Hitoshi Takahashi

T. Nakada, A. Kakita, Hitoshi Takahashi, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A quantitative pathological investigation of the cervical cord, roots and ganglia after long-term amputation of the unilateral upper arm

Hitoshi Takahashi, K. Oyanagi, F. Ikuta, 2004, Acta Neuropathologica.

AMBRA1, a novel α‐synuclein‐binding protein, is implicated in the pathogenesis of multiple system atrophy

A. Kakita, Hitoshi Takahashi, G. Fimia, 2018, Brain pathology.

Plasma matrix metalloproteinase‐3 correlates with the clinical severity in men with multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2013 .

Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy

T. Iwatsubo, M. Hasegawa, Hitoshi Takahashi, 2004, Acta Neuropathologica.

Expression of α- and β-synucleins in cultured astrocytes and the effects of inflammatory cytokines

Hitoshi Takahashi, K. Wakabayashi, F. Mori, 2003 .

Expression of β-synuclein in normal human astrocytes

T. Hirabayashi, Hitoshi Takahashi, K. Wakabayashi, 2001 .

Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity

A. Kakita, Hitoshi Takahashi, Takeshi Fujiwara, 2012, Journal of neurochemistry.

Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis

S. Tsuji, K. Sakimura, Hitoshi Takahashi, 1996, Neuroscience Letters.

Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin‐proteasome system, autophagy and aggresome formation

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Polyglutamine disease: Recent advances in the neuropathology of dentatorubral‐pallidoluysian atrophy

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

Genotype‐phenotype correlation in CAG‐repeat diseases

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2002, Neuropathology : official journal of the Japanese Society of Neuropathology.

Involvement of lysosomes in the pathogenesis of CAG repeat diseases

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2002, Annals of neurology.

[Pathology of familial Parkinson's disease].

Hitoshi Takahashi, K. Wakabayashi, 2007, Brain and nerve = Shinkei kenkyu no shinpo.

Enhanced Accumulation of Phosphorylated α-Synuclein and Elevated β-Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 ΔT440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease

A. Kakita, T. Iwatsubo, A. Miyashita, 2007, The Journal of Neuroscience.

Significance of horizontal propagation of synchronized activities in human epileptic neocortex investigated by optical imaging and immunohistological study

Y. Fujii, H. Kitaura, A. Kakita, 2013, Epilepsy Research.

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

John L. Robinson, Kevin F. Bieniek, Janna H. Neltner, 2017, Journal of neuropathology and experimental neurology.

Argyrophilic grains are reliable disease-specific features of corticobasal degeneration.

A. Kakita, R. Takahashi, Hitoshi Takahashi, 2014, Journal of neuropathology and experimental neurology.

Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration?

A. Kakita, Hitoshi Takahashi, Y. Piao, 2005, Acta Neuropathologica.

Hitoshi Takahashi, K. Wakabayashi, 1996 .

Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration

T. Iwatsubo, M. Hasegawa, Hitoshi Takahashi, 2001, Acta Neuropathologica.

Cardiac sympathetic denervation in Parkinson’s disease linked to SNCA duplication

A. Kakita, Hitoshi Takahashi, T. Uchihara, 2008, Acta Neuropathologica.

Decreased cardiac uptake of MIBG is a potential biomarker for the presence of Lewy bodies

A. Kakita, Hitoshi Takahashi, T. Uchihara, 2007, Journal of Neurology.

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.

J. Trojanowski, D. Mann, T. Iwatsubo, 2002, The Journal of biological chemistry.

Late‐onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation

T. Iwatsubo, M. Hasegawa, Hitoshi Takahashi, 2002, Annals of neurology.

Analysis of Chromosome 19q13.42 Amplification in Embryonal Brain Tumors with Ependymoblastic Multilayered Rosettes

A. Kakita, T. Sugino, Hitoshi Takahashi, 2012, Brain pathology.

A case of congenital supratentorial tumor: Atypical teratoid/rhabdoid tumor or primitive neuroectodermal tumor?

Y. Fujii, Hitoshi Takahashi, Hideaki Takahashi, 2007, Neuropathology (Kyoto. 1993).

A fourth ventricle atypical teratoid/rhabdoid tumor in an infant

Hitoshi Takahashi, R. Tanaka, H. Mori, 2006, Brain Tumor Pathology.

Accumulation of phosphorylated α‐synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Widespread expression of α-synuclein in neuronal cytoplasm and glial cells in the central and peripheral nervous systems in human

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2003 .

α-Synuclein, synphilin-1 and inclusion body formation in α-synucleinopathies

Hitoshi Takahashi, K. Wakabayashi, H. Takahashi, 2003 .

Pick's disease: α- and β-synuclein-immunoreactive Pick bodies in the dentate gyrus

Hitoshi Takahashi, S. Yagihashi, S. Hayashi, 2002, Acta Neuropathologica.

Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid Pretreatment

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Experimental Neurology.

α-Synuclein immunoreactivity in normal and neoplastic Schwann cells

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Acta Neuropathologica.

Gallyas-positive, tau-negative glial inclusions in Parkinson's disease midbrain

Hitoshi Takahashi, K. Wakabayashi, H. Takahashi, 1996, Neuroscience Letters.

[Clinical and pathological spectrum of TDP-43 associated ALS].

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2010, Rinsho shinkeigaku = Clinical neurology.

Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado–Joseph disease

A. Kakita, Hitoshi Takahashi, M. Yamada, 2009, Acta Neuropathologica.

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions

A. Kakita, Hitoshi Takahashi, M. Yamada, 2008, Acta Neuropathologica.

Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology

A. Kakita, Hitoshi Takahashi, M. Yamada, 2008, Acta Neuropathologica.

Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia

Hitoshi Takahashi, K. Wakabayashi, F. Mori, 2008, Acta Neuropathologica.

Association of SNPs linked to increased expression of SLC1A1 with schizophrenia

M. Itokawa, A. Kakita, Hitoshi Takahashi, 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Title The role of NEDD 8 Ultimate Buster 1 , NUB 1 , in neurodegenerative α-synucleinopathies

Hitoshi Takahashi, K. Wakabayashi, K. Tanji, 2016 .

The Role of NEDD8 Ultimate Buster 1, NUB1, in Neurodegenerative α-Synucleinopathies [Emerging Theories of Host Defense. The 10th Meeting Hirosaki International Forum of Medical Science. Communication Center Hirosaki University School of Medicine. Hirosaki on November 21-22, 2006]

Hitoshi Takahashi, K. Wakabayashi, F. Mori, 2007 .

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

D. Standley, Keiji Tanaka, Hitoshi Takahashi, 2011, The Journal of clinical investigation.

Pathology of CAG repeat diseases

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2000, Neuropathology : official journal of the Japanese Society of Neuropathology.

Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease

Hitoshi Takahashi, K. Oyanagi, K. Wakabayashi, 1989, Brain Research.

Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats.

A. Kakita, Hitoshi Takahashi, M. Sakamoto, 2004, Brain research. Developmental brain research.

Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2009, Brain : a journal of neurology.

Venous congestive myelopathy: Three autopsy cases showing a variety of clinicopathologic features

A. Kakita, Hitoshi Takahashi, T. Morita, 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

Venous congestive myelopathy of the cervical spinal cord: An autopsy case showing a rapidly progressive clinical course

Hitoshi Takahashi, T. Inuzuka, I. Hozumi, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Neuropathology of sporadic amyotrophic lateral sclerosis of long duration

S. Tsuji, Hitoshi Takahashi, S. Hayashi, 1997, Journal of the Neurological Sciences.

Aprosencephaly: histopathological features of the rudimentary forebrain and retina

A. Kakita, Hitoshi Takahashi, S. Hayashi, 2001, Acta Neuropathologica.

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 1997, Neuroscience Letters.

A Fulminant Case of Granulomatosis with Polyangiitis with Meningeal and Parenchymal Involvement

Hitoshi Takahashi, I. Narita, M. Yamada, 2015, Case Reports in Neurology.

GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma.

Y. Fujii, M. Suvà, V. Hovestadt, 2020, Journal of neuropathology and experimental neurology.

An Inducer of VGF Protects Cells against ER Stress-Induced Cell Death and Prolongs Survival in the Mutant SOD1 Animal Models of Familial ALS

Hitoshi Takahashi, H. Hara, M. Yamada, 2010, PloS one.

Primary frontal‐lobe germinoma appearing as a large cyst

Hitoshi Takahashi, K. Kawasaki, M. Yamada, 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism

Hitoshi Takahashi, A. Ishikawa, H. Takahashi, 1998, Journal of Neurology.

Immunohistochemical localization of NUB1, a synphilin-1-binding protein, in neurodegenerative disorders

A. Kakita, Hitoshi Takahashi, K. Kito, 2007, Acta Neuropathologica.

No mutation in the entire coding region of the α-synuclein gene in pathologically confirmed cases of multiple system atrophy

S. Tsuji, Hitoshi Takahashi, T. Shimohata, 1999, Neuroscience Letters.

Results of treatment of 112 cases of primary CNS lymphoma.

Hitoshi Takahashi, R. Tanaka, N. Yajima, 2008, Japanese journal of clinical oncology.

Intracranial malignant lymphomas: clinicopathological study of 26 autopsy cases

Hitoshi Takahashi, K. Wakabayashi, R. Tanaka, 2006, Brain Tumor Pathology.

An autopsy case of autosomal‐recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene

Hitoshi Takahashi, S. Hayashi, K. Wakabayashi, 2000, Movement disorders : official journal of the Movement Disorder Society.

Genetic Variations and Neuropathologic Features of Patients with PRKN Mutations

A. Kakita, R. Matsumoto, A. Miyashita, 2021, Movement disorders : official journal of the Movement Disorder Society.

Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2

N. Hattori, Hitoshi Takahashi, T. Uchihara, 2005, Movement disorders : official journal of the Movement Disorder Society.

NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1.

Hitoshi Takahashi, Tomoaki Tanaka, K. Kito, 2006, The American journal of pathology.

Glycogen synthase kinase‐3β phosphorylates synphilin‐1 in vitro

Hitoshi Takahashi, T. Toki, K. Wakabayashi, 2003 .

Familial amyotrophic lateral sclerosis: a SOD1-unrelated Japanese family of bulbar type with Bunina bodies and ubiquitin-positive skein-like inclusions in lower motor neurons

Hitoshi Takahashi, M. Nishizawa, O. Onodera, 2007, Acta Neuropathologica.

Autosomal dominant diffuse Lewy body disease

S. Tsuji, Hitoshi Takahashi, S. Hayashi, 1998, Acta Neuropathologica.

Sporadic Creutzfeldt–Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties

T. Iwaki, Hitoshi Takahashi, Y. Matsuura, 2016, Brain pathology.

Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans

M. Takada, T. Yamamori, A. Watakabe, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Primary lateral sclerosis: Upper‐motor‐predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration – immunohistochemical and biochemical analyses of TDP‐43

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2007, Acta Neuropathologica.

Sporadic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease

A. Kakita, A. Lees, T. Révész, 2005, Acta Neuropathologica.

Is motor neuron disease‐inclusion dementia a forme fruste of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept

Hitoshi Takahashi, Y. Toyoshima, Masaharu Tanaka, 2005, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease-inclusion dementia

Hitoshi Takahashi, K. Okamoto, Y. Piao, 2003, Acta Neuropathologica.

Primary lateral sclerosis: a rare upper-motor-predominant form of amyotrophic lateral sclerosis often accompanied by frontotemporal lobar degeneration with ubiquitinated neuronal inclusions?

A. Kakita, Hitoshi Takahashi, K. Okamoto, 2003, Acta Neuropathologica.

Neuropathology with Clinical Correlations of Sporadic Amyotrophic Lateral Sclerosis: 102 Autopsy Cases Examined Between 1962 and 2000

A. Kakita, Hitoshi Takahashi, Y. Piao, 2003, Brain pathology.

Variants associated with Gaucher disease in multiple system atrophy

J. Trojanowski, S. Gilman, Y. Kuroiwa, 2015, Annals of clinical and translational neurology.

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy

S. Ichinose, A. Kakita, Y. Eishi, 2014, Acta neuropathologica communications.

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy

S. Ichinose, A. Kakita, Y. Eishi, 2014, Acta Neuropathologica Communications.

Alteration of autophagosomal proteins in the brain of multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2013, Neurobiology of Disease.

Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: Impact on dopamine metabolism

A. Kakita, K. Araki, Hitoshi Takahashi, 2013, Neuroscience Letters.

Adrenoleukodystrophy with involvement of the cerebral cortex

S. Tsuji, A. Kakita, Hitoshi Takahashi, 1997 .

Cytoplasmic Location of α1A Voltage-Gated Calcium Channel C-Terminal Fragment (Cav2.1-CTF) Aggregate Is Sufficient to Cause Cell Death

R. Dolmetsch, Takeo Kato, Y. Eishi, 2013, PloS one.

Reduced brain‐derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF‐immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum

Takeo Kato, Y. Eishi, Hitoshi Takahashi, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Multiplex families with multiple system atrophy.

I. Kanazawa, S. Tsuji, A. Kakita, 2007, Archives of neurology.

Involvement of Onuf’s nucleus in Machado–Joseph disease: a morphometric and immunohistochemical study

Hitoshi Takahashi, M. Yamada, H. Shimizu, 2010, Acta Neuropathologica.

Degeneration of spinal dorsal root ganglia in adult rats treated with methylmercury: Chronological observations on the cell bodies, centrally directed axons and presynaptic terminals

A. Kakita, Hitoshi Takahashi, M. Yamada, 1997 .

Spinocerebellar degeneration: Discrepancies between clinical and pathological diagnoses

A. Kakita, Hitoshi Takahashi, M. Yamada, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2015, Neuropathology : official journal of the Japanese Society of Neuropathology.

Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy.

A. Kakita, Hitoshi Takahashi, Y. Piao, 2007, Archives of neurology.

Early clinical features of patients with progressive supranuclear palsy with predominant cerebellar ataxia.

Hitoshi Takahashi, T. Shimohata, M. Nishizawa, 2013, Parkinsonism & related disorders.

Parkinson's disease and parkinsonism: Clinicopathological discrepancies on diagnosis in three patients

A. Kakita, Hitoshi Takahashi, Y. Toyoshima, 2021, Neuropathology : official journal of the Japanese Society of Neuropathology.

The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

G. Sobue, Hitoshi Takahashi, H. Hara, 2012, Scientific Reports.

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

Hitoshi Takahashi, H. Hara, T. Inuzuka, 2009, Neurobiology of Disease.

Activation of Signal Transducer and Activator of Transcription-3 in the Spinal Cord of Sporadic Amyotrophic Lateral Sclerosis Patients

A. Kakita, S. Sakoda, Hitoshi Takahashi, 2009, Neurodegenerative Diseases.

Protein‐bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase‐1 mutation‐associated familial amyotrophic lateral sclerosis and its transgenic mouse model

A. Kakita, S. Sakoda, Hitoshi Takahashi, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

A. Kakita, T. Iwatsubo, A. Miyashita, 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Novel mutations, pseudo‐dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism

S. Tsuji, T. Yuasa, Hitoshi Takahashi, 2000, Annals of neurology.

alpha-Synuclein pathology in the neostriatum in Parkinson's disease.

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2008, Acta neuropathologica.

Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.

T. Iwatsubo, M. Hasegawa, Hitoshi Takahashi, 2004, Acta neuropathologica.

Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy

S. Tsuji, Hitoshi Takahashi, K. Wakabayashi, 2001, Acta Neuropathologica.

Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene

A. Kakita, Hitoshi Takahashi, T. Shimohata, 2013, Acta Neuropathologica.

Pathology and sensitivity of current clinical criteria in corticobasal syndrome

Hitoshi Takahashi, T. Shimohata, I. Tomita, 2014, Movement disorders : official journal of the Movement Disorder Society.

TDP‐43 mutation in familial amyotrophic lateral sclerosis

A. Kakita, Hitoshi Takahashi, K. Okamoto, 2008, Annals of neurology.

Modified ProMACE-MOPP hybrid regimen with moderate-dose methotrexate for patients with primary CNS lymphoma

Hitoshi Takahashi, Hideaki Takahashi, R. Tanaka, 2005, Annals of Hematology.

Alteration of mitochondrial protein PDHA1 in Lewy body disease and PARK14.

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2017, Biochemical and biophysical research communications.

PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2017, Neuroscience Letters.

Oligodendrocytic polyglutamine pathology in dentatorubral‐pallidoluysian atrophy

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2002, Annals of neurology.

Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration

A. Kakita, Hitoshi Takahashi, Y. Piao, 2002, Acta Neuropathologica.

A serial MRI study in a patient with progressive supranuclear palsy with cerebellar ataxia.

Hitoshi Takahashi, T. Shimohata, M. Nishizawa, 2012, Parkinsonism & related disorders.

Progressive supranuclear palsy on Guam

Hitoshi Takahashi, K. Oyanagi, Y. Katayama, 2001, Acta Neuropathologica.

Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity

A. Kakita, A. Miyashita, Hitoshi Takahashi, 2010, Acta Neuropathologica.

Differences in a dinucleotide repeat polymorphism in the tau gene between Caucasian and Japanese populations: implication for progressive supranuclear palsy

L. Thal, R. Katzman., E. Masliah, 1998, Neuroscience Letters.

Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.

K. Arima, Hitoshi Takahashi, M. Nishizawa, 2011, Human molecular genetics.

Novel eosinophilic intracytoplasmic inclusions in a meningioma

Hitoshi Takahashi, K. Kawasaki, F. Ikuta, 1993, Cancer.

Hippocampal sclerosis in the parkinsonism‐dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP‐43 immunoreactivity in CA1

Hitoshi Takahashi, K. Oyanagi, K. Wakabayashi, 2015, Neuropathology : official journal of the Japanese Society of Neuropathology.

Localization of Bcl‐xβ in the developing and adult rat central nervous system

M. Mizuguchi, Hitoshi Takahashi, M. Yamada, 2000 .

Tentorial cavernous angioma with profuse bleeding. Case report.

Hitoshi Takahashi, T. Uzuka, R. Tanaka, 2009, Journal of Neurosurgery: Pediatrics.

Neuropathology Training Worldwide—Evolution and Comparisons

S. Powell, J. Hainfellner, M. D. Del Bigio, 2014, Brain pathology.

Globular glial tauopathies (GGT): consensus recommendations

Isidro Ferrer, Zeshan Ahmed, Bernardino Ghetti, 2013, Acta Neuropathologica.

Globular glial tauopathy Type II: Clinicopathological study of two autopsy cases

A. Kakita, Hitoshi Takahashi, K. Otani, 2019, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: With Special Reference to Astrocytic Tau Pathology

A. Kakita, Hitoshi Takahashi, T. Someya, 2016, Brain pathology.

Cardiac sympathetic denervation in Lewy body disease

Hitoshi Takahashi, T. Uchihara, K. Wakabayashi, 2006 .

Pick’s disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system

S. Tsuji, A. Kakita, Hitoshi Takahashi, 1997, Acta Neuropathologica.

Increased Levels of Soluble LR11 in Cerebrospinal Fluid of Patients with Alzheimer Disease

A. Kakita, Hitoshi Takahashi, Hiroyuki Ebinuma, 2010, Dementia and Geriatric Cognitive Disorders.

Animal model of axonal Guillain‐Barré syndrome induced by sensitization with GM1 ganglioside

K. Hirata, Hitoshi Takahashi, A. Ohnishi, 2001, Annals of neurology.

Relationship between lobar intracerebral hemorrhage and leukoencephalopathy associated with cerebral amyloid angiopathy: Clinicopathological study of 64 Japanese patients

Hitoshi Takahashi, S. Ikeda, T. Oide, 2003, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside.

K. Hirata, Hitoshi Takahashi, A. Ohnishi, 2001 .

Phagocytized corpora amylacea as a histological hallmark of astrocytic injury in neuromyelitis optica

A. Kakita, Hitoshi Takahashi, Y. Harigaya, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 1

A. Kakita, H. Akiyama, Hitoshi Takahashi, 2008, Acta Neuropathologica.

Immunocytochemical demonstration of IGF-II-like immunoreactivity in human paraganglioma of the craniocervical region

Hitoshi Takahashi, N. Yanaihara, Toshimitsu Suzuki, 2004, Virchows Archiv A.

Neuroblastoma ampliﬁed sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger e Hue¨t anomaly

A. Miyashita, Hitoshi Takahashi, Svetlana Potapova, 2022 .

ALS‐associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Familial amyotrophic lateral sclerosis with bulbar onset and a novel Asp101Tyr Cu/Zn superoxide dismutase gene mutation

S. Tsuji, Hitoshi Takahashi, Y. Piao, 2004, Acta Neuropathologica.

Familial amyotrophic lateral sclerosis with a mutation in the Cu/Zn superoxide dismutase gene

S. Tsuji, K. Sakimura, M. Mishina, 2004, Acta Neuropathologica.

Is angiomatosis an intrinsic pathohistological feature of massive osteolysis? Report of an autopsy case and a review of the literature

Hitoshi Takahashi, K. Kawasaki, Takui Ito, 2003, Virchows Archiv.

Biochemical and histopathological alterations in TAR DNA‐binding protein‐43 after acute ischemic stroke in rats

T. Nakada, A. Kakita, Hitoshi Takahashi, 2011, Journal of neurochemistry.

Sporadic motor neuron disease with severe sensory neuronopathy

Hitoshi Takahashi, K. Wakabayashi, T. Morita, 1998, Acta Neuropathologica.

Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Acta Neuropathologica.

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

A. Kakita, Toshio Shimizu, Hitoshi Takahashi, 2016, Acta neuropathologica communications.

Bunina bodies in motor and non‐motor neurons revisited: A pathological study of an ALS patient after long‐term survival on a respirator

A. Kakita, Hitoshi Takahashi, Haishan Jiang, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

S. Tsuji, Hitoshi Takahashi, T. Inuzuka, 1998, Nature Genetics.

C9ORF72 repeat‐associated non‐ATG‐translated polypeptides are distributed independently of TDP‐43 in a Japanese patient with c9ALS

A. Kakita, M. Hasegawa, Hitoshi Takahashi, 2014, Neuropathology and applied neurobiology.

Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72

Hitoshi Takahashi, M. Nishizawa, S. Kuwabara, 2012, Journal of Neurology, Neurosurgery & Psychiatry.

TDP‐43 pathology in polyglutamine diseases: With reference to amyotrphic lateral sclerosis

Hitoshi Takahashi, Y. Toyoshima, H. Takahashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Widespread multiple system degeneration in a patient with familial amyotrophic lateral sclerosis

Hitoshi Takahashi, Kiyomitsu Oyanagi, T. Yuasa, 1993, Journal of the Neurological Sciences.

Familial amyotrophic lateral sclerosis with an I104F mutation in the SOD1 gene: Multisystem degeneration with neurofilamentous aggregates and SOD1 inclusions

A. Kakita, Hitoshi Takahashi, Haishan Jiang, 2017, Neuropathology : official journal of the Japanese Society of Neuropathology.

Formation of granular cytoplasmic aggregates in COS7 cells expressing mutant Cu/Zn superoxide dismutase associated with familial amyotrophic lateral sclerosis

S. Tsuji, Hitoshi Takahashi, T. Inuzuka, 1998, Neuroscience Letters.

An autopsy case of incipient Pick's disease: Immunohistochemical profile of early‐stage Pick body formation

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Neuroscience Letters.

A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients

M. Iyo, E. Shimizu, A. Kakita, 2003, Neuroscience Research.

[FTLD/ALS as TDP-43 proteinopathies].

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2010, Rinsho shinkeigaku = Clinical neurology.

Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington’s, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Acta Neuropathologica.

GPNMB ameliorates mutant TDP‐43‐induced motor neuron cell death

A. Kakita, Hitoshi Takahashi, H. Hara, 2017, Journal of neuroscience research.

Suprachiasmatic nucleus in a patient with multiple system atrophy with abnormal circadian rhythm of arginine-vasopressin secretion into plasma

S. Tsuji, Hitoshi Takahashi, K. Oyanagi, 1998, Journal of the Neurological Sciences.

[Neuropathological similarities and differences between frontotemporal lobar degeneration with ubiquitin inclusions and amyotrophic lateral sclerosis with dementia].

A. Kakita, Hitoshi Takahashi, Y. Toyoshima, 2009, Brain and nerve = Shinkei kenkyu no shinpo.

Sporadic fatal insomnia with spongiform degeneration in the thalamus and widespread PrPSc deposits in the brain

A. Kakita, Hitoshi Takahashi, Y. Piao, 2005, Neuropathology : official journal of the Japanese Society of Neuropathology.

Epidermoid cyst involving the medial temporal lobe: Surgical pathologic features of the epileptogenic lesion

Y. Fujii, H. Kitaura, A. Kakita, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Clinicopathological study of diffuse type brainstem gliomas: analysis of 40 autopsy cases.

Hitoshi Takahashi, R. Tanaka, J. Yoshimura, 2002, Neurologia medico-chirurgica.

Epstein‐Barr virus‐associated primary central nervous system cytotoxic T‐cell lymphoma

Y. Fujii, K. Ohshima, A. Kakita, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Serial CT and MRI findings in a patient with isolated angiitis of the central nervous system associated with cerebral amyloid angiopathy

T. Tokuda, Hitoshi Takahashi, S. Ikeda, 2002, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation

A. Kakita, Hitoshi Takahashi, H. Hashidate, 2018, Neuropathology : official journal of the Japanese Society of Neuropathology.

Lymphoplasmacyte‐rich meningioma: A convexity mass with regional enhancement in the adjacent brain parenchyma

A. Kakita, Hitoshi Takahashi, Y. Toyoshima, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Vertebral basilar system dolichoectasia with marked infiltration of IgG4‐containing plasma cells: A manifestation of IgG4‐related disease?

A. Kakita, Hitoshi Takahashi, Y. Toyoshima, 2012, Neuropathology (Kyoto. 1993).

Neuropathology of dentatorubropallidoluysian atrophy

Hitoshi Takahashi, S. Takeda, H. Takahashi, 1996 .

Phosphorylated NUB1 distinguishes α‐synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2019, Brain pathology.

Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2018, Neuroscience Letters.

Nonfunctional intra‐ and suprasellar tumor in a patient with visual disturbance and panhypopituitarism

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

A. Kakita, Hitoshi Takahashi, H. Takebayashi, 2016, Annals of neurology.

Periventricular nodular heterotopia functionally couples with the overlying hippocampus

Y. Fujii, H. Kitaura, A. Kakita, 2012, Epilepsia.

Alterations of oligodendrocytes and demyelination in the spinal cord of patients with mitochondrial encephalomyopathy

T. Miyatake, S. Ohara, Hitoshi Takahashi, 1988, Journal of the Neurological Sciences.

Progressive multifocal leukoencephalopathy showing extensive spinal cord involvement in a patient with lymphocytopenia

Hitoshi Takahashi, S. Takeda, F. Ikuta, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases

K. Arima, A. Kakita, H. Akiyama, 2006, Acta Neuropathologica.

Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonism

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 1999, Journal of the Neurological Sciences.

Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.

A. Kakita, Hitoshi Takahashi, Y. Piao, 2003, Acta neuropathologica.

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

Hitoshi Takahashi, K. Wakabayashi, F. Mori, 2012, Molecular Neurobiology.

Immunohistochemical localization of exoribonucleases (DIS3L2 and XRN1) in intranuclear inclusion body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2018, Neuroscience Letters.

Primary leptomeningeal meningiomatosis with widespread whorl formation

Hitoshi Takahashi, K. Kawasaki, K. Wakabayashi, 2006, Brain Tumor Pathology.

Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients

A. Kakita, S. Sakoda, Hitoshi Takahashi, 2009, Acta Neuropathologica.

Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease

Hitoshi Takahashi, K. Okamoto, M. Takatama, 2006, Journal of the Neurological Sciences.

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

Hitoshi Takahashi, Koichi Wakabayashi, S. Tsuji, 1998, Neuroscience Letters.

Prognostic significance of S-phase fractions in peritumoral invading zone analyzed by laser scanning cytometry in patients with high-grade glioma: A preliminary study.

Y. Fujii, Hitoshi Takahashi, R. Yamanaka, 2016, Oncology letters.

Autopsy findings of a craniopharyngioma with a natural course over 60 years.

A. Kakita, Hitoshi Takahashi, K. Yamatani, 2004, Surgical neurology.

Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury

A. Kakita, Hitoshi Takahashi, M. Sakamoto, 2002, Acta Neuropathologica.

A case of lymphomatosis cerebri mimicking inflammatory diseases

A. Kakita, Kiyoshi Saito, Koichiro Nakamura, 2016, BMC Neurology.

A primary CNS lymphoma in spontaneous remission for 3.5 years after initial detection of the lesions by MRI

A. Kakita, Hitoshi Takahashi, R. Tanaka, 2006, Brain Tumor Pathology.

Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations

A. Kakita, Hitoshi Takahashi, S. Takeda, 2014, Neuropathology and applied neurobiology.

Developmental profile of ganglioside GD3 in the central nervous system: an immunocytochemical study in the rat

Hitoshi Takahashi, S. Kuroda, S. Watarai, 1994, Neuroscience Research.

Demonstration of ganglioside GD3 in human reactive astrocytes

Hitoshi Takahashi, O. Yokota, S. Kuroda, 1999, Psychiatry and clinical neurosciences.

Malignant peripheral nerve sheath tumor of the trigeminal nerve: Clinicopathologic features in a young adult patient

A. Kakita, Hitoshi Takahashi, A. Shiga, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Tyrosine hydroxylase-immunoreactive intrinsic neurons in the Auerbach's and Meissner's plexuses of humans

Hitoshi Takahashi, K. Wakabayashi, E. Ohama, 1989, Neuroscience Letters.

Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease

Satoshi Orimo, Hitoshi Takahashi, Yoshinori Itoh, 2005, Acta Neuropathologica.

Late relapse of primary central nervous system lymphoma

Y. Fujii, Hitoshi Takahashi, A. Kawaguchi, 2017, Leukemia & lymphoma.

Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats

Toshiyuki Someya, Jan Ko, Hitoshi Takahashi, 2004, Neuroscience Research.

Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex

Renzo Guerrini, Hitoshi Takahashi, Christopher A. Walsh, 2002, Acta Neuropathologica.

Clinicopathologic Features of Two Patients With Sporadic Amyotrophic Lateral Sclerosis Who Maintained Communication Ability for Over 30 Years

A. Kakita, Hitoshi Takahashi, H. Shimizu, 2018, Journal of neuropathology and experimental neurology.

Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels.

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Neuroscience letters.

Distribution of serotonin-containing cell bodies in the brainstem of the human fetus determined with immunohistochemistry using antiserotonin serum

Hitoshi Takahashi, S. Takeda, E. Ohama, 1986, Brain and Development.

Enhancement of native and phosphorylated TDP‐43 immunoreactivity by proteinase K treatment following autoclave heating

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

Familial idiopathic basal ganglia calcification: Histopathologic features of an autopsied patient with an SLC20A2 mutation

A. Kakita, Hitoshi Takahashi, T. Ikeuchi, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

CAG repeat disorder models and human neuropathology: similarities and differences

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2007, Acta Neuropathologica.

A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele

H. Akiyama, T. Mizutani, Hitoshi Takahashi, 1997 .

Entrapment of the inferior horns of the lateral ventricle with enlargement of the bilateral choroid plexus

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Neurocutaneous melanosis: surgical pathological features of an apparently hamartomatous lesion in the amygdala.

A. Kakita, Hitoshi Takahashi, A. Nakagawa, 2010, Journal of neurosurgery. Pediatrics.

Neuronal differentiation associated with Gli3 expression predicts favorable outcome for patients with medulloblastoma

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Cellular pathology in multiple system atrophy

Hitoshi Takahashi, Koichi Wakabayashi, Hitoshi Takahashi, 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

Lung carcinoma metastasis presenting as a pineal region tumor

A. Kakita, Hitoshi Takahashi, T. Morita, 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

Large neurons in the neostriatum in Alzheimer's disease and progressive supranuclear palsy: a topographic, histologic and ultrastructural investigation

Hitoshi Takahashi, K. Oyanagi, K. Wakabayashi, 1991, Brain Research.

Expression of Ganglioside GD3 in Choroid Plexus

Hitoshi Takahashi, S. Kuroda, S. Watarai, 1994, The Japanese journal of psychiatry and neurology.

Transganglionic gracile response following limb amputation in man

Masahiro Kato, S. Ohara, Hitoshi Takahashi, 2000, Acta Neuropathologica.

Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis

A. Kakita, T. Mizutani, Hitoshi Takahashi, 2011, Brain Research.

Widespread ischemic brain lesions caused by vasculopathy associated with neurofibromatosis type 1

A. Kakita, Hitoshi Takahashi, Hajime Tanaka, 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

Gene expression signature‐based prognostic risk score in patients with glioblastoma

Y. Fujii, Hitoshi Takahashi, A. Kawaguchi, 2013, Cancer science.

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

A. Kakita, Hitoshi Takahashi, T. Shimohata, 2009, Movement disorders : official journal of the Movement Disorder Society.

MicroRNA expression profiles of multiple system atrophy from formalin-fixed paraffin-embedded samples

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2016, Neuroscience Letters.

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

A. Kakita, Hitoshi Takahashi, Y. Ugawa, 2012, Journal of neuropathology and experimental neurology.

EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2019, Neurologia medico-chirurgica.

Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger–Huët anomaly

Osamu Onodera, Masatoyo Nishizawa, Akinori Miyashita, 2010, Journal of Medical Genetics.

Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.

I. Kanazawa, S. Tsuji, T. Asada, 2009, Genomics.

Genetic association study on in and around the APOE in late-onset Alzheimer disease

S. Tsuji, T. Asada, H. Arai, 2009 .

Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2015, Neuropathology : official journal of the Japanese Society of Neuropathology.

Cerebral and spinal cord tanycytic ependymomas in a young adult with a mutation in the NF2 gene

Hitoshi Takahashi, K. Okamoto, K. Matsushima, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study

A. Kakita, Hitoshi Takahashi, K. Okamoto, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Supportive evidence for reduced expression of GNB1L in schizophrenia.

M. Itokawa, A. Kakita, Hitoshi Takahashi, 2010, Schizophrenia bulletin.

Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods

Hitoshi Takahashi, Akiyoshi Kakita, Koichi Wakabayashi, 2002, Brain Research.

PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex

A. Kakita, T. Sugino, Hitoshi Takahashi, 2017, Oncotarget.

Disclosure of a pro-apoptotic glyceraldehyde-3-phosphate dehydrogenase promoter: anti-dementia drugs depress its activation in apoptosis.

Hitoshi Takahashi, M. Yamada, K. Sunaga, 2004, Life sciences.

Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs

Hitoshi Takahashi, M. Yamada, N. Tatton, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.

Takashi Asada, Ichiro Kanazawa, Mikio Shoji, 2006, Human molecular genetics.

Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein

S. Tsuji, Hitoshi Takahashi, S. Hayashi, 2004, Annals of neurology.

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia.

M. Itokawa, A. Kakita, M. Yaniv, 2009, Human molecular genetics.

A mutant PSEN1 causes dementia with lewy bodies and variant Alzheimer's disease

A. Miyashita, Hitoshi Takahashi, R. Kuwano, 2005, Annals of neurology.

Aβ1–40 but not Aβ1–42 levels in cortex correlate with apolipoprotein E ϵ4 allele dosage in sporadic Alzheimer's disease

S. Tsuji, M. Gearing, S. Mirra, 1997, Brain Research.

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2015, Neuropathology : official journal of the Japanese Society of Neuropathology.

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2013, Human molecular genetics.

Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2014, Acta neuropathologica communications.

Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Neuroscience Letters.

A quantitative investigation of the substantia nigra in Huntington's disease

Hitoshi Takahashi, S. Takeda, K. Oyanagi, 1989, Annals of neurology.

Assessment of copy number variations in the brain genome of schizophrenia patients

Toshiyuki Someya, Noboru Kitamura, Hirooki Yabe, 2015, Molecular Cytogenetics.

Thomas Wisniewski, Radoslav Matej, Colin Smith, 2015, Acta Neuropathologica.

Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2011, Neurobiology of Disease.

Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice

A. Kakita, K. Shibuki, Hitoshi Takahashi, 2006, Neuroreport.

Disruption of Postnatal Progenitor Migration and Consequent Abnormal Pattern of Glial Distribution in the Cerebrum Following Administration of Methylmercury

A. Kakita, Hitoshi Takahashi, M. Sakamoto, 2003, Journal of neuropathology and experimental neurology.

Experimentally Induced Leptomeningeal Glioneuronal Heterotopia and Underlying Cortical Dysplasia of the Lateral Limbic Area in Rats Treated Transplacentally with Methylmercury

A. Kakita, Hitoshi Takahashi, Y. Piao, 2001, Journal of neuropathology and experimental neurology.

Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain

Hitoshi Takahashi, K. Wakabayashi, S. Orimo, 2010, Acta Neuropathologica.

[A case report of primary central nervous system lymphoma preceded by cerebral and cerebellar lesion diminishing spontaneously: consideration of two brain biopsy at the onset and after two years].

Takako Shimizu, Hitoshi Takahashi, Hiroshi Kobayashi, 2009, Rinsho shinkeigaku = Clinical neurology.

Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody.

A. Kakita, K. Akazawa, Hitoshi Takahashi, 2014, Brain : a journal of neurology.

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

Allan R. Martin, A. Curt, V. Rahimi-Movaghar, 2022, Global spine journal.

Cerebral lipoma and the underlying cortex of the temporal lobe: pathological features associated with the malformation

A. Kakita, S. Kameyama, Hitoshi Takahashi, 2005, Acta Neuropathologica.

[An autopsy case of systemic vasculitis associated with hepatitis C virus-related mixed cryoglobulinemia presenting severe peripheral neuropathy].

S. Tsuji, A. Kakita, Hitoshi Takahashi, 2004, Rinsho shinkeigaku = Clinical neurology.

The carboxy-terminal fragment of α1A calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells

R. Dolmetsch, Hitoshi Takahashi, Fuminori Tsuruta, 2009, Acta Neuropathologica.

Autosomal recessive spastic paraplegia with hypoplastic corpus callosum, multisystem degeneration and ubiquitinated eosinophilic granules

Hitoshi Takahashi, K. Wakabayashi, Hisashi Kobayashi, 2000, Acta Neuropathologica.

TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2007, Acta Neuropathologica.

Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster

S. Hanai, Hitoshi Takahashi, M. Kanai, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Dropped head syndrome in amyotrophic lateral sclerosis

Hitoshi Takahashi, T. Shimohata, M. Nishizawa, 2013, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Hemifacial spasm associated with an ependymal cyst in the cerebellopontine angle. Case report.

Hitoshi Takahashi, R. Tanaka, S. Takeuchi, 2002, Journal of neurosurgery.

Suppressed Expression of Autophagosomal Protein LC3 in Cortical Tubers of Tuberous Sclerosis Complex

Y. Fujii, A. Kakita, S. Kameyama, 2013, Brain pathology.

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

Hitoshi Takahashi, K. Wakabayashi, F. Mori, 2013, Molecular Neurobiology.

A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: Consideration of the pathology of post‐polio syndrome

Hitoshi Takahashi, Y. Toyoshima, R. Koike, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pleomorphic xanthoastrocytoma: New ultrastructural observations

A. Kakita, S. Kameyama, Hitoshi Takahashi, 1995 .

Germ‐line and somatic mutations of the APC gene in patients with turcot syndrome and analysis of APC mutations in brain tumors

Yusuke Nakamura, M. Shibuya, Y. Hayashi, 1994, Genes, chromosomes & cancer.

Primary central nervous system lymphomas and related diseases: Pathological characteristics and discussion of the differential diagnosis

A. Kakita, K. Ohshima, Hitoshi Takahashi, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Neuropathology Associated with Exposure to Different Concentrations and Species of Mercury: A Review of Autopsy Cases and the Literature.

Hitoshi Takahashi, T. Love, G. Myers, 2020, Neurotoxicology.

Cervical Spondylotic Myelopathy: Clinicopathologic Study on the Progression Pattern and Thin Myelinated Fibers of the Lesions of Seven Patients Examined During Complete Autopsy

Hitoshi Takahashi, K. Oyanagi, F. Ikuta, 1996, Spine.

Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

T. Nakada, Y. Fujii, A. Kakita, 2014, Acta neuropathologica communications.

Ultrastructural localization of CD38 immunoreactivity in rat brain

N. Otsuka, M. Mizuguchi, Hitoshi Takahashi, 1997, Brain Research.

Brain expression level and activity of HDAC6 protein in neurodegenerative dementia.

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2013, Biochemical and biophysical research communications.

Widespread occurrence of intranuclear atrophin‐1 accumulation in the central nervous system neurons of patients with dentatorubral‐pallidoluysian atrophy

C. Ross, S. Tsuji, Hitoshi Takahashi, 2001, Annals of neurology.

Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

A. Kakita, S. Sakoda, Hitoshi Takahashi, 2010, Acta Neuropathologica.

Anaplastic astrocytoma with angiocentric ependymal differentiation

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

Occurrence of ganglioside GD3 in neoplastic astrocytes

Hitoshi Takahashi, S. Kuroda, S. Watarai, 1999, Virchows Archiv.

Extracerebral ectopic mass with huge cysts in the anterior cranial cavity

A. Kakita, Hitoshi Takahashi, M. Yamada, 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

Basal ganglion hamartoma in a patient presenting with precocious puberty

Hitoshi Takahashi, Y. Piao, Hideaki Takahashi, 2005, Brain Tumor Pathology.

The occurrence of catecholamine neurons in a parietal lobe ganglioglioma

Hitoshi Takahashi, Y. Honda, K. Tanimura, 1987, Cancer.

Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy

H. Kitaura, A. Kakita, S. Kameyama, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

Balloon cells in the dentate gyrus in hippocampal sclerosis associated with non-herpetic acute limbic encephalitis

H. Kitaura, A. Kakita, S. Kameyama, 2011, Seizure.

Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy

A. Kakita, Hitoshi Takahashi, Y. Ando, 2017, Acta Neuropathologica.

Creutzfeldt‐Jakob disease with an M232R substitution: report of a patient showing slowly progressive disease with abundant plaque‐like PrP deposits in the cerebellum

Hitoshi Takahashi, M. Yamada, M. Nishizawa, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Intraventricular pleomorphic xanthoastrocytoma with anaplastic features

Y. Fujii, Hitoshi Takahashi, T. Hirose, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

A mouse model of adult-onset multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2019, Neurobiology of Disease.

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

A. Kakita, Toshio Shimizu, Hitoshi Takahashi, 2016, Acta neuropathologica communications.

ApoE–ε4 and early–onset Alzheimer's

Ichiro Kanazawa, Osamu Onodera, Hitoshi Takahashi, 1994, Nature Genetics.

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

J. Trojanowski, P. Riederer, T. Iwatsubo, 2001 .

The perivascular microenvironment in Epstein–Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1

Y. Fujii, A. Kakita, K. Ohshima, 2018, Neuropathology : official journal of the Japanese Society of Neuropathology.

Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP‐43 pathology in a patient after long‐term survival on a respirator

Hitoshi Takahashi, Y. Toyoshima, T. Nakajima, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions*

J. Trojanowski, D. Mann, T. Iwatsubo, 2002, The Journal of Biological Chemistry.

Spinal cord involvement of primary central nervous system lymphomas: Histopathological examination of 14 autopsy cases

Hitoshi Takahashi, K. Kawasaki, K. Wakabayashi, 2002, Neuropathology : official journal of the Japanese Society of Neuropathology.

Are Bunina Bodies of Endoplasmic Reticulum Origin? An Ultrastructural Study of Subthalamic Eosinophilic Inclusions in a Case of Atypical Motor Neuron Disease

Hitoshi Takahashi, E. Ohama, F. Ikuta, 1991, Acta pathologica japonica.

Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy

A. Kakita, Hitoshi Takahashi, H. Mizusawa, 2016, Acta Neuropathologica.

Clinical Aspects of ‘Senile Dementia of the Tangle Type’ – A Subset of Dementia in the Senium Separable from Late-Onset Alzheimer’s Disease

Masanori Kato, H. Akiyama, Hitoshi Takahashi, 1998, Dementia and Geriatric Cognitive Disorders.

Dementia and delirium in 4 patients with Machado-Joseph disease.

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2002, Archives of neurology.

Selective decrease of large neurons in the neostriatum in progressive supranuclear palsy

Hitoshi Takahashi, K. Oyanagi, K. Wakabayashi, 1988, Brain Research.

Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation

Hitoshi Takahashi, K. Oyanagi, K. Wakabayashi, 1987, Brain Research.

Influences of dopaminergic lesion on epidermal growth factor‐ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons

A. Kakita, Hitoshi Takahashi, H. Nawa, 2005, Journal of neurochemistry.

Fine structural study of a cerebral tumor characterized by a honeycomb appearance after a 20‐year post‐mortem interval

Hitoshi Takahashi, T. Kubota, R. Tanaka, 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

Selective reduction of a PDZ protein, SAP‐97, in the prefrontal cortex of patients with chronic schizophrenia

Masahiko Watanabe, A. Kakita, Hitoshi Takahashi, 2002, Journal of neurochemistry.

Chordoid glioma of the third ventricle: A report of two cases, one with ultrastructural findings

Y. Fujii, Hitoshi Takahashi, K. Kawasaki, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Induction of autophagy in temozolomide treated malignant gliomas

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report.

A. Kakita, Hitoshi Takahashi, Hideaki Takahashi, 2007, Neurologia medico-chirurgica.

Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice

R. Shin, C. Ross, M. Katsuki, 2008, Human molecular genetics.

Nuclear Accumulation of Truncated Atrophin-1 Fragments in a Transgenic Mouse Model of DRPLA

D. Borchelt, D. Price, C. Ross, 1999, Neuron.

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

S. Tsuji, A. Kakita, Hitoshi Takahashi, 2012, Neurobiology of Disease.

Indication of intraoperative immunohistochemistry for accurate pathological diagnosis of brain tumors

Y. Fujii, A. Kakita, Hitoshi Takahashi, 2011, Brain Tumor Pathology.

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

I. Kanazawa, S. Tsuji, Hitoshi Takahashi, 2000, Nature Genetics.

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles

S. Tsuji, Hitoshi Takahashi, K. Takao, 2012, Neurobiology of Disease.

Organization of the human synphilin-1 gene, a candidate for Parkinson's disease

Christopher A. Ross, Roxann Ashworth, Hitoshi Takahashi, 2000, Mammalian Genome.

Synphilin‐1 is present in Lewy bodies in Parkinson's disease

C A Ross, C. Ross, S. Tsuji, 2000, Annals of neurology.

Marinesco‐Sjögren syndrome with atrophy of the brain stem tegmentum and dysplastic cytoarchitecture in the cerebral cortex

A. Kakita, Hitoshi Takahashi, O. Onodera, 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

Relationship Among &agr;-Synuclein Accumulation, Dopamine Synthesis, and Neurodegeneration in Parkinson Disease Substantia Nigra

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2006, Journal of neuropathology and experimental neurology.

Pursuit of the origin of the large myelinated fibers of the anterolateral funiculus in the spinal cord in humans in relation to the pathomechanism in amyotrophic lateral sclerosis

Hitoshi Takahashi, K. Oyanagi, T. Morita, 1999, Acta Neuropathologica.

RADIATION THERAPY OF PRIMARY MALIGNANT LYMPHOMA OF THE BRAIN

Hitoshi Takahashi, K. Sakai, R. Tanaka, 1990 .

Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy

T. Nakada, Y. Fujii, A. Kakita, 2018, Neurosurgical Review.

Long‐term survivors of primary central nervous system lymphoma

Y. Fujii, Hitoshi Takahashi, A. Kawaguchi, 2017, Japanese journal of clinical oncology.

Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.

A. Kakita, T. Iwatsubo, Hitoshi Takahashi, 2008, Archives of neurology.

Endothelin‐1 in the brain of patients with galactosialidosis: Its abnormal increase and distribution pattern

Hitoshi Takahashi, K. Oyanagi, H. Sakuraba, 2000, Annals of neurology.

SCA17 homozygote showing Huntington's disease‐like phenotype

Osamu Onodera, Hitoshi Takahashi, S. Tsuji, 2004, Annals of neurology.

Immunocytochemical localization of synphilin-1, an α-synuclein-associated protein, in neurodegenerative disorders

Christopher A. Ross, Hitoshi Takahashi, Koichi Wakabayashi, 2002, Acta Neuropathologica.

p62/sequestosome 1 binds to TDP‐43 in brains with frontotemporal lobar degeneration with TDP‐43 inclusions

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Journal of neuroscience research.

SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.

N. Kitamura, A. Kakita, A. Miyashita, 2013, Journal of Alzheimer's disease : JAD.

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

M. Hagiwara, A. Kakita, D. Teplow, 2015, Proceedings of the National Academy of Sciences.

Direct, Ca2+-dependent Interaction between Tubulin and Synaptotagmin I

Hitoshi Takahashi, H. Saisu, T. Abe, 2002, The Journal of Biological Chemistry.

TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2010, Neurobiology of Disease.

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS

Takashi Inuzuka, Makoto Yoneda, Osamu Onodera, 2014, Neurology.

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains*

K. Imahori, A. Kakita, D. Teplow, 2009, The Journal of Biological Chemistry.

Brain Cannabinoid CB2 Receptor in Schizophrenia

M. Itokawa, A. Kakita, Hitoshi Takahashi, 2010, Biological Psychiatry.

Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia

Norio Ozaki, Masanari Itokawa, Hitoshi Takahashi, 2010, Neuropsychopharmacology.

Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.

A. Kakita, Hitoshi Takahashi, H. Yabe, 2016, Journal of psychiatric research.

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

I. Kanazawa, S. Tsuji, Hitoshi Takahashi, 1995, Nature Genetics.

Regional specificity of alterations in NGF, BDNF and NT‐3 levels in Alzheimer's disease

S. Tsuji, Hitoshi Takahashi, H. Nawa, 1996, Neuroreport.

Loss of Motor Neurons Innervating Cervical Muscles in Patients With Multiple System Atrophy and Dropped Head

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2018, Journal of neuropathology and experimental neurology.

Erratum to: “Intrauterine methylmercury intoxication. Consequence of the inherent brain lesions and cognitive dysfunction in maturity” [Brain Res. 877 (2000) 322–330] 1 1 PII of original article: S0006-8993(00)02717-7

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2000, Brain Research.

Intrauterine methylmercury intoxication Consequence of the inherent brain lesions and cognitive dysfunction in maturity

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2000, Brain Research.

Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer’s disease☆

Hitoshi Takahashi, H. Nawa, K. Wakabayashi, 1999, Neurobiology of Aging.

Accumulation of the sigma‐1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

Molecular characterization and gene disruption of a novel zinc‐finger protein, HIT‐4, expressed in rodent brain

S. Itohara, A. Kakita, T. Iwasato, 2010, Journal of neurochemistry.

Spinocerebellar Ataxia Type 17 (SCA17).

Hitoshi Takahashi, Y. Toyoshima, H. Takahashi, 2018, Advances in experimental medicine and biology.

Spinocerebellar ataxia type 6: CAG repeat expansion in α1a voltage‐dependent calcium channel gene and clinical variations in japanese population

S. Tsuji, Hitoshi Takahashi, H. Tsukagoshi, 1997, Annals of neurology.

Pathologic features of dysplasia and accompanying alterations observed in surgical specimens from patients with intractable epilepsy.

Hiroshi Masuda, Hitoshi Takahashi, Shigeki Kameyama, 2004, Journal of child neurology.

Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2015, Acta neuropathologica communications.

Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2012, Acta Neuropathologica.

Selective cauda equina hypertrophy with idiopathic inflammation

Y. Hayashi, Hitoshi Takahashi, T. Inuzuka, 2008, Muscle & nerve.

Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia

A. Kakita, Hitoshi Takahashi, H. Nawa, 2018, Psychiatry Research.

Giant cell reparative granuloma of the temporal bone: neuroradiological and immunohistochemical findings.

Hitoshi Takahashi, R. Tanaka, J. Yoshimura, 2002, Neurologia medico-chirurgica.

Degeneration of Cardiac Sympathetic Nerve Begins in the Early Disease Process of Parkinson’s Disease

A. Kakita, Hitoshi Takahashi, T. Uchihara, 2007, Brain pathology.

Globular Glial Mixed Four Repeat Tau and TDP‐43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia

A. Kakita, Hitoshi Takahashi, M. Nishizawa, 2016, Brain pathology.

Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes

Shinji Ohara, Masato Hasegawa, Masatoyo Nishizawa, 2006, Acta Neuropathologica.

Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: a model of fetal-type Minamata disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 1998, Brain Research.

Cognitive impairment and cortical degeneration in neuromyelitis optica

M. Otsuki, A. Kakita, Hitoshi Takahashi, 2013, Annals of neurology.

Expression of α-synuclein, the precursor of non-amyloid β component of Alzheimer's disease amyloid, in human cerebral blood vessels

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Neuroscience Letters.

Surgical Strategy and Outcomes for Epileptic Patients with Focal Cortical Dysplasia or Dysembryoplastic Neuroepithelial Tumor

A. Kakita, S. Kameyama, Hitoshi Takahashi, 2001, Epilepsia.

Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas: Marked Response to Chemotherapy

Y. Fujii, Hitoshi Takahashi, T. Kon, 2013 .

Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation

Y. Hayashi, Hitoshi Takahashi, M. Takemura, 2013, Journal of Neuroinflammation.

Multiple cerebral infarcts with a few vasculitic lesions in the chronic stage of cerebral amyloid angiopathy‐related inflammation

Hitoshi Takahashi, S. Hayashi, M. Yamada, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies

K. Arima, T. Iwatsubo, M. Hasegawa, 2004, Neuroscience Letters.

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2015, Neuroscience Letters.

Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration

Hitoshi Takahashi, Koichi Wakabayashi, Hitoshi Takahashi, 2004, Neuropathology : official journal of the Japanese Society of Neuropathology.

Spatiotemporal dynamics of epileptiform propagations: Imaging of human brain slices

Hiroshi Masuda, Katsuei Shibuki, Masafumi Fukuda, 2011, NeuroImage.

Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.

Hideo Fujiwara, Takeshi Iwatsubo, Masato Hasegawa, 2003, Journal of neuropathology and experimental neurology.

Eosinophilic intranuclear inclusions in the hippocampal pyramidal neurons of a patient with amyotrophic lateral sclerosis

A. Kakita, Hitoshi Takahashi, K. Oyanagi, 1997, Acta Neuropathologica.

Cyclopia: histogenesis of the single optic nerve

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 1997, Acta Neuropathologica.

G protein‐coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases

Yasuo Miki, Mari Yoshida, Hitoshi Takahashi, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Valosin‐containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Reply to Altschuler

A. Kakita, Hitoshi Takahashi, 1999, Acta Neuropathologica.

Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies

Hitoshi Takahashi, T. Inuzuka, S. Hayashi, 1996, Brain Research.

Coexistence of Huntington’s disease and amyotrophic lateral sclerosis: a clinicopathologic study

H. Paulson, A. Kakita, M. Wieler, 2012, Acta Neuropathologica.

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

Hitoshi Takahashi, Shintaro Hayashi, Akiyoshi Kakita, 1998, Acta Neuropathologica.

Immunocytochemical localization of synaptic vesicle-specific protein in lewy body-containing neurons in Parkinson's disease

K. Obata, Hitoshi Takahashi, K. Wakabayashi, 1992, Neuroscience Letters.

YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2018, Neurobiology of Disease.

Difference in MSA phenotype distribution between populations: genetics or environment?

N. Quinn, A. Kakita, A. Lees, 2012, Journal of Parkinson's disease.

Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases

A. Kakita, Hitoshi Takahashi, K. Itoh, 2013, Journal of neuropathology and experimental neurology.

A Case of Chondroblastoma arising from the Convexity of the Frontal Bone

Hitoshi Takahashi, H. Umezu, S. Takeuchi, 2006 .

Clinicopathological features in anterior visual pathway in neuromyelitis optica

A. Kakita, Hitoshi Takahashi, K. Akazawa, 2016, Annals of neurology.

Remote astrocytic response of prefrontal cortex is caused by the lesions in the nucleus basalis of Meynert, but not in the ventral tegmental area

T. Miyatake, Hitoshi Takahashi, K. Yanagisawa, 1992, Brain Research.

Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis

A. Kakita, Hitoshi Takahashi, T. Inuzuka, 2015, Journal of neuroscience research.

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

A. Kakita, Hitoshi Takahashi, H. Takebayashi, 2016, Acta neuropathologica communications.

Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y

Hitoshi Takahashi, Shigeki Kameyama, Shintaro Hayashi, 1999, Brain Research.

Involvement of the γ‐Secretase‐Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease

A. Kakita, Hitoshi Takahashi, Y. Takai, 2012, Brain pathology.

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

A. Kakita, Hitoshi Takahashi, K. Itoh, 2010, Acta Neuropathologica.

Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system.

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Brain research.

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

A. Kakita, Hitoshi Takahashi, H. Takebayashi, 2016, Acta Neuropathologica Communications.

Alzheimer's disease: Report of two autopsy cases with a clinical diagnosis of corticobasal degeneration

Hitoshi Takahashi, M. Nishizawa, K. Okamoto, 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

Progressive supranuclear palsy: Neuropathology of patients with a short disease duration due to unexpected death

A. Kakita, Hitoshi Takahashi, I. Tomita, 2020, Neuropathology : official journal of the Japanese Society of Neuropathology.

Spinal cord tau pathology in cervical spondylotic myelopathy

Hitoshi Takahashi, Akiyoshi Kakita, Hiroshi Shimizu, 2008, Acta Neuropathologica.

α-Synuclein pathology in the neostriatum in Parkinson’s disease

Hitoshi Takahashi, Akiyoshi Kakita, Koichi Wakabayashi, 2008, Acta Neuropathologica.

Three-repeat Tau 69 is a major tau isoform in laser-microdissected Pick bodies

K. Arima, K. Kaneko, Hitoshi Takahashi, 2006, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study

A. Kakita, Hitoshi Takahashi, K. Akazawa, 2019, Annals of neurology.

Global democratic consensus on neuropathological disease criteria

D. Graham, B. Scheithauer, J. Trojanowski, 2002, The Lancet Neurology.

Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.

I. Kanazawa, N. Kitamura, T. Asada, 2014, Journal of Alzheimer's disease : JAD.

Accumulation of histone deacetylase 6, an aggresome‐related protein, is specific to Lewy bodies and glial cytoplasmic inclusions

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

EGF Downregulates Presynaptic Maturation and Suppresses Synapse Formation In Vitro and In Vivo

T. Ushiki, A. Kakita, Hitoshi Takahashi, 2022, Neurochemical Research.

EGF Downregulates Presynaptic Maturation and Suppresses Synapse Formation In Vitro and In Vivo

T. Ushiki, A. Kakita, Hitoshi Takahashi, 2022, Neurochemical Research.

Dentatorubral‐pallidoluysian atrophy: Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat

Osamu Onodera, Hitoshi Takahashi, Takeshi Ikeuchi, 1995, Annals of neurology.

Evidence for transneuronal degeneration in the spinal cord in man: a quantitative investigation of neurons in the intermediate zone after long-term amputation of the unilateral upper arm

Hitoshi Takahashi, K. Oyanagi, F. Ikuta, 2004, Acta Neuropathologica.

Neuronal atrophy and synaptic alteration in a mouse model of dentatorubral-pallidoluysian atrophy.

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2006, Brain : a journal of neurology.

Reciprocal accumulation of β-synuclein in α-synuclein lesions in multiple system atrophy

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2003 .

Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy.

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2003, NeuroReport.

Some glial progenitors in the neonatal subventricular zone migrate through the corpus callosum to the contralateral cerebral hemisphere

Hitoshi Takahashi, Akiyoshi Kakita, A. Kakita, 2003, The Journal of comparative neurology.

Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy

A. Kakita, Hitoshi Takahashi, T. Uchihara, 2006, Autonomic Neuroscience.

The intermediolateral nucleus and Clarke’s column in Parkinson’s disease

Hitoshi Takahashi, Hitoshi Takahashi, K. Wakabayashi, 1997, Acta Neuropathologica.

Synphilin-1-Binding Protein NUB1 is Colocalized With Nonfibrillar, Proteinase K-Resistant &agr;-Synuclein in Presynapses in Lewy Body Disease

A. Kakita, Hitoshi Takahashi, K. Kito, 2011, Journal of neuropathology and experimental neurology.

α‐Synuclein pathology in the cranial and spinal nerves in Lewy body disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

Quantitative correlation between cardiac MIBG uptake and remaining axons in the cardiac sympathetic nerve in Lewy body disease

A. Kakita, Takayoshi Kobayashi, Hitoshi Takahashi, 2015, Journal of Neurology, Neurosurgery & Psychiatry.

Immunohistochemical comparison of α- and β-synuclein in adult rat central nervous system

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2002, Brain Research.

Apolipoprotein E ε4 allele and progression of cortical Lewy body pathology in Parkinson’s disease

S. Tsuji, A. Kakita, Hitoshi Takahashi, 1998, Acta Neuropathologica.

Co‐localization of β‐peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration

M. Hasegawa, Hitoshi Takahashi, K. Wakabayashi, 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

A possible variant of neuro-Behçet disease presenting chronic progressive ataxia without mucocutaneo-ocular symptoms

A. Kakita, Hitoshi Takahashi, S. Hayashi, 2006, Rheumatology International.

Co‐localization of Bunina bodies and TDP‐43 inclusions in lower motor neurons in amyotrophic lateral sclerosis

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2014, Neuropathology : official journal of the Japanese Society of Neuropathology.

PARKINSONʼS DISEASE: AN IMMUNOHISTOCHEMICAL STUDY OF LEWY BODY-CONTAINING NEURONS IN THE ENTERIC NERVOUS SYSTEM

Hitoshi Takahashi, K. Wakabayashi, E. Ohama, 1989 .

Lewy bodies in Betz cells of the motor cortex in a patient with Parkinson's disease

Hitoshi Takahashi, K. Wakabayashi, M. Yoshimoto, 2003, Acta Neuropathologica.

ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis

Hitoshi Takahashi, H. Hara, T. Inuzuka, 2013, Journal of Neurology.

An Autopsy Case of Atypical Motor Neuron Disease with Bunina Bodies in the Lower Motor and Subthalamic Neurons

Hitoshi Takahashi, E. Ohama, F. Ikuta, 1991, Acta pathologica japonica.

Evidence of impaired macroautophagy in human degenerative cervical myelopathy

Hitoshi Takahashi, B. Davies, M. Kotter, 2022, Scientific reports.

Clinical and pathological features affecting cardiac sympathetic denervation in autopsy‐confirmed dementia with Lewy bodies

A. Kakita, Hitoshi Takahashi, T. Uchihara, 2020, European journal of neurology.

Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter

Hitoshi Takahashi, Takeshi Ikeuchi, Koichi Wakabayashi, 1998, Journal of the Neurological Sciences.

Alteration of Upstream Autophagy‐Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2016, Brain pathology.

Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus.

Hitoshi Takahashi, S. Yagihashi, S. Hayashi, 2002, Acta neuropathologica.

DRPLA: recent advances in research using transgenic mouse models.

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2013, Methods in molecular biology.

Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation

Y. Hayashi, Hitoshi Takahashi, M. Takemura, 2013, Journal of Neuroinflammation.

Effects of the −141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia

A. Kakita, Hitoshi Takahashi, H. Nawa, 2018, Psychiatry Research.

Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism

A. Kakita, Hitoshi Takahashi, H. Nawa, 2014, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 2000, Brain Research.

Synaptic terminals wrapped in the somatic cytoplasm of pigmented neurons in the human locus ceruleus

Hitoshi Takahashi, M. Yamada, K. Iwanaga, 1995, Neuroscience Letters.

Metastatic pineocytoma of the spinal cord after long‐term dormancy

Hitoshi Takahashi, Takui Ito, Hiroshi Sato, 1994, Pathology international.

Dysembryoplastic neuroepithelial tumor: report of a case without typical glioneuronal elements

S. Kameyama, Hitoshi Takahashi, K. Iwanaga, 2004, Acta Neuropathologica.

A newly discovered age-related synaptic change in the human locus ceruleus: morphometric and ultrastructural studies

Hitoshi Takahashi, M. Yamada, K. Iwanaga, 1996, Acta Neuropathologica.

Anterior striatum with dysmorphic neurons associated with the epileptogenesis of focal cortical dysplasia

A. Takahashi, A. Kakita, Hitoshi Takahashi, 2010, Seizure.

Lewy bodies in the cerebellar dentate nucleus of a patient with Parkinson's disease

A. Kakita, Hitoshi Takahashi, H. Takahashi, 1994, Pathology international.

Characteristic expression of p57/Kip2 in balloon cells in focal cortical dysplasia

H. Kitaura, A. Kakita, S. Kameyama, 2015, Neuropathology (Kyoto. 1993).

Multiple gas-forming brain microabscesses due to Klebsiella pneumoniae.

Hitoshi Takahashi, K. Nishikura, Y. Toyoshima, 2006, Archives of neurology.

Ultrastructural Relationship between Lewy Bodies and Pale Bodies Studied in Locus Ceruleus Neurons of a Non‐Parkinsonian Patient

Hitoshi Takahashi, S. Egawa, K. Iwanaga, 1994 .

Occurrence of GD3 ganglioside in reactive astrocytes — an immunocytochemical study in the rat brain

Hitoshi Takahashi, S. Kuroda, S. Watarai, 1994, Neuroscience Letters.

A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients

A. Kakita, Hitoshi Takahashi, H. Nawa, 2001, Neuroscience Letters.

Selective Insolubility of (cid:2) -Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

J. Trojanowski, P. Riederer, T. Iwatsubo, 2010 .

Spinocerebellar ataxia type 17

S. Tsuji, Hitoshi Takahashi, M. Yamada, 2012, Definitions.

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.

Sonja W. Scholz, A. Singleton, Y. Kusakabe, 2023, medRxiv.

Novel pathological abnormalities of deep brain structures including dysplastic neurons in anterior striatum associated with focal cortical dysplasia in epilepsy.

A. Takahashi, A. Kakita, Hitoshi Takahashi, 2012, Journal of neurosurgery. Pediatrics.

Selective involvement of large motor neurons in the spinal cord of rats treated with methylmercury

A. Kakita, Hitoshi Takahashi, K. Wakabayashi, 1998, Journal of the Neurological Sciences.

Pathologic Features of Dysplasia and Accompanying Alterations Observed in Surgical Specimens From Patients With Intractable Epilepsy

A. Kakita, S. Kameyama, Hitoshi Takahashi, 2004 .

Prefrontal Abnormality of Schizophrenia Revealed by DNA Microarray: Impact on Glial and Neurotrophic Gene Expression

A. Kakita, K. Araki, Hitoshi Takahashi, 2004, Annals of the New York Academy of Sciences.

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT

S. Tsuji, Hitoshi Takahashi, H. Takahashi, 1996, Nature Genetics.

Oligodendroglioma (WHO grade I) in a young epilepsy patient: A specific entity lying within the spectrum of dysembryoplastic neuroepithelial tumor?

A. Kakita, S. Kameyama, Hitoshi Takahashi, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger–Huët anomaly

M. Takagi, A. Miyashita, Hitoshi Takahashi, 2010, Journal of Medical Genetics.

An unusual meningioma variant with glial fibrillary acidic protein expression

Hitoshi Takahashi, H. Takahashi, R. Tanaka, 1997, Acta Neuropathologica.

Parkinsonism in HIV encephalopathy

A. Kakita, Takashi Suzuki, Hitoshi Takahashi, 2000, Movement disorders : official journal of the Movement Disorder Society.

Clinical features of familial diffuse Lewy body disease.

Hitoshi Takahashi, H. Takahashi, Hajime Tanaka, 1997, European neurology.

Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)

O. Onodera, S. Tsuji, Hitoshi Takahashi, 1994, Nature Genetics.

Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system

Hitoshi Takahashi, K. Wakabayashi, H. Takahashi, 2004, Acta Neuropathologica.

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

A. Kakita, Hitoshi Takahashi, K. Itoh, 2014, Acta neuropathologica communications.

Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

Hitoshi Takahashi, S. Takeda, K. Wakabayashi, 2004, Acta Neuropathologica.