P. Mathews

发表

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

S. Hébert, C. Delay, F. Calon, 2011, Molecular Neurodegeneration.

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2000, Nature.

In vivo reduction of amyloid-beta by a mutant copper transporter.

P. S. St George-Hyslop, D. Westaway, G. Carlson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl‐terminal fragments in cerebral neurons in vivo

M. Ehrlich, S. Gandy, Huaxi Xu, 2007, Journal of neurochemistry.

Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models

D. Radvinsky, S. Schmidt, P. Mathews, 2007, Nature Genetics.

Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Hartwig Wolburg, Bernardino Ghetti, Mathias Jucker, 2006, EMBO reports.

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

J. Rohrer, P. Mehta, M. Mercken, 2002, The Journal of biological chemistry.

BACE (beta-secretase) modulates the processing of APLP2 in vivo.

J. Buxbaum, P. Mathews, S. Harroch, 2004, Molecular and cellular neurosciences.

Alzheimer Amyloid Precursor Aspartyl Proteinase Activity in CHAPSO Homogenates of Spodoptera frugiperda Cells

Stefani N. Thomas, P. S. St George-Hyslop, R. Martins, 2004, Alzheimer disease and associated disorders.

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

D. Holtzman, E. Sigurdsson, T. Wisniewski, 2004, The American journal of pathology.

FE65 as a link between VLDLR and APP to regulate their trafficking and processing

Y. Suh, S. Dumanis, Toshiharu Suzuki, 2012, Molecular Neurodegeneration.

Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice

P. Mathews, S. Ginsberg, M. Alldred, 2021, Neurobiology of Aging.

Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins* 210

P. S. St George-Hyslop, P. Fraser, S. Gandy, 2002, The Journal of Biological Chemistry.

Functional Domains in Presenilin 1

U. Lendahl, S. Gandy, P. Mathews, 2004, Journal of Biological Chemistry.

Co‐expressed presenilin 1 NTF and CTF form functional γ‐secretase complexes in cells devoid of full‐length protein

B. Winblad, U. Lendahl, S. Gandy, 2004, Journal of neurochemistry.

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide

S. Schmidt, P. Mathews, R. Nixon, 2007, Journal of Molecular Neuroscience.

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

Veeranna, M. Staufenbiel, P. Mathews, 2012, Neurobiology of Aging.

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein

M. Mercken, S. Schmidt, P. Mathews, 2002, The Journal of Biological Chemistry.

Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised

D. Feinstein, E. Galea, G. Landreth, 2004, Journal of Neuroinflammation.

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins.

P. Fraser, P. Mathews, R. Hay, 2007, The Biochemical journal.

Aβ measurement by enzyme-linked immunosorbent assay.

S. Schmidt, P. Mathews, R. Nixon, 2012, Methods in molecular biology.

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.

S. Schmidt, P. Mathews, R. Nixon, 2012, Methods in molecular biology.

Aβ vaccination of a genetic model of Alzheimer's disease

D. Westaway, P. Fraser, P. George-Hyslop, 2003 .

Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice

S. Hébert, P. Mathews, A. Amrani, 2013, Diabetes.

Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1

P. S. St George-Hyslop, B. Strooper, D. Westaway, 1999, Molecular medicine.

Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells

R. Martins, P. Schofield, P. Fraser, 2004, Molecular Psychiatry.

Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

Kurt Bürki, Mathias Jucker, M. Staufenbiel, 2004, Nature Neuroscience.

Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP

R. Rozmahel, D. Westaway, P. George-Hyslop, 2002, Neurobiology of Aging.

Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation

P. Saftig, P. Mathews, J. Walter, 2011, The Journal of Neuroscience.

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

R. Rozmahel, You-Qiang Song, P. S. St George-Hyslop, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Setback for an Alzheimer’s disease vaccine

P. Mathews, R. Nixon, 2003, Neurology.

Macroautophagy—a novel (cid:1) -amyloid peptide-generating pathway activated in Alzheimer’s disease

L. Tjernberg, M. Mercken, S. Schmidt, 2005 .

ELISA Method for Measurement of Amyloid-ß Levels

S. Schmidt, P. Mathews, R. Nixon, 2005 .

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.

D. Radvinsky, S. Schmidt, P. Mathews, 2007, Nature genetics.

Tissue processing prior to protein analysis and amyloid-beta quantitation.

S. Schmidt, P. Mathews, R. Nixon, 2005, Methods in molecular biology.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases

R. Rozmahel, C. Ebeling, D. Westaway, 2005 .

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

W. Klunk, M. Staufenbiel, K. Nilsson, 2015, Neurobiology of Aging.

Degradation and Endoplasmic Reticulum Retention of Unassembled α- and β-Subunits of Na,K-ATPase Correlate with Interaction of BiP*

K. Geering, P. Mathews, P. Béguin, 1996, The Journal of Biological Chemistry.

In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology

H. Sershen, S. Schmidt, P. Mathews, 2002 .

Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPase.

K. Geering, F. Jaisser, P. Mathews, 1995, The American journal of physiology.

Extracellular amyloid formation and associated pathology in neural grafts

M. Staufenbiel, M. Mercken, M. Meyer-Luehmann, 2003, Nature Neuroscience.

Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

D. Walsh, M. Staufenbiel, M. Meyer-Luehmann, 2006, Science.

Cystatin C in aging and in Alzheimer’s disease

P. Mathews, E. Levy, 2016, Ageing Research Reviews.

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

O. Arancio, S. Schmidt, P. Mathews, 2008, The Journal of clinical investigation.

Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.

K. Geering, F. Jaisser, P. Mathews, 1994, The Journal of biological chemistry.

In vivo reduction of amyloid-β by a mutant copper transporter

D. Westaway, G. Carlson, P. George-Hyslop, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

L. Tjernberg, M. Mercken, S. Schmidt, 2005, The Journal of cell biology.

Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases Aβ Secretion

J. Rohrer, P. Mehta, M. Mercken, 2002, The Journal of Biological Chemistry.

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Brain : a journal of neurology.

Kerry A. Mullaney, S. Schmidt, P. Mathews, 2009, Proceedings of the National Academy of Sciences.

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

F. Heppner, A. Aguzzi, M. Staufenbiel, 2009, Nature Neuroscience.

Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia

F. Heppner, A. Aguzzi, M. Staufenbiel, 2010 .

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin

P. Hof, P. Schofield, D. Dickstein, 2015, Scientific Reports.

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment.

P. Mathews, B. Tate, 2006, Science of aging knowledge environment : SAGE KE.

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production*

S. Schmidt, P. Mathews, R. Nixon, 2003, Journal of Biological Chemistry.

Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

Kelly V. Ruggles, B. Ueberheide, I. Osman, 2019, bioRxiv.

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

M. Goedert, H. Akiyama, M. Jucker, 2010, Proceedings of the National Academy of Sciences.

Interactome analyses of mature gamma-secretase complexes reveals distinct molecular environments of presenilin paralogs and preferential binding of signal peptide peptidase to PS2

P. S. St George-Hyslop, P. Fraser, P. Mathews, 2013, Alzheimer's & Dementia.

Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes*

Hiroshi Hasegawa, Paul M. Mathews, Gerold Schmitt-Ulms, 2004, Journal of Biological Chemistry.

The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review

P. Mathews, R. Nixon, A. Cataldo, 2000, Neurochemical Research.

The neuronal endosomal-lysosomal system in Alzheimer's disease.

P. Mathews, R. Nixon, A. Cataldo, 2001, Journal of Alzheimer's disease : JAD.

Brain Expression of Presenilins in Sporadic and Early-onset, Familial Alzheimer’s Disease

P. Fraser, T. Bird, C. Hulette, 2000, Molecular medicine.

Age‐dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

P. Mathews, S. Ginsberg, R. Nixon, 2009, Journal of neurochemistry.

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

Y. Matsuoka, P. Mathews, L. Roberts, 2009, Neurobiology of Aging.

The in Vivo Brain Interactome of the Amyloid Precursor Protein*S

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2008, Molecular & Cellular Proteomics.

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.

L. Mucke, E. Masliah, T. Wyss-Coray, 2006, The Journal of clinical investigation.

Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases

P. Mathews, E. Levy, 2019, Front. Neurosci..

Apolipoprotein E4 genotype compromises brain exosome production

P. Mathews, S. Ginsberg, M. Alldred, 2018, Brain : a journal of neurology.

Cerebral hemorrhage after passive anti-Abeta immunotherapy.

M. Staufenbiel, M. Jucker, P. Mathews, 2002, Science.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Ralph A. Nixon, Paul M. Mathews, Patrick Horne, 2000, Nature.

High resolution approaches for the identification of amyloid fragments in brain

E. V. Van Bockstaele, P. Mathews, J. A. Ross, 2019, Journal of Neuroscience Methods.

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

J. Smiley, P. Mathews, S. Ginsberg, 2016, Neurobiology of Aging.

Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice.

P. Mathews, E. Levy, Gurjinder Kaur, 2013, Journal of Alzheimer's disease : JAD.

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.

R. Neve, Kerry A. Mullaney, P. Mathews, 2008, The American journal of pathology.

Elevated plasma cholesterol does not affect brain Aβ in mice lacking the low‐density lipoprotein receptor

J. Buxbaum, V. Haroutunian, G. Elder, 2007, Journal of neurochemistry.

Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation

S. Schmidt, P. Mathews, R. Nixon, 2004, Neurobiology of Aging.

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Aβ peptides and F2‐isoprostanes in the absence of detectable amyloid deposits

D. Holtzman, T. Montine, R. Martins, 2004, Journal of neurochemistry.

Functional expression of the gastric H,K-ATPase in Xenopus oocytes

K. Geering, F. Jaisser, P. Mathews, 1994 .

Human ATP1AL1 gene encodes a ouabain-sensitive H-K-ATPase.

A. Grishin, P. Mathews, B. Rossier, 1995, The American journal of physiology.

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

Ottavio Arancio, O. Arancio, F. Battaglia, 2004, Annals of neurology.

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition.

T. Beach, P. Mathews, J. Ghiso, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Mechanistic studies of antibody mediated clearance of tau aggregates using an ex vivo brain slice model

E. Sigurdsson, P. Mathews, P. Krishnamurthy, 2010, Alzheimer's & Dementia.

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

Sang Han Lee, E. Petkova, P. Mathews, 2015, Neurobiology of Aging.

BACE (β-secretase) modulates the processing of APLP2 in vivo

J. Buxbaum, P. Mathews, S. Harroch, 2004, Molecular and Cellular Neuroscience.

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

M. Staufenbiel, M. Jucker, P. Mathews, 2002, Science.

Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo

M. Mercken, Y. Matsuoka, P. Mathews, 2003, The Journal of Neuroscience.

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model

D. Wesson, M. Jucker, S. Schmidt, 2013, Neurobiology of Aging.

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

M. Cookson, A. Dillman, P. Mathews, 2017, Front. Neurosci..

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

Y. Matsuoka, P. Mathews, E. Levy, 2009, PloS one.

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes

Sang Han Lee, E. Petkova, P. Mathews, 2016, The Journal of Neuroscience.

Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age

H. Scharfman, P. Mathews, Á. M. Duffy, 2015, Neurobiology of Aging.

Unusual degradation of α-β complexes in Xenopus oocytes by β-subunits of Xenopus gastric H-K-ATPase.

P. Good, K. Geering, P. Mathews, 1998, American journal of physiology. Cell physiology.

Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology

S. Schmidt, P. Mathews, R. Nixon, 2004, Journal of neuropathology and experimental neurology.

ELISA method for measurement of amyloid-beta levels.

S. Schmidt, P. Mathews, R. Nixon, 2005, Methods in molecular biology.

A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice

Thomas Wisniewski, Paul M. Mathews, Stephen D. Schmidt, 2004 .

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice

Jonas K. Olofsson, Kathy Peng, P. Mathews, 2018, Neuroscience.

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Autophagy.

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

H. Scharfman, M. Cammer, P. Mathews, 2019, Molecular and Cellular Neuroscience.

Synaptic Autoregulation by Metalloproteases and γ-Secretase

R. Weinberg, P. Mathews, E. Ziff, 2011, The Journal of Neuroscience.

Tissue Processing Prior to Protein Analysis and Amyloid-ß Quantitation

S. Schmidt, P. Mathews, R. Nixon, 2005 .

Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model

D. Wesson, P. Mathews, J. Morales-Corraliza, 2013, Behavioural Brain Research.

Physiological Mouse Brain Aβ Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP

Y. Sano, S. Itohara, S. Takeda, 2006, PloS one.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

R. Rozmahel, P. S. St George-Hyslop, C. Ebeling, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A b peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer ' s disease

D. Westaway, P. Fraser, P. George-Hyslop, 2022 .

Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

P. Mathews, E. Levy, D. Wilson, 2017, Neuroscience.

Complexes of amyloid-beta and cystatin C in the human central nervous system.

F. Tagliavini, S. Schmidt, P. Mathews, 2009, Journal of Alzheimer's disease : JAD.

Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na,K-ATPase correlate with interaction of BiP.

K. Geering, P. Mathews, P. Béguin, 1996, The Journal of biological chemistry.

Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization.

K. Geering, F. Jaisser, P. Mathews, 1993, The American journal of physiology.

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

R. Rozmahel, P. S. St George-Hyslop, D. Westaway, 2002, Neurobiology of aging.

Impaired release of a soluble natural killer cytotoxic factor in systemic lupus erythematosus.

P. Mathews, A. Bankhurst, W. Sibbitt, 1984, Arthritis and rheumatism.

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

C. Delay, F. Calon, P. Mathews, 2011, Molecular Neurodegeneration.

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: Greater stability of sAPP in the β-amyloid-depositing mice

Y. Matsuoka, P. Mathews, E. Levy, 2010, Alzheimer's & Dementia.

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

C. Delay, F. Calon, P. Mathews, 2011, Molecular Neurodegeneration.

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

J. Smiley, P. Mathews, S. Ginsberg, 2016, Neurobiology of Aging.

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

L. Tjernberg, M. Mercken, S. Schmidt, 2005, The Journal of cell biology.

Macroautophagy—a novel (cid:1) -amyloid peptide-generating pathway activated in Alzheimer’s disease

L. Tjernberg, P. Mathews, P. Mohan, 2005 .