Alexander J. Valvezan

发表

Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

N. Perrimon, Bahar Yilmazel, Charles Roesel, 2015, Science Signaling.

Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

N. Perrimon, Yanhui Hu, B. Manning, 2017, bioRxiv.

Molecular Neuroscience Review Article Gsk-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

J. Beaulieu, Alexander J. Valvezan, O. Kaidanovich‐Beilin, 2022 .

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

N. Perrimon, D. Kwiatkowski, J. Asara, 2017, Cancer cell.

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

J. Asara, B. Manning, Alexander J. Valvezan, 2020, bioRxiv.

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

L. Cantley, G. Hoxhaj, B. Manning, 2014, Cell.

Novel roles for the tumor suppressor APC through regulation of GSK-3

Alexander J. Valvezan, 2013 .

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R

E. Henske, Alexander J. Valvezan, C. Priolo, 2017, Oncotarget.

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)

N. Perrimon, Yanhui Hu, B. Manning, 2017, Proceedings of the National Academy of Sciences.

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity*

Alexander J. Valvezan, J. Diehl, P. S. Klein, 2011, The Journal of Biological Chemistry.

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

C. Lengner, Alexander J. Valvezan, M. Pack, 2013, Disease Models & Mechanisms.

Molecular logic of mTORC1 signalling as a metabolic rheostat

B. Manning, Alexander J. Valvezan, 2019, Nature Metabolism.

Molecular logic of mTORC1 signalling as a metabolic rheostat

B. Manning, Alexander J. Valvezan, Alexander J Valvezan, 2019, Nature Metabolism.

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

Shane T. Jensen, Angela Nakauka-Ddamba, C. Lengner, 2015, Cell reports.

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice.

Alexander J. Valvezan, P. S. Klein, G. Berry, 2011, The Journal of clinical investigation.

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

X. Chen, W. Zong, Alexander J. Valvezan, 2022, The Journal of clinical investigation.

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

D. Kwiatkowski, E. Henske, Chin-Lee Wu, 2022, iScience.

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.

J. Asara, E. Henske, B. Manning, 2020, JCI insight.

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complex

J. Asara, E. Henske, B. Manning, 2019 .

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish

Ning Li, Christopher Joachim Lengner, Alexander J. Valvezan, 2023, Journal of developmental biology.

Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

N. Perrimon, Bahar Yilmazel, Yanhui Hu, 2015, Science Signaling.