Kui Lin

发表

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

C. Kenyon, Kui Lin, H. Hsin, 2001, Nature Genetics.

Heterobifunctional molecules induce dephosphorylation of kinases - a proof of concept study.

Kui Lin, W. Fairbrother, Jie Lin, 2019, Journal of medicinal chemistry.

Novel Quantitative Autophagy Analysis by Organelle Flow Cytometry after Cell Sonication

Kui Lin, M. Reichelt, M. Degtyarev, 2014, PloS one.

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

Scott E. Martin, F. Gnad, Zhaoshi Jiang, 2022, Nature Communications.

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors.

J. Baselga, J. Tabernero, Kui Lin, 2017, Cancer discovery.

Autophagy, an Achilles’ heel AKTing against cancer?

Kui Lin, J. Klumperman, A. De Mazière, 2009, Autophagy.

Cancer Therapy: Preclinical TargetingActivatedAktwithGDC-0068, aNovel SelectiveAkt Inhibitor That Is Efficacious in Multiple Tumor Models

Tyler T. Risom, M. Belvin, S. Gross, 2013 .

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Jun Liang, J. Blake, B. Brandhuber, 2012, Journal of medicinal chemistry.

Heterobifunctional Molecules Induce Dephosphorylation of Kinases - a Proof of Concept Study

Kui Lin, W. Fairbrother, Jie Lin, 2019 .

Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.

C. Hui, Kui Lin, F. D. de Sauvage, 2002, Cancer research.

NH 2-Terminal Fragment Alters Skin Tumor Phenotype Dissecting the Oncogenic Potential of Gli 2 : Deletion of an Updated Version

C. Hui, Kui Lin, H. Sheng, 2002 .

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

C. Caldas, A. Gonzalez-Perez, N. López-Bigas, 2021, Nature Communications.

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

Tyler T. Risom, M. Belvin, S. Gross, 2013, Clinical Cancer Research.

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

Thomas D. Wu, H. Phillips, H. Koeppen, 2011, PloS one.

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

David P. Davis, K. Hoeflich, L. Friedman, 2008, The Journal of cell biology.

Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers

Somasekar Seshagiri, Thomas D. Wu, Jeremy Stinson, 2012, Proceedings of the National Academy of Sciences.

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

B. Brandhuber, S. Gloor, G. Vigers, 2012, Science Signaling.

Abstract B154: A first-in-human trial of GDC-0068: A novel, oral, ATP-competitive Akt inhibitor, demonstrates robust suppression of the Akt pathway in surrogate and tumor tissues.

J. Tabernero, Kui Lin, Yibing Yan, 2011 .

The Akt DUBbed InAktive

Kui Lin, 2013, Science Signaling.

Abstract PD14-03: Molecular mechanism of ipatasertib (IPAT) and its combination with atezolizumab (atezo) in patients (pts) with locally advanced/metastatic triple-negative breast cancer (aTNBC)

P. Savas, A. Italiano, E. Espinosa, 2021 .

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations.

M. Belvin, L. Friedman, Kui Lin, 2012, Cancer letters.

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

C. Kenyon, Kui Lin, K. Lin, 1997, Science.

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

C. Kenyon, Kui Lin, H. Hsin, 2001, Nature Genetics.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .