A. Edkins

发表

Analysis of the African coelacanth genome sheds light on tetrapod evolution

Sonja J. Prohaska, Bronwen L. Aken, J. Levin, 2013, Nature.

Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

C. Cerf, I. Ansorge, A. Edkins, 2016 .

Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones

A. Edkins, N. Boel, 2018 .

The Hsp90 chaperone system from the African trypanosome, Trypanosoma brucei

A. Edkins, A. Boshoff, Miebaka Jamabo, 2021, bioRxiv.

Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity

Clinton G. L. Veale, A. Edkins, B. Wilhelmi, 2020, Drug and chemical toxicology.

Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition

A. Edkins, M. Isaacs, Jason N Sterrenberg, 2018, JBIC Journal of Biological Inorganic Chemistry.

HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature

G. Blatch, A. Edkins, Stacey A Mattison, 2017, Cell Stress and Chaperones.

Hsp90 Co-chaperones as Drug Targets in Cancer: Current Perspectives

A. Edkins, 2016 .

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines.

G. Blatch, A. Edkins, T. Willmer, 2013, Cancer letters.

Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model.

G. Blatch, A. Edkins, E. Prinsloo, 2011, Biochemical and biophysical research communications.

SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines

A. Edkins, B. Ozanne, M. Acharya, 2009, Leukemia.

Analysis of the CD23-αv integrin interaction: a study with model peptides.

A. Edkins, B. Ozanne, R. Cogdell, 2012, Biochemical and biophysical research communications.

Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23

A. Edkins, B. Ozanne, R. Cogdell, 2012, Immunology.

αvβ5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein*

Janet M. Allen, J. Allen, A. Edkins, 2007, Journal of Biological Chemistry.

Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors.

P. T. Kaye, A. Edkins, M. Isaacs, 2016, Bioorganic & medicinal chemistry letters.

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

A. Edkins, Ö. T. Bishop, Victor Barozi, 2022, bioRxiv.

Hsp90 and Associated Co-Chaperones of the Malaria Parasite

G. Blatch, A. Edkins, Tanima Dutta, 2022, Biomolecules.

A native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90-HOP protein-protein interaction.

Clinton G. L. Veale, F. Albericio, A. Edkins, 2021, Chemical communications.

Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin.

A. Edkins, S. Kituyi, 2018, Biochemical and biophysical research communications.

Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective

G. Blatch, A. Edkins, A. Pockley, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

The Networking of Chaperones by Co-chaperones

G. Blatch, A. Edkins, 2011, Subcellular Biochemistry.

alphavbeta5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein.

J. Allen, A. Edkins, B. Ozanne, 2007, The Journal of biological chemistry.

Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay

Clinton G. L. Veale, A. Edkins, Jude M. Przyborski, 2020, Scientific Reports.

Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency

A. Edkins, Laura M. K. Dingle, Dustin Laming, 2021, Molecules.

Anticancer evaluation of ruthenium(III) complexes with N-donor ligands tethered to coumarin or uracil moieties

A. Edkins, Laura M. K. Dingle, I. Booysen, 2019, Inorganica Chimica Acta.

The in Vitro Antiplasmodial and Antiproliferative Activity of New Ferrocene‐Based α‐Aminocresols Targeting Hemozoin Inhibition and DNA Interaction

Dale Taylor, C. Biot, A. Edkins, 2020, Chembiochem : a European journal of chemical biology.

The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity.

A. Edkins, B. Loos, L. Costa-Lotufo, 2021, Biochemical pharmacology.

NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum

Clinton G. L. Veale, A. Edkins, M. Isaacs, 2018 .

Expanding the SAR of Nontoxic Antiplasmodial Indolyl‐3‐ethanone Ethers and Thioethers

Clinton G. L. Veale, Dale Taylor, A. Edkins, 2018, ChemMedChem.

Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate

Clinton G. L. Veale, Peter J. Smith, A. Edkins, 2015 .

Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives.

Dale Taylor, A. Edkins, Laura M. K. Dingle, 2019, European journal of medicinal chemistry.

Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity.

A. Edkins, M. Isaacs, N. Boel, 2017, Journal of inorganic biochemistry.

Ruthenium complexes with mono- or bis-heterocyclic chelates: DNA/BSA binding, antioxidant and anticancer studies

A. Edkins, Laura M. K. Dingle, I. Booysen, 2020, Journal of biomolecular structure & dynamics.

In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum

A. Edkins, A. Afolayan, S. Odeyemi, 2019, Journal of complementary & integrative medicine.

Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.

Clinton G. L. Veale, A. Edkins, M. Caira, 2013, European journal of medicinal chemistry.

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro

G. Blatch, A. Edkins, D. Beukes, 2012, Investigational New Drugs.

Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis

A. Edkins, M. Caira, G. Dziwornu, 2017, Molecules.

HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation

A. Edkins, N. Boel, Abir Chakraborty, 2020, Cells.

Integrin-ligand interactions and cytokine production by monocytic cells

A. Edkins, 2008 .

Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum

A. Edkins, E. Antunes, J. Bolton, 2019, Phytochemistry Letters.

Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy

A. Edkins, B. Pletschke, S. Malgas, 2021, Marine drugs.

Regulation of Kaposi’s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones

A. Edkins, Z. Jackson, A. Whitehouse, 2020 .

Human DNAJ in cancer and stem cells.

G. Blatch, A. Edkins, Jason N Sterrenberg, 2011, Cancer letters.

In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model

A. Edkins, J. de la Mare, Cindy Slater, 2018, Oncology letters.

Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells

A. Edkins, Kyle L O'Hagan, E. Prinsloo, 2014, PloS one.

Characterisation of a Plasmodium falciparum type II Hsp40 chaperone exported to the cytosol of infected erythrocytes

A. Edkins, 2013 .

Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model

A. Edkins, J. de la Mare, Tamarin Jurgens, 2017, BMC Cancer.

Heat Shock Protein Inhibitors: Success Stories

A. Edkins, S. McAlpine, 2016 .

Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system.

A. Edkins, C. Frost, E. Prinsloo, 2014, Biochemical and biophysical research communications.

STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin

G. Blatch, A. Edkins, M. C. Hunter, 2020, International journal of molecular sciences.

Nonspecific nuclear uptake of anti-MUC1 aptamers by dead cells: the role of cell viability monitoring in aptamer targeting of membrane-bound protein cancer biomarkers.

A. Edkins, R. Fogel, J. Limson, 2021, Analytical methods : advancing methods and applications.

Cancer stem cells in breast cancer and metastasis

G. Blatch, A. Edkins, Jessica C. Lawson, 2009, Breast Cancer Research and Treatment.

CHIP: a co-chaperone for degradation by the proteasome.

A. Edkins, 2015, Sub-cellular biochemistry.

Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins.

G. Blatch, A. Edkins, S. Baindur-Hudson, 2015, Sub-cellular biochemistry.

The African coelacanth genome provides insights into tetrapod evolution

Eric S. Lander, Sonja J. Prohaska, Peter F. Stadler, 2013 .

Breast cancer: current developments in molecular approaches to diagnosis and treatment.

A. Edkins, Jason N Sterrenberg, Adrienne L Edkins, 2014, Recent patents on anti-cancer drug discovery.

HSP90 as a regulator of extracellular matrix dynamics.

A. Edkins, Abir Chakraborty, 2021, Biochemical Society transactions.

Theiler’s murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin

G. Blatch, A. Edkins, G. Luke, 2011, Cell Stress and Chaperones.

A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40.

G. Blatch, A. Edkins, M. Ludewig, 2004, The international journal of biochemistry & cell biology.

Synthetic, characterization and cytotoxic studies of ruthenium complexes with Schiff bases encompassing biologically relevant moieties

A. Edkins, Laura M. K. Dingle, I. Booysen, 2020 .

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3‐L1

A. Edkins, H. Hoppe, E. Prinsloo, 2015, Journal of cellular biochemistry.

General Structural and Functional Features of Molecular Chaperones.

A. Edkins, A. Boshoff, 2021, Advances in experimental medicine and biology.

Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function.

G. Blatch, A. Edkins, Ö. T. Bishop, 2014, Journal of experimental zoology. Part B, Molecular and developmental evolution.

General Structural and Functional Features of Molecular Chaperones

A. Edkins, A. Boshoff, 2014 .

Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response

G. Blatch, A. Edkins, 2012 .

Hsp40 Co-chaperones as Drug Targets: Towards the Development of Specific Inhibitors

G. Blatch, A. Edkins, E. Pesce, 2015 .

Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression.

A. Edkins, P. Mandal, Sayan Chakraborty, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin

A. Edkins, William John Samson, K. Dhanani, 2017, Scientific Reports.

STAT3 interacts directly with Hsp90

G. Blatch, A. Edkins, E. Prinsloo, 2012, IUBMB life.

Tenth International Symposium on the Hsp90 chaperone machine

A. Edkins, M. Zweckstetter, Ritwick Sawarkar, 2023, Cell stress & chaperones.

LRP1 is required for novobiocin-mediated fibronectin turnover

A. Edkins, N. Boel, M. C. Hunter, 2018, Scientific Reports.

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells.

A. Edkins, S. Mapolie, S. Prince, 2015, Cancer letters.

Localisation of Theiler's murine encephalomyelitis virus protein 2C to the Golgi apparatus using antibodies generated against a peptide region.

A. Edkins, C. Knox, A. Boshoff, 2010, Journal of virological methods.

Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells

A. Edkins, B. Pletschke, C. Daub, 2023, Marine drugs.

Semi-Synthesis and Evaluation of Sargahydroquinoic Acid Derivatives as Potential Antimalarial Agents

A. Edkins, T. C. Munedzimwe, D. Beukes, 2019, Medicines.

The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3‐4, 2021

R. Morimoto, A. Edkins, D. Bourboulia, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Biological and Medicinal Chemistry in Africa

Clinton G. L. Veale, A. Edkins, Temitope O. Olomola, 2023, Chembiochem : a European journal of chemical biology.

Reaction of Perrhenate with Phthalocyanine Derivatives in the Presence of Reducing Agents and Rhenium Oxide Nanoparticles in Biomedical Applications

A. Edkins, Z. Tshentu, T. Nyokong, 2022, ChemistryOpen.

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

G. Blatch, A. Edkins, D. Beukes, 2013, Cancer Cell International.

Hop depletion reduces HSF1 levels and activity and coincides with reduced stress resilience.

A. Edkins, Abantika Chakraborty, 2020, Biochemical and biophysical research communications.

Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies

A. Edkins, A. Boshoff, Miebaka Jamabo, 2023, International journal of molecular sciences.

Mutations F352A and Y528A in human HSP90α reduce fibronectin association and fibrillogenesis in cell-derived matrices.

A. Edkins, R. Tonui, Abir Chakraborty, 2023, Cell stress & chaperones.

A Combination Approach in Inhibiting Type 2 Diabetes-Related Enzymes Using Ecklonia radiata Fucoidan and Acarbose

A. Edkins, B. Pletschke, S. Malgas, 2021, Pharmaceutics.