J. Panetta

A. Srinivasan, D. Srivastava, J. Panetta, 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice

E. Schuetz, J. Panetta, S. Ganguly, 2018, Drug Metabolism and Disposition.

Ketamine pharmacokinetics and pharmacodynamics are altered by Pgp and Bcrp efflux transporters in mice

E. Schuetz, J. Panetta, S. Ganguly, 2018 .

Prophylactic Trimethoprim-Sulfamethoxazole Does Not Affect Pharmacokinetics or Pharmacodynamics of Methotrexate

M. Relling, Cheng Cheng, C. Pui, 2016, Journal of pediatric hematology/oncology.

Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study

J. Panetta, W. Furman, C. Stewart, 2021, Clinical and translational science.

Comparison of Native E. coli and PEG Asparaginase Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia

W. Liu, M. Relling, J. Panetta, 2009, Clinical pharmacology and therapeutics.

Phase I and pharmacokinetic study of topotecan administered orally once daily for 5 days for 2 consecutive weeks to pediatric patients with refractory solid tumors.

P. Houghton, J. Panetta, N. Daw, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Clinical Pharmacokinetics of Amifostine and WR1065 in Pediatric Patients with Medulloblastoma

J. Panetta, A. Gajjar, C. Stewart, 2010, Clinical Cancer Research.

leukemia determinants of osteonecrosis in children with acute lymphoblastic Pharmacokinetic, pharmacodynamic, and pharmacogenetic

M. Relling, Cheng Cheng, C. Pui, 2011 .

Population pharmacokinetic studies in pediatrics: Issues in design and analysis

Stephanie Läer, Bernd Meibohm, B. Meibohm, 2005, The AAPS Journal.

Voriconazole plasma concentrations in immunocompromised pediatric patients vary by CYP2C19 diplotypes.

M. Relling, W. Evans, U. Broeckel, 2014, Pharmacogenomics.

Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.

J. Panetta, A. Gajjar, L. Iacono, 2006, Neuro-oncology.

Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase

M. Relling, Cheng Cheng, C. Pui, 2021, Cancer Chemotherapy and Pharmacology.

Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug

K. Anderson, J. Garcia, J. Panetta, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pharmacokinetics and Pharmacodynamics of Treosulfan in Patients With Thalassemia Major Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

J. Panetta, B. George, K. Lakshmi, 2018, Clinical pharmacology and therapeutics.

Population pharmacokinetic (PK) analysis of gefitinib in pediatric cancer patients

J. Panetta, N. Daw, W. Furman, 2008 .

Model Informed Precision Dosing Tool Forecasts Trough Infliximab and Associates with Disease Status and Tumor Necrosis Factor-Alpha Levels of Inflammatory Bowel Diseases

D. Mould, J. Panetta, W. Reinisch, 2022, Journal of clinical medicine.

Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial.

S. Raimondi, M. Relling, Cheng Cheng, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia

J. Opferman, C. Mullighan, D. Finkelstein, 2017, Clinical Cancer Research.

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.

Taosheng Chen, Junmin Peng, Jing Ma, 2015, Cancer cell.

Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.

Ching-Hon Pui, Melissa M Hudson, M. Relling, 2006, Blood.

Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models

M. Relling, W. Evans, J. Panetta, 2019, PloS one.

Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

Ching-Hon Pui, Mary Relling, John C. Panetta, 2010, PLoS Comput. Biol..

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

Ching-Hon Pui, Wenjian Yang, M. Relling, 2005, Blood.

In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile

Cheng Cheng, Ching-Hon Pui, Deqing Pei, 2008, PLoS medicine.

Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.

M. Relling, Cheng Cheng, C. Pui, 2020, The Journal of clinical investigation.

Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients

M. H. van den Berg, J. Panetta, J. van der Werff Ten Bosch, 2020, Cancers.

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

J. Panetta, A. Gajjar, G. Robinson, 2016, Drug Metabolism and Disposition.

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG 2 rs 4148157 on the Absorption Rate

J. Panetta, A. Gajjar, G. Robinson, 2016 .

Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.

P. Houghton, J. Panetta, J. Schuetz, 2006, Cancer research.

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Peter J Houghton, P. Houghton, R. Gilbertson, 2004, Cancer Research.

A mathematical model of drug resistance: heterogeneous tumors.

J. Panetta, J C Panetta, J. C. Panetta, 1998, Mathematical biosciences.

Development and validation of limited sampling models for topotecan lactone pharmacokinetic studies in children

J. Panetta, N. Daw, A. Gajjar, 2006, Cancer Chemotherapy and Pharmacology.

Genome-wide study of methotrexate clearance replicates SLCO1B1.

M. Loh, M. Relling, Cheng Cheng, 2013, Blood.

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

Cheng Cheng, Ching-Hon Pui, Diana Chan, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial.

J. McCarthy, R. Guy, F. Gusovsky, 2020, The Lancet. Infectious diseases.

Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice

J. Panetta, S. Baker, A. Vasilyeva, 2016, Cancer Chemotherapy and Pharmacology.

MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression

Edward C. Uberbacher, Philip F. LoCascio, Mark R. Wilkinson, 2016, PLoS Comput. Biol..

Hypersensitivity reaction to high‐dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma

J. Panetta, K. Crews, Jeffrey R Scott, 2014, Pediatric blood & cancer.

Erratum to: Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments

M. Relling, Cheng Cheng, C. Pui, 2013, Cancer Chemotherapy and Pharmacology.

Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments

M. Relling, Cheng Cheng, C. Pui, 2013, Cancer Chemotherapy and Pharmacology.

Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.

C. Waters, J. Panetta, C. Stewart, 2009, Cancer research.

Phase I study of the safety and pharmacokinetics of plerixafor in children undergoing a second allogeneic hematopoietic stem cell transplantation for relapsed or refractory leukemia.

Asha B. Pillai, A. Srinivasan, J. Panetta, 2014, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

High‐dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma

M. Tan, M. Link, J. Panetta, 2004, Cancer.

Pharmacokinetics of alemtuzumab in pediatric patients undergoing ex vivo T-cell-depleted haploidentical hematopoietic cell transplantation

J. Panetta, S. Cross, B. Triplett, 2020, Cancer Chemotherapy and Pharmacology.

Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation.

J. Panetta, S. Baker, R. Handgretinger, 2009, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Using Pharmacokinetic and Pharmacodynamic Modeling and Simulation to Evaluate Importance of Schedule in Topotecan Therapy for Pediatric Neuroblastoma

J. Panetta, C. Stewart, Clinton F Stewart, 2008, Clinical Cancer Research.

A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas.

John Carl Panetta, J. Panetta, M. Kirstein, 2003, Mathematical biosciences.

Formalizing an integrative, multidisciplinary cancer therapy discovery workflow.

Heiko Enderling, Eddy Pasquier, Mary F. McGuire, 2013, Cancer research.

Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase

M. Relling, C. Pui, J. Panetta, 2020, Pediatric blood & cancer.

Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia.

M. Relling, Cheng Cheng, D. Campana, 2012, Blood.

Title: Models of Asparaginase and Asparagine Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia

Cheng Cheng, J. Panetta, A. Gajjar, 2008 .

Predicting success of desensitization after pegaspargase allergy.

M. Relling, C. Pui, J. Panetta, 2019, Blood.

Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation

J. Panetta, B. George, K. Lakshmi, 2017, Bone Marrow Transplantation.

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

Shondra M. Pruett-Miller, J. Opferman, C. Mullighan, 2020, Molecular Cancer Research.

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.

M. Relling, C. Pui, W. Evans, 2004, Pharmacogenetics.

A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia

Ching-Hon Pui, William E. Evans, Mary V. Relling, 2002, Cancer Chemotherapy and Pharmacology.

Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia.

D. Campana, J. Rehg, J. Panetta, 2011, Journal of the National Cancer Institute.

Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Amar Gajjar, Arzu Onar-Thomas, Thomas E Merchant, 2013, Clinical Cancer Research.

Cancer Therapy : Clinical Phase I Trial , Pharmacokinetics , and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

T. Merchant, J. Panetta, A. Davidoff, 2013 .

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

M. Relling, Cheng Cheng, C. Pui, 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia

M. Relling, C. Pui, W. Evans, 2020, Nature Cancer.

Phase 1 study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies

Cheng Cheng, C. Pui, R. Ribeiro, 2021, Cancer.

A logistic model of periodic chemotherapy with drug resistance

J. Panetta, J. C. Panetta, 1997 .

Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.

J. Panetta, C. Stewart, Charles H. Fraga, 2009, Biomedical chromatography : BMC.

Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL.

P. Hinds, J. Gattuso, J. Panetta, 2010, European journal of cancer.

Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors.

P. Houghton, J. Panetta, C. Rodríguez-Galindo, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia

C. Pui, J. Klco, R. Ribeiro, 2020, Cancer.

Chemotherapeutic Effects on Hematopoiesis: A Mathematical Model

J. Panetta, Penn Stute Erie, 1998 .

Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.

M. Relling, W. Evans, Wenjian Yang, 2007, Human molecular genetics.

Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration

Fan Zhang, Fangyi Zhu, R Kiplin Guy, 2011, Drug Metabolism and Disposition.

The importance of pharmacokinetic limited sampling models for childhood cancer drug development.

P. Adamson, J. Panetta, L. Iacono, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Preclinical pharmacokinetic and pharmacodynamic evaluation of dasatinib and ponatinib for the treatment of T-cell acute lymphoblastic leukemia

C. Pui, D. Teachey, C. Mullighan, 2023, Leukemia.

Modelling the Effects of Paclitaxel and Cisplatin on Breast and Ovarian Cancer

M. Chaplain, D. Cameron, J. Panetta, 2000 .

Limited and Optimal Sampling Strategies for Etoposide and Etoposide Catechol in Children with Leukemia

Ching-Hon Pui, John Carl Panetta, Mary V. Relling, 2002, Journal of Pharmacokinetics and Pharmacodynamics.

Late-onset delayed excretion of methotrexate

M. Relling, C. Pui, J. Panetta, 2004, Cancer Chemotherapy and Pharmacology.

Optimal Control Applied to Competing Chemotherapeutic Cell-Kill Strategies

John Carl Panetta, K. Renee Fister, J. Panetta, 2003, SIAM J. Appl. Math..

Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy

John Carl Panetta, K. Renee Fister, J. Panetta, 2000, SIAM J. Appl. Math..

Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.

M. Relling, Cheng Cheng, C. Pui, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacokinetics of Erlotinib for the Treatment of High‐Grade Glioma in a Pediatric Patient with Cystic Fibrosis: Case Report and Review of the Literature

J. Panetta, C. Stewart, A. Broniscer, 2009, Pharmacotherapy.

Mathematical modeling of folate metabolism

W. Evans, J. Panetta, Steven W. Paugh, 2013, Wiley interdisciplinary reviews. Systems biology and medicine.

Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer Patients

J. Panetta, A. Gajjar, L. Iacono, 2007, Clinical Cancer Research.

Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression

S. Strom, E. Schuetz, J. Panetta, 2010, Journal of Pharmacology and Experimental Therapeutics.

Genetic Predictors of Interindividual Variability in Hepatic

S. Strom, E. Schuetz, J. Panetta, 2010 .

Genetic predictors of inter-individual variability in hepatic CYP 3 A 4 expression

S. Strom, E. Schuetz, J. Panetta, 2009 .

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

M. Relling, Cheng Cheng, C. Pui, 2021, Clinical and translational science.

M. Relling, Cheng Cheng, C. Pui, 2020, Blood.

The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia.

M. Relling, Cheng Cheng, W. Evans, 2008, Journal of the National Cancer Institute.

The effect of body mass index at diagnosis on clinical outcome in children with newly diagnosed acute lymphoblastic leukemia

M. Relling, D. Campana, C. Pui, 2017, Blood Cancer Journal.

Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia.

M. Relling, C. Pui, R. Ribeiro, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Expression of SMARCB 1 modulates steroid sensitivity in human lymphoblastoid cells : identification of a promoter snp that alters PARP 1 binding and SMARCB 1 expression

M. Relling, W. Evans, Wenjian Yang, 2007 .

Association between obesity and neurocognitive function in survivors of childhood acute lymphoblastic leukemia treated only with chemotherapy

C. Pui, D. Srivastava, K. Krull, 2021, Cancer.

Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells

W. Evans, J. Panetta, M. Cheok, 2005, British Journal of Cancer.

Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia

M. Relling, Cheng Cheng, C. Pui, 2020, Pediatric blood & cancer.

in acute lymphoblastic leukemia Dexamethasone exposure and asparaginase antibodies affect relapse risk

Cheng Cheng, C. Pui, W. Evans, 2011 .

A logistic model of periodic chemotherapy

J. Panetta, 1995 .

Genome‐Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy

M. Loh, M. Relling, Cheng Cheng, 2017, Clinical pharmacology and therapeutics.

Incidence of hip and knee osteonecrosis and their associations with bone mineral density in children with acute lymphoblastic leukaemia

M. Relling, Cheng Cheng, C. Pui, 2020, British journal of haematology.

UGT1A1 promoter genotype correlates with pharmacokinetics but not toxicity in patients receiving protracted irinotecan (IRN).

J. Panetta, L. McGregor, W. Furman, 2006, Journal of Clinical Oncology.

The mathematical modelling of cancer: a review: a review

J. Adam, M. Chaplain, J. Panetta, 1998 .

Pharmacogenetic Pathway Analysis of Irinotecan

M. Ratain, J. Panetta, F. Innocenti, 2008, Clinical pharmacology and therapeutics.

A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment

John Carl Panetta, J. Panetta, 1996 .

A mathematical model of cycle-specific chemotherapy

John A. Adam, J. Adam, J. Panetta, 1995 .

Treosulfan Exposure Predicts Thalassemia‐Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation

J. Panetta, B. George, P. Balasubramanian, 2023, Clinical pharmacology and therapeutics.

A simple mathematical model and alternative paradigm for certain chemotherapeutic regimens

John A. Adam, J. Adam, J. Panetta, 1995 .

Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development

J. McCarthy, F. Gusovsky, J. Panetta, 2022, EBioMedicine.

Phase I study of the tolerability and pharmacokinetics of palifermin in children undergoing allogeneic hematopoietic stem cell transplantation.

A. Srinivasan, D. Srivastava, J. Panetta, 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.