P. D. de Tombe

发表

Cardiac myofilaments: mechanics and regulation.

P. D. de Tombe, 2003, Journal of biomechanics.

Titin Isoform Switch in Ischemic Human Heart Disease

Roger J Hajjar, Wolfgang A Linke, W. Linke, 2002, Circulation.

Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes.

Brenda Russell, B. Russell, P. D. de Tombe, 2008, Journal of molecular and cellular cardiology.

Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations.

J. Rice, D. Bers, P. D. de Tombe, 2008, Biophysical journal.

Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes.

A. Zima, E. Bovo, P. D. de Tombe, 2011, Journal of molecular and cellular cardiology.

Sarcomeric mutations in cardiac diseases

P. D. de Tombe, S. Harris, 2019, Pflügers Archiv - European Journal of Physiology.

Approaches to modeling crossbridges and calcium-dependent activation in cardiac muscle.

John Jeremy Rice, J. Rice, P. D. de Tombe, 2004, Progress in biophysics and molecular biology.

Effects of Calcium and EMD‐453998 on Oxygen Consumption in Isolated Canine Hearts

D. Burkhoff, W. Hunter, P. D. de Tombe, 1992, Circulation.

Frequency‐dependent myofilament Ca2+ desensitization in failing rat myocardium

P. D. de Tombe, L. Walker, J. van der Velden, 2007, The Journal of physiology.

Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure

P. D. de Tombe, Li Xu, Renzhi Han, 2011, Journal of biomedicine & biotechnology.

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.

L. Leinwand, P. D. de Tombe, J. Tardiff, 2001, American journal of physiology. Heart and circulatory physiology.

Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.

A. Samarel, P. D. de Tombe, Y. Koshman, 2014, Journal of molecular and cellular cardiology.

Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes

P. D. de Tombe, O. Lookin, O. Cazorla, 2022, Frontiers in Physiology.

Myofilament Calcium Sensitivity in Skinned Rat Cardiac Trabeculae: Role of Interfilament Spacing

T. Irving, P. D. de Tombe, John P. Konhilas, 2002, Circulation research.

Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.

T. Irving, P. D. de Tombe, S. Blot, 2016, Journal of molecular and cellular cardiology.

Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium.

T. Irving, P. D. de Tombe, Gerrie P. Farman, 2006, American journal of physiology. Heart and circulatory physiology.

Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.

P. D. de Tombe, M. Greaser, R. Mateja, 2013, Biochimica et biophysica acta.

Cardiac muscle mechanics: Sarcomere length matters.

H. T. ter Keurs, P. D. de Tombe, 2016, Journal of molecular and cellular cardiology.

Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation

M. Yacoub, K. Campbell, C. D. dos Remedios, 2020, Cardiovascular research.

Phenotyping cardiomyopathy in adult zebrafish.

A. V. Dvornikov, P. D. de Tombe, Xiaolei Xu, 2018, Progress in biophysics and molecular biology.

Which way to grow? Force over time may be the heart’s Dao de jing

P. Kohl, P. D. de Tombe, 2016, Global cardiology science & practice.

Synergistic effect of nifedipine and propranolol on adenosine (catabolite) release from ischemic rat heart.

P. D. de Tombe, E. Harmsen, J. D. de Jong, 1983, European journal of pharmacology.

Actin Capping Protein: An Essential Element in Protein Kinase Signaling to the Myofilaments

J. Cooper, P. D. de Tombe, W. Pyle, 2002, Circulation research.

Removal of the Cardiac Troponin I N-terminal Extension Improves Cardiac Function in Aged Mice*

P. D. de Tombe, Jian-Ping Jin, R. Solaro, 2010, The Journal of Biological Chemistry.

Impact of titin strain on the cardiac slow force response.

P. D. de Tombe, Jody L. Martin, M. Greaser, 2017, Progress in biophysics and molecular biology.

Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway

P. D. de Tombe, B. Wolska, R. Solaro, 2021, Scientific Reports.

Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro

P. D. de Tombe, S. Harding, T. Thum, 2021, Cardiovascular research.

Enhanced ATP and GTP synthesis from hypoxanthine or inosine after myocardial ischemia.

P. D. de Tombe, P. Achterberg, E. Harmsen, 1984, The American journal of physiology.

Losartan prevents contractile dysfunction in rat myocardium after left ventricular myocardial infarction.

P. D. de Tombe, M. Daniëls, R. Keller, 2001, American journal of physiology. Heart and circulatory physiology.

Simultaneous determination of myocardial adenine nucleotides and creatine phosphate by high-performance liquid chromatography.

P. D. de Tombe, J. de Jong, E. Harmsen, 1982, Journal of chromatography.

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.

D. Kass, R. Tunin, P. D. de Tombe, 2014, The Journal of clinical investigation.

Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.

B. Russell, S. Boateng, P. D. de Tombe, 2007, American journal of physiology. Heart and circulatory physiology.

Functional Effects of Rho-Kinase–Dependent Phosphorylation of Specific Sites on Cardiac Troponin

P. D. de Tombe, R. Solaro, C. Warren, 2005, Circulation research.

Force and velocity of sarcomere shortening in trabeculae from rat heart. Effects of temperature.

H. T. ter Keurs, P. D. de Tombe, 1990, Circulation research.

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.

P. D. de Tombe, S. Sadayappan, Mohit Kumar, 2014, American journal of physiology. Heart and circulatory physiology.

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium*

T. Irving, P. D. de Tombe, Ying Ge, 2014, The Journal of Biological Chemistry.

Expression of Slow Skeletal Troponin I in Hearts of Phospholamban Knockout Mice Alters the Relaxant Effect of &bgr;-Adrenergic Stimulation

P. D. de Tombe, E. Kranias, B. Wolska, 2002, Circulation research.

Curvilinearity of LV end-systolic pressure-volume and dP/dtmax-end-diastolic volume relations.

P. D. de Tombe, W. Little, T. Noda, 1993, The American journal of physiology.

Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?

P. D. de Tombe, Steven B Marston, 2008, Journal of molecular and cellular cardiology.

Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure

Benjamin J. Whalley, S. Boateng, P. D. de Tombe, 2016, The Journal of physiology.

Cardiac Troponin I Threonine 144: Role in Myofilament Length–Dependent Activation

P. D. de Tombe, Gerrie P. Farman, K. Tachampa, 2007, Circulation research.

Troponin I serines 43/45 and regulation of cardiac myofilament function.

P. D. de Tombe, R. Solaro, W. Pyle, 2002, American journal of physiology. Heart and circulatory physiology.

Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure.

P. D. de Tombe, L. Walker, R. Solaro, 2006, American journal of physiology. Heart and circulatory physiology.

Basal metabolism adds a significant offset to unloaded myocardial oxygen consumption per minute.

W. Hunter, P. D. de Tombe, Y. Harasawa, 1992, Circulation research.

Diltiazem administered before or during myocardial ischemia decreases adenine nucleotide catabolism.

P. D. de Tombe, E. Harmsen, J. D. de Jong, 1984, Journal of molecular and cellular cardiology.

Myofilament length-dependent activation develops within 5 ms in guinea-pig myocardium.

P. D. de Tombe, R. Mateja, 2012, Biophysical journal.

Sarcomere dynamics in cat cardiac trabeculae.

H. T. ter Keurs, P. D. de Tombe, 1991, Circulation research.

Estrogen but not testosterone preserves myofilament function from doxorubicin-induced cardiotoxicity by reducing oxidative modifications.

M. Papadaki, P. D. de Tombe, J. Kirk, 2019, American journal of physiology. Heart and circulatory physiology.

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

Jonathan P. Davis, P. D. de Tombe, Shane D. Walton, 2014, Journal of molecular and cellular cardiology.

Decreased myocyte tension development and calcium responsiveness in rat right ventricular pressure overload.

P. D. de Tombe, T. Wannenburg, D. Fan, 1997, Circulation.

Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function.

P. D. de Tombe, R. Solaro, 2007, Cardiovascular research.

p38-MAPK Induced Dephosphorylation of &agr;-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity

P. D. de Tombe, Yibin Wang, R. Solaro, 2007, Circulation research.

Increased Cross-bridge Cycling Kinetics after Exchange of C-terminal Truncated Troponin I in Skinned Rat Cardiac Muscle*

P. D. de Tombe, R. Solaro, B. Biesiadecki, 2008, Journal of Biological Chemistry.

Release of purine nucleosides and oxypurines from the isolated perfused rat heart.

P. D. de Tombe, E. Harmsen, J. D. de Jong, 1983, Advances in myocardiology.

Identification of a Functionally Critical Protein Kinase C Phosphorylation Residue of Cardiac Troponin T *

P. D. de Tombe, W. Pyle, R. Solaro, 2003, Journal of Biological Chemistry.

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation*

P. D. de Tombe, Jody L. Martin, S. Sadayappan, 2015, The Journal of Biological Chemistry.

Myocardial xanthine oxidase/dehydrogenase.

P. D. de Tombe, P. Achterberg, E. Harmsen, 1983, Biochimica et biophysica acta.

Excitation-contraction coupling in myocardium: implications of calcium release and Na+-Ca2+ exchange.

H. T. ter Keurs, P. D. de Tombe, J. Bucx, 1987, Canadian journal of physiology and pharmacology.

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy–Associated Mutation in Human Cardiac Troponin I (K206I)

M. Ackerman, P. D. de Tombe, J. Bos, 2015, Circulation. Cardiovascular genetics.

Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ.

P. D. de Tombe, W. Pyle, R. Solaro, 2006, Journal of molecular and cellular cardiology.

Acute inhibitory effect of alpha‐mangostin on sarcoplasmic reticulum calcium‐ATPase and myocardial relaxation

P. D. de Tombe, Tepmanas Bupha-Intr, A. Kijtawornrat, 2017, Journal of biochemical and molecular toxicology.

The Troponin C G159D Mutation Blunts Myofilament Desensitization Induced by Troponin I Ser23/24 Phosphorylation

P. D. de Tombe, R. Solaro, John S. Walker, 2007, Circulation research.

Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method

P. D. de Tombe, Jody L. Martin, B. Wolska, 2020, The journal of venomous animals and toxins including tropical diseases.

A model of propagating calcium-induced calcium release mediated by calcium diffusion

H. T. ter Keurs, P. D. de Tombe, P. Backx, 1989, The Journal of general physiology.

Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxia.

P. D. de Tombe, P. Achterberg, E. Harmsen, 1985, Biochimica et biophysica acta.

The role of thin filament cooperativity in cardiac length-dependent calcium activation.

P. D. de Tombe, P. Backx, Peter H Backx, 2010, Biophysical journal.

Sarcolemma, sarcoplasmic reticulum, and sarcomeres as limiting factors in force production in rat heart.

H. T. ter Keurs, P. D. de Tombe, J. Bucx, 1990, Circulation research.

An internal viscous element limits unloaded velocity of sarcomere shortening in rat myocardium.

P. D. de Tombe, H E ter Keurs, P P de Tombe, 1992, The Journal of physiology.

Spontaneous and propagated contractions in rat cardiac trabeculae

H. T. ter Keurs, P. D. de Tombe, B. J. Mulder, 1989, The Journal of general physiology.

Force-interval relationship in heart muscle of mammals. A calcium compartment model.

A. A. Verveen, P. D. de Tombe, V. Schouten, 1987, Biophysical journal.

Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics.

P. D. de Tombe, Anne F. Martin, V. Manaves, 2005, American journal of physiology. Heart and circulatory physiology.

Rapid exchange of actin-bound nucleotide in perfused rat heart.

M. Bárány, P. D. de Tombe, M. Bárány, 2004, American journal of physiology. Heart and circulatory physiology.

Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways

P. D. de Tombe, A. Herren, B. Wolska, 2022, Molecular and Cellular Biochemistry.

Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.

T. Irving, P. D. de Tombe, B. Wolska, 2003, The Journal of physiology.

Depressed cardiac myofilament function in human diabetes mellitus.

P. D. de Tombe, L. Walker, P. Buttrick, 2005, American journal of physiology. Heart and circulatory physiology.

Balance of purine nucleotides and catabolites in the isolated ischemic rat heart.

P. D. de Tombe, P. Achterberg, E. Harmsen, 1984, Advances in experimental medicine and biology.

Nifedipine reduces adenine nucleotide breakdown in ischemic rat heart.

P. D. de Tombe, E. Harmsen, J. D. de Jong, 1982, European journal of pharmacology.

Contractile strength and mechanical efficiency of left ventricle are enhanced by physiological afterload.

D. Kass, D. Burkhoff, W. Hunter, 1991, The American journal of physiology.

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

T. Irving, P. D. de Tombe, M. Greaser, 2016, Proceedings of the National Academy of Sciences.

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro

P. D. de Tombe, S. Sadayappan, N. Sundaresan, 2012, Journal of Muscle Research and Cell Motility.

Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics.

C. Poggesi, P. D. de Tombe, A. Belus, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Frank's law of the heart: Found in translation.

J. Tyberg, P. D. de Tombe, 2018, Journal of molecular and cellular cardiology.

Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation

T. Irving, P. D. de Tombe, John P. Konhilas, 2002, Pflügers Archiv.

Some rat: a very special rat with a rather special titin.

P. D. de Tombe, O. Cazorla, 2008, Journal of molecular and cellular cardiology.

Ablation of Ventricular Myosin Regulatory Light Chain Phosphorylation in Mice Causes Cardiac Dysfunction in Situ and Affects Neighboring Myofilament Protein Phosphorylation*

Sarah B. Scruggs, P. D. de Tombe, L. Walker, 2009, Journal of Biological Chemistry.

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent

S. Weintraub, P. D. de Tombe, S. Sadayappan, 2017, Pflügers Archiv - European Journal of Physiology.

Physiological significance of troponin T binding domains in striated muscle tropomyosin.

G. Boivin, P. D. de Tombe, R. Solaro, 2004, American journal of physiology. Heart and circulatory physiology.

Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading.

W C Hunter, D. Kass, D. Burkhoff, 1993, The American journal of physiology.

Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae.

P. D. de Tombe, P. Janssen, 1997, American journal of physiology. Heart and circulatory physiology.

Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae.

P. D. de Tombe, P. Janssen, 1997, The American journal of physiology.

Alterations in left ventricular mechanics, energetics, and contractile reserve in experimental heart failure.

D. Kass, D. Burkhoff, W. Hunter, 1992, Circulation research.

Functional consequences of caspase activation in cardiac myocytes

P. D. de Tombe, R. Hajjar, J. Narula, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure.

P. D. de Tombe, S. Sadayappan, M. Cismowski, 2014, American journal of physiology. Heart and circulatory physiology.

Integration of Cardiac Myofilament Activity and Regulation with Pathways Signaling Hypertrophy and Failure

P. D. de Tombe, R. Solaro, Pieter P. de Tombe, 2000, Annals of Biomedical Engineering.

Fluorometric liquid chromatographic assay of the antiarrhythmic agent flecainide in blood plasma.

P. D. de Tombe, J. de Jong, E. Harmsen, 1982, Journal of chromatography.

Cardiac myosin binding protein-C: redefining its structure and function

P. D. de Tombe, S. Sadayappan, P. Tombe, 2012, Biophysical Reviews.

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

J. Seidman, C. Seidman, J. Gorham, 2015, Journal of molecular and cellular cardiology.

R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes.

A. Zima, E. Bovo, P. D. de Tombe, 2016, American journal of physiology. Heart and circulatory physiology.

Myofilament length dependent activation.

Kittipong Tachampa, T. Irving, P. D. de Tombe, 2010, Journal of molecular and cellular cardiology.

Cooperative activation in cardiac muscle: impact of sarcomere length.

P. D. de Tombe, Pieter P de Tombe, J. Konhilas, 2002, American journal of physiology. Heart and circulatory physiology.

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

P. D. de Tombe, Mohit Kumar, O. Cazorla, 2023, The Journal of general physiology.

Impact of temperature on cross‐bridge cycling kinetics in rat myocardium

P. D. de Tombe, G. Stienen, Pieter P de Tombe, 2007, The Journal of physiology.

Augmented Protein Kinase C-α–Induced Myofilament Protein Phosphorylation Contributes to Myofilament Dysfunction in Experimental Congestive Heart Failure

P. D. de Tombe, R. Solaro, Edward J Allen, 2007, Circulation research.

Development of contractile dysfunction in rat heart failure: hierarchy of cellular events.

P. D. de Tombe, V. Rundell, M. Daniels, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression.

P. D. de Tombe, P. Buttrick, D. Geenen, 2004, American journal of physiology. Heart and circulatory physiology.

Uncontrolled sarcomere shortening increases intracellular Ca2+ transient in rat cardiac trabeculae.

P. D. de Tombe, P P de Tombe, P. Janssen, 1997, The American journal of physiology.

Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae.

P. D. de Tombe, G. Stienen, P. Tombe, 1995, Circulation research.

Inotropic effects of ejection are myocardial properties.

P. D. de Tombe, W. Little, P P De Tombe, 1994, The American journal of physiology.

Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes

P. D. de Tombe, R. Solaro, W. Pyle, 2004, Circulation research.

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models

A. Mugelli, I. Olivotto, C. Poggesi, 2017, Journal of the American Heart Association.

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Jalal K. Siddiqui, Jonathan P. Davis, P. D. de Tombe, 2016, Front. Physiol..

Pacemaker-induced transient asynchrony suppresses heart failure progression

Theodore P Abraham, Jennifer E Van Eyk, Jonathan A Kirk, 2015, Science Translational Medicine.

Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments.

M. Beeby, P. Luther, P. D. de Tombe, 2023, Journal of muscle research and cell motility.

Exploring cardiac biophysical properties

C. Bollensdorff, P. D. de Tombe, O. Cazorla, 2015, Global cardiology science & practice.

Impact of ejection on magnitude and time course of ventricular pressure-generating capacity.

W C Hunter, D. Burkhoff, W. Hunter, 1993, The American journal of physiology.

Ising model of cardiac thin filament activation with nearest-neighbor cooperative interactions.

Gustavo Stolovitzky, John Jeremy Rice, Yuhai Tu, 2003, Biophysical journal.

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres*

A. V. Dvornikov, P. D. de Tombe, N. Smolin, 2016, The Journal of Biological Chemistry.

The role of dyadic organization in regulation of sarcoplasmic reticulum Ca(2+) handling during rest in rabbit ventricular myocytes.

A. Zima, E. Bovo, P. D. de Tombe, 2014, Biophysical journal.

Myosin head orientation: a structural determinant for the Frank-Starling relationship.

T. Irving, P. D. de Tombe, D. Gore, 2011, American journal of physiology. Heart and circulatory physiology.

Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.

M. Zilliox, T. Irving, R. Gilbert, 2021, Journal of molecular and cellular cardiology.

Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium.

T. Irving, R. Fischetti, P. D. de Tombe, 2000, American journal of physiology. Heart and circulatory physiology.

Myosin binding protein C in the heart.

P. D. de Tombe, 2006, Circulation research.

New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I.

Sarah B. Scruggs, P. Ping, P. D. de Tombe, 2013, Biochimica et biophysica acta.

Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation.

A. Zima, E. Bovo, P. D. de Tombe, 2015, Biophysical journal.

Acute Inotropic and Lusitropic Effects of Cardiomyopathic R9C Mutation of Phospholamban*

P. D. de Tombe, S. Robia, Neha Abrol, 2015, The Journal of Biological Chemistry.

Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.

P. D. de Tombe, B. Wolska, R. Solaro, 1999, Circulation research.

Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation.

P. D. de Tombe, P P De Tombe, P. Janssen, 2000, American journal of physiology. Heart and circulatory physiology.

The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.

P. D. de Tombe, P. Janssen, T. Wannenburg, 1997, The American journal of physiology.

Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.

P. D. de Tombe, P. Buttrick, D. Geenen, 2005, American journal of physiology. Heart and circulatory physiology.

Restoration of Resting Sarcomere Length After Uniaxial Static Strain Is Regulated by Protein Kinase C&egr; and Focal Adhesion Kinase

B. Russell, A. Samarel, P. D. de Tombe, 2004, Circulation research.

Right ventricular contractile protein function in rats with left ventricular myocardial infarction.

P. D. de Tombe, W. Little, T. Wannenburg, 1996, The American journal of physiology.

Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils.

P. D. de Tombe, L. Walker, P. Buttrick, 2011, American journal of physiology. Heart and circulatory physiology.

Beneficial effects of SR33805 in failing myocardium.

P. D. de Tombe, A. Lacampagne, Z. Papp, 2011, Cardiovascular research.

Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte

W. Linke, O. Sejersted, P. D. de Tombe, 2023, Circulation research.

Cardiac Contractility

P. D. de Tombe, F. Pitoulis, 2019, Heart of the Matter.

Titin and the developing heart.

P. D. de Tombe, John S. Walker, 2004, Circulation research.

Glass microneedles for force measurements: a finite-element analysis model

P. D. de Tombe, John S. Walker, J. Rice, 2009, Pflügers Archiv - European Journal of Physiology.

Chronic high‐dose testosterone treatment: impact on rat cardiac contractile biology

P. D. de Tombe, Tepmanas Bupha-Intr, J. Wattanapermpool, 2019, Physiological reports.

Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes

P. D. de Tombe, O. Lookin, O. Cazorla, 2023, Pflügers Archiv - European Journal of Physiology.

Ca2+ activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T

L. Leinwand, P. D. de Tombe, J. Tardiff, 2001 .

The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.

P. D. de Tombe, P. Janssen, T. Wannenburg, 1997, American journal of physiology. Heart and circulatory physiology.

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent

P. D. de Tombe, S. Sadayappan, R. Buffenstein, 2017, Pflügers Archiv: European Journal of Physiology.

Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes

P. D. de Tombe, R. Solaro, W. Pyle, 2004, Circulation research.

Ca2+ activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric γ-actin

P. D. de Tombe, J. Lessard, Ajit Kumar, 2002 .

Rapid large-scale purification of myofilament proteins using a cleavable His6-tag.

P. D. de Tombe, Jody L. Martin, Mohit Kumar, 2015, American journal of physiology. Heart and circulatory physiology.

An internal viscous element limits unloaded velocity of sarcomere shortening in rat myocardium.

P. D. de Tombe, P. P. De Tombe, K. E. D. J. Ter Keurs, 1992 .

Pacemaker-induced transient asynchrony suppresses heart failure progression

D. Kass, R. Tunin, T. Abraham, 2015, Science Translational Medicine.

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

T. Irving, P. D. de Tombe, M. Greaser, 2016, Proceedings of the National Academy of Sciences.

Development of contractile dysfunction in rat heart failure: hierarchy of cellular events.

P. D. de Tombe, V. Rundell, M. Daniels, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.

T. Irving, P. D. de Tombe, D. Gore, 2007, Biophysical Journal.

Some rat: a very special rat with a rather special titin.

P. D. de Tombe, O. Cazorla, 2008, Journal of molecular and cellular cardiology.

Myosin light chain phosphorylation to the rescue

H. Granzier, P. D. de Tombe, 2015, Proceedings of the National Academy of Sciences.

Excitation-contraction coupling in myocardium: implications of calcium release and Na+-Ca2+ exchange.

H. T. ter Keurs, H. E. Keurs, P. D. de Tombe, 1987, Canadian Journal of Physiology and Pharmacology.

Aftercontractions and excitation-contraction coupling in rat cardiac muscle.

H. T. ter Keurs, P. D. de Tombe, P. Backx, 1988, Canadian journal of physiology and pharmacology.