D. Ruden

发表

Pablo Cingolani, A. Platts, Le Wang, 2022 .

Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift

Pablo Cingolani, M. Coon, Tung Nguyen, 2012, Front. Gene..

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution

Xiangyi Lu, D. Ruden, V. Sollars, 2003, Nature Genetics.

Putative contributors to the secular increase in obesity: exploring the roads less traveled

L. Aronne, D. Allison, A. Westfall, 2006, International Journal of Obesity.

Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead.

H. Hirsch, G. Page, Luan Wang, 2009, Neurotoxicology.

Epigenetics as an answer to Darwin’s “special difficulty,” Part 2: natural selection of metastable epialleles in honeybee castes

Pablo Cingolani, Luan Wang, Xiangyi Lu, 2015, Front. Genet..

Generating yeast transcriptional activators containing no yeast protein sequences

Yi Li, Jun Ma, Mark Ptashne, 1991, Nature.

Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs.

Xiangyi Lu, Luan Wang, Xiangyi Lu, 2012, Biochemical pharmacology.

Personalized nutrigenomics: tailoring the diet to the aging diabesity population

Xiangyi Lu, D. Ruden, 2011 .

Size-Dependent Toxicity of Gold Nanoparticles on Human Embryonic Stem Cells and Their Neural Derivatives.

Guangzhao Mao, Fangchao Liu, D. Ruden, 2016, Small.

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Pablo Cingolani, Martha M Tellez-Rojo, Robert O Wright, 2015, Epigenetics.

Single-Cell RNA Sequencing of the Cardiovascular System: New Looks for Old Diseases

D. Ruden, Katherine Gurdziel, P. Levy, 2019, Front. Cardiovasc. Med..

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

Na-Yu Chia, Luan Wang, Xiangyi Lu, 2011, Epigenetics.

Mammalian Models of Traumatic Brain Injury and a Place for Drosophila in TBI Research

D. Ruden, Katherine Gurdziel, E. Shah, 2019, Front. Neurosci..

Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure

R. Pique-Regi, D. Ruden, Katherine Gurdziel, 2017, Front. Genet..

Phylogenetic Conservation of the Nrf2-Keap1 Signaling System

D. Ruden, Xue Zhang, Gark Garfinkel, 2003 .

Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss.

D. Ruden, J. Westrick, S. Jamesdaniel, 2018, Toxicology letters.

Cisplatin in 5% Ethanol Eradicates Cisplatin-Resistant Lung Tumor by Killing Lung Cancer Side Population (SP) Cells and Non-SP Cells

D. Ruden, Fenghua Wang, Qian Li, 2013, Front. Genet..

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

D. Ruden, J. Hur, E. Feldman, 2012, PloS one.

A Bioinformatics-Based Alternative mRNA Splicing Code that May Explain Some Disease Mutations Is Conserved in Animals

B. Zeeberg, Pablo Cingolani, D. Ruden, 2017, Front. Genet..

Percutaneous Fine-Needle 5% Ethanol-Cisplatin Intratumoral Injection Combined with Second-Line Chemotherapy Improves On the Standard of Care in Patients with Platinum-Pretreated Stage IV Non–Small Cell Lung Cancer

D. Ruden, Qian Li, Q. Niu, 2014, Translational oncology.

Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program

F. Tylavsky, A. Ferrara, M. Karagas, 2019, International Journal of Obesity.

Intronic Non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees

Radhika S. Khetani, G. Robinson, Xiaoyi Cao, 2013, BMC Genomics.

A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens

Carol J. Miller, G. Mor, D. Ruden, 2020, International journal of environmental research and public health.

Introduction to serial reviews on EpRE and its signaling pathway.

H. Forman, D. Ruden, 2004, Free Radical Biology & Medicine.

Radiation-induced epigenetic DNA methylation modification of radiation-response pathways

D. Ruden, S. Zielske, W. Lancaster, 2013, Epigenetics.

Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs.

D. Ruden, Li-Qing Xiao, P. Rasouli, 2007, Current medicinal chemistry.

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Xiangyi Lu, D. Ruden, 2006, Genes & Nutrition.

Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

D. Allison, D. Ruden, M. Elobeid, 2010, International journal of environmental research and public health.

No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene.

M. Ptashne, D. Ruden, J. Ma, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Schizosaccharomyces pombe transcription factor PGA4, which binds cooperatively to Saccharomyces cerevisiae GAL4-binding sites

D. Ruden, 1990, Molecular and cellular biology.

PKD2 Cation Channel Is Required for Directional Sperm Movement and Male Fertility

Xiangyi Lu, D. Ruden, Zhiqian Gao, 2003, Current Biology.

Smooth, an hnRNP-L Homolog, Might Decrease Mitochondrial Metabolism by Post-Transcriptional Regulation of Isocitrate Dehydrogenase (Idh) and Other Metabolic Genes in the Sub-Acute Phase of Traumatic Brain Injury

R. Pique-Regi, D. Ruden, Katherine Gurdziel, 2017, Front. Genet..

Using high throughput screens to predict miscarriages with placental stem cells and long‐term stress effects with embryonic stem cells

E. Puscheck, D. Rappolee, D. Ruden, 2022, Birth defects research.

Massively parallel resequencing of the isogenic Drosophila melanogaster strain w1118; iso-2; iso-3 identifies hotspots for mutations in sensory perception genes

G. Page, A. Platts, Luan Wang, 2009, Fly.

Personalized medicine and quantitative trait transcripts

D. Ruden, 2007, Nature Genetics.

Using Live Imaging and Fluorescence Ubiquitinated Cell Cycle Indicator Embryonic Stem Cells to Distinguish G1 Cell Cycle Delays for General Stressors like Perfluoro-Octanoic Acid and Hyperosmotic Sorbitol or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a)pyrene.

E. Puscheck, D. Rappolee, D. Ruden, 2022, Stem cells and development.

Frontiers in toxicology: A new frontiers journal that builds on 10 years of frontiers in genetics section on toxicogenomics

D. Ruden, 2022, Frontiers in Genetics.

Editorial [Hot Topic: Mini Hot Topic Title: Epigenetic Regulatory Mechanisms in Cancer, Development, and Evolution (Guest Editor: Douglas M. Ruden)]

D. Ruden, 2005 .

The EDGE hypothesis: Epigenetically directed genetic errors in repeat-containing proteins (RCPs) involved in evolution, neuroendocrine signaling, and cancer

J. Weinstein, B. Zeeberg, Xiangyi Lu, 2008, Frontiers in Neuroendocrinology.

Effectiveness of hsp90 inhibitors as anti-cancer drugs.

Xiangyi Lu, D. Ruden, Li-Qing Xiao, 2006, Mini-Reviews in Medical Chemistry.

Combining high dimensional biological data to study complex diseases and quantitative traits

G. Page, D. Ruden, 2005 .

Effects of Gravity, Microgravity or Microgravity Simulation on Early Mammalian Development.

E. Puscheck, D. Rappolee, D. Ruden, 2018, Stem cells and development.

Integrating 5hmC and gene expression data to infer regulatory mechanisms

Cristina Mitrea, Sorin Draghici, Aliccia Bollig-Fischer, 2018, Bioinform..

Drosophila as a Model for Toxicogenomics of Lead

H. Hirsch, G. Lnenicka, D. Ruden, 2019, Encyclopedia of Environmental Health.

Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research

H. Hirsch, G. Lnenicka, Luan Wang, 2012, Front. Gene..

Genetic aspects of behavioral neurotoxicology.

H. Hirsch, E. Levin, G. Page, 2009, Neurotoxicology.

Lead Modulates trans- and cis-Expression Quantitative Trait Loci (eQTLs) in Drosophila melanogaster Heads

R. Pique-Regi, D. Ruden, Katherine Gurdziel, 2018, Front. Genet..

Ten Putative Contributors to the Obesity Epidemic

David B. Allison, Peter Gluckman, Robert A. Waterland, 2009, Critical reviews in food science and nutrition.

Potential Long-Term Consequences of Fad Diets on Health, Cancer, and Longevity: Lessons Learned from Model Organism Studies

Xiangyi Lu, D. Ruden, P. Rasouli, 2007, Technology in cancer research & treatment.

Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila.

Xiangyi Lu, D. Ruden, V. Sollars, 2004, Methods in molecular biology.

Epigenetics of early-life lead exposure and effects on brain development.

H. Hirsch, A. Kruger, S. Suhr, 2012, Epigenomics.

Drosophila Exhibit Divergent Sex-Based Responses in Transcription and Motor Function After Traumatic Brain Injury

D. Ruden, Katherine Gurdziel, E. Shah, 2020, Frontiers in Neurology.

Waddington's widget: Hsp90 and the inheritance of acquired characters.

Xiangyi Lu, D. Ruden, V. Sollars, 2003, Seminars in cell & developmental biology.

Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation.

Pablo Cingolani, S. Land, D. Ruden, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution

Luan Wang, Xiangyi Lu, D. Ruden, 2013 .

Chromatin effects in nutrition, cancer, and obesity.

D. Ruden, M. Garfinkel, 2004, Nutrition.

Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene

C. S. Parker, D. Ruden, J. Topol, 1985, Cell.

Methods for nutrigenomics and longevity studies in Drosophila: effects of diets high in sucrose, palmitic acid, soy, or beef.

X. Cui, A. Loraine, Xiangyi Lu, 2007, Methods in molecular biology.

Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila

Xiangyi Lu, D. Ruden, 2008, Current genomics.

Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease

D. Ruden, Yueyue Yu, E. Claud, 2016, Epigenetics.

Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer.

Xiangyi Lu, D. Ruden, Li-Qing Xiao, 2005, Human molecular genetics.

Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storage

D. Allison, N. Yi, J. Leips, 2005 .

Phthalate Exposure and Long-Term Epigenomic Consequences: A Review

D. Rappolee, D. Ruden, D. Haggerty, 2020, Frontiers in Genetics.

An Examination of the Association of Selected Toxic Metals with Total and Central Obesity Indices: NHANES 99-02

David B. Allison, Miguel A. Padilla, D. Allison, 2010, International journal of environmental research and public health.

Low Molecular Weight Heparin Ablates Lung Cancer Cisplatin-Resistance by Inducing Proteasome-Mediated ABCG2 Protein Degradation

Fang Wang, D. Ruden, Kun Zheng, 2012, PloS one.

CloudAligner: A fast and full-featured MapReduce based tool for sequence mapping

Weisong Shi, Tung Nguyen, Douglas Ruden, 2011, BMC Research Notes.

Early life lead exposure causes gender-specific changes in the DNA methylation profile of DNA extracted from dried blood spots.

M. Dereski, S. Land, D. Ruden, 2015, Epigenomics.

Intronic Non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees

Radhika S. Khetani, G. Robinson, Xiaoyi Cao, 2013, BMC Genomics.

Accumulation, elimination, sequestration, and genetic variation of lead (Pb2+) loads within and between generations of Drosophila melanogaster.

Elizabeth K. Peterson, H. Hirsch, D. Ruden, 2017, Chemosphere.

Drosophila nutrigenomics can provide clues to human gene-nutrient interactions.

Xiangyi Lu, D. Ruden, M. De Luca, 2005, Annual review of nutrition.

Transgenerational Epigenetic Inheritance in Drosophila

Luan Wang, Xiangyi Lu, D. Ruden, 2013 .

Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm.

H. Jäckle, D. Ruden, 1995, Development.

Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

M. Dereski, S. Land, Xiangyi Lu, 2015, Scientific Reports.

The Role of Epigenetics in Evolution: The Extended Synthesis

D. Ruden, V. Sollars, C. Richards, 2012, Genetics research international.

Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth

D. Ruden, D. Dolinoy, V. Padmanabhan, 2022, Frontiers in Genetics.

DNA methylation and exposure to violence among African American young adult males

D. Ruden, Katherine Gurdziel, B. Kwabi-Addo, 2021, Brain, behavior, & immunity - health.

Traumatic brain injury causes retention of long introns in metabolic genes via regulation of intronic Histone 3 lysine 36 methylation levels in the sub-acute phase of injury

R. Pique-Regi, D. Ruden, Katherine Gurdziel, 2016, bioRxiv.

Hsp90 Inhibitors and the Reduction of Anti-Cancer Drug Resistance by Non-Genetic and Genetic Mechanisms

Luan Wang, Xiangyi Lu, D. Ruden, 2012, Pharmaceuticals.

The (new) new synthesis and epigenetic capacitors of morphological evolution

D. Ruden, 2011, Nature Genetics.

Epigenetic Regulation of Trinucleotide Repeat Expansions and Contractions and the “Biased Embryos” Hypothesis for Rapid Morphological Evolution

Xiangyi Lu, D. Ruden, Li-Qing Xiao, 2005 .

IL-10: A possible immunobiological component of positive mental health in refugees

B. Arnetz, D. Ruden, J. Arnetz, 2021, Comprehensive psychoneuroendocrinology.

Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns

D. Weisenberger, C. Ladd-Acosta, M. Karagas, 2023, JAMA network open.

Frontiers in Toxicogenomics in the Twenty-First Century—the Grand Challenge: To Understand How the Genome and Epigenome Interact with the Toxic Environment at the Single-Cell, Whole-Organism, and Multi-Generational Level

Katherine Gurdziel, Michael Aschner, M. Aschner, 2017, Front. Genet..

Using Live Imaging and FUCCI Embryonic Stem Cells to Rank DevTox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude

E. Puscheck, D. Rappolee, D. Ruden, 2021, Frontiers in Toxicology.

Behavioral effects of chronic exposure to low levels of lead in Drosophila melanogaster.

H. Hirsch, H. Ghiradella, D. Ruden, 2003, Neurotoxicology.

Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber.

D. Ruden, X. Wang, V. Sollars, 2000, Developmental biology.

The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor

D. Ruden, K. Ratzlaff, S. Fowler, 2001, Journal of Neuroscience Methods.

Drosophila Pkd2 Is Haploid-insufficient for Mediating Optimal Smooth Muscle Contractility*

Xiangyi Lu, D. Ruden, Zhiqian Gao, 2004, Journal of Biological Chemistry.

Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae.

H. Hirsch, G. Lnenicka, D. Ruden, 2009, Neurotoxicology.

Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster.

H. Hirsch, G. Lnenicka, D. Ruden, 2009, Neurotoxicology.

Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

D. Ruden, J. Ramadoss, P. Stemmer, 2023, iScience.

The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II

Azam Peyvandipour, R. Pique-Regi, R. Romero, 2021, ImmunoHorizons.

Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin-resistant lung tumors.

D. Ruden, Fenghua Wang, Qian Li, 2014, Molecular and clinical oncology.

Inhibiting Mitochondrial Cytochrome c Oxidase Downregulates Gene Transcription After Traumatic Brain Injury in Drosophila

D. Ruden, Katherine Gurdziel, T. Sanderson, 2021, Frontiers in Physiology.

Prenatal phthalate exposures and autism spectrum disorder symptoms in low-risk children.

Courtney C. Carignan, N. Paneth, D. Ruden, 2021, Neurotoxicology and teratology.

A Drosophila kinesin-like protein, Klp38B, functions during meiosis, mitosis, and segmentation.

D. Ruden, V. Sollars, W. Cui, 1997, Developmental biology.

A single cell transcriptomic fingerprint of stressed premature, imbalanced differentiation of embryonic stem cells

E. Puscheck, D. Rappolee, D. Ruden, 2023, bioRxiv.

Activating regions of yeast transcription factors must have both acidic and hydrophobic amino acids

D. Ruden, 1992, Chromosoma.

Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells

E. Puscheck, D. Rappolee, D. Ruden, 2021, Stem Cell Reviews and Reports.

10 Years of Toxicogenomics section in Frontiers in Genetics: Past discoveries and Future Perspectives

D. Ruden, 2022, Frontiers in Genetics.

Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development

Ashutosh Kumar Singh, D. Rappolee, D. Ruden, 2023, Cells.

Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease.

Ashutosh Kumar Singh, D. Ruden, Daniel A Rappolee, 2023, Epigenomics.

Sex-Differences in Traumatic Brain Injury in the Absence of Tau in Drosophila

D. Ruden, Katherine Gurdziel, E. Shah, 2021, Genes.

Ten Putative Contributors to the Obesity Epidemic

P. Gluckman, L. Aronne, D. Allison, 2009, Critical reviews in food science and nutrition.

Evaluation of pediatric epigenetic clocks across multiple tissues

C. Marsit, R. Habre, C. Ladd-Acosta, 2023, Clinical Epigenetics.

Biological Aging Acceleration Due to Environmental Exposures: An Exciting New Direction in Toxicogenomics Research

D. Ruden, D. Dolinoy, Jackie M. Goodrich, 2023, Genes.

Effectiveness of Hsp 90 Inhibitors as Anti-Cancer Drugs

Xiangyi Lu, D. Ruden, Li-Qing Xiao, 2006 .