J. Nix

发表

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

J. Kieft, B. Akiyama, H. Laurence, 2016, Science.

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.

Greg L. Hura, Kathryn H Burnett, J. Tainer, 2016, Structure.

Distinct Structural Features of the Peroxide Response Regulator from Group A Streptococcus Drive DNA Binding

J. Nix, M. Hammel, Shuying Wang, 2014, PloS one.

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

J. Nix, Zhen Xu, E. Kohli, 2008, BMC Structural Biology.

Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7

P. Marrack, J. Nix, J. Kappler, 2018, Scientific Reports.

The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH.

J. Nix, David N M Jones, A. B. Thode, 2008, Journal of molecular biology.

Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

J. Nix, L. Beamer, D. Jakeman, 2019, Structural dynamics.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

M. Beltramello, A. Telenti, R. Spreafico, 2020, bioRxiv.

Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail

J. Nix, David N M Jones, E. Murphy, 2020, Scientific Reports.

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

M. Beltramello, E. Bernasconi, A. Walls, 2020, Cell.

Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals

J. W. Peters, J. Nix, M. Adams, 2013, Hyperfine interactions.

The structural basis of tRNA mimicry and conformational plasticity by a viral RNA

J. Kieft, D. Costantino, J. Nix, 2014, Nature.

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

Z. Otwinowski, J. Nix, C. Basler, 2010, Nature Structural &Molecular Biology.

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

M. Beltramello, E. Bernasconi, A. Walls, 2020, Cell.

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

M. Beltramello, J. Chodera, A. Telenti, 2021, Cell.

Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.

J. Nix, R. Page, M. Moseng, 2019, The journal of physical chemistry. B.

A non-canonical metal center drives activity of the Sediminispirochaeta smaragdinae metallo-β- lactamase SPS-1

Stacey Lowery Bretz, R. Bonomo, J. Nix, 2018, bioRxiv.

Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels

Rhiju Das, Siqi Tian, J. Kieft, 2018, Nature Communications.

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.

J. Nix, C. Basler, D. Leung, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates

J. Nix, A. Waight, P. Senter, 2018, Molecular Cancer Therapeutics.

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

D. McRee, J. Nix, R. Swanson, 2006, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Z. Otwinowski, J. Nix, C. Basler, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structures of the rare-cutting restriction endonuclease NotI reveal a novel metal binding fold involved in DNA recognition

B. Stoddard, A. Lambert, Shuang-yong Xu, 2008 .

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

J. Nix, M. Tonelli, K. Glass, 2022, bioRxiv.

The Sampling of Conforma tional Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase Graphical Abstract Highlights

R. Brüschweiler, J. Nix, O. Davulcu, 2016 .

Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

J. Nix, L. Tari, S. Rodrı́guez, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein.

J. Qin, J. Nix, Zhen Xu, 2006, Biochemistry.

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.

E. Appella, Siddhartha Roy, J. Nix, 2010, Journal of molecular biology.

Neutron and high-resolution room-temperature X-ray data collection from crystallized lytic polysaccharide monooxygenase.

C. Unkefer, J. Bacik, J. Nix, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase.

J. Nix, J. Tanner, T. Reilly, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

L. Sibley, G. Bowman, J. Nix, 2022, Nature Communications.

Structural basis of nucleotide exchange and client binding by the novel Hsp70-cochaperone Bag2

J. Nix, Zhen Xu, C. Patterson, 2009 .

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

M. S. Chapman, Y. Ishikawa, J. Nix, 2012, BMC Research Notes.

Regulation of ATAD2B bromodomain binding activity by the histone code

Kathleen H. Quinn, S. Frietze, J. Nix, 2022 .

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

M. Beltramello, J. Chodera, A. Telenti, 2021, Nature.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

A. Walls, D. Veesler, John E. Bowen, 2021, bioRxiv.

Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation.

C. Unkefer, J. Bacik, J. Nix, 2017, Biochemistry.

Structures of Coxsackievirus, Rhinovirus, and Poliovirus Polymerase Elongation Complexes Solved by Engineering RNA Mediated Crystal Contacts

Jay C. Nix, Ralph E. Davis, J. Nix, 2013, PloS one.

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

M. S. Chapman, Y. Ishikawa, J. Nix, 2012, BMC Research Notes.

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

J. Kieft, D. Costantino, J. Nix, 2020, bioRxiv.

Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates.

J. Nix, J. Berberich, Rebecca M Falatach, 2016, Biomacromolecules.

Crystal structure of the nucleotide‐binding domain of mortalin, the mitochondrial Hsp70 chaperone

J. Nix, S. Misra, S. Ithychanda, 2014, Protein science : a publication of the Protein Society.

2‐ and N6‐functionalized adenosine‐5′‐diphosphate analogs for the inhibition of mortalin

J. Nix, R. Page, M. Moseng, 2019, FEBS letters.

Structures of Mammalian and Bacterial Fructose-1,6-bisphosphatase Reveal the Basis for Synergism in AMP/Fructose 2,6-Bisphosphate Inhibition*

H. Fromm, J. Nix, R. Honzatko, 2007, Journal of Biological Chemistry.

Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.

Michael S Chapman, M. S. Chapman, Takako Sasaki, 2009, Journal of molecular biology.

Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7

P. Marrack, J. Nix, J. Kappler, 2018, Scientific Reports.

Structure of human peptidyl‐prolyl cis–trans isomerase FKBP22 containing two EF‐hand motifs

M. S. Chapman, Y. Ishikawa, J. Nix, 2014, Protein science : a publication of the Protein Society.

Intrinsically disordered pathogen effector alters the STAT1 dimer to prevent recruitment of co-transcriptional activators CBP/p300

L. Sibley, G. Bowman, J. Nix, 2021, bioRxiv.

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

J. Nix, Zhen Xu, C. Patterson, 2008, Nature Structural &Molecular Biology.

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

C. Guthrie, J. Nix, Tao Xu, 2009, Nature Structural &Molecular Biology.

Structural Characterization of Carbohydrate Binding by LMAN1 Protein Provides New Insight into the Endoplasmic Reticulum Export of Factors V (FV) and VIII (FVIII)*

J. Nix, S. Misra, E. Wigren, 2013, The Journal of Biological Chemistry.

Gliogenic LTP spreads widely in nociceptive pathways

J. Kieft, B. Akiyama, H. Laurence, 2022 .

AÊ Crystal Structure of a Biotin-binding Pseudoknot and the Basis for RNA Molecular Recognition

Charles Wilson, J. Nix, D. Sussman, 2022 .

Structure of the Ebola VP35 interferon inhibitory domain

J. Nix, C. Basler, D. Leung, 2009, Proceedings of the National Academy of Sciences.

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

M. Beltramello, J. Chodera, A. Telenti, 2021, bioRxiv.

Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot.

J. Szostak, C. Wilson, Charles Wilson, 1998, Biochemistry.

Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA.

J. Nix, C. Bottoms, J. Tanner, 2008, Journal of molecular biology.

Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis

Walter G. Park, J. Norton, A. Iagaru, 2019, Nature Communications.

Structures of the rare-cutting restriction endonuclease NotI reveal a unique metal binding fold involved in DNA binding.

B. Shen, B. Stoddard, A. Lambert, 2008, Structure.

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, 2013, PloS one.

Structural Insights into Substrate Recognition by Clostridium difficile Sortase

Lee-Wei Yang, J. Nix, Shuying Wang, 2016, Front. Cell. Infect. Microbiol..

Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain

Gabriel Cornilescu, J. Markley, J. Nix, 2021, bioRxiv.

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

R. Joseph, A. Andreotti, J. Nix, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structures of Parasponia and Trema hemoglobins: differential heme coordination is linked to quaternary structure.

J. Nix, M. Hargrove, A. DiSpirito, 2011, Biochemistry.

Cofactor Complexes of DesD, a Model Enzyme in the Virulence-related NIS Synthetase Family.

J. Nix, M. Yamamoto, Caroline R. Amendola, 2020, Biochemistry.

Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-β-lactamase VIM-2

R. Bonomo, J. Nix, Amy R. Marts, 2014, Biochemistry.

The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.

M. S. Chapman, R. Brüschweiler, J. Nix, 2016, Structure.

Inelastic X-ray scattering of a transition-metal complex (FeCl4(-)): vibrational spectroscopy for all normal modes.

J. Fettinger, J. Nix, A. Baron, 2013, Inorganic chemistry.

Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A

J. Nix, M. Churchill, T. A. Gangelhoff, 2009, Nucleic acids research.

Crystal Structures of Progressive Ca2+ Binding States of the Ca2+ Sensor Ca2+ Binding Domain 1 (CBD1) from the CALX Na+/Ca2+ Exchanger Reveal Incremental Conformational Transitions*

V. Yurkov, J. Nix, A. Omelchenko, 2009, The Journal of Biological Chemistry.

Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification.

J. Nix, L. Hryshko, Meitian Wang, 2009, Journal of molecular biology.

Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.

J. Ybe, J. Nix, Sanjay Mishra, 2007, Journal of molecular biology.

Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus.

J. Nix, Zhen Xu, S. Misra, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity.

R. Bonomo, J. Nix, C. Bethel, 2017, ACS infectious diseases.

The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production

Jeffrey Wilusz, Jeffrey S. Kieft, David A. Costantino, 2014, Science.

A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-β-lactamase SPS-1.

Stacey Lowery Bretz, R. Bonomo, J. Nix, 2018, Biochemistry.

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

R. Bonomo, J. Nix, C. Bethel, 2019, mBio.

Interleukin-37 monomer is the active form for reducing innate immunity

E. Eisenmesser, J. Redzic, J. Kieft, 2019, Proceedings of the National Academy of Sciences.

Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail

J. Nix, E. Murphy, Jing Wang, 2020, Scientific Reports.

A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure

J. Kieft, B. Akiyama, D. Costantino, 2018, Proceedings of the National Academy of Sciences.

Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals

J. Nix, M. Adams, Yuming Xiao, 2012, Hyperfine Interactions.

Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus*

J. Nix, J. Tanner, P. Sobrado, 2012, The Journal of Biological Chemistry.

RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS

J. Nix, F. Schubot, Kylie M Ryan Kaler, 2021, The Journal of biological chemistry.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Toan B. Nguyen, Sergio E. Wong, J. Nix, 2013, Bioorganic & medicinal chemistry letters.

The structural basis for molecular recognition by the vitamin B 12 RNA aptamer

Charles Wilson, J. Nix, D. Sussman, 2000, Nature Structural Biology.

Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.

J. Nix, K. Matulef, F. Valiyaveetil, 2016, Structure.

YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.

J. Nix, J. P. Henderson, D. Kober, 2018 .

YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria

J. Nix, J. P. Henderson, D. Kober, 2018, The Journal of Biological Chemistry.

Biochemical Basis of the Interaction between Cystic Fibrosis Transmembrane Conductance Regulator and Immunoglobulin-like Repeats of Filamin*

J. Qin, J. Nix, Zhen Xu, 2010, The Journal of Biological Chemistry.

Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP

J. Nix, J. Gestwicki, A. Kao, 2023, bioRxiv.

The 1.3 A crystal structure of a biotin-binding pseudoknot and the basis for RNA molecular recognition.

C. Wilson, J. Nix, D. Sussman, 2000, Journal of molecular biology.

MOLECULAR RECOGNITION BY THE VITAMIN B12 RNA APTAMER

Jay C. Nix, Charles Wilson, J. Nix, 2000 .

Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains

S. Frietze, J. Nix, Cameron D. Montgomery, 2023, bioRxiv.

Crystal structure of Methanococcus jannaschii dihydroorotase

J. Nix, J. Vitali, M. Colaneri, 2022, Proteins.

A folded viral noncoding RNA blocks host cell exoribonucleases through programmed remodeling of RNA structure

J. Kieft, B. Akiyama, D. Costantino, 2018, bioRxiv.

Gliogenic LTP spreads widely in nociceptive pathways

J. Sandkühler, J. Kieft, B. Akiyama, 2016, Science.

Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.

M. S. Chapman, Takako Sasaki, J. Engel, 2009, Journal of molecular biology.

YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway

J. Nix, J. P. Henderson, D. Kober, 2018 .

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

A. Walls, D. Veesler, John E. Bowen, 2022, Science.

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

M. Beltramello, J. Chodera, A. Telenti, 2021, Cell.

Structure, dynamics, and function of the evolutionarily changing biliverdin reductase B family.

P. Agarwal, E. Eisenmesser, J. Redzic, 2020, Journal of biochemistry.