Y. Ihara

发表

Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.

I. Kanazawa, T. Asada, A. Kakita, 2007, Human molecular genetics.

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

T. Iwatsubo, Y. Ihara, N. Nukina, 1994, Neuron.

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

Yasuo Ihara, Masato Hasegawa, K. Titani, 1993, Neuron.

High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.

T. Iwatsubo, Y. Ihara, A. Odaka, 1994, The American journal of pathology.

GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

Y. Ihara, A. Odaka, N. Suzuki, 1995, Nature Medicine.

Ubiquitin is a component of paired helical filaments in Alzheimerʼs disease

Y. Ihara, H. Mori, J. Jondo, 1987 .

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

E. Masliah, Y. Ihara, M. Yoshimoto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Proliferating cell nuclear antigen (PCNA) expressed in human leptomeninges.

Y. Ihara, R. Okeda, M. Yoshimura, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

System in Alzheimer Disease Lysosomal - Proteasome System and the Autophagic - The Ubiquitin

A. Fagan, L. Mucke, K. Blennow, 2012 .

The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.

Y. Ihara, R. Nixon, M. Morishima-kawashima, 2012, Cold Spring Harbor Perspectives in Medicine.

Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch*

Y. Ihara, N. Dohmae, K. Takio, 2001, The Journal of Biological Chemistry.

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

Y. Ihara, N. Dohmae, C. Haass, 2003, The Journal of biological chemistry.

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein*

Y. Ihara, N. Dohmae, C. Haass, 2003, Journal of Biological Chemistry.

Gamma-secretase activity is present in rafts but is not cholesterol-dependent.

Y. Ihara, M. Morishima-kawashima, Y. Shimada, 2003, Biochemistry.

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

Y. Ihara, S. Funamoto, T. Saido, 2004, Biochemistry.

Truncated Carboxyl-Terminal Fragments of β-Amyloid Precursor Protein Are Processed to Amyloid β-Proteins 40 and 42†

Y. Ihara, S. Funamoto, T. Saido, 2004 .

Random Mutagenesis of Presenilin-1 Identifies Novel Mutants Exclusively Generating Long Amyloid β-Peptides*

P. S. St George-Hyslop, B. de Strooper, P. Fraser, 2005, Journal of Biological Chemistry.

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

Y. Ihara, T. Saido, M. Morishima-kawashima, 2005, FEBS Letters.

Phosphoinositides Suppress γ-Secretase in Both the Detergent-soluble and -insoluble States*

Y. Ihara, S. Funamoto, Masafumi Shimojo, 2008, Journal of Biological Chemistry.

Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages

A. Delacourte, Y. Ihara, C. Davies, 1989, Journal of the Neurological Sciences.

Selective Deposition of Mutant Tau in the FTDP‐17 Brain Affected by the P301L Mutation

W. Kamphorst, R. Ravid, Y. Ihara, 2001, Journal of neuropathology and experimental neurology.

Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).

Y. Ihara, N. Matsumura, T. Yamazaki, 1999, The American journal of pathology.

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

Y. Ihara, M. Morishima-kawashima, H. Misonou, 2000, Biochemistry.

Immunocytochemical and ultrastructural studies of Pick's disease

Y. Ihara, S. Murayama, H. Mori, 1990, Annals of neurology.

Deamidation and Isoaspartate Formation in Smeared Tau in Paired Helical Filaments

Y. Ihara, K. Takio, A. Watanabe, 1999, The Journal of Biological Chemistry.

Molecular aging of tau: disulfide‐independent aggregation and non‐enzymatic degradation in vitro and in vivo

Y. Ihara, N. Dohmae, M. Morishima-kawashima, 2004, Journal of neurochemistry.

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain

T. Iwatsubo, Mamoru Ito, Y. Ueyama, 1998, Journal of neurochemistry.

Aβ46 Is Processed to Aβ40 and Aβ43, but Not to Aβ42, in the Low Density Membrane Domains*

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, Journal of Biological Chemistry.

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2008, The Journal of biological chemistry.

Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer’s Disease*

Y. Ihara, A. Watanabe, H. Yoshida, 1998, The Journal of Biological Chemistry.

Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.

Y. Ihara, Y. Gu, N. Hamajima, 2000, Biochemistry.

Central nervous system‐specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

A. Fukamizu, Y. Ihara, Masayuki Yamamoto, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

Y. Ihara, H. Yoshida, 1993 .

Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau.

Y. Ihara, H. Yoshida, 1993, Journal of neurochemistry.

Amyloid β‐protein (Aβ) Accumulation in the Leptomeninges during Aging and in Alzheimer Disease

Y. Ihara, M. Yoshimura, M. Kuriyama, 1997 .

Proteolytic fragments of Alzheimer's paired helical filaments.

Y. Ihara, N. Nukina, 1985, Journal of biochemistry.

Neurofibrillary Tangles, Dystrophic IMeurites (Curly Fibers), and Abnormal Phosphorylation of Tau

Y. Ihara, H. Mori, H. Mori, 1991, Brain pathology.

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

T. Iwatsubo, Y. Ihara, N. Suzuki, 1996, The American journal of pathology.

Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant

M. Imagawa, Y. Ihara, K. Namekata, 1997, Human Genetics.

Genome-wide association study of Alzheimer's disease: A collaborative genetic study on Alzheimer's disease with Japan, Korea and the Alzheimer's Disease Genetics Consortium

M. Pericak-Vance, L. Farrer, A. Koike, 2012, Alzheimer's & Dementia.

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

J. Haines, M. Pericak-Vance, G. Schellenberg, 2013, PloS one.

Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

B. Winblad, P. Lantos, M. Rossor, 1996, The American journal of pathology.

Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein

T. Tokuda, G. Glenner, N. Yanagisawa, 2004, Acta Neuropathologica.

Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42*

Y. Ihara, C. Haass, U. Leimer, 1997, The Journal of Biological Chemistry.

Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase*

Y. Ihara, S. Funamoto, N. Dohmae, 2006, Journal of Biological Chemistry.

Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.

Y. Ihara, H. Yamaguchi, M. Morishima-kawashima, 2000, The American journal of pathology.

Tau 2: A Probe for a Ser Conformation in the Amino Terminus of τ

K. Titani, M. Hasegawa, Y. Ihara, 1992, Journal of neurochemistry.

Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination

K. Titani, N. Cairns, Y. Ihara, 1994 .

Alzheimer disease research in Japan: public funding

I. Kanazawa, T. Iwatsubo, Y. Ihara, 2006, Nature Medicine.

Longer Forms of Amyloid (cid:1) Protein: Implications for the Mechanism of Intramembrane Cleavage by (cid:2) -Secretase

F. Kametani, Y. Ihara, G. Dolios, 2005 .

The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section.

M. Hasegawa, Y. Ihara, H. Shimada, 1990, The American journal of pathology.

Immunocytochemical study on senile plaques in Alzheimer's disease. I. Preparation of an antimicrotubule-associated proteins (MAPs) antiserum and its specificity.:Preparation of an Antimicrotubule-associated Proteins (MAPs) Antiserum and its Specificity

Y. Ihara, N. Nukina, 1983 .

IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF LOWER MOTOR NEURONS IN AMYOTROPHIC LATERAL SCLEROSIS: 90

Y. Ihara, S. Murayama, H. Mori, 1989 .

Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein

R. Crowther, M. Goedert, M. Hasegawa, 1996 .

A Novel Correlation Between the Levels of β‐Amyloid Protein Precursor and τ Transcripts in the Aged Human Brain

K. Titani, Y. Ihara, F. Oyama, 1992 .

Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.

T. Iwatsubo, M. Hasegawa, Y. Ihara, 1992, The American journal of pathology.

Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

S. Hirai, M. Shoji, Y. Ihara, 1990, Brain Research.

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

S. Hirai, M. Shoji, Y. Ihara, 1991, The American journal of pathology.

A possible fetal antigen ofM r70,000 in neurofibrillary tangles

K. Titani, K. Kosik, Y. Ihara, 1991, Brain Research.

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

M. Hasegawa, Y. Ihara, T. Arai, 1990, Neuron.

Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system.

S. Tsuji, T. Miyatake, Y. Ihara, 1993, Brain research. Molecular brain research.

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.

Y. Ihara, C. Haass, T. Saido, 1997, Biochemistry.

Molecular diversity at the carboxyl terminus of human and rat tau.

A. Sawa, Y. Ihara, F. Oyama, 1994, Brain research. Molecular brain research.

Fetal-type phosphorylation of the tau in paired helical filaments.

K. Titani, Y. Ihara, K. Takio, 1992, Journal of neurochemistry.

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

Y. Ihara, A. Odaka, N. Suzuki, 1995, Nature medicine.

Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.

D. Selkoe, Y. Ihara, C. Abraham, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Widespread expression of α-synuclein and τ immunoreactivity in Hallervorden–Spatz syndrome with protracted clinical course

I. Kanazawa, H. Arai, Y. Ihara, 2000, Journal of the Neurological Sciences.

Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.

R. Ravid, P. Heutink, J. V. van Swieten, 2001, The American journal of pathology.

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.

Y. Ihara, T. Saido, R. Okeda, 1998, The American journal of pathology.

Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.

Y. Ihara, H. Yamaguchi, S. Sugihara, 2001, Journal of neuropathology and experimental neurology.

Accumulation of neurofilaments and SOD1-immunoreactive products in a patient with familial amyotrophic lateral sclerosis with I113T SOD1 mutation.

S. Tsuji, Y. Ihara, T. Inuzuka, 1999, Archives of neurology.

Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats.

Y. Ihara, Y. Uchida, M. Tomonaga, 1988, Biochemical and biophysical research communications.

Glypican‐1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease

T. Tabira, Y. Ihara, W. Araki, 2004 .

Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments.

M. Hasegawa, Y. Ihara, E. Miyamoto, 1996, Dementia.

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel

T. Kudo, R. Hashimoto, M. Takeda, 2010, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Supplemental Information Semagacestat Is a Pseudo-Inhibitor of g-Secretase

T. Kudo, M. Takeda, Y. Ihara, 2022 .

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

Y. Ihara, S. Funamoto, T. Saido, 2013, Nature Communications.

Amyloid β-protein (Aβ) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998 .

In vivo phosphorylation sites in fetal and adult rat tau.

K. Titani, K. Kosik, M. Hasegawa, 1993, The Journal of biological chemistry.

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA

N. Hirokawa, M. Yanagisawa, Y. Ihara, 1989, The Journal of cell biology.

Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells*

Y. Ihara, C. Haass, Ta-Yuan Chang, 2001, The Journal of Biological Chemistry.

Molecular cloning of human growth inhibitory factor cDNA and its down‐regulation in Alzheimer's disease.

S. Tsuji, T. Miyatake, Y. Ihara, 1992, The EMBO journal.

Localization of verotoxin receptors in nervous system

Y. Ihara, I. Utsunomiya, Jin Ren, 1999, Brain Research.

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

Y. Ihara, S. Funamoto, N. Dohmae, 2006, The Journal of biological chemistry.

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.

Y. Ihara, D. Schenk, K. Khan, 1999, The American journal of pathology.

What mediates between β-amyloid and paired helical filaments?

Y. Ihara, 1989, Neurobiology of Aging.

Astrocytes Containing Amyloid (3-Protein (Af3)-Positive Granules Are Associated with A1340-Positive Diffuse Plaques in the Aged Human Brain

Y. Ihara, R. Okeda, H. Funato, 2007 .

Amyloid β‐protein (Aβ) associated with lipid molecules: immunoreactivity distinct from that of soluble Aβ

Y. Ihara, J. McLaurin, A. Chakrabartty, 1997 .

Chloroquine treated rat: A possible model for alzheimer's disease

I. Nonaka, Y. Ihara, N. Murakami, 1995, Muscle & nerve.

A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.

K. Imahori, Y. Ihara, K. Ishiguro, 1988, Journal of biochemistry.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

T. Kudo, M. Takeda, Y. Ihara, 2008, The Journal of biological chemistry.

Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques.

D. Mann, T. Iwatsubo, Y. Ihara, 1995, Acta neuropathologica.

Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons.

Y. Ihara, A. Tamura, T. Kirino, 1996, The American journal of pathology.

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization

Y. Ihara, S. Funamoto, Mika Nobuhara, 2017, Journal of neurochemistry.

Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques

Y. Ihara, H. Yamaguchi, T. Saido, 1998, Acta Neuropathologica.

GM1 Ganglioside-Bound Amyloid β-Protein in Alzheimer’s Disease Brain

Y. Ihara, K. Yanagisawa, Yasuo Ihara, 1998, Neurobiology of Aging.

γ-Secretase Associated with Lipid Rafts

Y. Ihara, S. Funamoto, S. Tagami, 2013, The Journal of Biological Chemistry.

Microglial cells and amyloid ? protein (A?) deposition: association with A?40-containing plaques

D. Mann, T. Iwatsubo, Y. Ihara, 1995 .

γ-Cleavage and ε-cleavage of β-amyloid precursor protein

Y. Ihara, M. Morishima-kawashima, 2003 .

Posttranslational modifications of tau in paired helical filaments.

Y. Ihara, M. Morishima, 1994, Dementia.

Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain: Individual Variability and Correlation between APP‐751 and Four‐Repeat tau

K. Titani, Y. Ihara, F. Oyama, 1991, Journal of neuropathology and experimental neurology.

Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.

Y. Ihara, S. Ryu, P. Suh, 2009, Cellular signalling.

[Alzheimer paired helical filament].

Y. Ihara, 1985, Seikagaku. The Journal of Japanese Biochemical Society.

Lewy Bodies: Purification from Diffuse Lewy Body Disease Brains a

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, Annals of the New York Academy of Sciences.

The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells.

Y. Ihara, M. Morishima-kawashima, 1998, Biochemistry.

Secretory pathway of β A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation

T. Miyatake, Y. Ihara, K. Yanagisawa, 1992, Neuroscience Letters.

Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging

Y. Ihara, D. Schenk, K. Khan, 1999 .

Amyloid (B-protein (Aß) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998 .

A tale of protein kinase C and membrane lipid signaling

C. Tanaka, Y. Ihara, 2001 .

Quantitation of Amyloid (3-Protein (Af3) in the Cortex during Aging and in Alzheimer's Disease

Y. Ihara, K. Namekata, A. Tamaoka, 2007 .

530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells

Y. Ihara, N. Suzuki, A. Asami-Odaka, 1996, Neurobiology of Aging.

Alzheimer (cid:98) Amyloid Deposition Enhanced by ApoE (cid:171) 4 Gene Precedes Neuroﬁbrillary Pathology in the Frontal Association Cortex of Nondemented Senior Subjects

Y. Ihara, H. Yamaguchi, S. Sugihara, 2001 .

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

Y. Ihara, M. Morishima-kawashima, Rie Mitsumori, 2003, Biochemistry.

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer??s disease

Y. Ihara, N. Nukina, M. Ogawara, 1987 .

Tau protein immunoreactivity in muscle fibers with rimmed vacuoles differs from that in regenerating muscle fibers

K. Imahori, I. Nonaka, Y. Ihara, 2004, Acta Neuropathologica.

Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course.

I. Kanazawa, Y. Ihara, E. Nanba, 2000, Journal of the neurological sciences.

Immunohistochemical detection of verotoxin receptors in nervous system.

J. Ren, T. Miyatake, Y. Ihara, 2001, Brain research. Brain research protocols.

The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats.

Y. Ihara, K. Kitani, G. Ivy, 1991, Archives of gerontology and geriatrics (Print).

Significance of Neurofibrillary Tangles in Alzheimer’s Disease—Lessons from Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17

Y. Ihara, 2002 .

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

Y. Ihara, N. Nukina, M. Ogawara, 1986, Journal of biochemistry.

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles

S. Mitani, Y. Ihara, S. Murayama, 2014, PloS one.

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

T. Iwatsubo, Y. Ihara, N. Nukina, 1994, Neuron.

Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain

Y. Ihara, H. Yamaguchi, M. Morishima-kawashima, 2000 .

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

D. Selkoe, Y. Ihara, C. Abraham, 1983, Nature.

Purification of tubulin from bovine brain and its interaction with guanine nucleotides.

K. Arai, Y. Ihara, Y. Kaziro, 1975, Journal of biochemistry.

Senescence‐Accelerated Mouse

Y. Kitamura, Y. Oomura, Y. Yamanaka, 1996 .

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

K. Titani, Y. Ihara, K. Takio, 1991, Neuron.

Senescence-accelerated mouse. Neurochemical studies on aging.

Y. Kitamura, Y. Oomura, Y. Yamanaka, 1996, Annals of the New York Academy of Sciences.

Lewy bodies are ubiquitinated

Y. Ihara, H. Mori, M. Yoshimura, 1988, Acta Neuropathologica.

Potent amyloidogenicity and pathogenicity of Aβ43

C. Broeckhoven, K. Sleegers, Y. Ihara, 2011, Nature Neuroscience.

Molecular pathology of Alzheimer's disease

Y. Ihara, T. Yamazaki, 1997 .

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3*

D. Berman, Y. Ihara, Hyun-Ok Yang, 2013, The Journal of Biological Chemistry.

Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain

S. Ohta, Y. Ihara, K. Taira, 2003, The EMBO journal.

Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia

S. Hirai, Y. Ihara, H. Yamaguchi, 2004, Acta Neuropathologica.

Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.

I. Kanazawa, S. Tsuji, T. Asada, 2009, Genomics.

Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease

K. Mikoshiba, J. Honnorat, Y. Goshima, 2005, Genes to cells : devoted to molecular & cellular mechanisms.

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.

Takashi Asada, Ichiro Kanazawa, Mikio Shoji, 2006, Human molecular genetics.

Alzheimer's disease: β‐Amyloid protein and tau

Y. Ihara, M. Morishima-kawashima, 2002, Journal of neuroscience research.

The presence of an adenosine-5'-triphosphatase dependent on 6S tubulin and calcium ions in rat brain microtubules.

Y. Ihara, Y. Kaziro, T. Fujii, 1979, Journal of biochemistry.

Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

F. Kametani, Y. Ihara, M. Maeda, 2005, The Journal of Neuroscience.

Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.

M. Frosch, R. Tanzi, T. Tabira, 2000, Journal of Biological Chemistry.

Gem GTPase and Tau

N. Hirokawa, A. Harada, Mamoru Ito, 2004, Journal of Biological Chemistry.

Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin.

M. Hasegawa, Y. Ihara, E. Miyamoto, 1995, Journal of biochemistry.

Muscle fiber degeneration in distal myopathy with rimmed vacuole formation

Yasuo Ihara, Ikuya Nonaka, I. Nonaka, 2004, Acta Neuropathologica.

Accumulation of Tau in Autophagic Vacuoles in Chloroquine Myopathy

I. Nonaka, Y. Ihara, N. Murakami, 1998, Journal of neuropathology and experimental neurology.

Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease

Yasuo Ihara, Y. Ihara, N. Murakami, 1998, Neuroscience Research.

Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy

S. Mitani, Y. Ihara, S. Yoshimura, 2018, Front. Neurosci..

Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma.

Y. Ihara, N. Nukina, T. Shimoda, 1986, The American journal of pathology.

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease

N. Kitamura, A. Kakita, A. Miyashita, 2014, Translational Psychiatry.

Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain

Mamoru Ito, Y. Ihara, A. Takashima, 2018, The Journal of Neuroscience.

β‐Amyloid Protein Precursor and τ mRNA Levels Versus β‐Amyloid Plaque and Neurofibrillary Tangles in the Aged Human Brain

K. Titani, Y. Ihara, F. Oyama, 1993 .

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*)

K. Titani, M. Hasegawa, Y. Ihara, 1995, The Journal of Biological Chemistry.

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining

S. Hirai, M. Shoji, Y. Ihara, 2004, Acta Neuropathologica.

Alzheimer β Amyloid Deposition Enhanced by ApoE ϵ4 Gene Precedes Neurofibrillary Pathology in the Frontal Association Cortex of Nondemented Senior Subjects

Y. Ihara, H. Yamaguchi, S. Sugihara, 2001 .

Amyloid β‐protein deposition in the leptomeninges and cerebral cortex

Yasuo Ihara, Y. Ihara, K. Yanagisawa, 1997 .

Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain

T. Iwatsubo, Y. Ihara, K. Kanemaru, 1996, Neuroscience Letters.

Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population.

Y. Ihara, F. Oyama, H. Shimada, 1995, Brain research. Molecular brain research.

Research on Alzheimer's disease in Japan: a personal view on history and present status.

Y. Ihara, Yasuo Ihara, 1994, Archives of gerontology and geriatrics.

Identification of β protein precursor in newborn rat brain

K. Titani, M. Hasegawa, Y. Ihara, 1989 .

The car☐yl third of tau is tightly bound to paired helical filaments

Y. Ihara, H. Mori, T. Honda, 1988, Neuron.

Hyperphosphorylation of Tau in PHF

K. Titani, M. Hasegawa, Y. Ihara, 1995, Neurobiology of Aging.

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.

T. Kudo, M. Takeda, Y. Ihara, 2017, Cell reports.

γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment

Y. Ihara, S. Funamoto, M. Morishima-kawashima, 2009, The Journal of Neuroscience.

γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.

M. Takeda, Y. Ihara, K. Yanagida, 2013, Cell reports.

Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin.

Y. Ihara, Yutaka Suzuki, L. Jones, 2002, Cell calcium.

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

Y. Ihara, 1988, Brain Research.

Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis

Y. Ihara, S. Murayama, H. Mori, 1990, Annals of neurology.

Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, The American journal of pathology.

Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

D. Mann, T. Iwatsubo, Y. Ihara, 1995, Annals of neurology.

Accumulation of Amyloid β-Protein in the Low-Density Membrane Domain Accurately Reflects the Extent of β-Amyloid Deposition in the Brain

Y. Ihara, D. Schenk, K. Khan, 2001 .

PHF and PHF-like fibrils –cause or consequence?

Y. Ihara, 2001, Neurobiology of Aging.

Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.

Y. Ihara, T. Saido, K. Maruyama, 1994, The Journal of biological chemistry.

Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex

Y. Ihara, S. Murayama, M. Morishima-kawashima, 2005, Neurology.

Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex

T. Iwatsubo, M. Hasegawa, Y. Ihara, 1997, Neuroreport.

Dominant and differential deposition of distinct β-amyloid peptide species, Aβ N3(pE), in senile plaques

D. Mann, T. Iwatsubo, Y. Ihara, 1995, Neuron.

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

K Namekata, Y. Ihara, K. Namekata, 1998, The American journal of pathology.

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

D. Mann, T. Iwatsubo, Y. Ihara, 1995, Neuron.

Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation

Y. Ihara, M. Okochi, T. Ikeuchi, 2021, Translational Psychiatry.

Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

M. Miyajima, H. Arai, M. Shoji, 2012, EMBO molecular medicine.

Amyloid β-protein accumulation in the human brain during aging

Y. Ihara, M. Morishima-kawashima, 2001 .

Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation.

Y. Ihara, M. Morishima-kawashima, M. Yoshimura, 1999, The American journal of pathology.

Effects of Specific Protease Inhibitors on Amyloid β-Protein 42 Secretion

Y. Ihara, T. Yamazaki, 1998, Neurobiology of Aging.

SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.

N. Kitamura, A. Kakita, A. Miyashita, 2013, Journal of Alzheimer's disease : JAD.

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells

Y. Ihara, S. Funamoto, Mika Nobuhara, 2015, Acta Neuropathologica Communications.

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

S. Maeda, Y. Ihara, A. Takashima, 2015, Nature Communications.

One of the antigenic determinants of paired helical filaments is related to tau protein.

Y. Ihara, N. Nukina, 1986, Journal of biochemistry.

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

K. Titani, Y. Ihara, K. Takio, 1992 .

Effects of human apolipoprotein E isoforms on the amyloid β‐protein concentration and lipid composition in brain low‐density membrane domains

Xianlin Han, S. Fujita, Y. Ihara, 2007, Journal of neurochemistry.

Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels

Y. Ihara, A. Odaka, N. Suzuki, 1995 .

GAB2 is not associated with late-onset Alzheimer's disease in Japanese

Takashi Asada, Ichiro Kanazawa, Mikio Shoji, 2009, European Journal of Human Genetics.

Progressive neurodegeneration in C. elegans model of tauopathy

K. Gengyo-Ando, S. Mitani, Y. Ihara, 2005, Neurobiology of Disease.

Active γ-Secretase Complexes Contain Only One of Each Component*

B. de Strooper, M. Wolfe, Y. Ihara, 2007, Journal of Biological Chemistry.

Neural substrate for spatial memory in the monkey hippocampus

C. Tanaka, Y. Ihara, 2001 .

Association of transferrin C2 allele with late-onset Alzheimer’s disease

A. Terashi, M. Imagawa, Y. Ihara, 1997, Human Genetics.

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

K. Titani, M. Hasegawa, Y. Ihara, 1992, The Journal of biological chemistry.

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

F. Kametani, Y. Ihara, M. Maeda, 2005, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Posttranslational Modifications of the Tau in PHF: Phosphorylation and Ubiquitination

Y. Ihara, M. Morishima-kawashima, 1995 .

Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

Giovanni B. Frisoni, Alfredo Robles, Takeshi Iwatsubo, 1998 .

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Y. Ihara, S. Murayama, T. Nirasawa, 2017, Acta Neuropathologica Communications.

Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau

Y. Ihara, K. Tomoo, Y. Shinzaki, 2015, Journal of neurochemistry.

Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

Y. Ihara, H. Mori, Y Ihara, 1987, Science.

τ Is Widely Expressed in Rat Tissues

Y. Ihara, Yongjun Gu, F. Oyama, 1996 .

Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.

D. Selkoe, Y. Ihara, F. Salazar, 1982, Science.

SP-40,40 is a constituent of Alzheimer's amyloid

Y. Ihara, M. Takeda, T. Tobe, 1992, Acta Neuropathologica.

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

K. Titani, M. Hasegawa, Y. Ihara, 1993, Journal of neurochemistry.

The phosphorylation site of the tau in paired helical filaments: An immunochemical approach

Y. Ihara, J. Kondo, T. Hayase, 1990 .

Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments.

Y. Ihara, H. Mori, J. Kondo, 1990, Gerontology.

Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

Y. Ihara, K. Kitani, G. Ivy, 1989, Brain Research.

A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.

Y. Ihara, H. Mori, J. Kondo, 1989, Biochemical and biophysical research communications.

The N-terminal Portion of Growth Inhibitory Factor Is Sufficient for Biological Activity (*)

Y. Ihara, Y. Uchida, 1995, The Journal of Biological Chemistry.

Loss of Growth Inhibitory Factor in Degenerative Disease

N. Otsuka, Y. Ihara, Y. Uchida, 1995 .

Immunocytochemical study on senile plaques in Alzheimer's disease. II. Abnormal dendrites in senile plaques as revealed by antimicrotubule-associated proteins (MAPs) immunostaining.

Yasuo Ihara, Nobuyuki Nukina, Y. Ihara, 1983 .

Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.

T. Iwatsubo, Y. Ihara, K. Kanemaru, 1996, Neuroscience letters.

Distribution of endogenous normal tau in the mouse brain

Y. Ihara, A. Takashima, S. Murayama, 2018, The Journal of comparative neurology.

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Y. Ihara, S. Murayama, T. Nirasawa, 2017, Acta neuropathologica communications.

γ-Secretase activity is associated with Braak Senile Plaque stages.

Toshiharu Suzuki, K. Akazawa, Y. Ihara, 2020, The American journal of pathology.

Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics

T. Iwatsubo, M. Hasegawa, Y. Ihara, 2004, Acta Neuropathologica.

Amyloid beta-protein deposition in the leptomeninges and cerebral cortex.

Y. Ihara, K. Yanagisawa, M. Morishima-kawashima, 1997, Annals of neurology.

Immunocytochemical Study on Senile Plaques in Alzheimer's Disease. II

Yasuo Ihara, Nobuyuki Nukina, Y. Ihara, 1983 .

Visualization of Newly Deposited tau in Neurofibrillary Tangles and Neuropil Threads

D. Mann, R. Ravid, Y. Ihara, 2005, Journal of neuropathology and experimental neurology.

Blocking the cleavage at midportion between γ‐ and ε‐sites remarkably suppresses the generation of amyloid β‐protein

Y. Ihara, T. Saido, M. Morishima-kawashima, 2005 .

Curcumin improves tau-induced neuronal dysfunction of nematodes

S. Mitani, Y. Ihara, S. Yoshimura, 2016, Neurobiology of Aging.

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians

J. Haines, M. Pericak-Vance, G. Schellenberg, 2013, Alzheimer's & Dementia.

Collapsin Response Mediator Protein-2 Inhibits Neuronal Phospholipase D2 Activity by Direct Interaction*

Y. Goshima, Y. Ihara, S. Ryu, 2002, The Journal of Biological Chemistry.

Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.

I. Kanazawa, N. Kitamura, T. Asada, 2014, Journal of Alzheimer's disease : JAD.

[A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease].

H. Arai, M. Imagawa, M. Shoji, 2005, Rinsho shinkeigaku = Clinical neurology.

[Recent advances in Alzheimer's disease].

Y. Ihara, M. Morishima-kawashima, 2001, Seikagaku. The Journal of Japanese Biochemical Society.

Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules*

Y. Ihara, Yongjun Gu, 2000, The Journal of Biological Chemistry.

Association of primary hyperparathyroidism with myotonic dystrophy in two patients.

E. Ogata, Y. Ihara, S. Fukumoto, 1987, Archives of internal medicine.

105 ANTIBODIES TO THE FAIL TO REACT WITH NEUROFILAMENTS AND OTHER NORMAL PROTEINS

D. Selkoe, Y. Ihara, C. Abraham, 1983 .

Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

T. Tabira, Y. Ihara, W. Araki, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

Y. Ihara, S. Murayama, T. Nirasawa, 2019, Journal of visualized experiments : JoVE.

GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.

Y. Ihara, K. Yanagisawa, 1998, Neurobiology of aging.

Immunostaining of Oxidized DJ-1 in Human and Mouse Brains

E. Niki, K. Takahashi-Niki, H. Ariga, 2014, Journal of neuropathology and experimental neurology.

Inhibition by E-64-c of neurofilament degeneration induced by calcium ions

Y. Ihara, Y. Toyokura, H. Sugita, 1981 .

Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis

Y. Ihara, S. Murayama, H. Mori, 2004, Acta Neuropathologica.

Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques

S. Hirai, M. Shoji, Y. Ihara, 2004, Acta Neuropathologica.

Lewy Bodies: Purification from Diffuse Lewy Body Disease Brains a

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, Annals of the New York Academy of Sciences.

[Immunocytochemistry of Pick's argentophilic bodies: evidence for the involvement of high molecular weight microtubule-associated proteins (HMWP) before the appearance of tubulin].

Y. Ihara, N. Nukina, S. Murayama, 1985, Rinsho shinkeigaku = Clinical neurology.

Amyloid beta-protein (A beta) accumulation in the leptomeninges during aging and in Alzheimer disease.

Y. Ihara, K. Yanagisawa, M. Yoshimura, 1997, Journal of neuropathology and experimental neurology.

DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase†

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006 .

Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.

Y. Ihara, D. Schenk, K. Khan, 2001, The American journal of pathology.

Microglial cells and amyloid β protein (Aβ) deposition: association with Aβ40-plaques

D. Mann, T. Iwatsubo, Y. Ihara, 1995, Acta Neuropathologica.

[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people].

Y. Ihara, H. Shimada, Y. Toyokura, 1989, No to shinkei = Brain and nerve.

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

Y. Ihara, M. Morishima-kawashima, S. Ishiura, 2006, Biochemistry.

UBIQUITIN IN ALZHEIMER'S PAIRED HELICAL FILAMENTS: 2

Y. Ihara, H. Mori, J. Kondo, 1987 .

Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease.

Y. Ihara, M. Morishima-kawashima, T. Miyakawa, 1998, Journal of neuropathology and experimental neurology.

Tau is widely expressed in rat tissues.

Y. Ihara, F. Oyama, Y. Gu, 1996, Journal of Neurochemistry.

Staining of Alzheimer's Neurofibrillary Tangles with Antiserum against 200K Component of Neurofilament

Y. Ihara, N. Nukina, Y. Toyokura, 1981 .

Suspected limited efficacy of γ-secretase modulators

K. Akazawa, Y. Ihara, S. Murayama, 2013, Neurobiology of Aging.

Dissociation of β‐amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β‐amyloid‐42 assembly

E. Matsubara, M. Shoji, Y. Ihara, 2011, Journal of neuroscience research.

Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination.

K. Titani, N. Cairns, Y. Ihara, 1994, Journal of neurochemistry.

Polypeptide composition of paired helical filaments.

Y. Ihara, J. Kondo, 1989, Annals of medicine.

Ubiquitin: A Newly Identified Component of Paired Helical Filaments

Y. Ihara, H. Mori, J. Kondo, 1988 .

Curcumin Improves Tau-mediated Neuronal Dysfunction in Nematode

S. Mitani, Y. Ihara, S. Yoshimura, 2010, Alzheimer's & Dementia.

Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

J. Haines, M. Pericak-Vance, G. Schellenberg, 2013, PLoS ONE.

Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.

Y. Ihara, J. McLaurin, A. Chakrabartty, 1997, FEBS letters.

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.

I. Kanazawa, T. Asada, A. Kakita, 2006, Human molecular genetics.

Neurofibrillary tangles/paired helical filaments (1981-83).

Y. Ihara, 2006, Journal of Alzheimer's disease : JAD.

Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia.

S. Hirai, M. Shoji, Y. Ihara, 1990, Brain research.

[Alzheimer's paired helical filaments].

Y. Ihara, 1986, Rinsho shinkeigaku = Clinical neurology.

β-Amyloid Plaques and Dementia: An Immunohistochemical Study

Y. Ihara, S. Kuzuhara, H. Shimada, 1990 .

Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain.

K. Titani, Y. Ihara, F. Oyama, 1993, Journal of neurochemistry.