P. McCarren

发表

The Drug Repurposing Hub: a next-generation drug library and information resource

Jacob K. Asiedu, Joshua A. Bittker, T. Golub, 2017, Nature Medicine.

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction

W. Sellers, D. Porter, P. McCarren, 2021, bioRxiv.

Origins of regioselectivity and alkene-directing effects in nickel-catalyzed reductive couplings of alkynes and aldehydes.

T. Jamison, K. Houk, P. McCarren, 2010, Journal of the American Chemical Society.

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

Ted Natoli, Aravind Subramanian, Carol A. Fierke, 2014, ACS chemical biology.

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.

W. Sellers, M. Drysdale, D. Porter, 2021, Journal of medicinal chemistry.

Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study.

K. Houk, E. Toone, P. McCarren, 2005, Journal of the American Chemical Society.

Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase

S. Schreiber, A. Joachimiak, F. Gusovsky, 2020, Protein science : a publication of the Protein Society.

Conformational studies of methyl 3-O-methyl-alpha-D-arabinofuranoside: an approach for studying the conformation of furanose rings.

P. McCarren, J. B. Houseknecht, T. Lowary, 2001, Journal of the American Chemical Society.

The photoarrangement of alpha-santonin is a single-crystal-to-single-crystal reaction: a long kept secret in solid-state organic chemistry revealed.

K. Houk, P. McCarren, C. Tsai, 2007, Journal of the American Chemical Society.

The Chemical Tuning of a Weak Zinc Binding Motif for Histone Deacetylase Using Electronic Effects

P. McCarren, L. Whitehead, M. Hall, 2012, Chemical biology & drug design.

Mechanism and transition-state structures for nickel-catalyzed reductive alkyne-aldehyde coupling reactions.

T. Jamison, K. Houk, P. McCarren, 2009, Journal of the American Chemical Society.

Synthesis of octyl arabinofuranosides as substrates for mycobacterial arabinosyltransferases.

P. McCarren, T. Lowary, R. Gadikota, 2003, Carbohydrate research.

Arabinofuranosyl Oligosaccharides from Mycobacteria: Synthesis and Effect of Glycosylation on Ring Conformation and Hydroxymethyl Group Rotamer Populations

F. D’Souza, P. McCarren, T. Lowary, 2000 .

Avoidance of the Ames test liability for aryl-amines via computation.

Peter Gedeck, Susanne Glowienke, Lewis Whitehead, 2011, Bioorganic & medicinal chemistry.

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

S. Schreiber, A. Joachimiak, P. McCarren, 2017, Nature chemical biology.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.

B. Wagner, N. Morgan, S. Richardson, 2016, ACS chemical biology.

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, E. Scolnick, P. McCarren, 2014, Chemical science.

An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

Clayton Springer, Lewis Whitehead, Patrick McCarren, 2011, J. Cheminformatics.

Computational methods for early predictive safety assessment from biological and chemical data

Meir Glick, Florian Nigsch, Ben Cornett, 2011, Expert opinion on drug metabolism & toxicology.

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35

W. Sellers, P. McCarren, D. Raymond, 2020, ACS medicinal chemistry letters.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.

P. McCarren, C. Garvie, M. Mesleh, 2017, Biochemistry.

Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).

G. Wei, M. Palmer, P. McCarren, 2014, ACS medicinal chemistry letters.

Nitroxyl disulfides, novel intermediates in transnitrosation reactions.

J. Stamler, K. Houk, E. Toone, 2003, Journal of the American Chemical Society.

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, L. Tsai, E. Scolnick, 2014, Chemical science.

Origins of regioselectivity and alkene-directing effects in nickel-catalyzed reductive couplings of alkynes and aldehydes.

T. Jamison, P. McCarren, Peng Liu, 2010, Journal of the American Chemical Society.