H. Holden

发表

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.

F. Raushel, C. Hill, Wen‐Shan Li, 2003, Journal of the American Chemical Society.

High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.

F. Raushel, H. Holden, M. Benning, 2001, Biochemistry.

Phosphotriesterase: an enzyme in search of its natural substrate.

F. Raushel, H. Holden, 2000, Advances in enzymology and related areas of molecular biology.

The Binding of Substrate Analogs to Phosphotriesterase*

F. Raushel, H. Holden, M. Benning, 2000, The Journal of Biological Chemistry.

Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.

F. Raushel, H. Holden, M. Benning, 1996, Biochemistry.

Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.

F. Raushel, H. Holden, J. Kuo, 1994, Biochemistry.

Three-dimensional structure of the binuclear metal center of phosphotriesterase.

F. Raushel, H. Holden, J. Kuo, 1995, Biochemistry.

Channeling of substrates and intermediates in enzyme-catalyzed reactions.

F. Raushel, H. Holden, X. Huang, 2001, Annual review of biochemistry.

X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.

H M Holden, I. Rayment, D. Hartshorne, 1992, Journal of molecular biology.

Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.

H M Holden, I. Rayment, H. Holden, 1994, Biochemistry.

PurT-encoded Glycinamide Ribonucleotide Transformylase

Stephen J Benkovic, S. Benkovic, J. Thoden, 2002, The Journal of Biological Chemistry.

Enzymes with molecular tunnels.

F. Raushel, J. Thoden, H. Holden, 2003, Accounts of chemical research.

Fe-S-Based l-Serine Dehydratases

J. Thoden, H. Holden, G. A. Grant, 2016 .

Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily.

J. Thoden, H. Holden, A. Salinger, 2016, Biochemistry.

Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.

W. Cleland, J. Thoden, H. Holden, 2012, Biochemistry.

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond.

H M Holden, D E Tronrud, B. Matthews, 1987, Science.

Structural analysis of QdtB, an aminotransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.

J. Thoden, H. Holden, P. Messner, 2009, Biochemistry.

Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.

H. Holden, E. S. Burgie, 2007, Biochemistry.

Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.

J. Fridovich-Keil, J. Thoden, H. Holden, 2000, Biochemistry.

Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism.

P. Frey, J. Thoden, H. Holden, 1996, Biochemistry.

Importance of a conserved hydrogen-bonding network in cytochromes c to their redox potentials and stabilities.

F. Daldal, H. Holden, M. Caffrey, 1991, Biochemistry.

Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution.

I. Rayment, H. Holden, W. Rypniewski, 1993 .

Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.

P. Frey, J. Kim, J. Thoden, 1997, Biochemistry.

Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni.

F. Raushel, J. Thoden, H. Holden, 2021, Biochemistry.

Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.

J. Quinn, B. Martin, D. Dunaway-Mariano, 2011, Biochemistry.

Structural and Functional Studies of QdtC : An N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3 , 6-dideoxy-RD-glucose † , ‡

J. Thoden, H. Holden, P. Messner, 2009 .

Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.

H. Holden, E. S. Burgie, 2008, Biochemistry.

The molecular architecture of glucose‐1‐phosphate uridylyltransferase

J. Thoden, H. Holden, 2007, Protein science : a publication of the Protein Society.

uridylyltransferase The molecular architecture of glucose-1-phosphate

J. Thoden, H. Holden, 2007 .

Active site geometry of glucose‐1‐phosphate uridylyltransferase

J. Thoden, H. Holden, 2007, Protein science : a publication of the Protein Society.

The Molecular Architecture of Human N-Acetylgalactosamine Kinase*

J. Thoden, H. Holden, 2005, Journal of Biological Chemistry.

Crystal structure of gene locus At3g16990 from Arabidopsis thaliana

G. Phillips, I. Rayment, Paul G. Blommel, 2004, Proteins.

Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.

H. Holden, P. D. Cook, A. E. Carney, 2008, Biochemistry.

Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli.

P. Frey, J. Thoden, H. Holden, 1997, Biochemistry.

Residues C123 and D58 of the 2-Methylisocitrate Lyase (PrpB) Enzyme of Salmonella enterica Are Essential for Catalysis

I. Rayment, H. Holden, J. Escalante‐Semerena, 2003, Journal of bacteriology.

Reaction Mechanism and Three-Dimensional Structure of GDP-d-glycero-α-d-manno-heptose 4,6-Dehydratase from Campylobacter jejuni.

F. Raushel, J. Thoden, H. Holden, 2022, Biochemistry.

4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase

Jennifer J. Kohler, J. Thoden, H. Holden, 2021, ACS chemical biology.

Structure and function of an N‐acetyltransferase from the human pathogen Acinetobacter baumannii isolate BAL_212

J. Thoden, H. Holden, Noah R. Herkert, 2022, Proteins.

DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI

P. Frey, J. Thoden, H. Holden, 1998 .

The structure of GDP‐4‐keto‐6‐deoxy‐d‐mannose‐3‐dehydratase: A unique coenzyme B6‐dependent enzyme

J. Thoden, H. Holden, P. D. Cook, 2006, Protein science : a publication of the Protein Society.

The isolation, purification, and preliminary crystallographic characterization of udp‐galactose‐4‐epimerase from Escherichia coli

P. Frey, I. Rayment, H. Holden, 1991, Proteins.

Crystallization and preliminary analysis of oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120.

J. Markley, H. Holden, Y. Chae, 1992, Archives of biochemistry and biophysics.

Crystallization and Structure Determination to 2 . 581 Resolution of the Oxidized [ 2 Fe2 SI Ferredoxin Isolated from Anabaena 7 120 t

B. Oh, I. Rayment, J. Markley, 2001 .

From the Three-Dimensional Structure of Phosphotriesterase.

F. Raushel, H. Holden, 2021, Biochemistry.

Enzymes required for the biosynthesis of N-formylated sugars.

J. Thoden, H. Holden, M. Gilbert, 2016, Current opinion in structural biology.

Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase.

L. Pedersen, H. Holden, M. Benning, 1995, Biochemistry.

Crystal structure of 4-hydroxybenzoyl CoA thioesterase from arthrobacter sp. strain SU complexed with 4-hydroxybenzyl CoA

Zhihao Zhuang, D. Dunaway-Mariano, J. Thoden, 2003 .

Kinetic and Structural Analysis of α-d-Glucose-1-phosphate Cytidylyltransferase from Salmonella typhi*

W. Cleland, H. Holden, N. Koropatkin, 2005, Journal of Biological Chemistry.

X-ray Structures of the Apo and MgATP-bound States ofDictyostelium discoideum Myosin Motor Domain*

H M Holden, I. Rayment, J. Thoden, 2000, The Journal of Biological Chemistry.

Molecular structure of the oxidized high-potential iron-sulfur protein isolated from Ectothiorhodospira vacuolata.

I. Rayment, T. Meyer, H. Holden, 1994, Biochemistry.

Preliminary X-ray crystallographic analysis of biotin carboxylase isolated from Escherichia coli.

I. Rayment, H. Holden, G. Waldrop, 1994, Journal of molecular biology.

Crystallization and preliminary crystallographic analysis of a thermostable mutant of kanamycin nucleotidyltransferase.

I. Rayment, H. Holden, J. Sakon, 1992, Archives of biochemistry and biophysics.

Crystallization and preliminary analysis of crystals of cytochrome c2 from Rhodopseudomonas capsulata.

I. Rayment, F. Daldal, T. Meyer, 1987, Journal of molecular biology.

Carbamoyl phosphate synthetase: a crooked path from substrates to products.

F. Raushel, J. Thoden, H. Holden, 1998, Current opinion in chemical biology.

Catalysis Are Essential for Salmonella enterica 2-Methylisocitrate Lyase ( PrpB ) Enzyme of Residues C 123 and D 58 of the

I. Rayment, H. Holden, T. L. Grimek, 2003 .

Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.

J. Thoden, H. Holden, S. Firestine, 2009, Bioorganic & medicinal chemistry.

GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar.

H. Holden, P. D. Cook, 2008, Biochemistry.

Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli.

J. Thoden, H. Holden, A. Gulick, 1997, Biochemistry.

Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.

J. Thoden, H. Holden, P. Messner, 2009, Biochemistry.

Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli.

P. Frey, J. Thoden, H. Holden, 1996, Biochemistry.

Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site.

P. Frey, I. Rayment, J. Thoden, 1997, Biochemistry.

The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis.

H M Holden, B. Matthews, H. Holden, 1989, The Journal of biological chemistry.

The X-ray Structure of dTDP-4-Keto-6-deoxy-D-glucose-3,4-ketoisomerase*

J. Thoden, H. Holden, Melissa L. Davis, 2007, Journal of Biological Chemistry.

W. W. "Mo" Cleland: a catalytic life.

F. Raushel, D. Dunaway-Mariano, H. Holden, 2013, Biochemistry.

Structure of l-Serine Dehydratase from Legionella pneumophila: Novel Use of the C-Terminal Cysteine as an Intrinsic Competitive Inhibitor

J. Thoden, H. Holden, G. A. Grant, 2014, Biochemistry.

Structural studies on KijD1, a sugar C‐3′‐methyltransferase

J. Thoden, H. Holden, G. Dow, 2016, Protein science : a publication of the Protein Society.

Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni.

C. Szymanski, F. Raushel, H. Holden, 2017, Journal of the American Chemical Society.

Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.

H M Holden, D E Tronrud, B. Matthews, 1989, Biochemistry.

Structure of the β2 homodimer of bacterial luciferase from vibrio harveyi: X‐ray analysis of a kinetic protein folding trap

A. Fisher, I. Rayment, J. Thoden, 1997, Protein science : a publication of the Protein Society.

The Three-dimensional Structure of the Core Domain of Naf Y from Azotobacter vinelandii determined at 1.8-Å Resolution*

I. Rayment, J. Thoden, H. Holden, 2003, Journal of Biological Chemistry.

Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase.

A. E. Hodges, G. Tollin, J. Markley, 1997, Biochemistry.

High‐resolution X‐ray structure of UDP‐galactose 4‐epimerase complexed with UDP‐phenol

P. Frey, J. Thoden, H. Holden, 1996, Protein science : a publication of the Protein Society.

Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.

I. Rayment, F. Raushel, J. Thoden, 1997, Biochemistry.

Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.

H. Holden, R. K. Phillips, R. Kubiak, 2012, Biochemistry.

The enzymes of biotin dependent CO2 metabolism: What structures reveal about their reaction mechanisms

H. Holden, G. Waldrop, M. Maurice, 2012, Protein science : a publication of the Protein Society.

Molecular Structure of Human Galactokinase

David J. Timson, D. Timson, J. Thoden, 2005, Journal of Biological Chemistry.

Galactokinase: structure, function and role in type II galactosemia

H. M. Holden, D. Timson, J. Thoden, 2004, Cellular and Molecular Life Sciences CMLS.

Molecular Structure of Human Galactose Mutarotase*

D. Timson, J. Thoden, H. Holden, 2004, Journal of Biological Chemistry.

Molecular structure of an N‐formyltransferase from Providencia alcalifaciens O30

J. Thoden, H. Holden, M. Benning, 2015, Protein science : a publication of the Protein Society.

New role for the ankyrin repeat revealed by a study of the N-formyltransferase from Providencia alcalifaciens.

J. Thoden, H. Holden, C. R. Woodford, 2015, Biochemistry.

The crotonase superfamily: divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters.

H M Holden, J. Gerlt, H. Holden, 2001, Accounts of chemical research.

The Molecular Architecture of Galactose Mutarotase/UDP-Galactose 4-Epimerase from Saccharomyces cerevisiae*

J. Thoden, H. Holden, 2005, Journal of Biological Chemistry.

The catalytic mechanism of galactose mutarotase

F. Raushel, J. Thoden, H. Holden, 2003, Protein science : a publication of the Protein Society.

Structural and Kinetic Studies of Sugar Binding to Galactose Mutarotase from Lactococcus lactis *

F. Raushel, J. Thoden, H. Holden, 2002, The Journal of Biological Chemistry.

High Resolution X-ray Structure of Galactose Mutarotase from Lactococcus lactis *

J. Thoden, H. Holden, 2002, The Journal of Biological Chemistry.

X-ray structure of kijd3, a key enzyme involved in the biosynthesis of D-kijanose.

J. Thoden, H. Holden, N. Bruender, 2010, Biochemistry.

Structural studies of AntD: an N-Acyltransferase involved in the biosynthesis of D-Anthrose.

H. Holden, R. Kubiak, 2012, Biochemistry.

Three-dimensional structure of myosin subfragment-1: a molecular motor.

D A Winkelmann, H M Holden, I. Rayment, 1993, Science.

Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose.

H. Holden, R. Kubiak, 2011, Biochemistry.

Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.

J. Thoden, H. Holden, M. Kaur, 2010, Biochemistry.

Active site architecture of a sugar N-oxygenase.

Megan C. Branch, J. Thoden, H. Holden, 2013, Biochemistry.

Structure of the actin-myosin complex and its implications for muscle contraction.

R A Milligan, K C Holmes, H M Holden, 1993, Science.

The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.

I. Rayment, J. H. Law, H. Holden, 1987, The EMBO journal.

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.

H M Holden, C A Smith, A. Fisher, 1995, Biochemistry.

Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1

Ivan Rayment, I. Rayment, J. Spudich, 1993, Nature.

The three-dimensional structure of a molecular motor.

I. Rayment, H. Holden, Hazel M. Holden, 1994, Trends in biochemical sciences.

Structure and Function of Enzymes of the Leloir Pathway for Galactose Metabolism*

I. Rayment, J. Thoden, H. Holden, 2003, Journal of Biological Chemistry.

Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis.

I. Rayment, J. Gerlt, J. Thoden, 2004, Biochemistry.

Determinants of Function and Substrate Specificity in Human UDP-galactose 4′-Epimerase*

J. Fridovich-Keil, J. Thoden, H. Holden, 2004, Journal of Biological Chemistry.

Structural Analysis of the Y299C Mutant of Escherichia coli UDP-galactose 4-Epimerase

J. Henderson, J. Fridovich-Keil, J. Thoden, 2002, The Journal of Biological Chemistry.

Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia.

J. Fridovich-Keil, J. Thoden, H. Holden, 2005, Molecular genetics and metabolism.

Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy.

I. Rayment, J. Sellers, L. Fananapazir, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Three‐dimensional structure of a sugar N‐formyltransferase from Francisella tularensis

J. Thoden, H. Holden, A. Zimmer, 2014, Protein science : a publication of the Protein Society.

Molecular structure of an apolipoprotein determined at 2.5-A resolution.

I. Rayment, J. H. Law, H. Holden, 1991, Biochemistry.

Biochemical investigation of an N‐acetyltransferase from Helicobacter pullorum

J. Thoden, H. Holden, W. Griffiths, 2021, Protein Science.

Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus

J. Thoden, H. Holden, C. A. Seltzner, 2021, Protein science : a publication of the Protein Society.

Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12.

F. Raushel, J. Thoden, H. Holden, 2019, Biochemistry.

Structural and Functional Characterization of YdjI , an Aldolase of Unknown Speci fi city in Escherichia coli K 12

F. Raushel, J. Thoden, H. Holden, 2019 .

The Interaction between an Acidic Transcriptional Activator and Its Inhibitor

J. Thoden, H. Holden, R. J. Reece, 2008, Journal of Biological Chemistry.

Crystallization and preliminary analysis of crystals of high potential iron-sulfur protein from Rhodospirillum tenue.

I. Rayment, T. Meyer, H. Holden, 1986, The Journal of biological chemistry.

Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids.

Brian F Pfleger, Costas D Maranas, Brian F. Pfleger, 2017, ACS catalysis.

Structure-function studies of [2Fe-2S] ferredoxins

B. Oh, G. Tollin, J. Markley, 1994, Journal of Bioenergetics and Biomembranes.

The structure of carbamoyl phosphate synthetase determined to 2 . 1 AÊ resolution

I. Rayment, F. Raushel, J. Thoden, 1998 .

Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.

G. H. Reed, I. Rayment, H. Holden, 1994, Biochemistry.

Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution.

I. Rayment, H. Holden, M. Benning, 1993, Biochemistry.

Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116†

Jianjun Li, J. Thoden, H. Holden, 2017, Glycobiology.

Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry.

J. Thoden, H. Holden, M. Gilbert, 2015, Biochemistry.

The molecular architecture of QdtA, a sugar 3,4‐ketoisomerase from Thermoanaerobacterium thermosaccharolyticum

J. Thoden, H. Holden, 2014, Protein science : a publication of the Protein Society.

Structural and biochemical characterization of a bifunctional ketoisomerase/N-acetyltransferase from Shewanella denitrificans.

J. Thoden, H. Holden, D. Chantigian, 2013, Biochemistry.

Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.

S. Benkovic, J. Thoden, H. Holden, 2000, Biochemistry.

Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.

J. Thoden, H. Holden, J. Stubbe, 1999, Biochemistry.

Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution.

I. Rayment, H. Holden, W. Rypniewski, 1993, Biochemistry.

The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.

Zhihao Zhuang, F. Song, D. Dunaway-Mariano, 2012, Biochemistry.

Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants.

G. Tollin, J. Markley, J. Thoden, 1997, Biochemistry.

Structural Analysis of Cj1427, an Essential NAD-dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni.

F. Raushel, J. Thoden, H. Holden, 2020, Biochemistry.

Molecular structure of the oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120 determined to 1.7-A resolution.

I. Rayment, J. Markley, H. Holden, 1993, Biochemistry.

Crystallization, structure determination and least-squares refinement to 1.75 A resolution of the fatty-acid-binding protein isolated from Manduca sexta L.

H. Holden, M. Benning, M. Wells, 1992, Journal of molecular biology.

The Structural Determination of an Insect Sterol Carrier Protein-2 with a Ligand-bound C16 Fatty Acid at 1.35-Å Resolution*

I. Rayment, J. Thoden, H. Holden, 2003, Journal of Biological Chemistry.

Molecular structure of cytochrome c2 isolated from Rhodobacter capsulatus determined at 2.5 A resolution.

I. Rayment, H. Holden, M. Benning, 1991, Journal of Molecular Biology.

Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase.

J. Thoden, H. Holden, P. Tipton, 2016, Biochemistry.

Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution

I. Rayment, H. Holden, M. Benning, 1993 .

Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.

F. Raushel, H. Holden, Zane W Taylor, 2017, Biochemistry.

The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.

H M Holden, F. Raushel, J. Thoden, 1999, Biochemistry.

Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography.

I. Rayment, H. Holden, Hazel M. Holden, 1991, Archives of biochemistry and biophysics.

Crystallization of insecticyanin from the hemolymph of the tobacco hornworm Manduca sexta L. in a form suitable for a high resolution structure determination.

I. Rayment, J. H. Law, H. Holden, 1986, The Journal of biological chemistry.

Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product

F. Raushel, J. Thoden, H. Holden, 1999, Cellular and Molecular Life Sciences CMLS.

Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.

H M Holden, F. Raushel, J. Thoden, 1999, Biochemistry.

Molecular structure of a high potential cytochrome c2 isolated from Rhodopila globiformis.

T. Meyer, H. Holden, M. Benning, 1996, Archives of biochemistry and biophysics.

Understanding a Transcriptional Paradigm at the Molecular Level

J. Thoden, H. Holden, R. J. Reece, 2007, Journal of Biological Chemistry.

Human UDP-galactose 4-Epimerase

J. Fridovich-Keil, J. Thoden, H. Holden, 2001, The Journal of Biological Chemistry.

The molecular structure of UDP‐galactose 4‐epimerase from Escherichia coli determined at 2.5 Å resolution

P A Frey, H M Holden, P. Frey, 1992, Proteins.

Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.

S. Schuster, I. Rayment, N. Richards, 1999, Biochemistry.

Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.

Ricardo Martí-Arbona, F. Raushel, J. Thoden, 2005, Biochemistry.

Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation.

D. Dunaway-Mariano, H. Holden, M. Benning, 1996, Biochemistry.

Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP.

I. Rayment, J. Thoden, H. Holden, 2001, Biochemistry.

Biosynthetic enzymes of unusual microbial sugars.

J. Thoden, H. Holden, P. D. Cook, 2010, Current opinion in structural biology.

New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli.

H M Holden, J. Gerlt, H. Holden, 2000, Biochemistry.

Structure of L-3-hydroxyacyl-coenzyme A dehydrogenase: preliminary chain tracing at 2.8-A resolution.

N. Xuong, R. Hamlin, L. Banaszak, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Differences in the binding of coenzyme to L‐3‐hydroxyacyl‐coenzyme A dehydrogenase in the crystalline state and in solution

L. Banaszak, H. Holden, Carl Frieden, 1981, FEBS letters.

Three-dimensional structure of the high-potential iron-sulfur protein isolated from the purple phototrophic bacterium Rhodocyclus tenuis determined and refined at 1.5 A resolution.

H M Holden, I. Rayment, T. Meyer, 1992, Journal of molecular biology.

Two-dimensional magnetization exchange spectroscopy of Anabaena 7120 ferredoxin. Nuclear Overhauser effect and electron self-exchange cross peaks from amino acid residues surrounding the 2Fe-2S* cluster.

B. Oh, I. Rayment, W. M. Westler, 1991, Biochemistry.

The molecular structure of the high potential iron-sulfur protein isolated from Ectothiorhodospira halophila determined at 2.5-A resolution.

H M Holden, I. Rayment, T. Meyer, 1991, The Journal of biological chemistry.

Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli.

J. Thoden, H. Holden, 1998, Biochemistry.

Molecular Structure of Galactokinase*

J. Thoden, H. Holden, 2003, Journal of Biological Chemistry.

Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-d-Manno-Octulosonic Acid.

J. Thoden, H. Holden, T. R. Zachman-Brockmeyer, 2016, Biochemistry.

Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase .

J. Thoden, H. Holden, S. Firestine, 2010, Biochemistry.

The three‐dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin

J. Thoden, H. Holden, G. Dow, 2018, Protein science : a publication of the Protein Society.

Synthetic chimeras of mouse growth factor‐associated glandular kallikreins. II. Growth factor binding properties

M. Blaber, R. Bradshaw, H. Holden, 1993, Protein science : a publication of the Protein Society.

Long‐range allosteric transitions in carbamoyl phosphate synthetase

F. Raushel, J. Thoden, H. Holden, 2004, Protein science : a publication of the Protein Society.

Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.

A. Fisher, I. Rayment, C. Smith, 1995, Biophysical journal.

The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.

F. Raushel, J. Thoden, H. Holden, 1999, Biochemistry.

Kinetic mechanism of asparagine synthetase from Vibrio cholerae.

F. Raushel, J. Thoden, H. Holden, 2004, Bioorganic chemistry.

Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

H M Holden, G. Phillips, F. Raushel, 2001, Biochemistry.

The Three-dimensional Structure of 4-Hydroxybenzoyl-CoA Thioesterase from Pseudomonas sp. Strain CBS-3*

D. Dunaway-Mariano, H. Holden, M. Benning, 1998, The Journal of Biological Chemistry.

Misannotations of the genes encoding sugar N‐formyltransferases

J. Thoden, H. Holden, N. M. Girardi, 2019, Protein science : a publication of the Protein Society.

The structure of DesR from Streptomyces venezuelae, a β‐glucosidase involved in macrolide activation

J. Thoden, H. Holden, James B. Thoden, 2013, Protein science : a publication of the Protein Society.

The Structure of 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. strain SU*

Zhihao Zhuang, D. Dunaway-Mariano, J. Thoden, 2003, Journal of Biological Chemistry.

Movement of the Biotin Carboxylase B-domain as a Result of ATP Binding*

H M Holden, J. Thoden, H. Holden, 2000, The Journal of Biological Chemistry.

Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism.

J. Blanchard, J. Thoden, H. Holden, 1999, Biochemistry.

Probing the catalytic mechanism of a C‐3′‐methyltransferase involved in the biosynthesis of D‐tetronitrose

H. Holden, N. Bruender, 2012, Protein science : a publication of the Protein Society.

Molecular Basis for Severe Epimerase Deficiency Galactosemia

J. Fridovich-Keil, J. Thoden, H. Holden, 2001, The Journal of Biological Chemistry.

Carbamoyl phosphate synthetase: a tunnel runs through it.

F. Raushel, J. Thoden, H. Holden, 1998, Current opinion in structural biology.

The structure of glucose‐1‐phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA‐type enzymes

J. Thoden, H. Holden, P. Tipton, 2018, Protein science : a publication of the Protein Society.

Three-dimensional structure of the muscle fatty-acid-binding protein isolated from the desert locust Schistocerca gregaria.

I. Rayment, H. Holden, N. Haunerland, 1994, Biochemistry.

Molecular Structure of α-d-Glucose-1-phosphate Cytidylyltransferase from Salmonella typhi*

H. Holden, N. Koropatkin, 2004, Journal of Biological Chemistry.

UDP-GALACTOSE 4-EPIMERASE FROM ESCHERICHIA COLI

J. Thoden, H. Holden, 1997 .

Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis.

Ivan Rayment, John A Gerlt, I. Rayment, 2004, Biochemistry.

pH‐rate profiles support a general base mechanism for galactokinase (Lactococcus lactis)

W. Cleland, J. Thoden, H. Holden, 2013, FEBS letters.

Carbamoyl-phosphate Synthetase

F. Raushel, J. Thoden, H. Holden, 2002, The Journal of Biological Chemistry.

The Binding of Inosine Monophosphate to Escherichia coli Carbamoyl Phosphate Synthetase*

F. Raushel, J. Thoden, H. Holden, 1999, The Journal of Biological Chemistry.

Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.

H M Holden, F. Raushel, A. Howard, 1998, Biochemistry.

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.

J. Thoden, H. Holden, P. Tipton, 2017, Biochemistry.

High Resolution X-ray Structure of dTDP-Glucose 4,6-Dehydratase from Streptomyces venezuelae*

W. Cleland, H. Holden, S. Allard, 2004, Journal of Biological Chemistry.

Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin*

F. Raushel, J. Thoden, H. Holden, 2002, The Journal of Biological Chemistry.

Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase.

H. Holden, P. D. Cook, D. Toomey, 2009, Biochemistry.

X-ray Crystallographic Analyses of Inhibitor and Substrate Complexes of Wild-type and Mutant 4-Hydroxybenzoyl-CoA Thioesterase*

Zhihao Zhuang, D. Dunaway-Mariano, J. Thoden, 2002, The Journal of Biological Chemistry.

Investigation of a sugar N‐formyltransferase from the plant pathogen Pantoea ananatis

J. Thoden, H. Holden, Daniel L. Hofmeister, 2019, Protein science : a publication of the Protein Society.

Myosin subfragment-1: structure and function of a molecular motor

I. Rayment, H. Holden, 1993 .

Molecular architectures of Pen and Pal: Key enzymes required for CMP‐pseudaminic acid biosynthesis in Bacillus thuringiensis

J. Thoden, H. Holden, N. A. Delvaux, 2018, Protein science : a publication of the Protein Society.

C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni.

F. Raushel, J. Thoden, H. Holden, 2022, Biochemistry.

Biochemical analysis of a sugar 4,6‐dehydratase from Acanthamoeba polyphaga Mimivirus

J. Thoden, H. Holden, J. D. Ferek, 2020, Protein science : a publication of the Protein Society.

Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily.

J. Thoden, H. Holden, D. Watson, 2017, Biochemistry.

Mutations of surface residues in Anabaena vegetative and heterocyst ferredoxin that affect thermodynamic stability as determined by guanidine hydrochloride denaturation

G. Tollin, J. Markley, H. Holden, 1995, Protein science : a publication of the Protein Society.

Biochemical and structural characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid.

J. Thoden, H. Holden, 2011, Biochemistry.

Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid .

J. Thoden, H. Holden, 2010, Biochemistry.

Investigation of the enzymes required for the biosynthesis of 2,3‐diacetamido‐2,3‐dideoxy‐d‐glucuronic acid in Psychrobacter cryohalolentis K5T

J. Thoden, H. Holden, N. J. Bockhaus, 2022, Protein science : a publication of the Protein Society.

Characterization of two enzymes from Psychrobacter cryohalolentis that are required for the biosynthesis of an unusual diacetamido-d-sugar

J. Thoden, H. Holden, M. Linehan, 2021, The Journal of biological chemistry.

Molecular structure of WlbB, a bacterial N-acetyltransferase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid .

J. Thoden, H. Holden, 2010, Biochemistry.

Structure of the external aldimine form of PglE, an aminotransferase required for N,N'‐diacetylbacillosamine biosynthesis

J. Thoden, H. Holden, D. Watson, 2015, Protein science : a publication of the Protein Society.

Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase

J. Thoden, H. Holden, M. Gilbert, 2017, Protein science : a publication of the Protein Society.

Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter jejuni.

F. Raushel, J. Thoden, H. Holden, 2022, Biochemistry.

A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: caught in the act of geminal diamine formation.

H. Holden, P. D. Cook, 2007, Biochemistry.

Crystallization of a high potential iron-sulfur protein from the halophilic phototrophic bacterium Ectothiorhodospira halophila.

I. Rayment, T. Meyer, H. Holden, 1986, The Journal of biological chemistry.

High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli.

Ricardo Martí-Arbona, F. Raushel, J. Thoden, 2003, Biochemistry.

Biological Crystallography the Structure of Carbamoyl Phosphate Synthetase Determined to 2.1 a Ê Resolution

I. Rayment, F. Raushel, J. Thoden, 2022 .

Structure of a sugar N-formyltransferase from Campylobacter jejuni.

J. Thoden, H. Holden, M. Gilbert, 2013, Biochemistry.

Molecular architecture of DesV from Streptomyces venezuelae: A PLP‐dependent transaminase involved in the biosynthesis of the unusual sugar desosamine

J. Thoden, H. Holden, E. S. Burgie, 2007, Protein science : a publication of the Protein Society.

Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis.

J. Thoden, H. Holden, M. Gilbert, 2017, Biochemistry.

Biochemical Investigation of Rv 3404 c from Mycobacterium tuberculosis

J. Thoden, H. Holden, M. Gilbert, 2017 .

Molecular Structure of Saccharomyces cerevisiae Gal1p, a Bifunctional Galactokinase and Transcriptional Inducer*

D. Timson, J. Thoden, H. Holden, 2005, Journal of Biological Chemistry.

Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids.

Brian F. Pfleger, Matthew J. Grisewood, C. Maranas, 2017, ACS catalysis.

Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120.

B. Oh, I. Rayment, H. Holden, 1991 .

No Job Name

I. Rayment, J. Gerlt, J. Thoden, 2022 .

Guanidinoacetate methyltransferase deficiency

S. Berkovic, D. Timson, J. Thoden, 2020, Definitions.

Kinetic Mechanism of Kanamycin Nucleotidyltransferase from Staphylococcus aureus

F. Raushel, H. Holden, J. Vanhooke, 1999 .

Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis

J. Thoden, H. Holden, W. Griffiths, 2021, Protein science : a publication of the Protein Society.

The catalytic mechanism of galactose mutarotase

F. Raushel, J. Thoden, H. Holden, 2003, Protein science : a publication of the Protein Society.