process in Cell Culture

D. Nebert, I. Owens, T. Guenthner, 1979 .

Inducible monooxygenase activities and 3-methyl-cholanthrene-initiated tumorigenesis in mouse recombinant inbred sublines.

B. Taylor, D. Nebert, B. Diwan, 1976, Genetics.

Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles.

M. Ingelman-Sundberg, D. Nebert, A. Daly, 2000, Pharmacogenetics.

Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line.

A. Tulpule, D. Nebert, K. Cowan, 1988, The Journal of biological chemistry.

Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.

M. Makishima, D. Nebert, S. Uno, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.

D. Nebert, G. Oakley, M. Chames, 2004, Free radical biology & medicine.

Possible effect of neonatal polybrominated biphenyl exposure on the developmental abilities of children.

J. Elashoff, D. Nebert, K. R. Wilcox, 1983, American journal of public health.

Ligands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthrene.

V. Vasiliou, D. Nebert, M. Marselos, 1995, Biochemical pharmacology.

Further studies on genetically mediated differences in monooxygenase activities and spin state of cytochrome P450 iron from rabbit, rat, and mouse liver.

D. Nebert, J. Robinson, H. Kon, 1973, The Journal of biological chemistry.

Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice.

R. Tukey, D. Nebert, M. Negishi, 1982, Molecular pharmacology.

Transgenic Zebrafish as Sentinels for Aquatic Pollution

D. Nebert, M. Carvan, G. Stuart, 2000, Annals of the New York Academy of Sciences.

Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene.

R. Tukey, D. Nebert, F. Gonzalez, 1984, Molecular pharmacology.

Characterization of the MTF-1 transcription factor from zebrafish and trout cells.

D. Nebert, M. Carvan, T. Dalton, 2000, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Given the complexity of the human genome, can 'personalised medicine' or 'individualised drug therapy' ever be achieved?

D. Nebert, 2009, Human Genomics.

Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.

D. Nebert, S. Atlas, J. Zweier, 1980, Developmental pharmacology and therapeutics.

Identification of genetic differences in debrisoquine hydroxylase activity

D. Nebert, C. Wolf, N. Spurr, 1992, Hepatology.

Update of the human and mouse Fanconi anemia genes

E. Bruford, D. Thompson, V. Vasiliou, 2015, Human Genomics.

Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology.

Y. T. Chen, R. Tukey, D. Nebert, 1983, Progress in clinical and biological research.

Improved drug therapy: triangulating phenomics with genomics and metabolomics

C. Brocker, D. Thompson, V. Vasiliou, 2014, Human Genomics.

Genetic differences in alcohol drinking preference between inbred strains of mice.

V. Vasiliou, D. Nebert, H. Zhu, 1997, Pharmacogenetics (London).

Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility.

D. Nebert, A. Puga, G. Grabowski, 1997, Pharmacogenetics (London).

Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins.

D. Nebert, F. Gonzalez, P. Fernández-Salguero, 1996, Archives of biochemistry and biophysics.

Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.

D. Nebert, T. Dalton, H. Shertzer, 2004, Free radical biology & medicine.

Structural gene products of the Ah complex. Increases in large mRNA from mouse liver associated with cytochrome P1-450 induction by 3-methylcholanthrene.

D. Nebert, M. Negishi, 1981, The Journal of biological chemistry.

Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis

D. Nebert, T. Dalton, K. Holland, 2023, Antioxidants.

Evolution of the P450 gene superfamily and regulation of the murine Cyp1a1 gene.

D. Nebert, A. Puga, 1990, Biochemical Society transactions.

P450 genes and evolutionary genetics.

D. Nebert, F. Gonzalez, 1987, Hospital practice.

Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes

D. Nebert, 2002, Human mutation.

Human P3(450): cDNA and complete amino acid sequence.

D. Nebert, F. Gonzalez, A. Jaiswal, 1986, Nucleic acids research.

CYTOCHROME P450 KNOCKOUT MICE: NEW TOXICOLOGICAL MODELS

D. Nebert, Ross A. McKinnon, 1998, Clinical and experimental pharmacology & physiology.

Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro.

D. Nebert, O. Pelkonen, A. Okey, 1979, Journal of the National Cancer Institute.

Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice.

D. Nebert, J. Gielen, M. Lang, 1981, The Journal of biological chemistry.

Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b.

D. Nebert, I. Stupans, D. Kessler, 1984, DNA.

SYMPOSIUM OVERVIEW Drug Metabolic Enzymes in Developmental Toxicology1

D. Nebert, M. S. Miller, F. Guengerich, 1996 .

Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole.

Y. T. Chen, R. Tukey, D. Nebert, 1983, European journal of biochemistry.

Selective mouse breeding for short ethanol sleep time has led to high levels of hepatic aromatic hydrocarbon (Ah) receptor.

A. C. Collins, A. Collins, D. Nebert, 1989, Biochemical pharmacology.

Dibenz[a,h]anthracene-induced subcutaneous tumors in mice. Strain sensitivity and the role of carcinogen metabolism.

R. E. Kouri, D. Nebert, R. Lubet, 1983, Carcinogenesis.

Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping.

V. Vasiliou, C. Kozak, D. Nebert, 1996, DNA and cell biology.

Mouse class 3 aldehyde dehydrogenases.

V. Vasiliou, C. Kozak, D. Nebert, 1995, Advances in experimental medicine and biology.

Mouse class 3 aldehyde dehydrogenases: positive and negative regulation of gene expression.

V. Vasiliou, D. Nebert, A. Puga, 1993, Advances in experimental medicine and biology.

Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver.

D. Nebert, M. Lang, P. Kaipainen, 1984, European journal of biochemistry.

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation

D. Nebert, C. Kasper, F. Gonzalez, 1986, Molecular and cellular biology.

Genetic control of drug metabolism: relationship to birth defects.

D. Nebert, S. W. Bigelow, 1982, Seminars in perinatology.

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

T. Pineau, S. Rudikoff, D. Hilbert, 1995, Science.

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

M. J. Coon, O. Gotoh, D. Waxman, 1993, DNA and cell biology.

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I

V. Arlt, D. Phillips, D. Nebert, 2013 .

Pharmacogenomics, ethnicity, and susceptibility genes

D. Nebert, A. Menon, 2001, The Pharmacogenomics Journal.

Molecular and Cellular Pathobiology the Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis

G. Boivin, D. Nebert, E. Knudsen, 2022 .

Feedback Control of AHR Signaling Regulates Intestinal Immunity

Y. Li, B. Stockinger, A. Metidji, 2017, Nature.

Olfactory Receptor Gene Polymorphisms and Nonallergic Vasomotor Rhinitis

Ge Zhang, Li Jin, J. Bernstein, 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

ASSOCIATION BETWEEN SUSCEPTIBILITY TO AND THE Ah LOCUS DIBENZANTHRACENE-INDUCED FIBROSARCOMA FORMATION

R. E. Kouri, D. Nebert, G. Connolly, 2006 .

Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo(−/−) knockout mice

C. Vorhees, D. Nebert, C. Curran, 2012, Genes, brain, and behavior.

Pharmacogenetics and human cancer.

D. Nebert, 1982, IARC scientific publications.

Genes for cytochrome P-450 and their regulation.

D. Nebert, M. Atchison, M. Adesnik, 1986, CRC critical reviews in biochemistry.

Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population.

A. Brøgger, D. Ryberg, V. Skaug, 1991, Pharmacogenetics.

Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype

Ge Zhang, D. Nebert, K. Wilson, 2016, Human Genomics.

ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.

D. Nebert, D. Killilea, D. Knoell, 2013, Cell reports.

Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse

D. Nebert, F. Gonzalez, C. Karp, 2008, Molecular Pharmacology.

STRUCTURAL GENE PRODUCTS OF THE MURINE Ah LOCUS. IMMUNOCHEMICAL CHARACTERIZATION OF TWO FORMS OF P-450 INDUCED BY POLYCYCLIC AROMATIC COMPOUNDS

D. Nebert, M. Negishi, 1980 .

Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women.

D. Nebert, H. Gelboin, J. Winker, 1969, Cancer research.

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics

Xiping Wang, V. Vasiliou, A. Wood, 2012, Planta.

Structural gene products of the murine Ah complex. Differences in ontogenesis and glucosamine incorporation between liver microsomal cytochromes P1-450 and P-448 induced by polycyclic aromatic compounds.

D. Nebert, M. Negishi, N. M. Jensen, 2005, European journal of biochemistry.

Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4

R. Stallings, D. Nebert, F. Gonzalez, 1985, Somatic cell and molecular genetics.

Applying new biotechnologies to the study of occupational cancer--a workshop summary.

Paolo Vineis, Paul Schulte, Stefano Bonassi, 2004, Environmental health perspectives.

Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal

D. Nebert, 1973, Clinical pharmacology and therapeutics.

Perceptions of genetic research in three rural Appalachian Ohio communities

A. N. Fullenkamp, P. Succop, D. Nebert, 2012, Journal of Community Genetics.

Pharmacogenetics and Pharmacogenomics

D. Nebert, 2006 .

Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids.

W. Benedict, D. Nebert, B. Paul, 1972, Biochemical and biophysical research communications.

Environmental factors influencing the hyperfine structure of manganous low-temperature electron paramagnetic resonance spectra.

D. Nebert, B. T. Allen, 1966, Biophysical journal.

Relationship between "aromatic hydrocarbon responsiveness" and the survival times in mice treated with various drugs and environmental compounds.

S. Thorgeirsson, D. Nebert, R. Levitt, 1975, Molecular pharmacology.

Fate of inducer during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. I. Intracellular entry, binding, distribution, and metabolism.

D. Nebert, Bausserman Ll, 1970, Molecular pharmacology.

Subcellular events occurring during aryl hydrocarbon hydroxylase induction: no requirement for metabolism of polycyclic hydrocarbon inducer.

D. Jerina, D. Nebert, J. Gielen, 1977, Molecular pharmacology.

Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice.

S. Thorgeirsson, D. Nebert, J. Felton, 1975, Molecular pharmacology.

Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450.

T. Sugimura, D. Nebert, M. Nagao, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Genetic control of drug metabolism.

D. Nebert, 1978, Advances in experimental medicine and biology.