N. Kieffer

N. Kieffer, E. Papadimitriou, Constantinos M Mikelis, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structure of the human blood platelet membrane glycoprotein Ibα gene

R. Wenger, N. Kieffer, K. Clemetson, 1988 .

RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.

N. Kieffer, Saijuan Chen, P. Flevaris, 2008, Blood.

RGT, a synthetic peptide corresponding to the integrin (cid:1) 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin (cid:2) IIb (cid:1) 3 with Src kinase

N. Kieffer, P. Flevaris, Xiaoping Du, 2008 .

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.

J. George, N. Kieffer, P. Newman, 1986, The Journal of clinical investigation.

Fibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction.

N. Kieffer, S. Stevenson, R. Hantgan, 1990, The American journal of pathology.

Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor.

C. Legrand, W. Vainchenker, N. Kieffer, 1989, The Biochemical journal.

Aggregation of chymotrypsin-treated thrombasthenic platelets is mediated by fibrinogen binding to glycoproteins IIb and IIIa.

J. Soria, C. Soria, N. Kieffer, 1985, The Journal of laboratory and clinical medicine.

The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens

D. Mason, N. Kieffer, H. Turley, 1988, Histopathology.

Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein.

G. Lippens, H. Drobecq, N. Kieffer, 1999, The Journal of biological chemistry.

The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha.

R. Wenger, H. Hameister, N. Kieffer, 1989, Gene.

HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.

W. Ouwehand, N. Watkins, N. Kieffer, 2002, Blood.

Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis.

W. Vainchenker, N. Debili, N. Kieffer, 1990, Blood.

New hematopoietic differentiation antigens detected by anti-K562 monoclonal antibodies.

W. Vainchenker, N. Kieffer, T. Tursz, 1988, Cancer research.

Human megakaryocytopoiesis: in vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers.

W. Vainchenker, N. Kieffer, 1988, Blood reviews.

Up‐regulated expression of the β3 integrin and the 92‐kDa gelatinase in human HT‐144 melanoma cell tumors grown in nude mice

N. Kieffer, L. Kraus-Berthier, G. Tucker, 1996, International journal of cancer.

Identification of platelet membrane thrombospondin binding molecules using an anti-thrombospondin antibody.

N. Kieffer, M. Titeux, A. Nurden, 1988, Biochimica et biophysica acta.

Interplay between αvβ3 Integrin and Nucleolin Regulates Human Endothelial and Glioma Cell Migration*

D. Iliopoulos, U. Hellman, N. Kieffer, 2012, The Journal of Biological Chemistry.

A three amino acid deletion in glycoprotein IIIa is responsible for type I Glanzmann's thrombasthenia: importance of residues Ile325Pro326Gly327 for beta3 integrin subunit association.

N. Kieffer, M. Morel-Kopp, V. Jallu, 1997, Blood.

A Three Amino Acid Deletion in Glycoprotein IIIa Is Responsible for Type I Glanzmann’s Thrombasthenia: Importance of Residues IleProGly for b3 Integrin Subunit Association

N. Kieffer, M. Morel-Kopp, V. Jallu, 1997 .

Structure and function of platelet membrane glycoproteins

N. Kieffer, 1993 .

Interaction between the cytodomains of the alpha 3 and beta 1 integrin subunits regulates remodelling of adhesion complexes on laminin.

E. Laplantine, N. Kieffer, L. Vallar, 2000, Journal of cell science.

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: Its relationship to type β transforming growth factor (TGF‐β)

W. Vainchenker, N. Kieffer, U. Testa, 1988 .

Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events.

N. Kieffer, J. Guinet, S. Michels, 1996, Cell adhesion and communication.

Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-β1 stimulation

B. Janji, N. Kieffer, L. Vallar, 2000, Oncogene.

USE OF A MONOCLONAL ANTIBODY TO MEASURE THE SURFACE EXPRESSION OF THROMBOSPONDIN FOLLOWING PLATELET ACTIVATION

C. Legrand, N. Kieffer, A. Nurden, 1987, Thrombosis and Haemostasis.

The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions.

N. Kieffer, S. Kreis, B. Steiner, 2005, Experimental cell research.

PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association

N. Kieffer, Saijuan Chen, Zhu Chen, 2010, Proceedings of the National Academy of Sciences.

Monoclonal Antibody to Human Platelet Glycoprotein I II. EFFECTS ON HUMAN PLATELET FUNCTION

A. McMichael, N. Kieffer, L. Drouet, 1981, British journal of haematology.

RGD, the Rho'd to cell spreading.

N. Kieffer, Nelly Kieffer, E. Schaffner-Reckinger, 2006, European journal of cell biology.

Immunochemical characterization of the platelet-specific alloantigen Leka: a comparative study with the PlA1 alloantigen.

N. Kieffer, A. Nurden, D. Didry, 1984, Blood.

Surface modifications in the platelets of a patient with alpha-N-acetyl-D-galactosamine residues, the Tn-syndrome.

N. Kieffer, J. Cartron, A. Nurden, 1982, The Journal of clinical investigation.

Expression of platelet glycoprotein Ib alpha in HEL cells.

W. Vainchenker, N. Debili, N. Kieffer, 1986, The Journal of biological chemistry.

Residual amounts of glycoproteins IIb and IIIa may be present in the platelets of most patients with Glanzmann's thrombasthenia.

N. Kieffer, R. McEver, D. Didry, 1985, Blood.

Cyclic RGD peptide by ring-closing metathesis

Jean Martínez, N. Kieffer, F. Lamaty, 2002 .

The human platelet membrane glycoprotein complex GP IIb-IIIa expresses antigenic sites not exposed on the dissociated glycoproteins.

N. Kieffer, A. Nurden, D. Didry, 1984, Blood.

Expression of platelet membrane glycoproteins and alpha‐granule proteins by a human erythroleukemia cell line (HEL).

W. Vainchenker, J. Rosa, N. Kieffer, 1984, The EMBO journal.

macrothrombocytopenia cosegregates dominantly with abnormal proplatelet formation and integrin and 3 β IIb α membrane-proximal cytoplasmic salt bridge in the gene disrupts the conserved ITGB3 A nonsynonymous SNP in the

N. Watkins, N. Debili, J. Stephens, 2012 .

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.

W. Ouwehand, N. Watkins, W. Vainchenker, 2008, Blood.

Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis

J. Mossong, N. Kieffer, C. Margue, 2007, International journal of cancer.

A New Functional Role of the Fibrinogen RGD Motif as the Molecular Switch That Selectively Triggers Integrin αIIbβ3-dependent RhoA Activation during Cell Spreading*

N. Kieffer, E. Schaffner-Reckinger, S. Plançon, 2005, Journal of Biological Chemistry.

Structure of the human blood platelet membrane glycoprotein Ib alpha gene.

R. Wenger, N. Kieffer, K. Clemetson, 1988, Biochemical and biophysical research communications.

A calreticulin‐like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins

Matthias Eberl, Colin Berry, Grit Kasper, 2001, Parasite immunology.

The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions

N. Kieffer, S. Kreis, B. Steiner, 2005 .

Autocrine TGF‐β‐regulated expression of adhesion receptors and integrin‐linked kinase in HT‐144 melanoma cells correlates with their metastatic phenotype

B. Janji, N. Kieffer, L. Vallar, 1999, International journal of cancer.

Probing conformational changes in the I-like domain and the cysteine-rich repeat of human beta 3 integrins following disulfide bond disruption by cysteine mutations: identification of cysteine 598 involved in alphaIIbbeta3 activation.

N. Kieffer, N. Brons, J. Caen, 2001, The Journal of biological chemistry.

Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species.

N. Kieffer, M. Hatziapostolou, E. Papadimitriou, 2015, Microvascular research.

HPA-1 a phenotype – genotype discrepancy reveals a naturally occurring Arg 93 Gln substitution in the platelet b 3 integrin that disrupts the HPA-1 a epitope

W. Ouwehand, N. Watkins, N. Kieffer, 2002 .

Thrombasthenia-Like Syndrome Domain of the Integrin ?IIb Subunit in a Patient With a Glanzmann's R to Q Amino Acid Substitution in the GFFKR Sequence of the Cytoplasmic

N. Kieffer, O. Peyruchaud, L. Macchi, 2013 .

R to Q amino acid substitution in the GFFKR sequence of the cytoplasmic domain of the integrin IIb subunit in a patient with a Glanzmann's thrombasthenia-like syndrome.

N. Kieffer, P. Bray, A. Nurden, 1998, Blood.

Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.

N. Kieffer, D. Phillips, L. Fitzgerald, 1990, The Journal of biological chemistry.

Early erythroid markers as probes for normal and leukaemic erythroid differentiation.

W. Vainchenker, N. Kieffer, J. Villeval, 1987, Annales de l'Institut Pasteur. Immunology.

Uncoupling in the expression of platelet GP IIb/IIIa in human endothelial cells and K562 cells: absence of immunologic crossreactivity between platelet GP IIb and the vitronectin receptor alpha chain.

W. Vainchenker, N. Kieffer, M. Titeux, 1988, Blood.

a comparative study with the PlA1 alloantigen Immunochemical characterization of the platelet-specific alloantigen Leka:

N. Kieffer, J. Wautier, A. Nurden, 2011 .

Evidence that the Monoclonal Antibody an 51 is Directed Against Platelet Membrane Glycoprotein IB

A. McMichael, N. Kieffer, G. Tobelem, 1983 .

Early Immunization against Platelet Glycoprotein Ilia in a Newborn Glanzmann Type I Patient

P. Bierling, N. Kieffer, P. Fromont, 1988, Vox sanguinis.

The integrin β1 subunit cytoplasmic tail forms oligomers: a potential role in β1 integrin clustering

Emmanuel Laplantine, E. Laplantine, N. Kieffer, 2002 .

Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.

R. Wenger, N. Kieffer, A. Walz, 1989, Blood.

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor

V. Megalooikonomou, N. Kieffer, E. Papadimitriou, 2015, Molecular Cancer.

The Integrin Binding Site 2 (IBS2) in the Talin Rod Domain Is Essential for Linking Integrin β Subunits to the Cytoskeleton*

E. Goormaghtigh, N. Kieffer, Sophie Rodius, 2007, Journal of Biological Chemistry.

A Fluorescence Cell Biology Approach to Map the Second Integrin-binding Site of Talin to a 130-Amino Acid Sequence within the Rod Domain*

Stephanie Kreis, Johan Hoebeke, N. Kieffer, 2004, Journal of Biological Chemistry.

Adhesive Properties of the/ 3 Integrins: Comparison of GP IIb-IIIa and the Vitronectin Receptor Individually Expressed in Human Melanoma Cells

N. Kieffer, D. Wolf, D. Cheresh, 2002 .

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells

N. Kieffer, D. Wolf, D. Cheresh, 1991, The Journal of cell biology.

αIIbβ3‐integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′‐bisphosphate accumulation

N. Kieffer, B. Payrastre, C. Racaud-Sultan, 1996 .

alphaIIb beta 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3',4'-biphosphate accumulation.

N. Kieffer, B. Payrastre, C. Racaud-Sultan, 1996, FEBS letters.

Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding.

P. Gane, N. Kieffer, I. Callebaut, 2004, European journal of biochemistry.

The CXC-Chemokine CXCL4 Interacts with Integrins Implicated in Angiogenesis

N. Kieffer, A. Bikfalvi, K. Bujakowska, 2008, PloS one.

Colon cancer in Luxembourg: a national population-based data report, 1988–1998

N. Kieffer, P. Pescatore, R. Scheiden, 2003, BMC Cancer.

Probing Conformational Changes in the I-like Domain and the Cysteine-rich Repeat of Human β3 Integrins following Disulfide Bond Disruption by Cysteine Mutations

N. Kieffer, N. Brons, J. Caen, 2001, The Journal of Biological Chemistry.

Membrane-bound hemagglutinin mediates antibody and complement-dependent lysis of influenza virus-treated human platelets in autologous serum.

M. Kazatchkine, N. Kieffer, C. Lambré, 1984, The Journal of clinical investigation.

Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen.

D. Baruch, N. Kieffer, D. Schoevaert, 1998, Cell adhesion and communication.

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of αIIb or β3 allows the expression of a fully functional integrin αIIbβ3: effect of β3GFP on αIIbβ3 ligand binding

N. Kieffer, M. Morel-Kopp, E. Schaffner-Reckinger, 2001 .

ILK as a potential marker gene to ascertain specific adenocarcinoma cell mRNA isolation from frozen prostate biopsy tissue sections.

N. Kieffer, C. Margue, S. Plançon, 2005, International Journal of Oncology.

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta).

W. Vainchenker, N. Kieffer, U. Testa, 1988, Journal of Cellular Physiology.

Evidence from Site-directed Mutagenesis that the Cytoplasmic Domain of the b3 Subunit Influences the Conformational State of the avb3 Integrin Ectodomain

N. Kieffer, N. Brons, E. Schaffner-Reckinger, 2017 .

Overexpression of the partially activated αIIbβ3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule‐dependent proplatelet–like extensions in Chinese hamster ovary cells

W. Ouwehand, W. Vainchenker, N. Debili, 2009, Journal of thrombosis and haemostasis : JTH.

Human platelets express the SERCA2-b isoform of Ca(2+)-transport ATPase.

J. Rosa, N. Kieffer, F. Wuytack, 1992, The Biochemical journal.

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.

N. Kieffer, M. Morel-Kopp, E. Schaffner-Reckinger, 2001, The Biochemical journal.

Testicular cancer in Luxembourg: incidence and outcome in relation to the different histo-pathological types (1980-2004).

N. Kieffer, S. Lamy, R. Scheiden, 2008, Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg.

Platelet membrane glycoproteins: functions in cellular interactions.

N. Kieffer, D. Phillips, 1990, Annual review of cell biology.

Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21.

N. Kieffer, J. Villeval, A. Henri, 1989, Leukemia.

Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation.

M. Moniatte, N. Kieffer, M. Chignard, 1997, The Journal of biological chemistry.

platelets of most patients with Glanzmann's thrombasthenia Residual amounts of glycoproteins IIb and IIIa may be present in the

N. Kieffer, R. McEver, D. Didry, 2013 .