P. Espenshade

发表

Hierarchical modularity and the evolution of genetic interactomes across species.

Sean R. Collins, T. Ideker, P. Cunningham, 2012, Molecular cell.

Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans

P. Espenshade, K. Kwon-Chung, Yun C Chang, 2007, Molecular microbiology.

Transport-Dependent Proteolysis of SREBP Relocation of Site-1 Protease from Golgi to ER Obviates the Need for SREBP Transport to Golgi

P. Espenshade, J. Goldstein, Michael S. Brown, 1999, Cell.

Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in Xanthophyllomyces dendrorhous

P. Espenshade, V. Cifuentes, M. Baeza, 2019, Front. Microbiol..

( SCAP ) of SREBP Cleavage-activating Protein Golgi-to-Endoplasmic Reticulum Recycling ( SREBP ) Cleavage Regulates Sterol Regulatory Element-binding Protein Lipids :

W. Shao, P. Espenshade, 2014 .

Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)*

W. Shao, P. Espenshade, 2014, The Journal of Biological Chemistry.

Regulation of HMG-CoA reductase in mammals and yeast.

P. Espenshade, J. S. Burg, J. Burg, 2011, Progress in lipid research.

Regulation of lipid metabolism: a tale of two yeasts.

Barry P. Young, P. Espenshade, S. Raychaudhuri, 2012, Current opinion in cell biology.

Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes

P. Espenshade, J. Goldstein, Michael S. Brown, 2000, Cell.

Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER

R. Aebersold, P. Espenshade, J. Goldstein, 2002, Cell.

max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors.

M. Cole, P. Espenshade, S. Berberich, 1992, Oncogene.

Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity*

P. Espenshade, S. Raychaudhuri, 2015, The Journal of Biological Chemistry.

Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2.

P. Espenshade, Jiwon Hwang, 2016, The Biochemical journal.

Lipid balance must be just right to prevent development of severe liver damage

T. Osborne, P. Espenshade, 2022, The Journal of clinical investigation.

Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans

P. Espenshade, K. Kwon-Chung, Yun C Chang, 2009, Eukaryotic Cell.

Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum.

W. Shao, T. Osborne, P. Espenshade, 2020, Cell chemical biology.

Cholesterol Synthesis and Regulation

P. Espenshade, 2013 .

SREPBs: Gene Regulation through Controlled Protein Trafficking

P. Espenshade, J. Goldstein, Michael S. Brown, 2003 .

Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

P. Espenshade, Wei-ping Li, D. Yabe, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Glucose Controls Phosphoregulation of Hydroxymethylglutaryl Coenzyme A Reductase through the Protein Phosphatase 2A-related Phosphatase Protein, Ppe1, and Insig in Fission Yeast*

P. Espenshade, J. Burg, 2011, The Journal of Biological Chemistry.

COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p.

C. Kaiser, P. Espenshade, R. Gimeno, 1996, Molecular biology of the cell.

Degradation of Sterol Regulatory Element-binding Protein Precursor Requires the Endoplasmic Reticulum-associated Degradation Components Ubc7 and Hrd1 in Fission Yeast*

P. Espenshade, B. T. Hughes, Christine C Nwosu, 2009, The Journal of Biological Chemistry.

4-Methyl Sterols Regulate Fission Yeast SREBP-Scap under Low Oxygen and Cell Stress*

P. Espenshade, Clara M. Bien, Adam L. Hughes, 2007, Journal of Biological Chemistry.

A Scientist's Oath.

P. Espenshade, R. Ziegelstein, Kelsey Bettridge, 2018, Molecular cell.

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP

S. Urban, P. Espenshade, A. Frost, 2016, The EMBO journal.

Oxygen‐regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member

P. Espenshade, B. T. Hughes, 2008, The EMBO journal.

Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.

P. Espenshade, C. Lee, B. T. Hughes, 2011, Molecular cell.

Sugar Makes Fat by Talking to SCAP.

W. Shao, P. Espenshade, 2015, Cancer cell.

Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p

C. Kaiser, P. Espenshade, R. Gimeno, 1995, The Journal of cell biology.

SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation

C. Kaiser, P. Espenshade, R. Gimeno, 1995, The Journal of cell biology.

Identification of substrates for the conserved prolyl hydroxylase Ofd1 using quantitative proteomics in fission yeast

P. Espenshade, B. T. Hughes, H. Gu, 2018, bioRxiv.

Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors*

Risa Burr, P. Espenshade, Emerson V. Stewart, 2017, The Journal of Biological Chemistry.

Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis

P. Espenshade, Clara M. Bien, 2010, Eukaryotic Cell.

Cryptococcus neoformans Site‐2 protease is required for virulence and survival in the presence of azole drugs

P. Espenshade, K. Kwon-Chung, Yun C Chang, 2009, Molecular microbiology.

Regulation of sterol synthesis in eukaryotes.

Peter J Espenshade, P. Espenshade, Adam L. Hughes, 2007, Annual review of genetics.

SREBP Controls Oxygen-Dependent Mobilization of Retrotransposons in Fission Yeast

P. Espenshade, A. Sehgal, C. Lee, 2007, PLoS genetics.

SREBP Pathway Responds to Sterols and Functions as an Oxygen Sensor in Fission Yeast

Peter J. Espenshade, P. Espenshade, Adam L. Hughes, 2005, Cell.

LST1 Is a SEC24 Homologue Used for Selective Export of the Plasma Membrane ATPase from the Endoplasmic Reticulum

C. Kaiser, P. Espenshade, R. Gimeno, 1999, The Journal of cell biology.

Lipids | Cholesterol Synthesis and Regulation

W. Shao, P. Espenshade, 2021, Encyclopedia of Biological Chemistry III.

Serum lipoprotein–derived fatty acids regulate hypoxia-inducible factor

W. Shao, P. Espenshade, S. Farber, 2020, The Journal of Biological Chemistry.

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.

P. Espenshade, M. Brown, J. Goldstein, 1998, Molecular cell.

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

M. Bard, A. Link, P. Espenshade, 2007, Cell metabolism.

Dap 1 / PGRMC 1 Binds and Regulates Cytochrome P 450 Enzymes

M. Bard, A. Link, P. Espenshade, 2022 .

Expanding roles for SREBP in metabolism.

W. Shao, P. Espenshade, 2012, Cell metabolism.

COPII Subunit Interactions in the Assembly of the Vesicle Coat*

D. Shaywitz, C. Kaiser, P. Espenshade, 1997, The Journal of Biological Chemistry.

Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition

W. Shao, X. Gong, H. Qian, 2015, Cell Research.

Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast*

Christer S. Ejsing, Risa Burr, W. Shao, 2016, The Journal of Biological Chemistry.

Syddansk Universitet Mga 2 transcription factor regulates an oxygen-responsive lipid homeostasis pathway in fission yeast

Christer S. Ejsing, Risa Burr, W. Shao, 2016 .

PGRMC1: An enigmatic heme-binding protein.

P. Espenshade, Meredith R. McGuire, 2022, Pharmacology & therapeutics.

Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization

W. Shao, Jun-Jie Liu, X. Gong, 2016, Cell Research.

Yeast Sterol Regulatory Element-binding Protein (SREBP) Cleavage Requires Cdc48 and Dsc5, a Ubiquitin Regulatory X Domain-containing Subunit of the Golgi Dsc E3 Ligase*

C. Nusbaum, C. Russ, R. Daza, 2011, The Journal of Biological Chemistry.

Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.

A. Link, P. Espenshade, Adam L. Hughes, 2008, Cell metabolism.

Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins*

P. Espenshade, J. Goldstein, Michael S. Brown, 1999, The Journal of Biological Chemistry.

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

P. Espenshade, Rita T. Brookheart, E. Selen, 2021, The Journal of biological chemistry.

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

T. Osborne, P. Espenshade, Timothy F Osborne, 2009, Genes & development.

SREBPs: sterol-regulated transcription factors.

P. Espenshade, 2006, Journal of cell science.

Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

N. Krogan, A. Roguev, J. Hayles, 2011, Molecular cell.

Targeting stearoyl-CoA desaturase in solid tumors.

Casie Kubota, P. Espenshade, 2022, Cancer research.

Identification of Candidate Substrates for the Golgi Tul1 E3 Ligase Using Quantitative diGly Proteomics in Yeast*

A. Pandey, Min-Sik Kim, Zongtian Tong, 2014, Molecular & Cellular Proteomics.

Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven hepatic lipogenesis

R. Zechner, P. Espenshade, R. Breinbauer, 2020, bioRxiv.

The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.

L. Amzel, P. Espenshade, M. Bianchet, 2011, Structure.

Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation

W. Shao, P. Espenshade, Sara J Clasen, 2017, eLife.

Cobalt chloride, a hypoxia‐mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans

P. Espenshade, K. Kwon-Chung, Clara M. Bien, 2007, Molecular microbiology.

Casein Kinase 1 Regulates Sterol Regulatory Element-binding Protein (SREBP) to Control Sterol Homeostasis*

P. Espenshade, Rita T. Brookheart, C. Lee, 2013, The Journal of Biological Chemistry.

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins*

C. Slaughter, P. Espenshade, J. Goldstein, 1999, The Journal of Biological Chemistry.

Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast

Risa Burr, P. Espenshade, J. Ho, 2017, The Journal of Biological Chemistry.

Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.

Risa Burr, P. Espenshade, 2017, Seminars in cell & developmental biology.

Sterol Regulatory Element Binding Protein Is a Principal Regulator of Anaerobic Gene Expression in Fission Yeast

John S. Burg, Peter J. Espenshade, P. Espenshade, 2006, Molecular and Cellular Biology.

Structural Requirements for Sterol Regulatory Element-binding Protein (SREBP) Cleavage in Fission Yeast*

P. Espenshade, Rocky Cheung, 2013, The Journal of Biological Chemistry.

Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function

P. Espenshade, Adam L. Hughes, Shanke Zhao, 2022, microPublication biology.

Subunit Architecture of the Golgi Dsc E3 Ligase Required for Sterol Regulatory Element-binding Protein (SREBP) Cleavage in Fission Yeast*

P. Espenshade, S. Raychaudhuri, S. Lloyd, 2013, The Journal of Biological Chemistry.

Ergosterol Regulates Sterol Regulatory Element Binding Protein (SREBP) Cleavage in Fission Yeast*

P. Iglesias, P. Espenshade, Joshua R. Porter, 2010, The Journal of Biological Chemistry.

The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking

P. Espenshade, J. Goldstein, Michael S. Brown, 2010 .

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

P. Espenshade, C. Machamer, Wei Shao (邵威), 2016, Journal of Lipid Research.

SREBPs: sterol-regulated transcription factors

P. Espenshade, 2006, Journal of Cell Science.

Overcoming data limitations to identify a static nonlinearity in a biological signaling cascade

Pablo A. Iglesias, Joshua R. Porter, John S. Burg, 2011, 2011 45th Annual Conference on Information Sciences and Systems.

Expression in Fission Yeast Is a Principal Regulator of Anaerobic Gene Sterol Regulatory Element Binding Protein

P. Espenshade, Bridget L. Todd, Emerson V. Stewart, 2014 .

Adam Expression in Fission Yeast Is a Principal Regulator of Anaerobic Gene Sterol Regulatory Element Binding Protein

P. Espenshade, Adam L. Hughes, Bridget L. Todd, 2006 .

Cleavage in Fission Yeast Element-binding Protein ( SREBP ) Ligase Required for Sterol Regulatory Subunit Architecture of the Golgi Dsc E 3 Protein Synthesis and Degradation :

P. Espenshade, S. Raychaudhuri, S. Lloyd, 2013 .

Identifying a static nonlinear structure in a biological system using noisy, sparse data.

Pablo A Iglesias, Joshua R Porter, John S Burg, 2012, Journal of theoretical biology.

Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast

P. Espenshade, A. Sehgal, B. T. Hughes, 2008, Nucleic acids research.

Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation

P. Iglesias, P. Espenshade, Joshua R. Porter, 2012, Molecular biology of the cell.

Oxygen‐regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member

P. Espenshade, B. T. Hughes, 2008, The EMBO journal.

Structural Requirements for Sterol Regulatory Element-binding Protein (SREBP) Cleavage in Fission Yeast*

P. Espenshade, Rocky Cheung, 2013, The Journal of Biological Chemistry.

Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.

P. Espenshade, C. Lee, B. T. Hughes, 2011, Molecular cell.

Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

N. Krogan, J. Hayles, K. Hoe, 2011, Molecular cell.

Cryptococcus neoformans Site‐2 protease is required for virulence and survival in the presence of azole drugs

P. Espenshade, K. Kwon-Chung, Clara M. Bien, 2009, Molecular microbiology.

Degradation of Sterol Regulatory Element-binding Protein Precursor Requires the Endoplasmic Reticulum-associated Degradation Components Ubc7 and Hrd1 in Fission Yeast*

P. Espenshade, B. T. Hughes, Christine C. Nwosu, 2009, The Journal of Biological Chemistry.

Oxygen‐dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast

P. Espenshade, C. Lee, Emerson V. Stewart, 2009, The EMBO journal.

Carbon dioxide regulates cholesterol levels through SREBP2

P. Espenshade, N. Bolshette, Marina Golik, 2023, PLoS biology.

Sample Variance in Cosmological Observations with a Narrow Field of View

P. Espenshade, Jaiyul Yoo, 2023, The Astrophysical Journal.