E. Abraham

发表

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

M. Levy, J. Marshall, S. Opal, 2003, Intensive care medicine.

Involvement of phosphatidylinositol 3-kinase γ in neutrophil apoptosis

R. Perng, E. Abraham, T. Pitts, 2003 .

Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury1

R. Shenkar, J. Penninger, E. Abraham, 2001, The Journal of Immunology.

Acute Lung Injury ofNeutrophil Activation and the Development Involvement of Phosphoinositide 3-Kinases in

R. Shenkar, J. Penninger, E. Abraham, 2001 .

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

N. Kaminski, J. Milošević, E. Abraham, 2010 .

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

N. Kaminski, J. Milošević, E. Abraham, 2010, The Journal of experimental medicine.

EARLY RENAL ISCHEMIA, WITH OR WITHOUT REPERFUSION, ACTIVATES NFκB AND INCREASES TNF-α BIOACTIVITY IN THE KIDNEY

R. Shenkar, A. Harken, E. Abraham, 2000 .

Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock.

E. Abraham, M. Schwartz, J. Repine, 1995, American journal of respiratory cell and molecular biology.

Hemorrhage and resuscitation induce alterations in cytokine expression and the development of acute lung injury.

R. Shenkar, W. Coulson, E. Abraham, 1994, American journal of respiratory cell and molecular biology.

Cardiorespiratory patterns in viral septicemia.

D. Winston, E. Abraham, D. Okrent, 1987, The American journal of medicine.

Continuous monitoring of tissue pH with a fiberoptic conjunctival sensor.

E. Abraham, D. Markle, S. Fink, 1985, Annals of emergency medicine.

Severe sepsis and septic shock: review of the literature and emergency department management guidelines.

David T. Huang, S. Trzeciak, T. Osborn, 2006, Annals of emergency medicine.

HMG-1 as a late mediator of endotoxin lethality in mice.

K. Tracey, L. Borovikova, S. Ivanova, 1999, Science.

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines1

E. Abraham, Zhiwei Xu, Yonggang Sha, 2008, The Journal of Immunology.

High mobility group box 1 protein interacts with multiple Toll-like receptors.

E. Abraham, S. Yamada, I. Maruyama, 2006, American journal of physiology. Cell physiology.

Studying a Study and Testing a Test

E. Abraham, 1983 .

Postoperative monitoring of conjunctival oxygen tension and temperature

E. Abraham, S. Fink, E Abraham, 1988, International journal of clinical monitoring and computing.

Tuberculosis, nontuberculous lung infection, pleural disorders, pulmonary function, respiratory muscles, occupational lung disease, pulmonary infections, and social issues in AJRCCM in 2004.

F. Martinez, D. Angus, W. MacNee, 2005, American journal of respiratory and critical care medicine.

Edward Abraham, Pearl Toy, A. Nathens, 2005, Critical care medicine.

Hemorrhage induces rapid in vivo activation of CREB and NF-kappaB in murine intraparenchymal lung mononuclear cells.

R. Shenkar, E. Abraham, 1997, American journal of respiratory cell and molecular biology.

Extracellular superoxide dismutase attenuates lung injury after hemorrhage.

R. Bowler, J. Slot, E. Abraham, 2001, American journal of respiratory and critical care medicine.

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Mitchell M. Levy, Edward Abraham, John C. Marshall, 2003, Intensive Care Medicine.

Coagulation abnormalities in acute lung injury and sepsis.

E. Abraham, 2000, American journal of respiratory cell and molecular biology.

HMGB1 contributes to the development of acute lung injury after hemorrhage.

I. Douglas, E. Abraham, K. Asehnoune, 2005, American journal of physiology. Lung cellular and molecular physiology.

H. Tiwari, Nianjun Liu, E. Abraham, 2012, Annals of human genetics.

The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States*

M. Levy, N. MacIntyre, M. Shabot, 2004, Critical care medicine.

Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004.

I. Pavord, W. MacNee, S. Wenzel, 2005, American journal of respiratory and critical care medicine.

The Effects of Hemorrhage and Trauma on Interleukin 2 Production

E. Abraham, R. Regan, 1985 .

Toward new paradigms in critical care research.

E. Abraham, 2009, Critical care medicine.

Involvement of Vitronectin in Lipopolysaccaride-Induced Acute Lung Injury1

E. Abraham, Gang Liu, G. Siegal, 2007, The Journal of Immunology.

Involvement of PKCα/β in TLR4 and TLR2 dependent activation of NF-κB

E. Abraham, K. Asehnoune, D. Strassheim, 2005 .

Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis

E. Abraham, M. Zerfaoui, A. Friggeri, 2012, Molecular medicine.

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin.

E. Abraham, Gang Liu, A. Friggeri, 2010, American journal of physiology. Cell physiology.

HMGB 1 inhibits macrophage activity in efferocytosis through binding to the v 3-integrin

E. Abraham, Gang Liu, A. Friggeri, 2010 .

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine1

E. Abraham, Gang Liu, Young‐Jun Park, 2008, The Journal of Immunology.

S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function*

E. Abraham, J. Zmijewski, Sami Banerjee, 2009, The Journal of Biological Chemistry.

Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism

E. Abraham, D. Chaplin, H. Bae, 2012, Molecular Medicine.

Conjunctival and transcutaneous oxygen monitoring during cardiac arrest and cardiopulmonary resuscitation

E. Abraham, L. Silver, M. Smith, 1984, Critical care medicine.

Detection of blood volume deficits through conjunctival oxygen tension monitoring

R. Oye, E. Abraham, M. Smith, 1984, Critical care medicine.

Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS.

E. Abraham, T. Fingerlin, K. Malcolm, 2017, American journal of physiology. Lung cellular and molecular physiology.

Variant IL-1 Receptor-Associated Kinase-1 Mediates Increased NF-κB Activity1

E. Abraham, Gang Liu, Young‐Jun Park, 2007, The Journal of Immunology.

Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.

E. Abraham, Gang Liu, Young‐Jun Park, 2007, Journal of immunology.

Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis.

E. Abraham, 2000, Critical care medicine.

Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis

J. Dhainaut, E. Abraham, Mark D. Williams, 2008, Critical care.

Better infrastructure: Industry–academia partnerships—A marriage of convenience?

E. Abraham, 2009, Critical care medicine.

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?

E. Abraham, H. Dupont, E. Lorne, 2010, Intensive Care Medicine.

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4.

K. Tracey, Huan Yang, E. Abraham, 2013, American journal of physiology. Lung cellular and molecular physiology.

The Role of Leptin in the Development of Pulmonary Neutrophilia in Infection and Acute Lung Injury*

Catherine M. Hayes, E. Wouters, J. Tavernier, 2014, Critical care medicine.

Year in review in Critical Care, 2004: sepsis and multi-organ failure

E. Abraham, N. Ali, J. O'Brien, 2005, Critical care.

Erratum: Targeted β2-Agonist Therapy

E. Abraham, 2005 .

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.

E. Abraham, Gang Liu, E. Lorne, 2008, American journal of physiology. Lung cellular and molecular physiology.

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group.

S. Nasraway, R. Wunderink, A. Anzueto, 1998, Lancet.

GENETIC POLYMORPHISMS AND SEPSIS

E. Abraham, M. Fessler, J. Arcaroli, 2005, Shock.

Modulation of SCFβ-TrCP-dependent IκBα Ubiquitination by Hydrogen Peroxide*

E. Abraham, Gang Liu, E. Lorne, 2009, The Journal of Biological Chemistry.

Continuous monitoring of critically ill patients with transcutaneous oxygen and carbon dioxide and conjunctival oxygen sensors.

E. Abraham, L. Silver, M. Smith, 1984, Annals of emergency medicine.

IMMUNOMODULATION AND SEPSIS: IMPACT OF THE PATHOGEN

E. Abraham, P. Moine, 2004, Shock.

Erratum: ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases

E. Abraham, 2007 .

Cystic fibrosis, pediatrics, control of breathing, pulmonary physiology and anatomy, and surfactant biology in AJRCCM in 2004.

W. MacNee, E. Abraham, F. Accurso, 2005, American journal of respiratory and critical care medicine.

Acid suppression in a critical care environment: state of the art and beyond.

E. Abraham, 2002, Critical care medicine.

When is a negative phase II trial truly negative?

G. Rubenfeld, E. Abraham, 2008, American journal of respiratory and critical care medicine.

Effectiveness of medical resident education in mechanical ventilation.

J. Garrett, Jesse B. Hall, E. Ely, 2003, American journal of respiratory and critical care medicine.

Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group.

L. Nelson, E. Fletcher, E. Abraham, 1999, Critical care medicine.

Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome.

R. Shenkar, E. Moore, F. Moore, 1996, Critical care medicine.

clinical investigations in critical care-Cardiorespiratory Effects of Pressure Controlled Ventilation in Severe Respiratory Failure *

E. Abraham, G. Yoshihara, Gary, 2006 .

Effects of Inverse-Ratio Ventilation on Cardiorespiratory Measurements in Severe Respiratory Failure

E. Abraham, Kevin M. Chan, 1994 .

Involvement of the Urokinase Kringle Domain in Lipopolysaccharide-Induced Acute Lung Injury1

E. Abraham, D. Cines, K. Bdeir, 2006, The Journal of Immunology.

Acute Lung Injury Domain in Lipopolysaccharide-Induced Involvement of the Urokinase Kringle Cines

E. Abraham, D. Cines, K. Bdeir, 2006 .

Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans.

T. van der Poll, E. Abraham, J. Nick, 2005, American journal of respiratory and critical care medicine.

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

A. Sauaia, E. Moore, E. Abraham, 2009, Shock.

Interstitial lung disease, lung cancer, lung transplantation, pulmonary vascular disorders, and sleep-disordered breathing in AJRCCM in 2004.

F. Martinez, D. Angus, Y. Miller, 2005, American journal of respiratory and critical care medicine.

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.

M. Netea, S. Girardin, E. Abraham, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Year in review in Intensive Care Medicine—2003

M. Antonelli, S. Nava, P. Metnitz, 2004, Intensive Care Medicine.

Year in review in Intensive Care Medicine—2003

M. Antonelli, S. Nava, P. Metnitz, 2004, Intensive Care Medicine.

Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.

E. Abraham, E. Lorne, J. Zmijewski, 2009, American journal of physiology. Lung cellular and molecular physiology.

Participation of superoxide in neutrophil activation and cytokine production.

E. Abraham, Sanchayita Mitra, 2006, Biochimica et biophysica acta.

Environmental health and the AJRCCM.

E. Abraham, B. Nemery, 2005, American journal of respiratory and critical care medicine.

Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness

A. Gaggar, C. Weaver, E. Abraham, 2011, Mucosal Immunology.

A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis.

E. Abraham, C. Dinarello, R. Rodriguez, 2006, The American journal of emergency medicine.

Alterations in the human lung proteome with lipopolysaccharide

R. Bowler, E. Abraham, N. Reisdorph, 2009, BMC pulmonary medicine.

Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing.

E. Abraham, H. Bae, J. Tadié, 2012, American journal of physiology. Cell physiology.

The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine

E. Abraham, 2007 .

Serum Estradiol Levels Predict Survival and Acute Kidney Injury in Patients with Septic Shock- A Prospective Study

E. Abraham, Kuang-Yao Yang, Kuan-Ting Liu, 2014, PloS one.

Critical care in AJRCCM 2004.

D. Angus, W. MacNee, F. Lemaire, 2005, American journal of respiratory and critical care medicine.

Corticosteroids and septic shock.

E. Abraham, T. Evans, 2002, JAMA.

Hemodynamic and oxygen transport patterns in surviving and nonsurviving postoperative patients

W. Shoemaker, E. Abraham, R. Bland, 1985, Critical care medicine.

Elevated levels of NO are localized to distal airways in asthma.

N. Fineberg, A. Gaggar, M. Dransfield, 2011, Free radical biology & medicine.

NF-κB activation

E. Abraham, 2000 .

Neutrophil apoptosis in the lung after hemorrhage or endotoxemia: apoptosis and migration are independent of IL-1beta.

R. Shenkar, E. Abraham, M. Parsey, 1999, Clinical immunology.

Effects of lisofylline on hyperoxia-induced lung injury.

G. Fantuzzi, E. Abraham, C. George, 1999, American journal of physiology. Lung cellular and molecular physiology.

Effects of lisofylline on hyperoxia-induced lung injury

G. Fantuzzi, E. Abraham, C. George, 1999 .

Future Clinical Trials of Pharmacologic Interventions

E. Abraham, 1998 .

Effects of treatment with the 21-aminosteroid, U7438F, on pulmonary cytokine expression following hemorrhage and resuscitation.

R. Shenkar, E. Abraham, 1995, Critical care medicine.

Anti-transforming growth factor-beta monoclonal antibodies prevent lung injury in hemorrhaged mice.

R. Shenkar, W. Coulson, E. Abraham, 1994, American journal of respiratory cell and molecular biology.

Immunologic mechanisms underlying sepsis in the critically ill surgical patient.

E. Abraham, 1985, The Surgical clinics of North America.

Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury.

R. Bowler, J. Crapo, E. Abraham, 2003, American journal of physiology. Lung cellular and molecular physiology.

Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis.

E. Abraham, Gang Liu, N. Xie, 2017, American journal of physiology. Lung cellular and molecular physiology.

Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes.

R. Shenkar, E. Abraham, R. Tuder, 1996, Journal of immunology.

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury.

R. Shenkar, E. Abraham, J. Arcaroli, 2000, American journal of physiology. Lung cellular and molecular physiology.

AMP‐activated protein kinase enhances the phagocytic ability of macrophages and neutrophils

E. Abraham, D. Chaplin, S. Takashima, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Conferences and Reviews Therapies for Sepsis Emerging Therapies for Sepsis and Septic Shock

E. Abraham, Discussant, E. Harris, 2005 .

PAI-1 inhibits neutrophil efferocytosis

E. Abraham, Gang Liu, E. Lorne, 2008, Proceedings of the National Academy of Sciences.

Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK–mediated pathway

E. Abraham, V. Ploplis, D. Cines, 2006, Thrombosis and Haemostasis.

HMGB 1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

K. Tracey, Huan Yang, E. Abraham, 2013 .

Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.

E. Abraham, Gang Liu, E. Lorne, 2009, American journal of respiratory and critical care medicine.

Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis

E. Abraham, S. Yamada, I. Maruyama, 2006, World Journal of Surgery.

Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.

E. Abraham, Gang Liu, D. Cines, 2010, American journal of respiratory and critical care medicine.

The kringle domain of urokinase‐type plasminogen activator potentiates LPS‐induced neutrophil activation through interaction with αVβ3 integrins

E. Abraham, D. Cines, K. Bdeir, 2005 .

Urokinase-Type Plasminogen Activator Potentiates Lipopolysaccharide-Induced Neutrophil Activation1

E. Abraham, S. Shetty, M. Gyetko, 2003, The Journal of Immunology.

Urokinase-Type Plasminogen Activator Potentiates Lipopolysaccharide-Induced Neutrophil Activation 1

E. Abraham, S. Shetty, M. Gyetko, 2003 .

Haemorrhage produces depressions in alloantigen‐specific immune responses in the mouse through activation of suppressor T cells

E. Abraham, M. Jagels, Y. H. Chang, 1990, Clinical and experimental immunology.

NF-kappaB activation.

E. Abraham, 2000, Critical care medicine.

Pulmonary edema fluid antioxidants are depressed in acute lung injury

R. Bowler, E. Chan, E. Abraham, 2003, Critical care medicine.

Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease.

A. Gaggar, M. Dransfield, E. Abraham, 2015, The Journal of allergy and clinical immunology.

Management of the agitated intensive care unit patient.

Edward Abraham, Joseph F. Dasta, I. L. Cohen, 2002, Critical care medicine.

Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB.

E. Abraham, K. Asehnoune, D. Strassheim, 2005, Cellular signalling.

Effects of therapy with soluble tumour necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation

W. Coulson, E. Abraham, M. Schwartz, 1994, Clinical and experimental immunology.

This information is current as of Macrophages by Targeting IL-10 miR-27 a Regulates Inflammatory Response Thannickal

E. Abraham, M. Fu, V. Thannickal, 2014 .

Neutrophils are major contributors to intraparenchymal lung IL-1 beta expression after hemorrhage and endotoxemia.

E. Abraham, R. Tuder, M. Parsey, 1998, Journal of immunology.

Hemorrhage activates myocardial NFkappaB and increases TNF-alpha in the heart.

R. Shenkar, A. Harken, E. Abraham, 1997, Journal of molecular and cellular cardiology.

Participation of the urokinase receptor in neutrophil efferocytosis.

E. Abraham, Gang Liu, E. Lorne, 2009, Blood.

Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response.

E. Abraham, 1992, Vaccine.

Anemia and blood transfusion in trauma patients admitted to the intensive care unit.

M. Levy, N. MacIntyre, M. Shabot, 2003, The Journal of trauma.

Erratum: Prevalence of Chronic Obstructive Pulmonary Disease in China

E. Abraham, 2007 .

Haemorrhage‐induced alterations in function and cytokine production of T cells and T cell subpopulations

E. Abraham, Y. Chang, Y. Chang, 1992, Clinical and experimental immunology.

Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation.

E. Abraham, A. Freitas, 1989, Journal of immunology.

Cardiorespiratory effects of pressure controlled inverse ratio ventilation in severe respiratory failure.

E. Abraham, G. Yoshihara, Gary Yoshihara, 1989, Chest.

Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia.

R. Shenkar, E. Abraham, J. Arcaroli, 2001, American journal of physiology. Lung cellular and molecular physiology.

Sequential cardiorespiratory patterns in septic shock

W. Shoemaker, E. Abraham, R. Bland, 1983, Critical care medicine.

Phagocytosis of Apoptotic Neutrophils High Mobility Group Protein-1 Inhibits

E. Abraham, E. Lorne, Y. Tsuruta, 2008 .

Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein.

R. Shenkar, E. Abraham, E. Abraham, 1999, Journal of immunology.

Central venous catheterization in the emergency setting

E. Abraham, S. Podolsky, M. Shapiro, 1983, Critical care medicine.

A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia

R. Wunderink, S. Opal, E. Abraham, 2009, Critical care.

miR-145 regulates myoﬁbroblast differentiation and lung ﬁbrosis

E. Abraham, Gang Liu, N. Xie, 2013 .

Modulation of bone marrow-derived neutrophil signaling by H 2 O 2 : disparate effects on kinases, NF- (cid:1) B, and cytokine expression

E. Abraham, K. Asehnoune, J. Arcaroli, 2004 .

Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages

E. Abraham, H. Bae, V. Thannickal, 2013, The Journal of Immunology.

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production.

E. Abraham, Gang Liu, H. Dupont, 2008, American journal of physiology. Cell physiology.

Human models of endotoxemia and recombinant human activated protein C

E. Abraham, J. O'Brien, 2004, Critical care medicine.

NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome.

R. McIntyre, R. Shenkar, E. Abraham, 2000, Shock.

Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation.

E. Abraham, R. Tuder, G. Jesmok, 1995, Critical care medicine.

Respiratory Syncytial Virus Inhibits Lung Epithelial Na+ Channels by Up-regulating Inducible Nitric-oxide Synthase*

S. Matalon, E. Abraham, Gang Liu, 2009, Journal of Biological Chemistry.

ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: One-year safety and efficacy evaluation*

E. Abraham, P. Laterre, F. Booth, 2007, Critical care medicine.

Futility of randomized, controlled ARDS trials--a new approach is needed.

R. Dellinger, E. Abraham, B. Fuhrman, 1999, Critical care medicine.

Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF- (cid:1) B activation requires cytosolic and nuclear activity

E. Abraham, Gang Liu, Young-Jun Park, 2008 .

Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.

M. Netea, Young Yang, E. Abraham, 2007, Journal of microbiology and biotechnology.

Alterations in cell signaling in sepsis.

E. Abraham, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Hemorrhage-induced acute lung injury is TLR-4 dependent.

R. McIntyre, A. Harken, E. Abraham, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB 1

E. Abraham, K. Asehnoune, D. Strassheim, 2004, The Journal of Immunology.

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB 1

E. Abraham, K. Asehnoune, D. Strassheim, 2004, The Journal of Immunology.

formation through interactions with Toll-like receptor 4 HMGB1 promotes neutrophil extracellular trap

K. Tracey, E. Abraham, H. Bae, 2013 .

HMGB1 PROMOTES NEUTROPHIL EXTRACELLULAR TRAP FORMATION

K. Tracey, Huan Yang, E. Abraham, 2013 .

Non-septic Acute Lung Injury and Inflammation: Role of TLR4

E. Abraham, H. Dupont, E. Lorne, 2009 .

Exposure to hydrogen peroxide diminishes NF- (cid:1) B activation, I (cid:1) B- (cid:2) degradation, and proteasome activity in neutrophils

E. Abraham, Zhiwei Xu, J. Zmijewski, 2007 .

Effects of Critical Illness on Macrophage, T and B Cell Function

E. Abraham, 1993 .

Akt/protein kinase B.

E. Abraham, 2005, Critical care medicine.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis GSK3 -dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury

K. Inoki, E. Abraham, G. Siegal, 2014 .

Purification and characterization of intraparenchymal lung lymphocytes.

A. Coutinho, E. Abraham, A. Freitas, 1990, Journal of immunology.

Clinical sepsis trials.

E. Abraham, 1994, Chest.

Pharmacokinetics of Intravenous and Oral Levofloxacin in Critically Ill Adults in a Medical Intensive Care Unit

E. Abraham, D. Fish, J. Rebuck, 2002, Pharmacotherapy.

Inhibition of Neutrophil Apoptosis by Pai-1

E. Abraham, D. Chaplin, H. Bae, 2022 .

Anticoagulants for acute lung injury: barking up the wrong tree.

E. Abraham, 2009, Critical care medicine.

The dichotomy of inhibiting nuclear factor kappa-B in pneumonia

E. Abraham, 2013, Critical Care.

β-Adrenergic Agonist Therapy as a Potential Treatment for Acute Lung Injury

E. Abraham, M. Matthay, 2006 .

Innate Immune Dysfunction in Trauma Patients: From Pathophysiology to Treatment

E. Abraham, K. Asehnoune, A. Roquilly, 2012, Anesthesiology.

The C‐terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis

E. Abraham, Gang Liu, A. Friggeri, 2010, Journal of leukocyte biology.

Expression of interleukin-18 in the lung after endotoxemia or hemorrhage-induced acute lung injury.

G. Fantuzzi, E. Abraham, P. Arndt, 2000, American journal of respiratory cell and molecular biology.

Systemic blood loss affects NF-kappa B regulatory mechanisms in the lungs.

R. Shenkar, E. Abraham, Y. le Tulzo, 1997, The American journal of physiology.

Systemic blood loss affects NF‐&kgr;B regulatory mechanisms in the lungs: 74

R. Shenkar, E. Abraham, Y. le Tulzo, 1997 .

Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia

E. Abraham, T. Pitts, Kuang-Yao Yang, 2002, Journal of leukocyte biology.

Role of p38 MAP kinase in the development of acute lung injury.

J. Park, E. Abraham, J. Arcaroli, 2001, Clinical immunology.

Phosphoinositide 3-Kinase and Akt Occupy Central Roles in Inflammatory Responses of Toll-Like Receptor 2-Stimulated Neutrophils1

E. Abraham, K. Asehnoune, D. Strassheim, 2004, The Journal of Immunology.

Toll-Like Receptor 2-Stimulated Neutrophils Central Roles in Inflammatory Responses of Phosphoinositide 3-Kinase and Akt Occupy

E. Abraham, K. Asehnoune, D. Strassheim, 2004 .

Plasma from hemorrhaged mice activates CREB and increases cytokine expression in lung mononuclear cells through a xanthine oxidase-dependent mechanism.

R. Shenkar, E. Abraham, 1996, American journal of respiratory cell and molecular biology.

Protein Cyclic AMP Response Element Binding B , and κ Reactive Oxygen Intermediates , NF-After Hemorrhage or Endotoxemia : Roles of Mechanisms of Lung Neutrophil Activation

R. Shenkar, E. Abraham, 1999 .

The Receptor for Urokinase Regulates TLR2 Mediated Inflammatory Responses in Neutrophils

E. Abraham, Gang Liu, A. Friggeri, 2011, PloS one.

Introduction: Acute Lung Injury

E. Abraham, L. Terada, 1999 .

Extracellular Histones Inhibit Efferocytosis

E. Abraham, Gang Liu, M. Zerfaoui, 2012, Molecular medicine.

Participation of the Receptor for Advanced Glycation End Products in Efferocytosis

E. Abraham, Gang Liu, A. Friggeri, 2011, The Journal of Immunology.

Hemorrhage Activates Myocardial NF?B and Increases TNF-a in the Heart

R. Shenkar, A. Harken, E. Abraham, 1997 .

Corticosteroids and the neutrophil: cutting both ways.

E. Abraham, 1999, Critical care medicine.

Anti-TNF Therapies

E. Abraham, 1999 .

Neutralizing antibodies and receptor constructs

E. Abraham, 1999 .

Involvement of SHIP in TLR2-Induced Neutrophil Activation and Acute Lung Injury1

E. Abraham, D. Strassheim, Jae-Yeol Kim, 2005, The Journal of Immunology.

InjuryNeutrophil Activation and Acute Lung Involvement of SHIP in TLR 2-Induced

E. Abraham, D. Strassheim, Sanchayita Mitra, 2005 .

Activation of Extracellular Signal-Regulated Kinases, NF-κB, and Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein in Lung Neutrophils Occurs by Differing Mechanisms After Hemorrhage or Endotoxemia1

R. Shenkar, E. Abraham, J. Arcaroli, 2001, The Journal of Immunology.

Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation.

R. Shenkar, E. Abraham, D. Kaneko, 1999, The American journal of physiology.

Peripheral Blood Neutrophil Activation Patterns Are Associated with Pulmonary Inflammatory Responses to Lipopolysaccharide in Humans1

E. Abraham, J. Nick, C. Dinarello, 2006, The Journal of Immunology.

This information is current as Lipopolysaccharide in Humans Inflammatory Responses to Patterns Are Associated with Pulmonary Peripheral Blood Neutrophil Activation

E. Abraham, J. Nick, C. Dinarello, 2006 .

From mouse to man: or what have we learned about cytokine-based anti-inflammatory therapies?

K. Tracey, E. Abraham, Kevin J Tracey, 1999, Shock.

High Mobility Group Box-1 protein ( HMGB 1 ) interacts with multiple Toll like receptors

E. Abraham, S. Yamada, I. Maruyama, 2005 .

Erratum: T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma.

E. Abraham, 2009 .

Clinical and translational medicine: Integrative and practical science.

F. Marincola, E. Abraham, Zhi-nan Chen, 2012, Clinical and Translational Medicine.

Anti-Cytokine Therapy

E. Abraham, Edward Abraham, 2002 .

Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury.

J. Takeda, E. Abraham, S. Yamada, 2006, American journal of respiratory and critical care medicine.

Reply to Kuriyama and Urushidani.

E. Abraham, K. Asehnoune, E. Marret, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial.

S. Opal, S. Lowry, G. Slotman, 2003, Critical care medicine.

EfferocytosisIntracellular HMGB1 Negatively Regulates

E. Abraham, Gang Liu, J. Zmijewski, 2022 .

p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group.

H. Bruining, T. Butler, K. Kudsk, 1997, JAMA.

Intranasal immunization with liposomes containing IL-2 enhances bacterial polysaccharide antigen-specific pulmonary secretory antibody response.

E. Abraham, S. Shah, 1992, Journal of immunology.

Differing Mechanisms After Hemorrhage or Protein in Lung Neutrophils Occurs by-Monophosphate Response Element-Binding ′ B , and Cyclic Adenosine 5 κ Kinases , NF-Activation of Extracellular Signal-Regulated

R. Shenkar, E. Abraham, J. Arcaroli, 2000 .

Derivation of a Myeloid Cell-Binding Adenovirus for Gene Therapy of Inflammation

D. Curiel, E. Abraham, S. Gerson, 2012, PloS one.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

Oral immunization with bacterial polysaccharide and adjuvant enhances antigen-specific pulmonary secretory antibody response and resistance to pneumonia.

E. Abraham, A. Robinson, 1991, Vaccine.

Do coagulation abnormalities contribute to sepsis associated organ failure?

E. Abraham, 2006, Critical care medicine.

Transfer of T or CD8+ cells from hemorrhaged mice produce alterations in bacterial antigen specific plasma cell repertoires in normal syngeneic recipients.

E. Abraham, A. Freitas, Y. Chang, 1990, Immunobiology.

Lipopolysaccaride-Induced Acute Lung Involvement of Vitronectin in and Edward

E. Abraham, Gang Liu, G. Siegal, 2007 .

Neutrophil apoptosis in the lung after hemorrhage or endotoxemia: apoptosis and migration are independent of interleukin-1beta.

R. Shenkar, E. Abraham, M. Parsey, 1999, Chest.

Fish and Edward Abraham Tube to Seriously Ill Patients Suspension Administered via Nasogastric Pharmacokinetics of a Clarithromycin

E. Abraham, D. Fish, 1999 .

Effects of therapy with interleukin-1 receptor antagonist on pulmonary cytokine expression following hemorrhage and resuscitation.

E. Abraham, J. Allbee, 1994, Lymphokine and cytokine research.

Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.

E. Abraham, D. Chaplin, H. Bae, 2012, American journal of respiratory cell and molecular biology.

Elevated levels of soluble ICAM-1 correlate with the development of multiple organ failure in severely injured trauma patients.

E. Abraham, H. Cryer, M. Law, 1994, The Journal of trauma.

Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis.

E. Abraham, J. Arcaroli, J. Kupfner, 2001, Journal of immunology.

Microbiologic findings and correlations with serum tumor necrosis factor-alpha in patients with severe sepsis and septic shock.

E. Abraham, J. Cohen, E. Abraham, 1999, The Journal of infectious diseases.

Temporal patterns of hemodynamics, oxygen transport, cytokine activity, and complement activity in the development of adult respiratory distress syndrome after severe injury.

W. Shoemaker, E. Abraham, P. Meade, 1994, The Journal of trauma.

Sequential cardiorespiratory patterns in septic shock.

W. Shoemaker, E. Abraham, R. Bland, 1983 .

Physiologic stress and cellular ischemia: Relationship to immunosuppression and susceptibility to sepsis

E. Abraham, 1991, Critical care medicine.

Hemodynamic and oxygen transport monitoring to titrate therapy in septic shock.

W. Shoemaker, E. Abraham, H. Kram, 1993, New horizons.

Year in review in intensive care medicine: 2003. II. Brain injury, hemodynamics, gastrointestinal tract, renal failure, metabolism, trauma, and postoperative

M. Antonelli, S. Nava, P. Metnitz, 2004, Intensive Care Medicine.

Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit.

Marek Ancukiewicz, Chirag R Parikh, Edward Abraham, 2005, Journal of the American Society of Nephrology : JASN.

Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.

R. Perng, E. Abraham, T. Pitts, 2003, Cellular signalling.

Clinical evaluation of a multiparameter intra-arterial blood-gas sensor

E. Abraham, S. Fink, T. Gallagher, 1996, Intensive Care Medicine.

Sequential cardiorespiratory patterns associated with outcome in septic shock.

W. Shoemaker, E. Abraham, R. Bland, 1984, Chest.

Neutrophils and acute lung injury

Edward Abraham, E. Abraham, 2003, Critical care medicine.

The Use of Near-Infrared Spectroscopy As a Substitute for Blood Pressure Monitoring in a Patient with Severe Osteogenesis Imperfecta

Joshua D. Dilley, E. Abraham, Taranjit S. Sangari, 2012 .

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group.

S. Opal, S. Lowry, C. Fisher, 1996, The New England journal of medicine.

Early renal ischemia, with or without reperfusion, activates NFkappaB and increases TNF-alpha bioactivity in the kidney.

R. Shenkar, A. Harken, E. Abraham, 2000, The Journal of urology.

Effects of accidental trauma on cytokine and endotoxin production

W. Shoemaker, E. Abraham, P. Mead, 1993, Critical care medicine.

Cytokine Neutralization: An Overview

E. Abraham, 2002 .

Why immunomodulatory therapies have not worked in sepsis

E. Abraham, Edward Abraham, 1999, Intensive Care Medicine.

Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure

Stephen F. Lowry, Venkata Bandi, Alex Dmitrienko, 2003, Critical care medicine.

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein*

E. Abraham, A. Ishizaka, D. Strassheim, 2004, Journal of Biological Chemistry.

International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: 28-day survival and safety.

M. Levy, J. Vincent, E. Abraham, 2007, Journal of critical care.

The last 100 years of sepsis.

J. Vincent, E. Abraham, 2006, American journal of respiratory and critical care medicine.

Effects of Recombinant Human Activated Protein C in Human Models of Endotoxin Administration Intravenous Administration of Endotoxin

E. Abraham, E. Abraham, Edward, 2022 .

IL-1 regulates in vivo C—X—C chemokine induction and neutrophil sequestration following endotoxemia

R. McIntyre, E. Abraham, C. Dinarello, 2002, Journal of endotoxin research.

Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice

R. Shenkar, E. Abraham, G. Rice, 1995, The Journal of experimental medicine.

Community-acquired pneumonia and sepsis.

E. Abraham, M. Beutz, 2005, Clinics in chest medicine.

MicroRNAs in immune response and macrophage polarization.

E. Abraham, Gang Liu, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Metformin reverses established lung fibrosis in a bleomycin model

E. Abraham, A. Zmijewska, S. Ravi, 2018, Nature Medicine.

Association between IL-32 genotypes and outcome in infection-associated acute lung injury

N. Yi, Nianjun Liu, E. Abraham, 2011, Critical care.

New approaches to the treatment of sepsis.

E. Abraham, J. O'Brien, 2003, Clinics in chest medicine.

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses

E. Abraham, Gang Liu, A. Friggeri, 2009, Proceedings of the National Academy of Sciences.

The human long noncoding RNA lnc‐IL7R regulates the inflammatory response

E. Abraham, Gang Liu, N. Xie, 2014, European journal of immunology.

miR‐145 regulates myofibroblast differentiation and lung fibrosis

E. Abraham, Gang Liu, N. Xie, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Participation of miR-200 in pulmonary fibrosis.

S. Matalon, E. Abraham, Gang Liu, 2012, The American journal of pathology.

MicroRNA let-7c Regulates Macrophage Polarization

E. Abraham, Gang Liu, N. Xie, 2013, The Journal of Immunology.

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial

G. Koch, S. Nasraway, B. Cunha, 1995 .

Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group.

S. Nasraway, R. Wunderink, R. Bone, 1995, JAMA.

miR-125a-5p Regulates Differential Activation of Macrophages and Inflammation*

E. Abraham, Gang Liu, N. Xie, 2013, The Journal of Biological Chemistry.

Nuclear Factor—κB and Its Role in Sepsis-Associated Organ Failure

Edward Abraham, E. Abraham, 2003 .

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

M. Nykter, Wei Zhang, U. Topaloglu, 2017, Journal of Hematology & Oncology.

Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.

E. Abraham, S. Ravi, V. Darley-Usmar, 2015, Cellular signalling.

Early alterations in neutrophil activation are associated with outcome in acute lung injury.

E. Abraham, Kuang-Yao Yang, J. Arcaroli, 2003, American journal of respiratory and critical care medicine.

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling.

E. Abraham, Gang Liu, N. Xie, 2012, American journal of physiology. Lung cellular and molecular physiology.

miR-27a Regulates Inflammatory Response of Macrophages by Targeting IL-10

E. Abraham, Gang Liu, M. Fu, 2014, The Journal of Immunology.

Reducing mortality in sepsis: new directions

Djillali Annane, Edward Abraham, G. Van den Berghe, 2002, Critical care.

Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression.

R. Shenkar, G. Fantuzzi, E. Abraham, 1997, The Journal of clinical investigation.

Textbook of critical care

J. Vincent, P. Kochanek, F. Moore, 2018 .

Interleukin‐1 receptor‐associated kinase (IRAK) ‐1‐ mediated NF‐κ activation requires cytosolic and nuclear activity

Young-Jun Park, E. Abraham, Gang Liu, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Outcome measures for clinical research in sepsis: A report of the 2nd Cambridge Colloquium of the International Sepsis Forum

G. Guyatt, C. Bombardier, G. Bernard, 2005, Critical care medicine.

Role of NF-κB in Endotoxemia-Induced Alterations of Lung Neutrophil Apoptosis1

E. Abraham, Kuang-Yao Yang, J. Arcaroli, 2001, The Journal of Immunology.

Alterations of Lung Neutrophil Apoptosis B in Endotoxemia-Induced κ Role of NF-Nadler

E. Abraham, Kuang-Yao Yang, J. Arcaroli, 2001 .

Hemorrhage in mice induces alterations in immunoglobulin-secreting B cells.

E. Abraham, A. Freitas, 1989, Critical care medicine.

Host defense abnormalities after hemorrhage, trauma, and burns.

E. Abraham, 1989, Critical care medicine.

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial

R. F. Johnston, Robert W. Taylor, Steven C. Johnson, 1994 .

Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center

V. Thorsson, M. Nykter, I. Shmulevich, 2017, Theranostics.

Functional and genomic changes induced by alveolar transmigration in human neutrophils.

M. Zamora, E. Abraham, J. Nick, 2006, American journal of physiology. Lung cellular and molecular physiology.

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock

S. Nasraway, R. Wunderink, A. Anzueto, 1998, The Lancet.

p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock: A Randomized Controlled Multicenter Trial

H. Bruining, T. Butler, K. Kudsk, 1997 .

Cardiorespiratory patterns in severe delirium tremens.

W. Shoemaker, E. Abraham, S. McCartney, 1985, Archives of internal medicine.

Activation of gene expression in human neutrophils by high mobility group box 1 protein.

K. Tracey, Huan Yang, Haichao Wang, 2003, American journal of physiology. Cell physiology.

Immunoglobulin VH gene expression following hemorrhage.

E. Abraham, A. Freitas, L. Andrade, 1990, Molecular immunology.

Mechanisms of sepsis-induced organ dysfunction

M. Singer, E. Abraham, 2007, Critical care medicine.

Effects of inverse ratio ventilation on cardiorespiratory parameters in severe respiratory failure.

E. Abraham, K. Chan, 1992, Chest.

Temporal hemodynamic and oxygen transport patterns in medical patients. Septic shock.

W. Shoemaker, E. Abraham, H. Kram, 1993, Chest.

Cardiorespiratory responses to fluid administration in peritonitis

W. Shoemaker, E. Abraham, P. Cheng, 1984, Critical care medicine.

The Expression of ICAM-1 and P-Selectin Are Increased Following Hemorrhage and Resuscitation in Mice

Y. Miller, R. Shenkar, E. Abraham, 1998 .

Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.

C. Sprung, R. Postier, C. Doig, 2003, JAMA.

Association between urokinase haplotypes and outcome from infection-associated acute lung injury

D. Allison, Nianjun Liu, E. Abraham, 2008, Intensive Care Medicine.

clinicalinvestigationsincriticalcare Temporal Hemodynamic and Oxygen Transport Patterns in Medical Patients

W. Shoemaker, E. Abraham, H. Kram, 2017 .

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group.

S. Opal, J. Vincent, S. Lowry, 1997, Critical care medicine.

Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study.

D. Cook, J. Marshall, S. Opal, 2004, The Journal of infectious diseases.

Continuous conjunctival and transcutaneous oxygen tension monitoring during resuscitation in a patient.

E. Abraham, 1984, Resuscitation.

Conjunctival oxygen tension monitoring in emergency department patients.

E. Abraham, S. Fink, 1988, American Journal of Emergency Medicine.

Cardiorespiratory and Conjunctival Oxygen Tension Monitoring During Crystalloid Resuscitation After Hemorrhage

E. Abraham, S. Fink, 1987 .

Effects of hemorrhage on cytokine gene transcription.

R. Shenkar, E. Abraham, Edward Abraham, 1993, Lymphokine and cytokine research.

Sequential hemodynamic and oxygen transport abnormalities in patients with acute pancreatitis.

W. Shoemaker, E. Abraham, R. Bland, 1984, Surgery.

Cardiorespiratory effects of pneumatic trousers in critically ill patients.

W. Shoemaker, E. Abraham, R. Bland, 1984, Archives of surgery.

Conjunctival oxygen tension monitoring during helicopter transport of critically ill patients.

E. Abraham, M. T. Morgan, G. Lee, 1986, Annals of emergency medicine.

Effects of stress on cytokine production.

E. Abraham, E Abraham, 1991, Methods and achievements in experimental pathology.

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.

Jerry A Nick, Edward Abraham, Robert C Murphy, 2004, Blood.

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

M. Singer, E. Abraham, 2007 .

Cardiorespiratory and conjunctival oxygen tension monitoring during resuscitation from hemorrhage

E. Abraham, S. Fink, 1986, Critical care medicine.

Conjunctival oxygen tension monitoring during hemorrhage.

E. Abraham, M. Smith, 1986, The Journal of trauma.

Conjunctival Oxygen Tension Monitoring

E. Abraham, 1987, International anesthesiology clinics.

Conjunctival and transcutaneous oxygen monitoring during resuscitation.

E. Abraham, H. Ehrlich, 1984, Annals of emergency medicine.

Introduction to the Third Margaux Conference on Critical Illness: The Endothelium—An Underrecognized Organ in Critical Illness?

S. Opal, J. Dhainaut, E. Abraham, 2002 .

Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo.

R. Shenkar, E. Abraham, M. Schwartz, 1996, The American journal of physiology.

Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.

E. Abraham, K. Asehnoune, D. Strassheim, 2004, Journal of immunology.

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

E. Abraham, Gang Liu, N. Xie, 2015, The Journal of Immunology.

Nuclear factor-kappaB and its role in sepsis-associated organ failure.

Edward Abraham, E. Abraham, 2003, The Journal of infectious diseases.

Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome

M. Strand, E. Abraham, K. Malcolm, 2016, PloS one.

GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury.

K. Inoki, E. Abraham, G. Siegal, 2014, American journal of physiology. Lung cellular and molecular physiology.

K. Inoki, E. Abraham, G. Siegal, 2014 .

Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.

E. Abraham, Gang Liu, E. Lorne, 2009, American journal of respiratory cell and molecular biology.

Pharmacokinetics and Pharmacodynamics of Imipenem during Continuous Renal Replacement Therapy in Critically Ill Patients

E. Abraham, D. Fish, I. Teitelbaum, 2005, Antimicrobial Agents and Chemotherapy.

ELEVATED SERUM LEVELS OF ICAM-1, BUT NOT TNF-RECEPTOR, CORRELATE WITH THE DEVELOPMENT OF MULTIPLE ORGAN FAILURE IN TRAUMA PATIENTS

E. Abraham, M. M. Law, H. G. Ctyer, 1993 .

Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism

E. Abraham, D. Chaplin, H. Bae, 2012, Molecular medicine.

Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury.

E. Abraham, S. Shetty, Y. Bhandary, 2009, American journal of respiratory and critical care medicine.

Identification of a microRNA signature in renal fibrosis: role of miR-21.

E. Abraham, Gang Liu, A. Agarwal, 2011, American journal of physiology. Renal physiology.

Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis.

E. Abraham, J. Arcaroli, Eliézer Silva, 2006, American journal of respiratory and critical care medicine.

New Definitions for Sepsis and Septic Shock: Continuing Evolution but With Much Still to Be Done.

Edward Abraham, E. Abraham, 2016, JAMA.

LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis*

A. Dmitrienko, E. Abraham, P. Laterre, 2005, Critical care medicine.

Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death.

R. Rossaint, E. Abraham, P. Laterre, 2005, The New England journal of medicine.

This information is current as Regulating Glucose Metabolism Participates in Macrophage Polarization via Pyruvate Dehydrogenase Kinase 1

E. Abraham, Gang Liu, N. Xie, 2015 .

Reply to Hurley.

E. Abraham, K. Asehnoune, E. Marret, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Cholesterol-25-hydroxylase promotes efferocytosis and resolution of lung inflammation.

M. Wurfel, W. Janssen, E. Abraham, 2020, JCI insight.

Does blocking cytokines in sepsis work?

E. Abraham, C. Dinarello, 2002, American journal of respiratory and critical care medicine.

Immunologic Abnormalities Following Hemorrhage and Trauma

E. Abraham, 1988 .

Sepsis: current concepts in intracellular signaling.

E. Abraham, D. Strassheim, J. Park, 2002, The international journal of biochemistry & cell biology.

Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.

J. Hokanson, R. Bowler, J. Crapo, 2009, American journal of respiratory and critical care medicine.

Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients

T. Butler, K. Kudsk, W. Lesslauer, 2001, Critical care medicine.

Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression.

E. Abraham, K. Asehnoune, J. Arcaroli, 2004, American journal of physiology. Cell physiology.

AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury

E. Abraham, J. Pittet, Zhongyu Liu, 2015, Molecular medicine.

Potential role of high-mobility group box 1 in cystic fibrosis airway disease.

J. Clancy, A. Gaggar, J. Blalock, 2008, American journal of respiratory and critical care medicine.

Human Resistin Promotes Neutrophil Proinflammatory Activation and Neutrophil Extracellular Trap Formation and Increases Severity of Acute Lung Injury

E. Abraham, J. Pittet, J. Tadié, 2014, The Journal of Immunology.

Identification of TLT2 as an Engulfment Receptor for Apoptotic Cells

E. Abraham, Gang Liu, M. Fu, 2012, The Journal of Immunology.

Beta-adrenergic agonist therapy as a potential treatment for acute lung injury.

E. Abraham, M. Matthay, 2006, American journal of respiratory and critical care medicine.

Generating Knowledge from Best Care: Advancing the Continuously Learning Health System

Maryan Zirkle, Richard Platt, Bray Patrick-Lake, 2016 .

Sepsis therapy trials. Continued disappointment or reason for hope?

T. Raffin, E. Abraham, 1994, JAMA.

NewDefinitions for Sepsis and Septic Shock Continuing Evolution butWithMuch Still to Be Done

E. Abraham, 2016 .

Pneumonia prevention to decrease mortality in intensive care unit: a systematic review and meta-analysis.

Edward Abraham, E. Abraham, K. Asehnoune, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase*

E. Abraham, A. Friggeri, E. Lazarowski, 2010, The Journal of Biological Chemistry.

Intracellular HMGB1 Negatively Regulates Efferocytosis

E. Abraham, Gang Liu, A. Friggeri, 2011, The Journal of Immunology.

Effect of pneumatic trousers on pulmonary function

E. Abraham, D. Tashkin, L. Baraff, 1982, Critical care medicine.

A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor.

A. Harken, E. Abraham, L. Ao, 2001, American journal of physiology. Lung cellular and molecular physiology.

Cytokine modifiers: pipe dream or reality?

E. Abraham, 1998, Chest.

Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome

Arthur S Slutsky, W. Sibbald, T. Clemmer, 2002, Critical care medicine.

Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury.

E. Abraham, Gang Liu, G. Siegal, 2008, American journal of respiratory and critical care medicine.

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial*

S. Opal, S. Lowry, W. McGee, 2004, Critical care medicine.

Year in review 2007: Critical Care – multiple organ failure and sepsis

E. Abraham, N. Ali, J. O'Brien, 2008, Critical care.

Review Year in review 2007: Critical Care - multiple organ failure and

E. Abraham, N. Ali, O'Brien, 2008 .

miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis.

E. Abraham, Gang Liu, N. Xie, 2012, The FASEB Journal.

Hemorrhage in mice produces alterations in intestinal B cell repertoires.

E. Abraham, Y. Chang, 1990, Cellular immunology.

Effects of haemorrhage on bacterial antigen specific pulmonary plasma cell function

E. Abraham, A. Robinson, 1992, Clinical and experimental immunology.

Hemorrhage in mice produces alterations in B cell repertoires.

A. Coutinho, E. Abraham, A. Freitas, 1989, Cellular immunology.

Generation of functionally active suppressor cells by haemorrhage and haemorrhagic serum.

E. Abraham, Y. Chang, 1988, Clinical and Experimental Immunology.

Cellular and humoral bases of hemorrhage‐induced [depression of lymphocyte function

E. Abraham, Y. Chang, Y. Chang, 1986, Critical care medicine.

Participation of mTOR Complex 1 in TLR2 and TLR4 Induced Neutrophil Activation and Acute Lung Injury.

E. Abraham, E. Lorne, J. Zmijewski, 2009, ATS 2009.

p53 Attenuates Lipopolysaccharide-Induced NF-κB Activation and Acute Lung Injury 1

E. Abraham, Gang Liu, E. Lorne, 2009, The Journal of Immunology.

Hemorrhage in mice produces alterations in pulmonary B cell repertoires.

E. Abraham, A. Robinson, 1990, Journal of immunology.

Effects of hemorrhage on inflammatory response.

E. Abraham, Y. Chang, Y. Chang, 1984, Archives of surgery.

Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis

C. Sprung, S. Opal, B. Light, 2013 .

Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing

E. Abraham, J. Tadié, Shaoning Jiang, 2013, Molecular Medicine.

The dichotomy of inhibiting nuclear factor kappa-B in pneumonia

E. Abraham, 2013, Critical Care.

From the bench to the bedside: The future of sepsis research - Executive summary of an American College of Chest Physicians, National Institute of Allergy and Infectious Disease, and National Heart, Lung, and Blood Institute Workshop

S. Hurd, D. Teres, G. Bernard, 1997 .

Immunological therapy of sepsis: experimental therapies

E. Abraham, P. Arndt, E. Abraham, 2001, Intensive Care Medicine.

Therapies for sepsis. Emerging therapies for sepsis and septic shock.

E. Abraham, 1997, The Western journal of medicine.

Free Radical-Producing MyeloidDerived Regulatory Cells: Potent Activators and Suppressors of Lung Inflammation and Airway Hyper-responsiveness

A. Gaggar, E. Abraham, D. Chaplin, 2010 .

Liposomal prostaglandin E1 in acute respiratory distress syndrome: a placebo-controlled, randomized, double-blind, multicenter clinical trial.

S A Conrad, E. Abraham, M. Schwartz, 1996, Critical care medicine.

Intensive insulin therapy in critical illness.

Edward Abraham, Derek C Angus, D. Angus, 2005, American journal of respiratory and critical care medicine.

Toward new definitions of acute respiratory distress syndrome.

E. Abraham, 1999, Critical care medicine.

Impact of immunomodulating therapy on morbidity in patients with severe sepsis.

D. Pittet, P. Suter, K. Reinhart, 1999, American journal of respiratory and critical care medicine.

A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation.

M. Levy, N. MacIntyre, E. Abraham, 2005, Chest.

Unraveling the role of high mobility group box protein 1 in severe trauma

E. Abraham, 2009, Critical care.

Sepsis and mediator-directed therapy: rethinking the target populations. Mediator-directed therapy in sepsis: rethinking the target populations. Toronto, Canada, 31 October-1 November 1998.

J. Marshall, E. Abraham, 1999, Molecular medicine today.

Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001.

G. Bernard, J. Marshall, J. Vincent, 2006, Journal of critical care.

Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock

K. Tarte, E. Abraham, J. Tadié, 2017, Journal of leukocyte biology.

HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury

E. Abraham, J. Nick, J. Arcaroli, 2007, Intensive Care Medicine.

Exposure to hydrogen peroxide diminishes NF-κB activation, IκB-α degradation, and proteasome activity in neutrophils

E. Abraham, Zhiwei Xu, J. Zmijewski, 2007 .

Glucose-6-phosphate dehydrogenase and sepsis: the jury is still out.

E. Abraham, 2007, Critical Care Medicine.

Immunological Monitoring, Functional Genomics and Proteomics

E. Abraham, 2006 .

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model

E. Abraham, A. Zmijewska, S. Ravi, 2018, Nature Network Boston.

Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?

E. Abraham, 2010, Critical care.

Severe sepsis and septic shock: review of the literature and emergency department management guidelines.

David T. Huang, S. Trzeciak, T. Osborn, 2006, Annals of emergency medicine.

Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils.

E. Abraham, Zhiwei Xu, J. Zmijewski, 2007, American journal of physiology. Cell physiology.

Hot times in the intensive care unit

E. Abraham, 2010, Critical Care.

Alterations in transcriptional regulation of proinflammatory and immunoregulatory cytokine expression by hemorrhage, injury, and critical illness.

E. Abraham, 1996, New horizons.

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis

E. Abraham, J. Nick, R. Murphy, 2004 .

High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis.

E. Abraham, C. Dinarello, S. Endres, 2004, European Cytokine Network.

Comprar Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery | Abraham, Edward | 9783540301585 | Springer

M. Singer, E. Abraham, 2007 .

Effects of hemorrhage on interleukin-1 production.

E. Abraham, Y. Chang, N. Richmond, 1988, Circulatory shock.

It's all in the genes: moving toward precision medicine in critical illness.

E. Abraham, 2013, Critical care medicine.

Hemorrhage and resuscitation alter the expression of ICAM-1 and P-selectin in mice.

Y. Miller, R. Shenkar, E. Abraham, 1995, Journal of inflammation.

EFFECTS OF ACCIDENTAL TRAUMA OF CYTOKINE AND ENDOTOXIN PRODUCTION. AUTHOR REPLIES

E. Moore, E. Abraham, A. Botha, 1994 .

CYTOKINE EXPRESSION IN PEYER'S PATCHES FOLLOWING HEMORRHAGE AND RESUSCITATION

R. Shenkar, E. Abraham, Yi-Han Chang, 1994, Shock.

Moving Forward With Refinement of Definitions for Sepsis.

E. Abraham, 2021, Critical care medicine.

Effects of hemorrhagic serum on interleukin-2 generation and utilization.

E. Abraham, T. Tanaka, Y. Chang, 1988, Critical care medicine.

The role of interleukin 2 in hemorrhage-induced abnormalities of lymphocyte proliferation.

E. Abraham, R. J. Lee, Y. Chang, 1986, Circulatory shock.

Innate Immune Dysfunction in Trauma Patients: From Pathophysiology to Treatment

E. Abraham, K. Asehnoune, A. Roquilly, 2012, Anesthesiology.

Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism

E. Abraham, D. Chaplin, H. Bae, 2012, Molecular medicine.

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.

E. Abraham, J. Nick, R. Murphy, 2004, Blood.

Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury.

E. Abraham, Gang Liu, G. Siegal, 2008, American Journal of Respiratory and Critical Care Medicine.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses

E. Abraham, Gang Liu, A. Friggeri, 2009, Proceedings of the National Academy of Sciences.

Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.

E. Abraham, S. Ravi, V. Darley-Usmar, 2015, Cellular signalling.

Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.

E. Abraham, Gang Liu, E. Lorne, 2009, American journal of respiratory and critical care medicine.

New Definitions for Sepsis and Septic Shock: Continuing Evolution but With Much Still to Be Done.

E. Abraham, 2016, JAMA.

MicroRNA let-7c Regulates Macrophage Polarization

E. Abraham, Gang Liu, N. Xie, 2013, The Journal of Immunology.

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.

M. Netea, S. Girardin, E. Abraham, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages

E. Abraham, H. Bae, V. Thannickal, 2013, The Journal of Immunology.

Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation.

R. Shenkar, E. Abraham, D. Kaneko, 1999, American journal of physiology. Lung cellular and molecular physiology.

The Role of Leptin in the Development of Pulmonary Neutrophilia in Infection and Acute Lung Injury*

Catherine M. Hayes, E. Wouters, J. Tavernier, 2014, Critical care medicine.

Computational Design of Variant TNF Molecules: A Novel Methodology for Inhibition of Proinflammatory Cascades

E. Abraham, 2003, Science's STKE.

ERYTHROMYCIN VS. METOCLOPRAMIDE FOR FACILITATING GASTRIC EMPTYING AND TOLERANCE TO INTRAGASTRIC NUTRITION.: 164-M

E. Abraham, P. Wischmeyer, R. MacLaren, 2005 .

Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS.

E. Abraham, T. Fingerlin, K. Malcolm, 2017, American journal of physiology. Lung cellular and molecular physiology.

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production.

E. Abraham, Gang Liu, H. Dupont, 2008, American journal of physiology. Cell physiology.

Effects of Propofol Containing EDTA on Mineral Metabolism in Medical ICU Patients With Pulmonary Dysfunction

E. Abraham, P. Papadakos, Jesse B. Hall, 2000, Intensive Care Medicine.

Identifying patients with idiopathic pulmonary fibrosis: quality or quantity?

Edward Abraham, Luca Richeldi, L. Richeldi, 2007, American journal of respiratory and critical care medicine.

Anti-TNF Strategies

E. Abraham, 1997 .

Effects of recombinant human activated protein C in human models of endotoxin administration.

E. Abraham, 2005, Proceedings of the American Thoracic Society.

S. Hurd, D. Teres, G. Bernard, 1997 .