A. Griffiths

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Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization

Dan S. Tawfik, A. Griffiths, 2003, The EMBO journal.

Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms.

Christoph A. Merten, D. Weitz, K. Humphry, 2008, Chemistry & biology.

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

A. Abate, D. Weitz, A. Klibanov, 2010, Proceedings of the National Academy of Sciences.

Enhanced chemical synthesis at soft interfaces: a universal reaction-adsorption mechanism in microcompartments.

Andrew D Griffiths, Martin Karplus, Thomas Mangeat, 2014, Physical review letters.

A fast and efficient microfluidic system for highly selective one-to-one droplet fusion.

Andrew D Griffiths, Jean-Christophe Baret, L. Mazutis, 2009, Lab on a chip.

Miniaturization and parallelization of biological and chemical assays in microfluidic devices.

Christoph A. Merten, A. Griffiths, Saurabh Vyawahare, 2010, Chemistry & biology.

Droplet-based microfluidics platform for ultra-high-throughput bioprospecting of cellulolytic microorganisms.

A. Griffiths, M. Najah, R. Calbrix, 2014, Chemistry & biology.

Phage antibodies: filamentous phage displaying antibody variable domains

G. Winter, A. Griffiths, J. McCafferty, 1990, Nature.

Functional single-cell hybridoma screening using droplet-based microfluidics

Christoph A. Merten, A. Griffiths, I. Balyasnikova, 2012, Proceedings of the National Academy of Sciences.

Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity.

D. Weitz, A. Griffiths, J. B. Hutchison, 2009, Lab on a chip.

High-throughput screening of enzymes by retroviral display using droplet-based microfluidics.

Christoph A. Merten, A. Griffiths, J. Baret, 2010, Chemistry and Biology.

Quantitative cell-based reporter gene assays using droplet-based microfluidics.

D. Moras, A. Griffiths, J. Baret, 2010, Chemistry & biology.

Single-cell analysis and sorting using droplet-based microfluidics

D. Weitz, L. Mazutis, J. Heyman, 2013, Nature Protocols.

Droplets as Microreactors for High‐Throughput Biology

A. Griffiths, Valerie Taly , B. T. Kelly, 2007, Chembiochem : a European journal of chemical biology.

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics.

L. Mazutis, P. Laurent-Puig, Jonathan W. Larson, 2011, Lab on a chip.

Droplet-based microfluidics at the femtolitre scale.

P. Tabeling, A. Griffiths, M. Leman, 2015, Lab on a chip.

In vitro compartmentalization by double emulsions: sorting and gene enrichment by fluorescence activated cell sorting.

Dan S. Tawfik, S. Magdassi, A. Griffiths, 2004, Analytical biochemistry.

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

D. Baker, D. Hilvert, P. Mittl, 2016, Nature Chemistry.

Reliable microfluidic on-chip incubation of droplets in delay-lines.

A. Griffiths, K. Blank, E. Brouzes, 2009, Lab on a chip.

Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients.

P. Laurent-Puig, A. Griffiths, H. Blons, 2013, Clinical chemistry.

High-resolution dose–response screening using droplet-based microfluidics

A. Griffiths, D. Link, M. Samuels, 2011, Proceedings of the National Academy of Sciences of the United States of America.

Drop-based microfluidic devices for encapsulation of single cells.

Christoph A. Merten, D. Weitz, D. Pisignano, 2008, Lab on a chip.

High-throughput screening of filamentous fungi using nanoliter-range droplet-based microfluidics

A. Griffiths, Angélique Couvent, M. Najah, 2016, Scientific Reports.

Making antibody fragments using phage display libraries

T. Clackson, G. Winter, A. Griffiths, 1991, Nature.

Making antibodies by phage display technology.

G. Winter, A. Griffiths, H. Hoogenboom, 1994, Annual review of immunology.

High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer

C. Vallot, F. Reyal, A. Griffiths, 2019, Nature Genetics.

Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles.

Christoph A. Merten, V. Beneš, P. Poignard, 2017, Cell chemical biology.

Man-made cell-like compartments for molecular evolution

Dan S. Tawfik, A. Griffiths, 1998, Nature Biotechnology.

High-throughput screens and selections of enzyme-encoding genes.

Andrew D Griffiths, Dan S. Tawfik, Dan S Tawfik, 2005, Current opinion in chemical biology.

Miniaturising the laboratory in emulsion droplets.

Andrew D Griffiths, Dan S. Tawfik, Dan S Tawfik, 2006, Trends in biotechnology.

By-passing immunization. Human antibodies from V-gene libraries displayed on phage.

H R Hoogenboom, G. Winter, A. Griffiths, 1991, Journal of molecular biology.

A completely in vitro ultrahigh-throughput droplet-based microfluidic screening system for protein engineering and directed evolution.

Andrew D Griffiths, Michael Ryckelynck, Jean-Christophe Baret, 2012, Lab on a chip.

Dynamic single-cell phenotyping of immune cells using the microfluidic platform DropMap

J. Baudry, J. Bibette, A. Griffiths, 2020, Nature Protocols.

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

P. T. Jones, G. Winter, A. Griffiths, 1989, Nature.

Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme.

Andrew D Griffiths, Valérie Taly, Michael Ryckelynck, 2009, Lab on a chip.

Droplet-based microreactors for the synthesis of magnetic iron oxide nanoparticles.

Andrew D Griffiths, Jean-Christophe Baret, A. Griffiths, 2008, Angewandte Chemie.

Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage.

J M Thornton, J. Thornton, G. P. Smith, 1998, Journal of molecular biology.

Miniaturizing chemistry and biology in microdroplets.

Andrew D Griffiths, Jean-Christophe Baret, Valerie Taly, 2007, Chemical communications.

Teaching single-cell digital analysis using droplet-based microfluidics.

Andrew D Griffiths, Michael Ryckelynck, A. Griffiths, 2012, Analytical chemistry.

Ultrahigh-throughput screening enables efficient single-round oxidase remodelling

D. Hilvert, A. Griffiths, A. Green, 2019, Nature Catalysis.

CotA laccase: high-throughput manipulation and analysis of recombinant enzyme libraries expressed in E. coli using droplet-based microfluidics.

Andrew D Griffiths, Valérie Taly, Jean-Christophe Baret, 2014, The Analyst.

Membraneless glucose/O2 microfluidic biofuel cells using covalently bound enzymes.

A. Griffiths, T. Beneyton, V. Taly, 2013, Chemical communications.

A competition-based assay for the screening of species-specific antibiotics.

Christoph A. Merten, A. Griffiths, Oliver J. Miller, 2009, The Journal of antimicrobial chemotherapy.

The Quantitative Assessment of the Secreted IgG Repertoire after Recall to Evaluate the Quality of Immunizations

J. Baudry, J. Bibette, A. Griffiths, 2020, The Journal of Immunology.

RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling†

Yoshiya J. Matsubara, S. Krishna, A. Griffiths, 2021, Chemical Communications.

DROPLETBASED MICROFLUIDICS FOR QUANTITATIVE CELLBASED REPORTER GENE ASSAYS

D. Moras, A. Griffiths, I. Billas, 2010 .

Promiscuous methylation of non-canonical DNA sites by HaeIII methyltransferase.

Dan S. Tawfik, A. Griffiths, H. M. Cohen, 2002, Nucleic acids research.

WHY IS THE MINIMUM UNIT OF LIFE A CELL ? : BUILDING AN “ RNA WORLD ” MODEL PROTOCELL USING DROPLET-BASED MICROFLUIDICS

A. Griffiths, Ali Fallah-Araghi, M. Ryckelynck, 2012 .

Cell-free selection of domain antibodies by in vitro compartmentalization.

A. Griffiths, A. Sepp, 2012, Methods in molecular biology.

Microtubule minus ends can be labelled with a phage display antibody specific to alpha-tubulin.

L. Amos, R. Cross, A. Griffiths, 1996, Journal of molecular biology.

In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation.

G. Winter, A. Griffiths, J. Marks, 1994, Journal of molecular biology.

Generating binding activities from Escherichia coli by expression of a repertoire of immunoglobulin variable domains.

G. Winter, A. Griffiths, E. Ward, 1989, Cold Spring Harbor symposia on quantitative biology.

Smith, G.P. et al. Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage. J. Mol. Biol. 277, 317-332

J. Thornton, G. Smith, G. Winter, 1998 .

Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms.

A. Griffiths, J. Baret, Ali Fallah-Araghi, 2013, Chemical communications.

Human anti‐self antibodies with high specificity from phage display libraries.

J. Bye, G. Winter, A. Griffiths, 1993, The EMBO journal.

A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.

R. Kontermann, G. Winter, A. Griffiths, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires.

G. Winter, A. Griffiths, P. Waterhouse, 1993, Nucleic acids research.

Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains.

H R Hoogenboom, G. Winter, A. Griffiths, 1991, Nucleic acids research.

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.

Gareth R. Williams, A. Fersht, A. Griffiths, 2006, Journal of medicinal chemistry.

Kinetic aspects of emulsion stabilization by surfactants: a microfluidic analysis.

Jean-Christophe Baret, A. Griffiths, J. Baret, 2009, Langmuir : the ACS journal of surfaces and colloids.

Using droplet-based microfluidics to improve the catalytic properties of RNA under multiple-turnover conditions

Andrew D Griffiths, Eric Westhof, Michael Ryckelynck, 2015, RNA.

Selection of ribozymes that catalyse multiple-turnover Diels-Alder cycloadditions by using in vitro compartmentalization.

A. Griffiths, J. Agresti, A. Jäschke, 2005, Proceedings of the National Academy of Sciences of the United States of America.

New generation of amino coumarin methyl sulfonate-based fluorogenic substrates for amidase assays in droplet-based microfluidic applications.

A. Griffiths, Oliver J. Miller, Abdeslam El Harrak, 2011, Analytical Chemistry.

Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine.

Dan S. Tawfik, A. Griffiths, D. Loakes, 2005, Organic and biomolecular chemistry.

Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry

Dan S. Tawfik, A. Griffiths, A. Sepp, 2002, FEBS letters.

Stereospecificity of nucleases towards phosphorothioate-substituted RNA: stereochemistry of transcription by T7 RNA polymerase.

I. Eperon, A. Griffiths, B. Potter, 1987, Nucleic acids research.

Building antibodies from their genes.

G. Winter, A. Griffiths, J. Marks, 1993, Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine.

Production of human antibodies using bacteriophage.

A. Griffiths, A D Griffiths, 1993, Current opinion in immunology.

By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling

Andrew D. Griffiths, James D. Marks, Jacqueline M. Bye, 1992, Bio/Technology.

Expression and Secretion of Repertoires of VH Domains in Escherichia Coli : Isolation of Antigen Binding Activities

P. T. Jones, G. Winter, A. Griffiths, 1989 .

Droplet-based microfluidic high-throughput screening of heterologous enzymes secreted by the yeast Yarrowia lipolytica

Andrew D Griffiths, Jean-Marc Nicaud, Tristan Rossignol, 2017, Microbial Cell Factories.

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

I. Graham, I. Eperon, A. Griffiths, 1988, Cell.

C1LC20128J 2156..2166

L. Mazutis, P. Laurent-Puig, Jonathan W. Larson, 2011 .

Deep phenotypic characterization of immunization-induced antibacterial IgG repertoires in mice using a single-antibody bioassay

J. Baudry, J. Bibette, A. Griffiths, 2020, Communications Biology.

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

J. Baudry, A. Griffiths, P. Bruhns, 2020, Nature Biotechnology.

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

Andrew D Griffiths, Jean Baudry, Klaus Eyer, 2017, Nature Biotechnology.

Strategies for selection of antibodies by phage display.

A. Griffiths, A D Griffiths, A. Duncan, 1998, Current opinion in biotechnology.

Darwinian properties and their trade-offs in autocatalytic RNA reaction networks

Bryce E. Clifton, A. Griffiths, Baptiste Saudemont, 2021, Nature communications.

Darwinian properties and their trade-offs in autocatalytic RNA networks

Sandeep Ameta, Simon Arsène, Sophie Foulon, 2019, bioRxiv.

Single-cell analysis and sorting using droplet-based

W. Lloyd Ung, Andrew D. Griffiths, David A. Weitz, 2013 .

DROPLET-BASED MICROFLUIDICS FOR THE QUANTITATIVE DETECTION OF RARE MUTATIONS

L. Mazutis, P. Laurent-Puig, A. Griffiths, 2010 .

Transient compartmentalization of RNA replicators prevents extinction due to parasites

Eörs Szathmáry, Andrew D. Griffiths, Philippe Nghe, 2016, Science.

Metabolic cost of rapid adaptation of single yeast cells

E. Braun, J. Baudry, J. Bibette, 2019, Proceedings of the National Academy of Sciences.

Lineage Tracking for Probing Heritable Phenotypes at Single-Cell Resolution

J. D. de Visser, J. Baudry, J. Bibette, 2016, PloS one.

Synthesis of new hydrophilic rhodamine based enzymatic substrates compatible with droplet-based microfluidic assays.

Andrew D Griffiths, Janine Cossy, Clément Nizak, 2017, Chemical communications.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Richard Obexer, Moritz Pott, Cathleen Zeymer, 2016, Protein engineering, design & selection : PEDS.

Activity‐Fed Translation (AFT) Assay: A New High‐Throughput Screening Strategy for Enzymes in Droplets

A. Griffiths, M. Ryckelynck, P. Soumillion, 2015, Chembiochem : a European journal of chemical biology.

New glycosidase substrates for droplet-based microfluidic screening.

Andrew D. Griffiths, Estelle Mayot, A. Griffiths, 2013, Analytical Chemistry.

Microfluidic Approaches for the Study of Emulsions: Transport of Solutes

A. Griffiths, J. Baret, V. Taly, 2013 .

Microfluidic platform for combinatorial synthesis in picolitre droplets.

Andrew D Griffiths, Wilhelm T S Huck, Estelle Mayot, 2012, Lab on a chip.

High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions.

A. Griffiths, E. Mastrobattista, V. Taly, 2005, Chemistry & biology.

Dynamics of molecular transport by surfactants in emulsions

L. Mazutis, A. Griffiths, J. B. Hutchison, 2012 .

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

J. Baudry, A. Griffiths, P. Bruhns, 2020, Nature Biotechnology.

High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer

C. Vallot, F. Reyal, A. Griffiths, 2019, Nature Genetics.

Directed evolution by in vitro compartmentalization

Andrew D Griffiths, Dan S. Tawfik, Shlomo Magdassi, 2006, Nature Methods.

An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries.

Andrew D Griffiths, Christoph A Merten, A. Griffiths, 2010, Lab on a chip.

Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR.

Qun Zhong, Valérie Taly, Jonathan W. Larson, 2011, Lab on a chip.

Amplification of complex gene libraries by emulsion PCR

Andrew D Griffiths, Dan S. Tawfik, Shlomo Magdassi, 2006, Nature Methods.

Man-made enzymes--from design to in vitro compartmentalisation.

Dan S. Tawfik, A. Griffiths, A D Griffiths, 2000, Current opinion in biotechnology.

Selective droplet coalescence using microfluidic systems.

Andrew D Griffiths, L. Mazutis, A. Griffiths, 2012, Lab on a chip.

Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library selection using in vitro compartmentalisation.

Dan S. Tawfik, A. Griffiths, Yin-Fai Lee, 2002, Nucleic acids research.

MULTIPLEX HIGHLY SENSITIVE DETECTION OF CANCER BIOMARKERS IN BIOLOGICAL SAMPLES

L. Mazutis, P. Laurent-Puig, A. Griffiths, 2011 .

Droplet-based microfluidic systems for high-throughput single DNA molecule isothermal amplification and analysis.

Andrew D Griffiths, Valérie Taly, Benjamin J Miller, 2009, Analytical chemistry.

Coupled catabolism and anabolism in autocatalytic RNA sets

Sandeep Ameta, Simon Arsène, Philippe Nghe, 2018, Nucleic acids research.

Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalization.

Dan S. Tawfik, A. Griffiths, H. M. Cohen, 2004, Protein engineering, design & selection : PEDS.

Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.

G. Winter, A. Griffiths, J. Marks, 1992, Journal of Biological Chemistry.

igh-throughput screens and selections of enzyme-encoding enes

A. Griffiths, D. Tawfik, M. Aharoni, 2005 .

Preparation of monodisperse emulsions by hydrodynamic size fractionation

L. Mazutis, A. Griffiths, 2009 .

Droplet-Based Microfluidics

Oliver J. Dressler, Soo-Ik Chang, Andrew J deMello, 2014, Journal of biomolecular screening.

Miniaturizing Chemistry and Biology in Microdroplets

Andrew D. Griffiths, Valérie Taly, Jean-Christophe Baret, 2007 .

The Thermophilic CotA Laccase from Bacillus subtilis: Bioelectrocatalytic Evaluation of O2 Reduction in the Direct and Mediated Electron Transfer Regime

W. Schuhmann, A. Griffiths, Yvonne Beyl, 2011 .

Microfluidic production of droplet pairs.

Andrew D Griffiths, Jean-Christophe Baret, A. Griffiths, 2008, Langmuir : the ACS journal of surfaces and colloids.

Immobilization of CotA, an extremophilic laccase from Bacillus subtilis, on glassy carbon electrodes for biofuel cell applications

Andrew D. Griffiths, Valérie Taly, Thomas Beneyton, 2011 .

Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant.

A. Fersht, A. Griffiths, C. Timperley, 2011, Protein engineering, design & selection : PEDS.

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters.

Andrew D Griffiths, A. Fersht, A. Griffiths, 2011, Protein engineering, design & selection : PEDS.

Isolation of high affinity human antibodies directly from large synthetic repertoires.

P. T. Jones, P. Waterhouse, W. Crosby, 1994, The EMBO journal.

Non-steroidal follicular factors attenuate the self-priming action of gonadotropin-releasing hormone on the pituitary gonadotroph.

A. Griffiths, S. Whitehead, N. J. Busbridge, 1990, Neuroendocrinology.

Droplet-based microfluidics

A. Abate, D. Densmore, A. deMello, 2023, Nature Reviews Methods Primers.

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics.

L. Mazutis, P. Laurent-Puig, Jonathan W. Larson, 2011, Lab on a chip.

A fast and efficient microfluidic system for highly selective one-to-one droplet fusion.

L. Mazutis, A. Griffiths, J. Baret, 2009, Lab on a chip.

High-resolution dose–response screening using droplet-based microfluidics

A. Griffiths, D. Link, M. Samuels, 2011, Proceedings of the National Academy of Sciences.

Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme.

L. Mazutis, A. Griffiths, J. Baret, 2009, Lab on a chip.

Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalization.

Dan S. Tawfik, A. Griffiths, H. M. Cohen, 2004, Protein engineering, design & selection : PEDS.

Darwinian properties and their trade-offs in autocatalytic RNA reaction networks

Bryce E. Clifton, A. Griffiths, Baptiste Saudemont, 2021, Nature Communications.

Kinetic aspects of emulsion stabilization by surfactants: a microfluidic analysis.

A. Griffiths, J. Baret, Abdeslam El Harrak, 2009, Langmuir : the ACS journal of surfaces and colloids.

Small-molecule autocatalysis drives compartment growth, competition and reproduction

E. Szathmáry, P. Pelupessy, A. Griffiths, 2023, Nature chemistry.

Author Correction: High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

J. Baudry, A. Griffiths, P. Bruhns, 2020, Nature Biotechnology.

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

J. Baudry, J. Bibette, A. Griffiths, 2017, Nature Biotechnology.