A. Szewczak

发表

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.

T. Cech, A. Szewczak, Thomas R. Cech, 1997, RNA.

High-Throughput Quality Control of DMSO Acoustic Dispensing Using Photometric Dye Methods

A. Szewczak, C. Quintero, Kristen Tran, 2013, Journal of laboratory automation.

SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).

C. Kenific, Melissa Chenard, A. Kral, 2008, Bioorganic & medicinal chemistry letters.

Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.

Jongwon Lim, Michael D Altman, Craig Rosenstein, 2011, Journal of medicinal chemistry.

The sarcin/ricin loop, a modular RNA.

P. Moore, A. Szewczak, A A Szewczak, 1995, Journal of molecular biology.

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

Joshua Close, Sriram Tyagarajan, C. Kenific, 2008, Bioorganic & medicinal chemistry letters.

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.

C. Kenific, Melissa Chenard, A. Kral, 2014, ACS medicinal chemistry letters.

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).

J. Grimm, Melissa Chenard, A. Kral, 2009, Bioorganic & medicinal chemistry letters.

Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test.

T. Roemer, A. Szewczak, P. Liberator, 2011, Journal of natural products.

Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.

C. Kenific, Melissa Chenard, A. Kral, 2009, Bioorganic & Medicinal Chemistry Letters.

Potent benzoazepinone γ-secretase modulators with improved bioavailability.

C. Kenific, A. Szewczak, C. Moxham, 2015, Bioorganic & medicinal chemistry letters.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

A. Szewczak, C. Moxham, Hua Zhou, 2012, Bioorganic & medicinal chemistry letters.

Triazoles as γ-secretase modulators.

C. Kenific, A. Szewczak, Hua Zhou, 2011, Bioorganic & medicinal chemistry letters.

Quinazolinones as γ-secretase modulators.

A. Szewczak, J. Crispino, B. Muñoz, 2011, Bioorganic & medicinal chemistry letters.

Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth in vitro and in vivo

P. Majumder, W. Lu, K. Kunii, 2009 .

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

K. Kunii, M. Altman, A. Szewczak, 2011, Journal of medicinal chemistry.

Two-dimensional hetero-TOCSY-NOESY. Correlation of phosphorus-31 resonances with anomeric and aromatic proton resonances in RNA

P. Moore, A. Szewczak, G. W. Kellogg, 1992 .

The conformation of the sarcin/ricin loop from 28S ribosomal RNA.

I. Wool, P. Moore, A. Szewczak, 1993, Proceedings of the National Academy of Sciences of the United States of America.

On the conformation of the alpha sarcin stem-loop of 28S rRNA.

I. Wool, P. Moore, Y. Chan, 1991, Biochimie.

A minor groove RNA triple helix within the catalytic core of a group I intron

S. Strobel, A. Szewczak, S. Ryder, 1998, Nature Structural Biology.

The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.

R. Gutell, S. Strobel, A. Szewczak, 1998, RNA.

Assignment of NH resonances in nucleic acids using natural abundance 15N‐1H correlation spectroscopy with spin‐echo and gradient pulses

P. Moore, A. Szewczak, G. W. Kellogg, 1993, FEBS letters.

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells

C. Paweletz, Youwei Yan, M. Wiznerowicz, 2010, The Journal of Biological Chemistry.

RNA Tertiary Structure Mediation by Adenosine Platforms

C. Kundrot, K. Zhou, J. Doudna, 1996, Science.

Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera

Shuxia Zhao, Joe Zhu, Lin Xu, 2012, PloS one.

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.

A. Kral, A. Szewczak, A. Hitz, 2007, Bioorganic & medicinal chemistry letters.

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.

Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.

T. Cech, E. Podell, P. Bevilacqua, 1998, Biochemistry.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

Wei Lu, Michael D Altman, Craig Rosenstein, 2013, Journal of medicinal chemistry.

An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.

S. Strobel, A. V. Kazantsev, A. Szewczak, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Selecting apt RNAs for NMR.

T. Cech, A. Szewczak, 1996, RNA.

Fluorinated piperidine acetic acids as gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

High-Throughput Analysis of HGF-Stimulated Cell Scattering

I. Kariv, A. Szewczak, B. Pan, 2008, Journal of biomolecular screening.

Data Analysis Approaches for High Content Screening

Grace Ka Yan Chan, Andy Liaw, Amir A. Handzel, 2012 .

A high-throughput competitive scintillation proximity aminoacyl-tRNA synthetase charging assay to measure amino acid concentration.

A. Szewczak, J. Landro, J. Myung, 2007, Analytical biochemistry.

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.

Alexey Rivkin, Chaomin Li, A. Szewczak, 2010, Bioorganic & Medicinal Chemistry Letters.

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.

Andrew M Haidle, H. Su, S. Munshi, 2017, Bioorganic & medicinal chemistry letters.

Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.

H. Su, S. Munshi, S. Edavettal, 2016, Bioorganic & medicinal chemistry letters.

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).

J. Grimm, A. Kral, A. Szewczak, 2008, Bioorganic & medicinal chemistry letters.

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.

Andrew M Haidle, M. Altman, A. Szewczak, 2017, Bioorganic & medicinal chemistry letters.

Direct Detection of Monovalent Metal Ion Binding to a DNA G-quartet by 205Tl NMR

S. Strobel, S. Basu, A. Szewczak, 2000 .

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.