D. Plas

发表

Akt Stimulates Aerobic Glycolysis in Cancer Cells

A. Alavi, C. Rudin, C. Thompson, 2004, Cancer Research.

Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells

J. Guan, D. Plas, Chenran Wang, 2019, Nature Metabolism.

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.

J. Blenis, J. Asara, D. Plas, 2015, Molecular cell.

Predicting mechanism of action of cellular perturbations with pathway activity signatures.

Nicholas A Clark, M. Medvedovic, S. Sivaganesan, 2020, Bioinformatics.

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

D. Plas, A. Chan, Matthew L. Thomas, 1996, Science.

Pharmacologic Targeting of S 6 K 1 in PTEN-Deficient Neoplasia Graphical Abstract Highlights

Hongqi Liu, David R. Plas, Tony T. Jiang, 2022 .

Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

R. Geha, D. Plas, D. Chaplin, 1996, Nature.

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

Aleksey A. Porollo, L. Brill, M. Medvedovic, 2013, Cell.

Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection.

P. Allen, D. Plas, J. White, 1999, Journal of immunology.

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

J. Qi, J. Bradner, Chuan He, 2018, Cell.

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

James E. Bradner, Jie Jin, Guido Marcucci, 2018, Cell.

Tuberin Regulates Prostaglandin Receptor–Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells

D. Kwiatkowski, D. Plas, B. Siroky, 2017, Molecular Cancer Research.

Chromatin structure predicts survival in glioma patients

K. Roskin, D. Plas, M. Lamba, 2022, Scientific reports.

Loss of Immunological Tolerance in Gimap5-Deficient Mice Is Associated with Loss of Foxo in CD4+ T Cells

D. Plas, K. Hoebe, M. Barnes, 2012, The Journal of Immunology.

Loss of Foxo in CD 4 Gimap 5-Deficient Mice Is Associated with Loss of Immunological Tolerance in

D. Plas, K. Hoebe, M. Barnes, 2011 .

Integrative signatures of signaling pathway response increase robustness and accuracy of pathway predictions

Nicholas A. Clark, M. Medvedovic, S. Sivaganesan, 2022, bioRxiv.

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

Shikha Khatri, D. Plas, Jennifer F. Barger, 2011, Proceedings of the National Academy of Sciences.

Recurrent Glioblastoma is Associated with a Closed DNA Conformation

K. Roskin, D. Plas, M. Lamba, 2021 .

HomeostasisA Major Role for Bim in Regulatory T Cell

P. Fink, D. Plas, C. Chougnet, 2010 .

HomeostasisA Major Role for Bim in Regulatory T Cell

P. Fink, D. Plas, C. Chougnet, 2010 .

Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.

D. Plas, M. Thomas, W. Yokoyama, 1999, Journal of immunology.

Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.

D. Plas, A. Chan, M. Thomas, 1999, Journal of immunology.

Activation Syk Tyrosine Kinase Activity and B Cell Tyrosine Phosphatase-1 Results in Increased Src-Homology Domain 2-Containing Protein Expression of Dominant-Negative

D. Plas, Yonghong Hu, A. Chan, 1999 .

SelectionSHP-1 Regulates Thymocyte Positive Cutting Edge: The Tyrosine Phosphatase

P. Allen, D. Plas, G. Kersh, 1999 .

Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis

J. Guan, D. Plas, Chenran Wang, 2021, British Journal of Cancer.

HomeostasisA Major Role for Bim in Regulatory T Cell

P. Fink, D. Plas, C. Chougnet, 2010 .

FOXO 3 a REGULATES GLYCOLYSIS VIA TRANSCRIPTIONAL CONTROL OF TUMOR SUPPRESSOR TSC 1

Shikha Khatri, D. Plas, H. Yepiskoposyan, 2010 .

Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy

D. Plas, K. Hoebe, E. Janssen, 2019, Science Immunology.

Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole

D. Plas, T. Wise-Draper, B. Dasgupta, 2022, Cancer Chemotherapy and Pharmacology.

TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.

D. Plas, Shailaja N Hegde, J. Meller, 2014, Cancer cell.

MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells

M. Medvedovic, D. Plas, J. Meller, 2022, bioRxiv.

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

Russell G. Jones, M. Birnbaum, C. Thompson, 2005, Molecular cell.

ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism

D. Plas, A. Alayev, M. Holz, 2017, Signal Transduction and Targeted Therapy.

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.

D. Plas, R. Chan, Michihiro Kobayashi, 2016, The Journal of clinical investigation.

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.

D. Plas, Jennifer F. Barger, 2010, Endocrine-related cancer.

Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema

D. Plas, A. Sasaki, B. Dasgupta, 2021, Gliomas.

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

P. Hammerman, C. Thompson, D. Plas, 2003, Molecular and Cellular Biology.

The CD28 signaling pathway regulates glucose metabolism.

C. Thompson, C. June, R. Elstrom, 2002, Immunity.

Homeostatic control of lymphocyte survival: potential origins and implications

C. Thompson, D. Plas, J. Rathmell, 2002, Nature Immunology.

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

David R. Plas, Craig B. Thompson, M. V. Vander Heiden, 2001, Molecular and Cellular Biology.

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

D. Plas, J. Rathmell, J. L. Coloff, 2011, Cancer research.

Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome*

C. Thompson, D. Plas, C. Thompson, 2003, The Journal of Biological Chemistry.

Akt-dependent transformation: there is more to growth than just surviving

C. Thompson, D. Plas, C. Thompson, 2005, Oncogene.

Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1α nor Sufficient for HIF-1-dependent Target Gene Transcription*

C. Thompson, D. Plas, M. Simon, 2002, The Journal of Biological Chemistry.

Akt and Bcl-xL Are Independent Regulators of the Mitochondrial Cell Death Pathways

C. Thompson, D. Plas, J. Rathmell, 2003 .

Predicting mechanism of action of cellular perturbations with pathway activity signatures

Mario Medvedovic, Siva Sivaganesan, Yan Ren, 2019, bioRxiv.

S6K1 determines the metabolic requirements for BCR-ABL survival

D. Plas, H. Grimes, Hongqi Liu, 2012, Oncogene.

Akt and Hypoxia-Inducible Factor-1 Independently Enhance Tumor Growth and Angiogenesis

C. Thompson, D. Plas, M. Simon, 2004, Cancer Research.

VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.

Jarek Meller, Jacek Biesiada, D. Plas, 2012, Cancer cell.

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology*

C. Thompson, D. Plas, J. Rathmell, 2001, The Journal of Biological Chemistry.

Cell metabolism in the regulation of programmed cell death

C. Thompson, D. Plas, C. Thompson, 2002, Trends in Endocrinology & Metabolism.

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1*

Shikha Khatri, D. Plas, H. Yepiskoposyan, 2010, The Journal of Biological Chemistry.

Identification of a Conserved Anti-Apoptotic Protein That Modulates the Mitochondrial Apoptosis Pathway

Marshall W. Anderson, D. Plas, R. Jänicke, 2011, PloS one.

Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Tony T. Jiang, D. Plas, A. Sasaki, 2017, Cell reports.

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

P. Hammerman, C. Thompson, D. E. Bauer, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.

D. Plas, E. Cahir-McFarland, T. Sommermann, 2011, Cancer research.

Tumor and Stem Cell Biology IKK b and NFk B Transcription Govern Lymphoma Cell Survival throughAKT-InducedPlasmaMembrane Traf fi cking of GLUT 1

D. Plas, E. Cahir-McFarland, T. Sommermann, 2011 .

Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma

D. Plas, J. Meller, M. Czyzyk-Krzeska, 2021, Genes.

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

R. Geha, D. Plas, D. Chaplin, 1996, Nature.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

S. Gygi, J. Blenis, Noah Dephoure, 2017, Molecular cell.

Bcl-xL and Akt cooperate to promote leukemogenesis in vivo

C. Rudin, Robyn Karnauskas, D. Plas, 2003, Oncogene.

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.

Lei Jiang, D. Ann, J. ten Hoeve, 2021, Molecular cell.

Reuse of Molecules for Glioblastoma Therapy

D. P. Pomeranz Krummel, J. Arbiser, Debanjan Bhattacharya, 2021, Pharmaceuticals.

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma

B. Aronow, K. Turner, D. Plas, 2014, International journal of cancer.

Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth

P. L. Bergsagel, M. Karin, D. Plas, 2015, Nature Communications.

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

P. Bouillet, D. Plas, C. Chougnet, 2013, Front. Immunol..

Negative regulation of antigen receptor signaling in lymphocytes

D. Plas, M. Thomas, 1998, Journal of Molecular Medicine.

Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin

D. Plas, W. Seibel, Jennifer F. Barger, 2010, Cancer biology & therapy.

Targeting bioenergetics to enhance cancer chemotherapy: Mitochondria SLP into apoptosis

Shikha Khatri, D. Plas, 2009, Cancer biology & therapy.

Tubers and tumors: rapamycin therapy for benign and malignant tumors.

D. Plas, G. Thomas, 2009, Current opinion in cell biology.

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.

A. Sidana, W. Linehan, L. Schmidt, 2020, The Journal of clinical investigation.

Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells

Aleksey A. Porollo, D. Plas, A. Porollo, 2011, Clinical & Experimental Metastasis.

Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide

N. Talbot, J. Guan, D. Plas, 2021, The Journal of cell biology.

Selective MAP1LC3C (LC3C) autophagy requires noncanonical initiation regulators and the paralog-specific C-terminal peptide

N. Talbot, J. Guan, D. Plas, 2021, bioRxiv.

mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment

K. Komurov, D. Plas, Jack Rubinstein, 2017, Molecular Cancer Therapeutics.

Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells

D. Plas, P. Sarma, 2020, Blood science.

Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells

M. Medvedovic, D. Plas, M. Czyzyk-Krzeska, 2023, The Journal of biological chemistry.

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

K. Roskin, D. Plas, H. Kornblum, 2023, Scientific reports.

Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking

D. Plas, J. Meller, M. Czyzyk-Krzeska, 2021, Molecular & Cellular Oncology.

Not all autophagy is equal

D. Plas, J. Meller, M. Czyzyk-Krzeska, 2012, Autophagy.

mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

K. Shokat, Mark P. Jedrychowski, D. Plas, 2023, Cell reports.

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

D. Plas, J. Rathmell, A. Macintyre, 2011, Cancer research.

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

Shikha Khatri, D. Plas, Jennifer F. Barger, 2011, Proceedings of the National Academy of Sciences.

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.

D. Plas, Jennifer F. Barger, 2010, Endocrine-related cancer.