S. Higuchi

S. Higuchi, T. Muramatsu, K. Okuyama, 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese.

S. Higuchi, T. Muramatsu, S. Matsushita, 1996, Alcoholism, clinical and experimental research.

Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.

T. Tokuda, H. Arai, Toshiharu Suzuki, 2014, Journal of Alzheimer's disease : JAD.

Certain Background Factors Exhibit an Association With an Increased Risk for Pancreatic Calcification Among Japanese Male Alcoholics

S. Higuchi, K. Maruyama, Yuji Nakamura, 2005, Pancreas.

Homozygous (TG)11 allele in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against bicarbonate decrease in pure pancreatic juice among Japanese male alcoholics.

S. Higuchi, H. Imazeki, K. Maruyama, 2004, Internal medicine.

Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease

J. Trojanowski, H. Arai, S. Higuchi, 1995, Journal of neural transmission. Parkinson's disease and dementia section.

Efficacy of acamprosate for the treatment of alcohol dependence long after recovery from withdrawal syndrome: a randomized, double-blind, placebo-controlled study conducted in Japan (Sunrise Study).

S. Higuchi, 2015, The Journal of clinical psychiatry.

Plasma orexin-A is lower in patients with narcolepsy

A. Yoshino, S. Kanba, S. Higuchi, 2002, Neuroscience Letters.

Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men.

S. Higuchi, T. Matsui, A. Yokoyama, 2013, Alcoholism, clinical and experimental research.

Aldehyde dehydrogenase-2 as a therapeutic target

S. Higuchi, A. Yokoyama, M. Kimura, 2019, Expert opinion on therapeutic targets.

No association between DLST gene and Alzheimer’s disease or Wernicke-Korsakoff syndrome

H. Arai, S. Higuchi, K. Urakami, 2001, Neurobiology of Aging.

Dopamine transporter gene polymorphism and alcoholism.

S. Higuchi, T. Muramatsu, 1995, Biochemical and biophysical research communications.

Enzymatic Aspects of Alcoholism-ADH and ALDH

S. Higuchi, A. Yokoyama, S. Matsushita, 2014 .

Aldehyde dehydrogenase genotypes In Japanese alcoholics

S. Higuchi, H. Imazeki, S. Matsushita, 1994, The Lancet.

A novel polymorphism (-357 G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism.

S. Higuchi, S. Harada, M. Tsutsumi, 1999, Alcoholism, clinical and experimental research.

Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai

S. Higuchi, T. Muramatsu, S. Harada, 1995, Human Genetics.

Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence

S. Higuchi, S. Matsushita, N. Nishiguchi, 1999, Molecular Psychiatry.

Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2

S. Higuchi, T. Muramatsu, S. Matsushita, 1996, Human Genetics.

Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study

S. Higuchi, T. Muramatsu, S. Matsushita, 2001, Psychiatry Research.

Alcohol and substance use among Japanese high school students.

S. Higuchi, S. Matsushita, S. Takagi, 1996, Alcoholism, clinical and experimental research.

Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase‐2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men

T. Hibi, T. Omori, S. Higuchi, 2007, Journal of gastroenterology and hepatology.

Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase‐2 genotype

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, International journal of cancer.

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

J. Haines, M. Pericak-Vance, G. Schellenberg, 2013, PloS one.

Risk of Squamous Cell Carcinoma of the Upper Aerodigestive Tract in Cancer-Free Alcoholic Japanese Men: An Endoscopic Follow-up Study

T. Hibi, T. Omori, S. Higuchi, 2006, Cancer Epidemiology Biomarkers & Prevention.

A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands

S. Higuchi, T. Arinami, R. Benno, 2010, Synapse.

Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus.

S. Higuchi, T. Muramatsu, N. Matsuura, 2003, Diabetes research and clinical practice.

Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population.

S. Higuchi, T. Arinami, H. Ishiguro, 2017, Alcohol.

Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population

S. Higuchi, T. Arinami, H. Ishiguro, 2007, Psychiatric genetics.

A method for estimating alcohol-related liver cirrhosis mortality in Japan.

F. Stinson, S. Higuchi, T. Harford, 1991, International journal of epidemiology.

Japan: alcohol today.

S. Higuchi, Y. Osaki, H. Maesato, 2007, Addiction.

Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk.

S. Higuchi, T. Muramatsu, A. Yokoyama, 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Role of GABRA2 in moderating subjective responses to alcohol.

Ting-kai Li, Go Suzuki, S. Higuchi, 2011, Alcoholism, clinical and experimental research.

Drinking practices, alcohol policy and prevention programmes in Japan

S. Higuchi, Y. Osaki, S. Matsushita, 2006 .

Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.

S. Higuchi, P. J. Brooks, T. Matsui, 2016, Alcoholism, clinical and experimental research.

Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men.

S. Higuchi, T. Matsui, A. Yokoyama, 2014, Alcohol and alcoholism.

Apolipoprotein E gene in Parkinson's disease with or without dementia

H. Arai, S. Higuchi, Hidetada Sasaki, 1994, The Lancet.

Role for Peroxisome Proliferator-Activated Receptor-g in Alzheimer’s Disease

A. Takeda, H. Arai, D. Feinstein, 2001 .

Metabolic and ethnic determinants of alcohol drinking habits and vulnerability to alcohol-related disorder.

S. Higuchi, D. Agarwal, S. Harada, 2001, Alcoholism, clinical and experimental research.

Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics.

S. Higuchi, T. Muramatsu, K. Okuyama, 1996, Alcoholism, clinical and experimental research.

Addiction research centres and the nurturing of creativity: the Kurihama medical and addiction centre-a profile.

S. Higuchi, A. Yokoyama, S. Matsushita, 2014, Addiction.

A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration?

T. Iwatsubo, H. Arai, S. Ohara, 2002, Neuroscience Letters.

Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.

A. Takeda, H. Arai, S. Higuchi, 1998, Experimental neurology.

Association between the brain‐derived neurotrophic factor 196G/A polymorphism and eating disorders

K. Hashimoto, M. Iyo, E. Shimizu, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

S182 and STM2 gene missense mutations in sporadic Alzheimer disease.

H. Arai, S. Higuchi, S. Itabashi, 1996, American journal of medical genetics.

Spirits and Gastrectomy Increase Risk for Chronic Pancreatitis in Japanese Male Alcoholics

S. Higuchi, H. Imazeki, Yuji Nakamura, 2003, Pancreas.

Apolipoprotein E epsilon 4 allele and pupillary response to tropicamide.

H. Arai, S. Higuchi, T. Muramatsu, 1997, The American journal of psychiatry.

Pupillary Response to Tropicamide in Japanese Patients with Alcoholic Dementia, Alzheimer's Disease, and Vascular Dementia

H. Arai, S. Higuchi, T. Muramatsu, 1997, Experimental Neurology.

Pupil dilatation assay by tropicamide is modulated by apolipoprotein E e4 allele dosage in Alzheimer's disease

H. Arai, S. Higuchi, Hidetada Sasaki, 1996, Neuroreport.

Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD‐10

S. Higuchi, A. Yoshimura, Y. Komoto, 2016, Alcoholism, clinical and experimental research.

Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.

T. Omori, S. Higuchi, T. Muramatsu, 1999, Alcoholism, clinical and experimental research.

Rapid Nonradioactive In-Situ Hybridization for mRNA Detection of Calcineurin in Rat Brain Using PCR DNA Probe

H. Arai, S. Higuchi, Hidetada Sasaki, 2000 .

Expression of β-amyloid precursor protein in the developing human spinal cord

J. Trojanowski, V. Lee, H. Arai, 1994, Brain Research.

Alcohol consumption and the risk of developing liver cirrhosis: implications for future research.

M. Dufour, S. Higuchi, K. Parrish, 1991, Journal of substance abuse.

Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population

S. Higuchi, S. Matsushita, A. Funakoshi, 2006, Journal of Neural Transmission.

Serotonin transporter gene regulatory region polymorphism and panic disorder

S. Higuchi, T. Muramatsu, O. Shirakawa, 1997, Molecular Psychiatry.

Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients

S. Higuchi, O. Shirakawa, Kenji Suzuki, 2001, Biological Psychiatry.

Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain.

H. Arai, S. Higuchi, H. Sasaki, 1996, Neuroreport.

Influence of Genetic Variations of Ethanol‐Metabolizing Enzymes on Phenotypes of Alcohol‐Related Disorders

Go Suzuki, S. Higuchi, H. Mochizuki, 2004, Annals of the New York Academy of Sciences.

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

Y. Itoyama, A. Takeda, H. Arai, 1997, Human Genetics.

Carboxylester Lipase Gene Polymorphism as a Risk of Alcohol-induced Pancreatitis

S. Higuchi, Y. Tando, A. Funakoshi, 2005, Pancreas.

SY05-4THE IMPACT OF THE GREAT EAST JAPAN EARTHQUAKE ON ALCOHOL, NICOTINE AND HYPNOTIC ABUSE AND GAMBLING IN DISASTER-STRICKEN AREAS

S. Higuchi, Y. Osaki, T. Takimura, 2014 .

Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patients Published, JLR Papers in Press, February 1, 2004. DOI 10.1194/jlr.M400008-JLR200

S. Higuchi, Y. Ueno, S. Matsushita, 2004, Journal of Lipid Research.

The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese.

M. Dufour, S. Higuchi, T. Harford, 1992, Journal of studies on alcohol.

Monoamine oxidase genes polymorphisms and mood disorder.

S. Kanba, E. Suzuki, S. Higuchi, 1997, American journal of medical genetics.

Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism.

S. Higuchi, T. Muramatsu, M. Murayama, 1994, Biochemical and biophysical research communications.

Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms.

S. Higuchi, S. Harada, S. Matsushita, 2003, Alcoholism, clinical and experimental research.

Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism.

S. Higuchi, S. Harada, S. Matsushita, 2002, Alcoholism, clinical and experimental research.

Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes.

S. Higuchi, T. Matsui, A. Yokoyama, 2014, Alcohol and Alcoholism.

Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism.

S. Higuchi, S. Matsushita, M. Kimura, 2011, Alcoholism, clinical and experimental research.

Association of cholecystokinin-a receptor gene polymorphisms and panic disorder in japanese

S. Higuchi, H. Shimokata, O. Shirakawa, 2003 .

Acute Axonal Polyneuropathy Associated with Alcoholism

S. Higuchi, S. Kusunoki, H. Mochizuki, 2003, European Neurology.

Herpes simplex virus and risk of Alzheimer's disease

H. Arai, S. Higuchi, Hidetada Sasaki, 1997, The Lancet.

Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa

S. Higuchi, O. Shirakawa, Kenji Suzuki, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome.

S. Higuchi, T. Muramatsu, S. Matsushita, 2000, Alcoholism, clinical and experimental research.

Genetics of alcohol dependence

Susumu Higuchi, S. Higuchi, Mitsuru Kimura, 2011, Psychiatry and clinical neurosciences.

Polymorphisms of ethanol metabolizing enzyme genes and alcoholism.

S. Higuchi, 1994, Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders.

S. Kanba, E. Suzuki, S. Higuchi, 1996, Journal of affective disorders.

No evidence of association between structural polymorphism at the dopamine D3 receptor locus and alcoholism in the Japanese.

S. Higuchi, T. Muramatsu, S. Matsushita, 1996, American journal of medical genetics.

Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.

I. Kanazawa, S. Tsuji, T. Asada, 2009, Genomics.

Genetic association study on in and around the APOE in late-onset Alzheimer disease

S. Tsuji, T. Asada, H. Arai, 2009 .

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.

Takashi Asada, Ichiro Kanazawa, Mikio Shoji, 2006, Human molecular genetics.

Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Α and modifies acute hepatic inflammation in rats

S. Higuchi, H. Ishii, Sachiko Hara, 2004, Journal of Gastroenterology.

Development of Biomarkers for Alcoholism and Polysubstance Abuse

S. Higuchi, M. Koga, H. Ishiguro, 2009 .

Reliability and validity of the alcohol use disorders identification test - consumption in screening for adults with alcohol use disorders and risky drinking in Japan.

S. Higuchi, Y. Osaki, S. Matsushita, 2014, Asian Pacific Journal of Cancer Prevention.

Reliability and validity of the alcohol use disorders identification test - consumption in screening for adults with alcohol use disorders and risky drinking in Japan.

S. Higuchi, Y. Osaki, S. Matsushita, 2014, Asian Pacific journal of cancer prevention : APJCP.

Severe chronic pancreatitis and severe liver cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics

S. Higuchi, K. Maruyama, Yuji Nakamura, 2004, Journal of Gastroenterology.

Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase‐2 genotype of Japanese alcoholics

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, Cancer.

Prevalence and Trends in Alcohol Dependence and Alcohol Use Disorders in Japanese Adults; Results from Periodical Nationwide Surveys.

S. Higuchi, Y. Osaki, H. Kanda, 2016, Alcohol and alcoholism.

Relationship between age and drinking patterns and drinking problems among Japanese, Japanese-Americans, and Caucasians.

M. Dufour, S. Higuchi, T. Harford, 1994, Alcoholism, clinical and experimental research.

Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.

T. Omori, S. Higuchi, T. Muramatsu, 2003, Carcinogenesis.

Pancreatic Volume Associated with Endocrine and Exocrine Function of the Pancreas among Japanese Alcoholics

S. Higuchi, K. Maruyama, Yuji Nakamura, 2005, Pancreatology.

Association of cholecystokinin‐A receptor gene polymorphisms and panic disorder in Japanese

S. Higuchi, H. Shimokata, O. Shirakawa, 2004 .

Benign type of central pontine myelinolysis in alcoholism

S. Higuchi, H. Mochizuki, K. Okuyama, 2003, Journal of Neurology.

Recent research on alcohol tolerance and dependence.

J. Crabbe, F. Weiss, T. Li, 2001, Alcoholism, clinical and experimental research.

S. Higuchi, T. Muramatsu, K. Okuyama, 1998, Carcinogenesis.

Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde.

S. Higuchi, Sachiko Hara, A. Yokoyama, 2019, Journal of psychiatric research.

Absence of Association of α1-Antichymotrypsin Polymorphisms with Alzheimer's Disease: A Report on Autopsy-Confirmed Cases

J. Trojanowski, H. Arai, S. Higuchi, 1998, Experimental Neurology.

Melanosis and squamous cell neoplasms of the upper aerodigestive tract in Japanese alcoholic men

T. Hibi, T. Omori, S. Higuchi, 2006, Cancer science.

Ethanol patch test--a simple and sensitive method for identifying ALDH phenotype.

S. Higuchi, T. Muramatsu, S. Takagi, 1989, Alcoholism, clinical and experimental research.

Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.

H. Kashima, H. Arai, S. Higuchi, 2008, Alcoholism, clinical and experimental research.

α1-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease

H. Arai, S. Higuchi, H. Sasaki, 2005, Journal of neural transmission.

Apolipoprotein E ε4 allele distribution in alcoholic dementia and in Alzheimer's disease in Japan

J. Trojanowski, H. Arai, S. Higuchi, 1994 .

Review: Use of Asian samples in genetic research of alcohol use disorders Genetic variation of alcohol metabolizing enzymes and the effects of acetaldehyde

M. Hesselbrock, V. Hesselbrock, S. Higuchi, 2017, The American journal on addictions.

Genetic differences in response to alcohol.

S. Higuchi, S. Matsushita, 2014, Handbook of clinical neurology.

New findings on the genetic influences on alcohol use and dependence

H. Kashima, S. Higuchi, S. Matsushita, 2006, Current opinion in psychiatry.

No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in Japanese

H. Arai, S. Higuchi, T. Yuzuriha, 2000, Journal of Neural Transmission.

Alpha 1-antichymotrypsin gene polymorphism and risk for Alzheimer's disease.

H. Arai, S. Higuchi, H. Sasaki, 1996, Journal of neural transmission.

No association between pancreatic and liver status in 132 Japanese male alcoholics

S. Higuchi, K. Maruyama, Yuji Nakamura, 2003 .

Is heavy alcohol consumption an attributable risk factor for cancer-related deaths among Japanese men?

S. Higuchi, K. Makimoto, H. Oda, 2000, Alcoholism, clinical and experimental research.

Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics.

T. Omori, S. Higuchi, T. Muramatsu, 2001, Carcinogenesis.

Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Alcohol consumption as a major risk factor for the rise in liver cancer mortality rates in Japanese men.

S. Higuchi, K. Makimoto, Susumu Higuchi, 1999, International journal of epidemiology.

Increased alcohol-related oesophageal cancer mortality rates in Japanese men.

S. Higuchi, L. Lucas, K. Parrish, 1993, International journal of epidemiology.

Presenilin-1 Polymorphism in Alzheimer's Disease and Vascular Dementia

H. Arai, S. Higuchi, Hidetada Sasaki, 1997, Experimental Neurology.

Cerebrospinal Fluid Amyloid β1–42 Levels in the Mild Cognitive Impairment Stage of Alzheimer's Disease

H. Arai, S. Higuchi, M. Higuchi, 2001, Experimental Neurology.

Elevated Plasma Homocysteine Levels and Risk of Silent Brain Infarction in Elderly People

H. Arai, S. Higuchi, Hidetada Sasaki, 2001, Stroke.

ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.

S. Higuchi, T. Muramatsu, M. Taniyama, 2004, Alcoholism, clinical and experimental research.

Association of aldehyde dehydrogenase with inheritance of NIDDM

S. Higuchi, T. Muramatsu, M. Taniyama, 2004, Diabetologia.

Functional relevance of human adh polymorphism.

J. Whitfield, H. Kashima, T. Foroud, 2001, Alcoholism, clinical and experimental research.

Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men

S. Higuchi, T. Matsui, A. Yokoyama, 2015, PloS one.

Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men

Yoichi Tanaka, T. Hibi, T. Omori, 2005, Journal of Gastroenterology.

[Nationwide survey of alcohol drinking and alcoholism among Japanese adults].

S. Higuchi, Y. Osaki, S. Matsushita, 2005, Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence.

GAB2 is not associated with late-onset Alzheimer's disease in Japanese

Takashi Asada, Ichiro Kanazawa, Mikio Shoji, 2009, European Journal of Human Genetics.

Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans

S. Higuchi, T. Arinami, T. Saito, 2007, The Pharmacogenomics Journal.

Functional polymorphism in the GPR55 gene is associated with anorexia nervosa

S. Higuchi, T. Arinami, Yuichiro Watanabe, 2011, Synapse.

Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects.

S. Kanba, S. Higuchi, T. Muramatsu, 1997, American journal of medical genetics.

Association between alcoholism and the dopamine D4 receptor gene.

S. Higuchi, T. Muramatsu, S. Matsushita, 1996, Journal of medical genetics.

Differential subcellular localization of neural isoforms of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin) in central nervous system neurons: immunohistochemistry on formalin-fixed paraffin sections employing antigen retrieval by microwave irradiation.

H. Arai, R. Kincaid, S. Higuchi, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Presenilin-1 polymorphism and Alzheimer's disease

J. Haines, M. Pericak-Vance, M. Owen, 1996, The Lancet.

Speaker 1: Chih-Ken Chen, Taiwan

S. Higuchi, H. Sugimura, M. Hayashida, 2016, International Journal of Neuropsychopharmacology.

Speaker 4: Gerhard Gründer, Germany

S. Higuchi, M. Hayashida, D. Nishizawa, 2016, International Journal of Neuropsychopharmacology.

Speaker 2: Kazutaka Ikeda, Japan

I. Sora, K. Ikeda, S. Higuchi, 2016, International Journal of Neuropsychopharmacology.

Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients

Susumu Higuchi, S. Higuchi, S. Ishiura, 2007, Neuroscience Letters.

Association of serotonin transporter regulatory region polymorphism and abnormal eating behaviors

S. Higuchi, S. Matsushita, N. Nishiguchi, 2002, Molecular Psychiatry.

Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease

J. Trojanowski, C. Clark, V. Lee, 1995, Annals of neurology.

Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses

J. Rehm, K. Shield, S. Higuchi, 2015, Bulletin of the World Health Organization.

Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers.

H. Arai, S. Higuchi, T. Matsui, 2010, Alcoholism, clinical and experimental research.

Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

Giovanni B. Frisoni, Alfredo Robles, Takeshi Iwatsubo, 1998 .

Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.

S. Higuchi, P. J. Brooks, T. Matsui, 2014, Alcoholism, clinical and experimental research.

Mitochondrial Aldehyde Dehydrogenase in Diabetes Associated With Mitochondrial tRNALeu(UUR) Mutation at Position 3243

M. Suematsu, S. Higuchi, T. Muramatsu, 1996, Diabetes Care.

Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.

S. Higuchi, T. Matsui, A. Yokoyama, 2013, Alcoholism, clinical and experimental research.

The association of drinking levels and drinking attitudes among Japanese in Japan and Japanese-Americans in Hawaii and California.

F. Stinson, M. Dufour, S. Higuchi, 1992, Journal of substance abuse.

Association study of serotonin transporter gene regulatory region polymorphism and alcoholism.

A. Yoshino, S. Higuchi, T. Muramatsu, 2001, American journal of medical genetics.

Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men.

S. Higuchi, T. Matsui, A. Yokoyama, 2016, Alcohol and alcoholism.

Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease

T. Iwatsubo, H. Arai, S. Higuchi, 1994, The Lancet.

Genetic Association Between Alcohol Withdrawal Symptoms and Polymorphism of CCK Gene Promoter.

S. Higuchi, S. Harada, S. Matsushita, 1999, Alcoholism, clinical and experimental research.

Genetic polymorphism of the CCK gene in patients with alcohol withdrawal symptoms.

S. Higuchi, S. Harada, S. Matsushita, 2000, Alcoholism, clinical and experimental research.

Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population.

S. Higuchi, S. Ohta, F. Ando, 2004, Alcohol and alcoholism.

Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism.

A. Yoshino, S. Higuchi, S. Matsushita, 2004, Alcoholism, clinical and experimental research.

Cerebrospinal fluid tau protein levels in demented and nondemented alcoholics.

H. Arai, S. Higuchi, M. Higuchi, 1999, Alcoholism, clinical and experimental research.

Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.

I. Kanazawa, N. Kitamura, T. Asada, 2014, Journal of Alzheimer's disease : JAD.

[A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease].

H. Arai, M. Imagawa, M. Shoji, 2005, Rinsho shinkeigaku = Clinical neurology.

Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism.

S. Higuchi, T. Matsui, A. Yokoyama, 2013, Alcohol and alcoholism.

Unguided Chatbot-Delivered Cognitive Behavioural Intervention for Problem Gamblers Through Messaging App: A Randomised Controlled Trial

T. Furukawa, S. Higuchi, S. Matsushita, 2020, Journal of Gambling Studies.

The relationship between three subtypes of the flushing response and DSM-III alcohol abuse in Japanese.

M. Dufour, S. Higuchi, T. Harford, 1992, Journal of studies on alcohol.

BRIEF COMMUNICATION Mutation in the α-Synuclein Gene and Sporadic Parkinson's Disease, Alzheimer's Disease, and Dementia with Lewy Bodies

A. Takeda, H. Arai, S. Higuchi, 1998, Experimental Neurology.

Effect of Genetic Risk Factors and Disease Progression on the Cerebrospinal Fluid Tau Levels in Alzheimer's Disease

J. Trojanowski, V. Lee, H. Arai, 1997, Journal of the American Geriatrics Society.

Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese.

S. Kanba, S. Higuchi, T. Muramatsu, 1997, American journal of medical genetics.

Alcohol dependence severity determines the course of treatment-seeking patients.

S. Higuchi, H. Nakayama, H. Sakuma, 2021, Alcoholism, clinical and experimental research.

A TRANSIENT INCREASE IN CEREBROSPINAL FLUID TAU LEVEL AFTER EPILEPTIC SEIZURE IN AN ELDERLY PATIENT

H. Arai, S. Higuchi, T. Matsui, 2007, Journal of the American Geriatrics Society.

Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and α1‐antichymotrypsin type A allele in Alzheimer's disease

H. Arai, S. Higuchi, M. Higuchi, 1997, Neuroreport.

ALDH2 promoter polymorphism has no effect on the risk for alcoholism.

H. Kashima, S. Higuchi, S. Matsushita, 2006, Alcohol and Alcoholism.

APOE ε4 allele in Alzheimer's and non-Alzheimer's dementias

J. Trojanowski, H. Arai, S. Higuchi, 1996, The Lancet.

Two-month stability of hyperbolic discount rates for delayed monetary gains in abstinent inpatient alcoholics.

Tomohiro Miyakawa, Susumu Higuchi, Taiki Takahashi, 2007, Neuro endocrinology letters.

Plasma Homocysteine and Risk of Coexisting Silent Brain Infarction in Alzheimer’s Disease

H. Arai, S. Higuchi, N. Tomita, 2006, Neurodegenerative Diseases.

Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer’s Disease

T. Iwatsubo, H. Arai, S. Higuchi, 2002, Biological Psychiatry.

Apolipoprotein E ɛ4 allele distribution in Wernicke-Korsakoff syndrome with or without global intellectual deficits

H. Kashima, S. Higuchi, H. Yoshimasu, 2005, Journal of Neural Transmission.

Apolipoprotein E and Alzheimer’s Disease

H. Arai, S. Higuchi, M. Higuchi, 1999 .

Influence of ADH and ALDH2 on Clinical Features of Alcohol Dependence

S. Higuchi, S. Matsushita, 2001 .

Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men

S. Higuchi, T. Matsui, A. Yokoyama, 2020, Pharmacogenetics and genomics.

Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial.

S. Higuchi, T. Matsui, A. Yoshimura, 2014, Alcoholism, clinical and experimental research.

p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.

Yoichi Tanaka, T. Hibi, T. Omori, 2007, Cancer letters.

CHANGES IN THE SERUM BONE METABOLISM MARKERS OF ELDERLY ALCOHOLICS DURING ABSTINENCE

H. Arai, S. Higuchi, T. Matsui, 2010, Journal of the American Geriatrics Society.

Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease.

A. Takeda, H. Arai, S. Higuchi, 2000, NeuroReport.

Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics.

H. Kashima, S. Higuchi, S. Matsushita, 2009, Alcoholism, clinical and experimental research.

Influence of ADHD, especially attention-deficit characteristics, on the course of alcohol-dependent individuals

S. Higuchi, A. Yokoyama, A. Yoshimura, 2022, BMC psychiatry.

Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans

S. Higuchi, H. Mochizuki, A. Yokoyama, 2004, Neuroscience Letters.

Disinhibition of somatosensory evoked potential recovery in alcoholics

S. Higuchi, H. Mochizuki, S. Matsushita, 2006, European journal of neurology.

Cognitive impairment and diffuse white matter atrophy in alcoholics

S. Higuchi, Y. Ugawa, H. Mochizuki, 2005, Clinical Neurophysiology.

Psychotic Symptoms Associated With Varenicline in a Patient With Alcohol and Nicotine Dependence: A Case Report.

M. Mimura, S. Higuchi, H. Uchida, 2017, Journal of clinical psychopharmacology.

Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease

H. Arai, S. Higuchi, K. Urakami, 2005, Journal of Neural Transmission.

The frequency of the methylenetetrahydrofolate reductase-gene mutation varies with age in the normal population.

H. Arai, S. Higuchi, T. Muramatsu, 1997, American journal of human genetics.

Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase‐2 genotype of Japanese alcoholics

S. Higuchi, T. Muramatsu, A. Yokoyama, 1996, Cancer.

[Alcohol-related dementia].

S. Higuchi, T. Matsui, A. Yokoyama, 2014, Nihon rinsho. Japanese journal of clinical medicine.

Genome-wide association study identifies a potent locus associated with human opioid sensitivity

A. Nishi, M. Iyo, I. Sora, 2012, Molecular Psychiatry.

Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

J. Haines, M. Pericak-Vance, G. Schellenberg, 2013, PLoS ONE.

Expression of beta-amyloid precursor protein in the developing human spinal cord.

J. Trojanowski, V. Lee, H. Arai, 1994, Brain research.

Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics.

S. Higuchi, T. Muramatsu, K. Okuyama, 1996, Alcoholism, clinical and experimental research.

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.

I. Kanazawa, T. Asada, A. Kakita, 2006, Human molecular genetics.

Diabetic vasculopathy and alcohol tolerance trait in type 2 diabetes.

S. Higuchi, T. Muramatsu, M. Taniyama, 2003, Diabetes care.

Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men.

S. Higuchi, T. Matsui, A. Yokoyama, 2014, Alcohol and alcoholism.

Genetic differences in response to alcohol.

S. Higuchi, S. Matsushita, 2014, Handbook of clinical neurology.

Lack of association of apolipoprotein E epsilon 4 allele with progressive supranuclear palsy.

H. Arai, S. Higuchi, S. Itabashi, 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.