Keqiang Chen

发表

Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1.

X. Bian, Yan Yang, Y. Liu, 2011, The American journal of pathology.

The G-Protein-Coupled Chemoattractant Receptor Fpr2 Exacerbates High Glucose-Mediated Proinflammatory Responses of Müller Glial Cells

W. Gong, Keqiang Chen, Ji Ming Wang, 2017, Front. Immunol..

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.

W. Gong, Keqiang Chen, Ji Ming Wang, 2013, The Journal of clinical investigation.

Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.

X. Bian, X. Yao, W. Gong, 2006, Biochemical and biophysical research communications.

Toll-interacting protein deficiency promotes neurodegeneration via impeding autophagy completion in high-fat diet-fed ApoE−/− mouse model

Keqiang Chen, Liwu Li, S. Geng, 2017, Brain, Behavior, and Immunity.

SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice.

Jingjing Cao, Keqiang Chen, Tianshu Yang, 2018, Biochemical and biophysical research communications.

The Role of Chemoattractant Receptors in the Progression of Glioma

X. Bian, Jian Huang, W. Gong, 2011 .

Interleukin 10 and TNFα synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia

S. Lockett, W. Gong, Keqiang Chen, 2007, Neurobiology of Disease.

Leukocyte chemotactic receptor Fpr1 protects against aging‐related posterior subcapsular cataract formation

William Kovacs, Keqiang Chen, M. Lizak, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Not to be ignored: The involvement of the G-protein coupled formylpeptide receptors in high glucose-promoted progression of metabolic diseases and glioblastoma

W. Gong, Keqiang Chen, Ji Ming Wang, 2019, Trends in Diabetes and Metabolism.

Function and Physiology Lysosomal Storage Disease: Revealing Lysosomal

Sean P. Dougherty, M. Yaylaoglu, L. Honigberg, 2015 .

Low‐grade inflammatory polarization of monocytes impairs wound healing

Keqiang Chen, Liwu Li, S. Geng, 2016, The Journal of pathology.

Epigenetic Dysregulation of the Expression of PRSS3 Splice Variants Increases the Heterogeneity of Transcripts and Functionality in Human Hepatocellular Carcinoma

W. Gong, Keqiang Chen, Ji Ming Wang, 2021 .

The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis

Chen-feng Qi, Keqiang Chen, W. Ling, 2016, Nature Communications.

Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis

A. Dzutsev, J. McCulloch, G. Trinchieri, 2020, The Journal of pathology.

The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance

A. Dzutsev, G. Trinchieri, X. Bian, 2018, The Journal of Immunology.

The Formylpeptide Receptor 2 (Fpr2) and Its Endogenous Ligand Cathelin-related Antimicrobial Peptide (CRAMP) Promote Dendritic Cell Maturation*

W. Gong, Keqiang Chen, Ji Ming Wang, 2014, The Journal of Biological Chemistry.

Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages.

W. Gong, Keqiang Chen, Ji Ming Wang, 2013, Cancer research.

Human Phagocytes Activator of N-Formyl Peptide Receptor in -Helical Peptide of Hepatitis Virus C, Is an a HCV Peptide (C5A), an Amphipathic

W. Gong, Keqiang Chen, Ji Ming Wang, 2011 .

HCV Peptide (C5A), an Amphipathic α-Helical Peptide of Hepatitis Virus C, Is an Activator of N-Formyl Peptide Receptor in Human Phagocytes

W. Gong, Keqiang Chen, Ji Ming Wang, 2011, The Journal of Immunology.

Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses

Jian Huang, W. Gong, Keqiang Chen, 2010, The Journal of Immunology.

Chemokines in homeostasis and diseases

W. Gong, Keqiang Chen, Ji Ming Wang, 2018, Cellular & Molecular Immunology.

Tissue-resident dendritic cells and diseases involving dendritic cell malfunction.

W. Gong, Keqiang Chen, Ji Ming Wang, 2016, International immunopharmacology.

Differential MUC22 expression by epigenetic alterations in human lung squamous cell carcinoma and adenocarcinoma

W. Gong, Keqiang Chen, Ji Ming Wang, 2021, Oncology reports.

A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors

X. Bian, X. Yao, Y. Ping, 2007, Journal of Neuro-Oncology.

Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells

Y. Liu, Jian Huang, W. Gong, 2009, Journal of Neuroimmunology.

CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system.

Jian Huang, W. Gong, Keqiang Chen, 2006, Cellular & molecular immunology.

Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

R. Helm, Keqiang Chen, Liwu Li, 2016, EBioMedicine.

Requirement of CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway

G. Trinchieri, W. Gong, Keqiang Chen, 2021, Journal of cell science.

Requirement of CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway

G. Trinchieri, W. Gong, Keqiang Chen, 2021 .

Requirement of the antimicrobial peptide CRAMP for macrophages to eliminate phagocytosed E. coli through an autophagy pathway

W. Gong, Keqiang Chen, Ji Ming Wang, 2020, bioRxiv.

Cooperation between NOD2 and Toll‐like receptor 2 ligands in the up‐regulation of mouse mFPR2, a G‐protein‐coupled Aβ42 peptide receptor, in microglial cells

Jian Huang, W. Gong, Keqiang Chen, 2008, Journal of leukocyte biology.

Non-Myeloid Cells are Major Contributors to Innate Immune Responses via Production of Monocyte Chemoattractant Protein-1/CCL2

Keqiang Chen, Ji Ming Wang, L. Tessarollo, 2013, Front. Immunol..

Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

Y. Liu, Keqiang Chen, Ji Ming Wang, 2013, PloS one.

Interleukin 1β (IL1B) Signaling is a Critical Component of Radiation-Induced Skin Fibrosis

P. Okunieff, Keqiang Chen, J. Olschowka, 2006, Radiation research.

Formylpeptide Receptors Mediate Rapid Neutrophil Mobilization to Accelerate Wound Healing

W. Gong, Keqiang Chen, Ji Ming Wang, 2014, PloS one.

CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma

Min Guo, W. Gong, Keqiang Chen, 2022, Frontiers in Oncology.

Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A

W. Gong, Keqiang Chen, Ji Ming Wang, 2018, Clinical Cancer Research.

The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer

W. Gong, Keqiang Chen, Ji Ming Wang, 2020, Technology in cancer research & treatment.

The G‐protein‐coupled chemoattractant receptor Fpr2 exacerbates neuroglial dysfunction and angiogenesis in diabetic retinopathy

Keqiang Chen, Ji Ming Wang, Shuang Liu, 2020, FASEB bioAdvances.

A Critical Role of Formyl Peptide Receptors in Host Defense against Escherichia coli

W. Gong, Keqiang Chen, Ji Ming Wang, 2020, The Journal of Immunology.

Regulation of inflammation by members of the formyl-peptide receptor family.

W. Gong, Keqiang Chen, Ji Ming Wang, 2017, Journal of autoimmunity.

IL-4 Inhibits the Expression of Mouse Formyl Peptide Receptor 2, a Receptor for Amyloid β1–42, in TNF-α-Activated Microglia12

W. Gong, Keqiang Chen, Ji Ming Wang, 2005, The Journal of Immunology.

Chemotactic Peptide Ligands for Formylpeptide Receptors Influencing Inflammation

Keqiang Chen, Ji Ming Wang, 2006 .

The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment

X. Bian, X. Yao, Jian Huang, 2014, BioMed research international.

Chemoattractant receptors as pharmacological targets for elimination of glioma stem-like cells.

X. Bian, X. Yao, W. Gong, 2011, International immunopharmacology.

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

W. Gong, Keqiang Chen, Ji Ming Wang, 2020, Frontiers in Endocrinology.

Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation*

W. Gong, Keqiang Chen, Ji Ming Wang, 2013, The Journal of Biological Chemistry.

Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

W. Gong, Keqiang Chen, Ji Ming Wang, 2012, Scientific Reports.

G-protein coupled chemoattractant receptors and cancer.

Jian Huang, W. Gong, Keqiang Chen, 2008, Frontiers in bioscience : a journal and virtual library.

Toll-like receptors in inflammation, infection and cancer.

Jian Huang, W. Gong, Keqiang Chen, 2007, International immunopharmacology.

The active contribution of Toll-like receptors to allergic airway inflammation.

X. Yao, W. Gong, Keqiang Chen, 2011, International immunopharmacology.

The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.

W. Gong, Keqiang Chen, P. Iribarren, 2005, Cellular & molecular immunology.

CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

W. Gong, Keqiang Chen, Ji Ming Wang, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Deficiency in Fpr2 results in reduced numbers of Lin−cKit+Sca1+ myeloid progenitor cells

W. Gong, Keqiang Chen, Ji Ming Wang, 2018, The Journal of Biological Chemistry.

FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

G. Trinchieri, X. Bian, X. Yao, 2020, Nature Communications.

Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality

Keqiang Chen, Keqiang Chen, Liwu Li, 2015, EBioMedicine.

Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

Keqiang Chen, Ji Ming Wang, C. Morrissey, 2023, bioRxiv.

Alteration of Lysosome Fusion and Low-grade Inflammation Mediated by Super-low-dose Endotoxin*

Sean P. Dougherty, Keqiang Chen, Liwu Li, 2015, The Journal of Biological Chemistry.

Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

Keqiang Chen, Ji Ming Wang, Tianshu Yang, 2016, Oncoimmunology.

The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases.

W. Gong, Keqiang Chen, Ji Ming Wang, 2021, Frontiers in bioscience.

Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.

X. Bian, Jian Huang, W. Gong, 2007, Cancer research.

G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma.

X. Bian, Keqiang Chen, Ji Ming Wang, 2012, International immunopharmacology.

Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression.

X. Bian, Jian Huang, W. Gong, 2008, Cancer letters.

Induction of the Formyl Peptide Receptor 2 in Microglia by IFN-γ and Synergy with CD40 Ligand12

S. Lockett, Jian Huang, W. Gong, 2007, The Journal of Immunology.

Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.

X. Bian, Jian Huang, W. Gong, 2009, Carcinogenesis.

Isolation of Mouse Tumor-Infiltrating Leukocytes by Percoll Gradient Centrifugation

W. Gong, Keqiang Chen, Ji Ming Wang, 2013 .

New development in studies of formyl‐peptide receptors: critical roles in host defense

X. Bian, Jianwei Zhu, Keqiang Chen, 2016, Journal of leukocyte biology.

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide*

S. Lockett, W. Gong, Keqiang Chen, 2006, Journal of Biological Chemistry.

Chemokines in homeostasis and diseases

W. Gong, Keqiang Chen, Ji Ming Wang, 2018, Cellular & Molecular Immunology.

Microglia α , in TNF-42 − 1 β Peptide Receptor 2 , a Receptor for Amyloid IL-4 Inhibits the Expression of Mouse Formyl

W. Gong, Keqiang Chen, Ji Ming Wang, 2005 .

G-protein–coupled formyl peptide receptors play a dual role in neutrophil chemotaxis and bacterial phagocytosis

T. Jin, Keqiang Chen, Ji Ming Wang, 2019, Molecular biology of the cell.

Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin

S. Kim, R. Linhardt, W. Gong, 2018, The Journal of Biological Chemistry.

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy

Keqiang Chen, Liwu Li, S. Geng, 2017, Journal of the American Heart Association.

Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.

W. Gong, Keqiang Chen, T. Yoshimura, 2023, International immunopharmacology.

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization

W. Gong, Keqiang Chen, Ji Ming Wang, 2017, Scientific Reports.

New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

Keqiang Chen, Ji Ming Wang, T. Yoshimura, 2023, Cellular & Molecular Immunology.

The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells

J. McCulloch, G. Trinchieri, W. Gong, 2023, Gut Pathogens.

The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells.

X. Bian, X. Yao, W. Gong, 2016, American journal of cancer research.

High Glucose Promotes Human Glioblastoma Cell Growth by Increasing the Expression and Function of Chemoattractant and Growth Factor Receptors1

W. Gong, Keqiang Chen, Ji Ming Wang, 2019, Translational oncology.

Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis

Keqiang Chen, Liwu Li, S. Geng, 2016, Scientific Reports.

Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand.

S. Lockett, Jian Huang, W. Gong, 2007, Journal of immunology.

Subclinical-Dose Endotoxin Sustains Low-Grade Inflammation and Exacerbates Steatohepatitis in High-Fat Diet–Fed Mice

Keqiang Chen, Honghui Guo, Liwu Li, 2016, The Journal of Immunology.

Enhanced Neutrophil Immune Homeostasis Due to Deletion of PHLPP

Keqiang Chen, Liwu Li, S. Geng, 2019, Front. Immunol..

Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

Keqiang Chen, Ji Ming Wang, C. Morrissey, 2023, bioRxiv.

FPR Ligands

Keqiang Chen, Ji Ming Wang, Y. Liu, 2013, Handbook of Biologically Active Peptides.

IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia.

W. Gong, Keqiang Chen, Ji Ming Wang, 2005, Journal of immunology.

Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib

W. Gong, Keqiang Chen, Ji Ming Wang, 2017, Oncotarget.

Androgen receptor inhibition suppresses anti-tumor neutrophil response against bone metastatic prostate cancer via regulation of TβRI expression.

Keqiang Chen, C. Morrissey, R. Fallet, 2023, Cancer letters.

SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice.

Jingjing Cao, Keqiang Chen, Tianshu Yang, 2018, Biochemical and biophysical research communications.

The Critical Role of the Antimicrobial Peptide LL-37/ CRAMP in Protection of Colon Microbiota Balance, Mucosal Homeostasis, Anti-Inflammatory Responses, and Resistance to Carcinogenesis.

W. Gong, Keqiang Chen, Ji Ming Wang, 2019, Critical reviews in immunology.