Y. Pang

发表

Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method

Y. Pang, 2001, Proteins.

Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide.

Yuan-Ping Pang, Michael K Gilson, Sandeep Somani, 2009, Journal of molecular biology.

Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors*

Ming-tao Li, P. Carlier, Y. Pang, 2005, Journal of Biological Chemistry.

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Y. Pang, S. Kaufmann, Haiming Dai, 2011, The Journal of cell biology.

FF12MC: A revised AMBER forcefield and new protein simulation protocol

Y. Pang, 2016, bioRxiv.

FF12MC: A revised AMBER forcefield and new protein simulation protocol

Y. Pang, 2016, bioRxiv.

Rapid screening and evaluation of antioxidants in alkaloid natural products by capillary electrophoresis with chemiluminescence detection

Y. Pang, Zhining Xia, Fengqing Yang, 2016 .

Preference of Small Molecules for Local Minimum Conformations when Binding to Proteins

Yuan-Ping Pang, Y. Pang, Qi Wang, 2007, PloS one.

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

Yuan-Ping Pang, Joel L. Sussman, Israel Silman, 1997, Nature Structural Biology.

Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.

S H Kaufmann, Y. Pang, S. Kaufmann, 2000, Journal of medicinal chemistry.

Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases

Y. Pang, W. Mcgrath, W. Mangel, 2001, FEBS letters.

Re-engineering butyrylcholinesterase as a cocaine hydrolase.

S. Brimijoin, Y. Pang, O. Lockridge, 2002, Molecular pharmacology.

From genome to drug lead: Identification of a small-molecule inhibitor of the SARS virus

Yuan-Ping Pang, Y. Pang, N. Shindo, 2005, Bioorganic & Medicinal Chemistry Letters.

In Silico Drug Discovery: Solving the “Target‐rich and Lead‐poor” Imbalance Using the Genome‐to‐drug‐lead Paradigm

Y. Pang, Y P Pang, Y P Pang, 2006, Clinical pharmacology and therapeutics.

Accurate Reproduction of 161 Small-Molecule Complex Crystal Structures using the EUDOC Program: Expanding the Use of EUDOC to Supramolecular Chemistry

Yuan-Ping Pang, Y. Pang, Qi Wang, 2007, PloS one.

Structure-based discovery of dengue virus protease inhibitors.

Yuan-Ping Pang, Suzanne M. Tomlinson, Stanley J Watowich, 2009, Antiviral research.

Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins

Y. Pang, 2016, bioRxiv.

Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins

Y. Pang, 2016, bioRxiv.

Chimeric Rat/Human Neurotensin Receptors Localize a Region of the Receptor Sensitive to Binding of a Novel, Species-specific, Picomolar Affinity Peptide*

Y. Pang, E. Richelson, D. Mccormick, 1996, The Journal of Biological Chemistry.

Low-mass molecular dynamics simulation for configurational sampling enhancement: More evidence and theoretical explanation

Y. Pang, 2015, Biochemistry and biophysics reports.

Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ.

Y. Pang, J. Aleu, J. Marsal, 2001, Journal of neurophysiology.

Organ Torpedo Activity and on the Nicotinic ACh Receptor of Effects of Bis ( 7 )-Tacrine on Spontaneous Synaptic

Y. Pang, J. Aleu, C. Solsona, 2001 .

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

P. Carlier, Y. Pang, D. Du, 1999, Bioorganic & medicinal chemistry letters.

Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design

S. Brimijoin, Y. Pang, C. Kern, 2003, Journal of Pharmacology and Experimental Therapeutics.

Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.

P. Carlier, Y. Pang, N. Lee, 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

Yi-fan Han, P. Carlier, Y. Pang, 2000, Neuroscience Letters.

Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents.

Wei Zhang, Jun Xia, Y. Pang, 2007, Biochemical and biophysical research communications.

Three‐dimensional model of a substrate‐bound SARS chymotrypsin‐like cysteine proteinase predicted by multiple molecular dynamics simulations: Catalytic efficiency regulated by substrate binding

Y. Pang, 2004, Proteins.

Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin.

Y. Pang, Jewn-Giew Park, Jinil Choi, 2008, Tetrahedron letters.

Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.

S. Brimijoin, Y. Pang, O. Lockridge, 2002, The Journal of pharmacology and experimental therapeutics.

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens

Y. Pang, S. Markovic, M. Block, 2018, ImmunoHorizons.

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens

Y. Pang, S. Markovic, M. Block, 2018, ImmunoHorizons.

Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo.

Y. Pang, J. Carpenter, C. Young, 2004, Experimental cell research.

Insect Acetylcholinesterase as a Target for Effective and Environmentally Safe Insecticides

Y. Pang, 2014 .

Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3

P. Merkel, J. Stone, C. Kallenberg, 2019, bioRxiv.

Inhibition of Mitochondrial Respiration as a Source of Adaphostin-induced Reactive Oxygen Species and Cytotoxicity*

E. Sausville, Y. Pang, K. Flatten, 2007, Journal of Biological Chemistry.

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

H. Mussaffi, H. Omran, S. Letteboer, 2020, Nature Communications.

Configurational Entropy in Protein-Peptide Binding. Computational Study of Tsg101 UEV Domain with an HIV-derived PTAP Nonapeptide

M. Gilson, Y. Pang, B. Killian, 2009 .

A Potent and Selective Tacrine Analog—Biomembrane Permeation and Physicochemical Characterization

Y. Pang, G. Patani, Y. Chien, 2005, Pharmaceutical development and technology.

Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

Y. Pang, L. Jánosi, N. Tumer, 2011, PloS one.

A selective small‐molecule inhibitor of c‐Jun N‐terminal kinase 1

Yong-Yeon Cho, A. Bode, Z. Dong, 2009, FEBS letters.

Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum

Y. Pang, Yoonseong Park, Haobo Jiang, 2012, Scientific Reports.

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

Y. Pang, Fouad H. Darras, 2017, bioRxiv.

Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences.

Y. Pang, 2004, Bioorganic & medicinal chemistry.

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle.

S. Brimijoin, Y. Pang, D. Ragsdale, 2010, Chemico-biological interactions.

Species marker for developing novel and safe pesticides.

Y. Pang, 2007, Bioorganic & medicinal chemistry letters.

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

Y. Pang, Wenming Li, Yifan Han, 2006, Neuroreport.

A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.

Y. Pang, E. Richelson, D. Mccormick, 2000, Biochemical pharmacology.

Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry.

Z. Zuo, Y. Pang, G. Lin, 2008, Biomedical chromatography : BMC.

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.

Yitao Wang, P. Carlier, Y. Pang, 2008, Journal of pharmaceutical and biomedical analysis.

Chemical Structure of Retro-2, a Compound That Protects Cells against Ribosome-Inactivating Proteins

Y. Pang, N. Tumer, Jewn-Giew Park, 2012, Scientific Reports.

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

J. Kappes, Y. Pang, S. Kaufmann, 2014, Journal of Cell Biology.

Normal-Mode-Analysis–Monitored Energy Minimization Procedure for Generating Small–Molecule Bound Conformations

Y. Pang, Qi Wang, 2007, PloS one.

Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C

Yuan-Ping Pang, Slobodan I Macura, John S. Lazo, 1993 .

Potent, Easily Synthesized Huperzine A‐Tacrine Hybrid Acetylcholinesterase Inhibitors.

P. Carlier, Y. Pang, D. Du, 1999 .

Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.

P. Carlier, Y. Pang, J. El Yazal, 1999, Journal of medicinal chemistry.

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.

P. Carlier, Y. Pang, H. Wong, 1999, Bioorganic & medicinal chemistry.

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A.

Y. Pang, C. Millard, Peter C. Sill, 2006, Bioorganic & medicinal chemistry.

Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins

Y. Pang, Shichao Yu, N. Tumer, 2013, Scientific Reports.

A route to optically pure (-)-huperzine A : molecular modeling and in vitro pharmacology

Y. Pang, A. Kozikowski, M. Mckinney, 1991 .

Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A

Y. Pang, C. Millard, Jing Tang, 2007, PloS one.

How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly

Y. Pang, 2022, Communications Chemistry.

How the water-soluble hemicarcerand incarcerates guests at room temperature decoded with modular simulations

Y. Pang, Katherine G. McFerrin, 2021, Communications Chemistry.

How a Hemicarcerand Incarcerates Guests at Room Temperature Decoded with Modular Simulations

Y. Pang, Katherine G. McFerrin, 2020, bioRxiv.

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2003, Journal of the American Chemical Society.

Polysaccharide elasticity governed by chair–boat transitions of the glucopyranose ring

Yuan-Ping Pang, Andres F. Oberhauser, Piotr E. Marszalek, 1998, Nature.

Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

S. Brimijoin, Y. Pang, P. Quiram, 1996, The Journal of Biological Chemistry.

Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A.

Y. Pang, C. Millard, Jason D. Thompson, 2006, Bioorganic & medicinal chemistry.

Pharmacological and Biochemical Profiles of Unique Neurotensin 8-13 Analogs Exhibiting Species Selectivity, Stereoselectivity, and Superagonism (*)

Y. Pang, E. Richelson, A. Fauq, 1995, The Journal of Biological Chemistry.

Flavopiridol binds to duplex DNA.

Y. Pang, S. Kaufmann, P. Svingen, 2000, Cancer research.

Flavopiridol Binds to Duplex DNA 1

Y. Pang, S. Kaufmann, P. Svingen, 2000 .

Ab Initio Calculations of Proton Dissociation Energies of Zinc Ligands: Hypothesis of Imidazolate as Zinc Ligand in Proteins

Yuan-Ping Pang, Y. Pang, Jamal El Yazal, 1999 .

Zinc′s Exclusive Tetrahedral Coordination Governed by Its Electronic Structure

Y. Pang, Rachel R. Roe, 1999 .

Novel Stable Configurations and Tautomers of the Neutral and Deprotonated Hydroxamic Acids Predicted from High-Level ab Initio Calculations

Y. Pang, J. Yazal, 1999 .

Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.

Y. Pang, K. Xu, Y P Pang, 2000, Protein science : a publication of the Protein Society.

Novel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases

Y. Pang, Sandeep Rana, Haobo Jiang, 2013, Scientific Reports.

Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides

S. Brimijoin, Y. Pang, K. Zhu, 2012, Current drug targets.

Predicted Michaelis-Menten Complexes of Cocaine-Butyrylcholinesterase

S. Brimijoin, Y. Pang, O. Lockridge, 2001, The Journal of Biological Chemistry.

Genome Organization, Phylogenies, Expression Patterns, and Three-Dimensional Protein Models of Two Acetylcholinesterase Genes from the Red Flour Beetle

Y. Pang, Yoonseong Park, K. Zhu, 2012, PloS one.

Synthesis of partial nonpeptidic peptide mimetics as potential neurotensin agonists and antagonists

Y. Pang, A. Kozikowski, E. Richelson, 1995 .

Proposed Ligand Binding Site of the Transmembrane Receptor for Neurotensin(8–13)*

Y. Pang, E. Richelson, B. Cusack, 1996, The Journal of Biological Chemistry.

Synthesis of Partial Nonpeptidic Peptide Mimetics as Potential Neurotensin Agonists and Antagonists.

Y. Pang, A. Kozikowski, E. Richelson, 1995 .

Pharmacological studies on novel neurotensin mimetics: discovery of a pharmacologically unique agent exhibiting concentration-dependent dual effects as antagonist and agonist.

Y. Pang, A. Kozikowski, E. Richelson, 1993, Molecular pharmacology.

Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

P. Carlier, Y. Pang, Wenming Li, 2021, Journal of neurochemistry.

Atomic levers control pyranose ring conformations.

A. Oberhauser, J. M. Fernández, Hongbin Li, 1999, Proceedings of the National Academy of Sciences of the United States of America.

On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

Y. Pang, Fouad H. Darras, 2017, bioRxiv.

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating

Yuan-Ping Pang, Martin Bienengraeber, Andre Terzic, 2004, Nature Genetics.

The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

N. Ziats, Y. Pang, A. Mazar, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Liewei Wang, J. Jen, Y. Pang, 2015, Molecular cell.

Parkin Regulates Mitosis a nd Genomic Stability through Cdc 20 / Cdh 1 Graphical Abstract Highlights

Boqin, Liewei Wang, J. Jen, 2015 .

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

D. O'Brien, Y. Pang, S. Kaufmann, 2016, Journal of Virology.

Regulation of error-prone translesion synthesis by Spartan/C1orf124

Y. Pang, A. Vashisht, J. Wohlschlegel, 2012, Nucleic acids research.

Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases

P. Taylor, B. P. Doctor, Y. Pang, 1994, Protein science : a publication of the Protein Society.

A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C

Y. Pang, K. Flatten, S. Kaufmann, 2022, Cell Death & Differentiation.

Characterization of an alternative BAK-binding site for BH3 peptides

Hongbin Sun, Y. Pang, Meng Chen, 2020, Nature Communications.

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator*

Y. Pang, S. Kaufmann, M. Ramirez-Alvarado, 2013, The Journal of Biological Chemistry.

Rational design of novel neurotensin mimetics: Discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

Yuan-Ping Pang, Alan P. Kozikowski, Javid Zaidi, 1994, J. Comput. Aided Mol. Des..

Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.

S. Brimijoin, Y. Pang, T. Kollmeyer, 2003, Chemistry & biology.

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.

S. Brimijoin, Y. Pang, Yang Gao, 2016, Chemico-biological interactions.

Plasma butyrylcholinesterase regulates ghrelin to control aggression

S. Brimijoin, Y. Pang, R. Parks, 2015, Proceedings of the National Academy of Sciences.

Novel Zinc Protein Molecular Dynamics Simulations: Steps Toward Antiangiogenesis for Cancer Treatment

Yuan-Ping Pang, Y. Pang, 1999 .

Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine.

Z. Zuo, Y. Pang, Kelvin Chan, 2008, International journal of pharmaceutics.

Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

S. Brimijoin, Y. Pang, Sandeep Rana, 2009, PloS one.

Selective and Irreversible Inhibitors of Aphid Acetylcholinesterases: Steps Toward Human-Safe Insecticides

S. Brimijoin, Y. Pang, K. Zhu, 2009, PloS one.

Cryptic proteolytic activity of dihydrolipoamide dehydrogenase

Yuan-Ping Pang, N. E. Babady, Y. Pang, 2007, Proceedings of the National Academy of Sciences.

Novel Acetylcholinesterase Target Site for Malaria Mosquito Control

Y. Pang, 2006, PloS one.

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

M. Mattson, Y. Pang, Na Zhao, 2021, Nature Neuroscience.

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

M. Mattson, Liewei Wang, D. Dickson, 2021, bioRxiv.

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

Y. Pang, S. Kaufmann, Haiming Dai, 2012, Scientific Reports.

Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad.

Y. Pang, F. Ekström, E. Artursson, 2010, Biochemical pharmacology.

Rabbit indolethylamine N-methyltransferase three-dimensional structure prediction: a model approach to bridge sequence to function in pharmacogenomic studies

Y. Pang, M. Thompson, J. El Yazal, 2001 .

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A

Y. Pang, M. Nambiar, C. Millard, 2010, PloS one.

A pilot clinical trial testing topical resiquimod and a xenopeptide as immune adjuvants for a melanoma vaccine targeting MART-1.

Y. Pang, S. Markovic, M. Block, 2019, Melanoma research.

Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons

Y. Pang, Chaoying Li, Zhi-wang Li, 2009, Neuropharmacology.

Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience letters.

Protection against ischemic injury in primary cultured astrocytes of mouse cerebral cortex by bis(7)-tacrine, a novel anti-Alzheimer's agent

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience Letters.

In vitro binding and CNS effects of novel neurotensin agonists that cross the blood–brain barrier

Y. Pang, C. L. Douglas, E. Richelson, 1999, Neuropharmacology.

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.

Y. Pang, Wenming Li, Yifan Han, 2009, European journal of pharmacology.

Substantial Neuroprotection Against K+ Deprivation‐Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)‐Cognitin Via the Activation of VEGFR‐2 Signaling Pathway

Y. Pang, Sheng-quan Hu, Daping Xu, 2013, CNS neuroscience & therapeutics.

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.

P. Carlier, Y. Pang, Y. Han, 1999, Bioorganic & medicinal chemistry.

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

G. Bu, Y. Pang, P. Dzeja, 2015, EBioMedicine.

Novel anti-Alzheimer’s dimer bis(7)-Cognitin: Cellular and molecular mechanisms of neuroprotection through multiple targets

Kaixian Chen, Hualiang Jiang, Y. Pang, 2011, Neurotherapeutics.

Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design

G. Schneider, Y. Pang, F. Ekström, 2009, PloS one.

Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.

Yuan-Ping Pang, Malin Boman, Fredrik Ekström, 2006, Biochemical pharmacology.

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2006, Journal of medicinal chemistry.

-1-CHOLINESTERASE REACTIVATION IN VIVO WITH A NOVEL BIS-OXIME OPTIMIZED BY COMPUTER-AIDED DESIGN

S. Brimijoin, Y. Pang, C. Kern, 2003 .

Supercomputing-Based Dimeric Analog Approach for Drug Optimization

Yuan-Ping Pang, Stephen Brimijoin, S. Brimijoin, 1998, Parallel Comput..

Applications of free energy derivatives to analog design

Yuan-Ping Pang, Peter A. Kollman, P. Kollman, 1995 .

Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program

Yuan-Ping Pang, Alan P. Kozikowski, Y. Pang, 1994, J. Comput. Aided Mol. Des..

Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies

Yuan-Ping Pang, Alan P. Kozikowski, Y. Pang, 1994, J. Comput. Aided Mol. Des..

Topography of the huperzine A binding site in AChE: Ab initio docking of reversible inhibitors of AChE into the dynamic enzyme

Y. Pang, A. Kozikowski, 1993 .

Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

Y. Pang, A. Kozikowski, F. Yamada, 1992 .

Bis(7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels

Y. Pang, Wenming Li, Yifan Han, 2006, Journal of neurochemistry.

Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin*

Dik‐Lung Ma, Jun Xia, Y. Pang, 2010, The Journal of Biological Chemistry.

Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product

Ian D. Williams, P. Carlier, Y. Pang, 2000 .

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.

Yitao Wang, Y. Pang, Wenming Li, 2007, Journal of pharmaceutical and biomedical analysis.

Robust Neuritogenesis‐Promoting Activity by Bis(heptyl)‐Cognitin Through the Activation of alpha7‐Nicotinic Acetylcholine Receptor/ERK Pathway

Yuan-Jia Hu, Y. Pang, Sheng-quan Hu, 2015, CNS neuroscience & therapeutics.

Comparison of DFT, Møller–Plesset, and coupled cluster calculations of the proton dissociation energies of imidazole and N-methylacetamide in the presence of zinc(II)

Y. Pang, J. Yazal, 2001 .

Synthesis of alkylene linked bis-THA and alkylene linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase

S. Brimijoin, Y. Pang, P. Quiram, 1997 .

One-Compound-Multi-Targets at Amyloid β Cascade Offered By Bis(7)-Cognitin, a Novel Anti-Alzheimer’s Dimer

Y. Pang, Wenming Li, Yifan Han, 2010 .

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.

Y. Pang, Wenming Li, Yifan Han, 2008, Biochemical and biophysical research communications.

Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.

Y. Pang, A. Kozikowski, I. Reynolds, 1992, Journal of Medicinal Chemistry.

Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability.

Y. Pang, X. Zheng, R. Weinshilboum, 2001, Biochemical and biophysical research communications.

Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect

Y. Pang, L. Karnitz, T. Hitosugi, 2021, Nature Metabolism.

EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases

Yuan-Ping Pang, Franklyn G. Prendergast, Kun Xu, 2001, J. Comput. Chem..

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

W. Robinson, Y. Pang, W. Volkmuth, 2019, bioRxiv.

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer.

Y. Pang, Yifan Han, Sheng-quan Hu, 2015, ACS chemical neuroscience.

Activation of Transcription Factor MEF2D by Bis(3)-cognitin Protects Dopaminergic Neurons and Ameliorates Parkinsonian Motor Defects*

Natalie L. Cápiro, Y. Pang, Wenming Li, 2012, The Journal of Biological Chemistry.

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience Letters.

Zinc's affect on proton transfer between imidazole and acetate predicted by ab initio calculations

Y. Pang, Jamal El Yazal, Rachel R. Roe, 2000 .

Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305]

G. Bu, Y. Pang, P. Dzeja, 2019, EBioMedicine.

Design, synthesis and pharmacological evaluation of active pyrrole based, nonpeptidic analogues of neurotensin(8-13)

Y. Pang, E. Richelson, J. Zaidi, 1997 .

Synthesis of methoxy and hydroxy analogues of 1,2,3,4,4a,9a-hexahydro-4a-fluorenamine : rigid phencyclidine analogues as probes of phencyclidine binding site topography

Y. Pang, A. Kozikowski, 1991 .

Synthesis of Methoxy and Hydroxy Analogues of 1,2,3,4,4a,9a-Hexahydro-4a-fluorenamine: Rigid Phencyclidine Analogues as Probes of Phencyclidine Binding Site Topography.

Y. Pang, A. Kozikowski, 1991 .

Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

Yuan-Ping Pang, Y. Pang, C. Millard, 2009, PloS one.

Computational and Experimental Studies of (2,2)-Bis(indol-1-yl-methyl)acetate Suggest the Importance of the Hydrophobic Effect in Aromatic Stacking Interactions

P. Kollman, Y. Pang, Jennifer L. Miller, 1999 .

Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-d-aspartate Receptors and Neuronal Nitric-Oxide Synthase

Kaixian Chen, Hualiang Jiang, Y. Pang, 2007, Molecular Pharmacology.

N-Methyl-D-aspartate Receptors and Neuronal Nitric Oxide Synthase

Kaixian Chen, Hualiang Jiang, Y. Pang, 2007 .

How Fast Fast-Folding Proteins Fold in Silico

Yuan-Ping Pang, Y. Pang, 2016, bioRxiv.

How Fast Fast-Folding Proteins Fold in Silico

Yuan-Ping Pang, Y. Pang, 2016, bioRxiv.

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

P. Carlier, Y. Pang, D. Mak, 2002, Planta medica.

Inhibition of NMDA-gated ion channels by bis(7)-tacrine: Whole-cell and single-channel studies

Y. Pang, Chaoying Li, Zhi-wang Li, 2008, Neuropharmacology.

Dimeric bis (heptyl)‐Cognitin Blocks Alzheimer's β‐Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

Y. Pang, Sheng-quan Hu, Ming-Yuen Lee, 2015, CNS neuroscience & therapeutics.

Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.

P. Carlier, Y. Pang, N. Lee, 1999, Neuroreport.

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

J. Kappes, Y. Pang, S. Kaufmann, 2014, The Journal of cell biology.

Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent.

Y. Pang, R. Pi, Yifan Han, 2020, European journal of pharmacology.

Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3

P. Merkel, J. Stone, C. Kallenberg, 2022, bioRxiv.

Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.

Hua Yu, Y. Pang, Wenming Li, 2007, Journal of proteome research.

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.

Y. Pang, F. Ekström, F. Worek, 2010, Biochemical pharmacology.

Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.

J H Miller, Y. Pang, A. Kozikowski, 1991, Journal of medicinal chemistry.

Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C

C. Vachon, F. Couch, J. Palmer, 2023, Cancer research.

Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors

W. Robinson, Y. Pang, W. Volkmuth, 2019, Front. Immunol..

Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.

P. Carlier, Y. Pang, H. Xue, 1999, Neuroreport.

Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A

Y. Pang, R. Urrutia, Jin-San Zhang, 2003, FEBS letters.

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration.

D. Craig, C. Lipinski, Y. Pang, 2006, Biochemical and biophysical research communications.

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Y. Pang, S. Kaufmann, X. Meng, 2011, The Journal of cell biology.

Erratum: Chimeric rat/human neurotensin receptors localize a region of the receptor sensitive to binding of a novel, species-specific picomolar affinity peptide (Journal of Biological Chemistry (1996) 271 (15054-15059))

Y. Pang, E. Richelson, D. Mccormick, 1996 .

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels

Y. Pang, Chaoying Li, Zhi-wang Li, 2007, Neuroscience Letters.

Novel Nerve‐Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun‐Conjugated Acetylcholinesterase in Complex with Antidotes

Y. Pang, F. Ekström, C. Åstot, 2007, Clinical pharmacology and therapeutics.

Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

P. Carlier, Y. Pang, Wenming Li, 2007, Neuropharmacology.

Synthesis of Alkylene Linked Bis‐THA and Alkylene Linked Benzyl‐THA as Highly Potent and Selective Inhibitors and Molecular Probes of Acetylcholinesterase.

S. Brimijoin, Y. Pang, P. Quiram, 1997 .

At least 10% shorter C-H bonds in cryogenic protein crystal structures than in current AMBER forcefields.

Y. Pang, 2015, Biochemical and biophysical research communications.

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Y. Pang, S. Kaufmann, Haiming Dai, 2011, The Journal of cell biology.

How fast can fast-folding proteins autonomously fold in silico?

Y. Pang, 2016 .