G. Leclercq

S. Rudaz, E. Lesniewska, G. Leclercq, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Oestrogen receptors in breast cancer: a changing concept.

G. Leclercq, J. Heuson, M. Deboel, 1975, British medical journal.

Loss of antagonistic activity of tamoxifen by replacement of one N-methyl of its side chain by fluorinated residues.

G. Leclercq, J. Blazejewski, A. Cleeren, 2006, Bioorganic & medicinal chemistry.

Extracellular calcium downregulates estrogen receptor alpha and increases its transcriptional activity through calcium-sensing receptor in breast cancer cells.

G. Leclercq, F. Journé, J. Body, 2004, Bone.

Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity

G. Leclercq, S. Chouaib, J. Thiery, 2005, Oncogene.

Metabolism of tamoxifen by isolated rat hepatocytes. Identification of the glucuronide of 4-hydroxytamoxifen.

G. Leclercq, M. Jarman, R. Mccague, 1990, Biochemical pharmacology.

Receptors for oestrogen, progesterone and epidermal growth factor in normal and tumorous canine mammary tissues.

G. Leclercq, I. Donnay, N. Devleeschouwer, 1993, Journal of reproduction and fertility. Supplement.

Abbott monoclonal enzyme immunoassay measurement of estrogen receptors in human breast cancer: a European multicenter study.

R. Nicholson, H. Bojar, G. Leclercq, 1986, Cancer research.

Modulatory effect of nonesterified fatty acids on structure and binding characteristics of estrogen receptor from MCF-7 human breast cancer cells.

G. Leclercq, M. Borrás, 1992, Journal of receptor research.

Competitive binding assay for estrogen receptor in monolayer culture: measure of receptor activation potency.

G. Leclercq, S. Stoessel, 1986, Journal of steroid biochemistry.

Whole transcriptome analysis of the ERα synthetic fragment P295‐T311 (ERα17p) identifies specific ERα‐isoform (ERα, ERα36)‐dependent and ‐independent actions in breast cancer cells

M. Kampa, E. Castanas, G. Leclercq, 2013, Molecular oncology.

ERα17p, an ERα P295‐T311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements

M. Kampa, E. Castanas, G. Leclercq, 2011, Journal of cellular biochemistry.

ERα36, a new variant of the ERα is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines

M. Kampa, E. Castanas, G. Leclercq, 2012, Steroids.

Hormone sensitivity in vitro and in vivo of v‐ras‐transfected mcf‐7 cell derivatives

W. Fiers, M. Mareel, F. van Roy, 1990, International journal of cancer.

The sequence Pro295-Thr311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells.

G. Leclercq, P. Robin, D. Leiber, 2015, The Biochemical journal.

Trophic effect in MCF-7 cells of ERα17p, a peptide corresponding to a platform regulatory motif of the estrogen receptor α—Underlying mechanisms

G. Leclercq, Y. Jacquot, G. Laurent, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Tangeretin inhibits extracellular‐signal‐regulated kinase (ERK) phosphorylation

G. Leclercq, V. S. Parmar, S. Van slambrouck, 2005, FEBS letters.

Morphology of MXT mouse mammary tumors. Correlation with growth characteristics and hormone sensitivity.

R. Kiss, J. Pasteels, G. Leclercq, 1986, European journal of cancer & clinical oncology.

The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer.

G. Leclercq, A. Vessières, G. Jaouen, 2004, Current medicinal chemistry.

Synthesis, structure and biological properties of Z-17α-(2-iodovinyl)-11β-chloromethyl estradiol-17β (Z-CMIV), a high affinity ligand for the characterization of estrogen receptor-positive tumors

B. Norberg, G. Leclercq, J. Quivy, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Contribution of Estrogen Receptors to the Strategy of Breast Cancer Treatment

R. Paridaens, R. Sylvester, G. Leclercq, 1981 .

Clinical significance of the quantitative assessment of estrogen receptors in advanced breast cancer

R. Paridaens, R. Sylvester, G. Leclercq, 1980, Cancer.

Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer—Considerations concerning related efficacy and safety

G. Leclercq, Y. Jacquot, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes.

G. Leclercq, P. de Cremoux, Y. Jacquot, 2011, Maturitas.

Controversies concerning the use of phytoestrogens in menopause management: bioavailability and metabolism.

G. Leclercq, P. de Cremoux, Y. Jacquot, 2010, Maturitas.

Changes in oestrogen, progesterone and epidermal growth factor receptor concentrations and affinities during the oestrous cycle in the normal mammary gland and uterus of dogs

G. Leclercq, I. Donnay, N. Devleeschouwer, 2005, Veterinary Research Communications.

Estrogen receptor of primary breast cancers: evidence for intracellular proteolysis

D. Larsimont, M. Lacroix, G. Leclercq, 2000, Breast Cancer Research.

Decrease of hormone binding capacity of estrogen receptor by calcium.

G. Leclercq, Y. Maaroufi, A. Ben Hardouze, 1997, Journal of receptor and signal transduction research.

Protein synthesis is not implicated in the ligand-dependent activation of the estrogen receptor in MCF-7 cells

G. Leclercq, A. Cleeren, M. Borrás, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Evaluation of estrogen receptor, antiestrogen binding sites and calmodulin for antiestrogen resistance of two clones derived from the MCF-7 breast cancer cell line.

L. Jin, G. Leclercq, N. Legros, 1994, Biochemical pharmacology.

Estrogen-like activity of a subpopulation of natural antiestrogen receptor autoantibodies in man.

G. Leclercq, J. Body, A. Borkowski, 1991, Endocrinology.

Estrogen and antiestrogen interaction with estrogen receptor of MCF-7 cells--relationship between processing and estrogenicity.

G. Leclercq, M. Gyling, 1988, Journal of steroid biochemistry.

Assay for estrogen and progesterone receptors of breast cancer cell lines in monolayer culture.

G. Leclercq, N. Devleeschouwer, J. Heuson, 1985, European journal of cancer & clinical oncology.

Guide-lines in the design of new antiestrogens and cytotoxic-linked estrogens for the treatment of breast cancer.

G. Leclercq, N. Devleeschouwer, J. Heuson, 1983, Journal of steroid biochemistry.

A subpopulation of immunoglobulin G in man selectively interacts with the hormone-binding sites of estrogen receptors.

G. Leclercq, J. Body, A. Borkowski, 1987, The Journal of clinical endocrinology and metabolism.

Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells☆ 1 1 ☆ Contribution of AEK and FJ to the present study is equivalent.

G. Leclercq, F. Journé, H. Seo, 2000, Steroids.

In situ amplification of oestrogen receptor α mRNA in breast cancer cell lines and tumours

D. Larsimont, G. Leclercq, D. Gancberg, 2001 .

Estrogen receptor status and estradiol sensitivity of MCF-7 cells in exponential growth phase.

C. Bosman, M. Piccart, G. Leclercq, 1988, European journal of cancer & clinical oncology.

Proliferative effect of estradiol on the uterus and the mxt hormone dependent mammary tumor of the mouse. Abstr.

R. Paridaens, G. Leclercq, J. Werry, 1983 .

Tamoxifen aziridine labeling of the estrogen receptor — potential utility in detecting biologically aggressive breast tumors

M. Piccart, G. Leclercq, D. Patel, 2005, Breast Cancer Research and Treatment.

Synthesis, Characterization and Biological Evaluation of 7α-Perfluoroalkylestradiol Derivatives

G. Leclercq, G. Laurent, D. Nonclercq, 2003 .

Antiestrogenic activity of two 11β-estradiol derivatives on MCF-7 breast cancer cells

M. Lacroix, G. Leclercq, Lu Jin, 1995, Steroids.

Estradiol derivatives bearing the side-chain of tamoxifen antagonize the association between the estrogen receptor and calmodulin.

G. Leclercq, A. Bouhoute, 1994, Biochemical pharmacology.

Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series

G. Leclercq, A. Vessières, G. Jaouen, 2001 .

Regulation of estrogen receptor levels by ligand-induced release of compound(s) in MCF-7 cells

D. Larsimont, G. Leclercq, Yan Ma, 2000, Molecular and Cellular Endocrinology.

Expression of c-erbB2, TGF-β1 and pS2 genes in primary human breast cancers

M. Piccart, J. Hustin, G. Leclercq, 1992 .

Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones

G. Leclercq, Y. Jacquot, A. Xicluna, 2013, Medicinal Chemistry Research.

Effect of low dose irradiation on estrogen receptor level in MCF‐7 breast cancer cells

P. van Houtte, G. Leclercq, F. Journé, 2001, International journal of cancer.

Length increase of the side chain of idoxifene does not improve its antagonistic potency in breast-cancer cell lines

G. Leclercq, I. Hardcastle, Lu Jin, 1998, Cancer Chemotherapy and Pharmacology.

Estrogen conjugates and serum factors mediating the estrogenic trophic effect on MCF-7 cell growth.

R. Paridaens, G. Leclercq, N. Devleeschouwer, 1987, Cancer research.

Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line.

G. Leclercq, N. Devleeschouwer, N. Legros, 1986, Journal of steroid biochemistry.

Synthesis and evaluation of novel N-substituted N'-(3-hydroxy-17-oxoestra-1,3,5(10)-trien-2- and -4-yl)thiourea derivatives for binding to the estrogen receptor and cytotoxic activity on MCF-7 cells.

G. Leclercq, O. Aboulwafa, A. Omar, 1984, Journal of pharmaceutical sciences.

Calcium-induced activation of estrogen receptor alpha – New insight

G. Leclercq, 2012, Steroids.

Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells

G. Leclercq, Y. Jacquot, G. Laurent, 2008, Molecular and Cellular Endocrinology.

Pathological Maintenance and Evolution of Breast Cancer: The Convergence of Irreversible Biological Actions of ER Alpha

G. Leclercq, 2020, Endocrines.

Palmitoylation regulates 17β-estradiol-induced estrogen receptor-α degradation and transcriptional activity.

G. Leclercq, M. Marino, F. Acconcia, 2012, Molecular endocrinology.

Effects of (R,S)/(S,R)-4,5-bis(2-chloro-4-hydroxyphenyl)-2-imidazolines and (R,S)/(S,R)-2,3-bis(2-chloro-4-hydroxyphenyl)piperazines on estrogen receptor alpha level and transcriptional activity in MCF-7 cells.

G. Leclercq, G. Laurent, D. Nonclercq, 2007, Biochemical pharmacology.

Estrogenic and antiestrogenic down-regulation of estrogen receptor levels: evidence for two different mechanisms.

G. Leclercq, J. Heuson, M. Gyling, 1990, Journal of receptor research.

Modulation of estradiol and DNA binding to estrogen receptor upon association with calmodulin.

G. Leclercq, A. Bouhoute, 1995, Biochemical and biophysical research communications.

Estrogen-induced protein in the human breast cancer cell line MCF7.

G. Leclercq, P. Galand, N. Devleeschouwer, 1980, Biochemical and Biophysical Research Communications - BBRC.

Estrogenic and anti‐estrogenic regulation of estrogen receptor in MCF‐7 breast‐cancer cells: Comparison of immunocytochemical data with biochemical measurements

D. Larsimont, G. Leclercq, H. Seo, 1998, International journal of cancer.

Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation.

G. Leclercq, P. Ducrot, D. Carrez, 2000, Bioorganic & medicinal chemistry.

Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF‐7 cells

G. Leclercq, S. Horman, P. Galand, 1997, Cell proliferation.

2 – ESTROGENS, ANTIESTROGENS, AND OTHER ESTRANE COMPOUNDS

G. Leclercq, 1992 .

Pharmacological profile of 6,12-dihydro-3-methoxy-1-benzopyrano[3,4-b] [1,4]benzothiazin-6-one, a novel human estrogen receptor agonist.

G. Leclercq, Y. Jacquot, G. Adessi, 2002, Biological & pharmaceutical bulletin.

Synthesis and properties of some new 3-substituted hexestrol derivatives

G. Leclercq, M. Vilkas, L. Masamba, 1987 .

The first organometallic antioestrogens and their antiproliferative effects

G. Leclercq, A. Vessières, G. Jaouen, 2000 .

Diethylstilbestrol-linked cytotoxic agents: synthesis and binding affinity for estrogen receptors.

G. Leclercq, K. Krohn, K. Kulikowski, 1989, Journal of medicinal chemistry.

First attachment of the stable organometallic moiety 〚Re(CO)3(η5-C5H4–C≡C–)〛 at position 11ß of oestradiol. Biochemical behaviour of the complex

G. Leclercq, A. Vessières, G. Jaouen, 2001 .

The first organometallic derivative of 11β-ethynylestradiol, a potential high-affinity marker for the estrogen receptor

G. Leclercq, D. Osella, A. Vessières, 2000 .

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

G. Leclercq, A. Vessières, G. Jaouen, 2001 .

Stereochemical effects during [M-H]− dissociations of epimeric 11-OH-17β-estradiols and distant electronic effects of substituents at C(11) position on gas phase acidity

G. Leclercq, Y. Jacquot, J. Tabet, 2009, Journal of the American Society for Mass Spectrometry.

Fluorous tolerance of the estrogen receptor alpha as probed by 11-polyfluoroalkylestradiol derivatives

G. Leclercq, J. Blazejewski, A. Cleeren, 2008, Steroids.

Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

F. de Longueville, V. Bertholet, J. Remacle, 2008, Cancer genomics & proteomics.

Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha

P. Brown, G. Leclercq, Y. Jacquot, 2006, Breast Cancer Research and Treatment.

Antagonism of estrogen receptor and calmodulin association by antiestrogens is not dependent on an interaction with calmodulin.

G. Leclercq, M. Rowlands, M. Jarman, 1997, Biochemical pharmacology.

The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

G. Leclercq, A. Vessières, G. Jaouen, 2002 .

Inhibition of estradiol binding to its receptor by the cupric ion

G. Leclercq, A. Cleeren, Y. Maaroufi, 1998, JBIC Journal of Biological Inorganic Chemistry.

Synthesis and biological studies of aminoestradiol-platinum (II) conjugates

G. Leclercq, C. Chesné, H. Patin, 1986 .

Antitumour effect of cyclofenil (F6066) on DMBA-induced rat mammary tumors.

G. Leclercq, A. Danguy, N. Devleeschouwer, 1978, European journal of cancer.

Peptides targeting estrogen receptor alpha-potential applications for breast cancer treatment.

Janine Cossy, Guy Leclercq, Denis Larsimont, 2011, Current pharmaceutical design.

Estrogen receptor alpha: impact of ligands on intracellular shuttling and turnover rate in breast cancer cells.

M. Lacroix, G. Leclercq, G. Laurent, 2006, Current cancer drug targets.

Molecular forms of the estrogen receptor in breast cancer

G. Leclercq, 2002, The Journal of Steroid Biochemistry and Molecular Biology.

A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines.

G. Leclercq, Jan-Martin Heldt, A. Vessières, 2010, Journal of inorganic biochemistry.

Estrogen receptors in the spectrum of breast cancer.

G. Leclercq, J. Heuson, 1976, Current problems in cancer.

Exchange of bound estrogens and antiestrogens in MCF-7 cells: evidence for ligand-induced stable configurations of the estrogen receptor

G. Leclercq, A. E. Khissiin, 1998, Steroids.

Nonisomerizable analogues of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes.

G. Leclercq, V. Jordan, R. Mccague, 1988, Journal of medicinal chemistry.

Synthesis, conformational considerations, and estrogen receptor binding of diastereoisomers and enantiomers of 1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenylbutane (dihydrotamoxifen).

G. Leclercq, R. Mccague, 1987, Journal of medicinal chemistry.

Electronic Effects of 11β Substituted 17β-Estradiol Derivatives and Instrumental Effects on the Relative Gas Phase Acidity

G. Leclercq, Y. Jacquot, J. Tabet, 2012, Journal of The American Society for Mass Spectrometry.

About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESR1) in breast cancer

G Leclercq, M. Lacroix, G. Leclercq, 2004, Molecular and Cellular Endocrinology.

Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different phenotypes.

C. Sotiriou, F. Lallemand, M. Piccart, 2004, Oncology reports.

Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells

F. Olea-Serrano, N. Olea, A. Rivas, 2002, The Journal of Steroid Biochemistry and Molecular Biology.

Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women.

J. Deslypere, R. Paridaens, G. Leclercq, 1986, European journal of cancer & clinical oncology.

Relation between estrogen receptor concentration and clinical and histological factors: their relative prognostic importance after radical mastectomy for primary breast cancer.

R. Sylvester, G. Leclercq, G. Andry, 1989, European journal of cancer & clinical oncology.

Biochemical assays for the selection of cytotoxic-linked estrogens with potential therapeutic activity.

G. Leclercq, J. Heuson, 1978, Cancer treatment reports.

Interaction Between Estrogen Receptor Alpha, Ionizing Radiation and (anti-) Estrogens in Breast Cancer Cells

N. Magné, P. Houtte, M. Lacroix, 2005, Breast Cancer Research and Treatment.

A Low-Density DNA Microarray for Analysis of Markers in Breast Cancer

J. Remacle, M. Lacroix, G. Leclercq, 2002 .

Identification of a human estrogen receptor α‐derived antiestrogenic peptide that adopts a polyproline II conformation

G. Leclercq, M. Desmadril, Y. Jacquot, 2009, Journal of peptide science : an official publication of the European Peptide Society.

Therapeutic significance of sex-steroid hormone receptors in the treatment of breast cancer.

G. Leclercq, J. Heuson, 1977, European journal of cancer.

Physiological and pharmacological effects of estrogens in breast cancer.

G. Leclercq, J. Heuson, 1979, Biochimica et biophysica acta.

Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer

R. Sylvester, G. Leclercq, J. Heuson, 1977, Cancer.

Oestrogen receptors in human breast cancer.

G. Leclercq, J. Heuson, W. Mattheiem, 1974 .

Estrogen receptors in human breast cancer.

G. Leclercq, J. Heuson, W. Mattheiem, 1973, European Journal of Cancer.

Specific estrogen receptor of the DMBA-induced mammary carcinoma of the rat and its estrogen-requiring molecular transformation.

G. Leclercq, J. Heuson, 1973, European journal of cancer.

Routine assays for steroid hormone receptors.

G. Leclercq, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells

G. Leclercq, H. Seo, N. Legros, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Estrogen and progesterone receptors in human breast cancer.

G. Leclercq, N. Legros, W. Mattheiem, 1977 .

Affinity of estradiol mustard for estrogen receptors and its enzymatic degradation in uterine and breast cancer cytosols

G. Leclercq, J. Heuson, M. Deboel, 1976, International journal of cancer.

Oestrogen receptors in male breast cancer.

G. Leclercq, A. Verhest, J. Heuson, 1976, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

Interaction of activated estradiol-receptor complex and chromatin in isolated uterine nuclei.

G. Leclercq, J. Heuson, N. Hulin, 1973, European journal of cancer.

Oestrogen-induced protein in rat mammary tumour and uterus.

G. Leclercq, P. Galand, J. Heuson, 1977, The Journal of endocrinology.

Tritiated actinomycin-D staining method: a valuable tool to study oestrogen receptor-induced modifications of transcriptional activity in normal and neoplastic cells.

G. Leclercq, A. Danguy, N. Devleeschouwer, 1985, Archives internationales de physiologie et de biochimie.

Estrogen receptors in DMBA-induced rat mammary tumors before and after ovariectomy.

G. Leclercq, J. Heuson-Stiennon, J. Heuson, 1977, Oncology.

Importance of A/B and C domains of the estrogen receptor for its adsorption to hydroxylapatite

G. Leclercq, Y. Maaroufi, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Comparison of immunohistochemical and biochemical measurement of steroid receptors in breast cancer: are both still necessary?

G. Leclercq, L. Kaufman, L. Gotlieb, 2001, Breast.

Estradiol-induced Down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression

G. Leclercq, N. Legros, F. Lempereur, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

The “portrait” of hereditary breast cancer

M. Lacroix, G. Leclercq, 2005, Breast Cancer Research and Treatment.

2 The ‘ ‘ portrait ’ ’ of hereditary breast cancer 3

M. Lacroix, G. Leclercq, 2004 .

Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-α regulation in MCF-7 breast cancer cells

G. Leclercq, H. Seo, 2002, The Journal of Steroid Biochemistry and Molecular Biology.

Estrogens decrease gamma-ray-induced senescence and maintain cell cycle progression in breast cancer cells independently of p53.

N. Magné, C. Desmedt, P. van Houtte, 2007, International journal of radiation oncology, biology, physics.

Expression of c-erbB 2 , TGF-131 and pS 2 Genes in Primary Human Breast Cancers

M. Piccart, J. Hustin, G. Leclercq, 2005 .

Adsorption of tamoxifen and 2-methyl derivatives under cell culture conditions

G. Leclercq, S. Chamart, M. Hanocq, 1993 .

Metabolism of tamoxifen by isolated rat hepatocytes. Identification of 1-[4-(2-hydroxyethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene and the dependence of N-oxidation on oxygen availability.

G. Leclercq, R. Mccague, S. Stoessel, 1987, Biochemical pharmacology.

Metabolism of tamoxifen by isolated rat hepatocytes: anti-estrogenic activity of tamoxifen N-oxide.

G. Leclercq, M. Jarman, A. B. Foster, 1982, Biochemical pharmacology.

A low-density DNA microarray for analysis of markers in breast cancer.

G Leclercq, J Remacle, J. Remacle, 2002, The International journal of biological markers.

Influence of the Nature of Serum on the Estrogen Sensitivity of the MCF‐7 Breast Cancer Cell Line a

G. Leclercq, N. Devleeschouwer, N. Olea-Serrano, 1986 .

Quality control for storage and transportation of breast cancer samples for the assessment of their estrogen receptor content.

R. Paridaens, R. Sylvester, G. Leclercq, 1985, Acta clinica Belgica.

Implication of proteasome in estrogen receptor degradation

G. Leclercq, Abdelhamid El Khissiin, 1999, FEBS letters.

Estradiol-dependent collagenolytic enzyme activity in long-term organ culture of human breast cancer.

J. Pasteels, G. Leclercq, J. Heuson-Stiennon, 1975, Cancer research.

Estrogen-induced synthesis and secretion of proteins in the human breast cancer cell line MCF-7.

G. Leclercq, P. Galand, N. Devleeschouwer, 1981, Journal of steroid biochemistry.

Tumor‐infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome

D. Larsimont, M. Piccart, G. Leclercq, 1999, International journal of cancer.

Cellular Responses Mediated by Estrogen Receptors — Fundamental Aspects

G. Leclercq, 1986 .

Bulk protein secretion induced by estradiol in MCF-7 cells.

G. Leclercq, J. Heuson, N. Mairesse, 1985, European journal of cancer & clinical oncology.

Estrogen action on the synthesis and secretion of a broad spectrum of proteins in mammary tumor cells.

G. Leclercq, P. Galand, N. Devleeschouwer, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

A new method for evaluating the inhibitory potency of antiestrogens on breast cancer cell lines.

G. Leclercq, L. Madeddu, F. Roy, 1986, Anticancer research.

Nafoxidine antagonism on estrogen 'induced proteins' synthesis in the human breast cancer cell line MCF-7

G. Leclercq, P. Galand, N. Devleeschouwer, 1983 .

Estrogen receptor status and the clinical response to a combination of aminoglutethimide and cortisol in advanced breast cancer.

R. Paridaens, G. Leclercq, J. Heuson, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Varying sensitivity of human mammary carcinoma cells to the toxic effect of parvovirus H-1.

G. Leclercq, J. Rommelaere, C. Van Pachterbeke, 1997, European journal of cancer.

Decrease of estrogen receptor expression and associated ERE-dependent transcription in MCF-7 breast cancer cells after oligomycin treatment

C. Sotiriou, D. Larsimont, G. Leclercq, 2003, Steroids.

Capacity of type I and II ligands to confer to estrogen receptor alpha an appropriate conformation for the recruitment of coactivators containing a LxxLL motif-Relationship with the regulation of receptor level and ERE-dependent transcription in MCF-7 cells.

G. Leclercq, Y. Jacquot, G. Laurent, 2010, Biochemical pharmacology.

Hormone receptors and cancer.

G. Leclercq, J. Body, A. Borkowski, 1988, European journal of cancer & clinical oncology.

Regulatory function of the P295-T311 motif of the estrogen receptor α - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?

G. Leclercq, Y. Jacquot, G. Laurent, 2008, Nuclear receptor signaling.

Role of the proteasome in the regulation of estrogen receptor α turnover and function in MCF-7 breast carcinoma cells

G. Leclercq, R. Toillon, F. Journé, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Analogues of tamoxifen: the role of the basic side-chain. Applications of a whole-cell oestrogen-receptor binding assay to N-oxides and quaternary salts.

G. Leclercq, R. Skilton, M. Jarman, 1986, Anti-Cancer Drug Design.

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis.

G. Leclercq, V. Pelekanou, 2011, The International journal of developmental biology.

Determination of 2-methyl derivatives of tamoxifen in cell culture medium using high-performance liquid chromatography and electrochemical detection.

G. Leclercq, S. Chamart, M. Hanocq, 1989, Journal of chromatography.

Non-isomerisable antiestrogens related to tamoxifen.

G. Leclercq, M. Jarman, R. Mccague, 1988, Journal of steroid biochemistry.

Estrogen receptor analysis in primary breast tumors by ligand-binding assay, immunocytochemical assay, and northern blot: a comparison

D. Larsimont, M. Lacroix, G. Leclercq, 2001, Breast Cancer Research and Treatment.

The estrogen receptor alpha‐derived peptide ERα17p (P295‐T311) exerts pro‐apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status

Guy Leclercq, George Notas, M. Kampa, 2011, Molecular oncology.

Estrogen Responsiveness of IBEP-2, A New Human Cell Line Derived from Breast Carcinoma

G. Leclercq, F. Journé, G. Laurent, 2004, Breast Cancer Research and Treatment.

Endocrine effects of Trilostane: in vitro and in vivo studies.

R. Paridaens, G. Leclercq, A. Vermeulen, 1987, European journal of cancer & clinical oncology.

Use of fluorescent sex-steroid conjugates for the histochemical detection of breast cancer cell receptors: a critique.

G. Leclercq, A. Danguy, J. Heuson, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Sensitivity of the hormone dependent MXT-mouse mammary carcinoma to estradiol during tumoral growth. An autoradiographic study.

R. Kiss, R. Paridaens, G. Leclercq, 1986, European journal of cancer & clinical oncology.

Estrogen receptors and distribution of prognostic factors in primary breast cancer.

R. Sylvester, G. Leclercq, G. Andry, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Cytochemical analysis of human breast cancer with fluorescent sex-steroid conjugates. Comparison with biochemical assessment of oestrogen receptors.

J. Pasteels, G. Leclercq, A. Danguy, 1981, Anticancer research.

[Immunocytochemical assay of estrogen receptors in puncture products of breast carcinomas].

G. Leclercq, D. Faverly, N. Devleeschouwer, 1990, Bulletin du Cancer.

Estrogen receptors interaction with Estracyt and degradation products, a biochemical study on a potential agent in the treatment of breast cancer

G. Leclercq, J. Heuson, M. Deboel, 1976, European Journal of Drug Metabolism and Pharmacokinetics.

Natural Anti-Estrogen Receptor Alpha Antibodies Able to Induce Estrogenic Responses in Breast Cancer Cells: Hypotheses Concerning Their Mechanisms of Action and Emergence †

G. Leclercq, 2018, International journal of molecular sciences.

Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers.

M. Lacroix, G. Leclercq, N. Legros, 1997, Cancer letters.

Estrogen receptor variations in neoplastic tissue during the course of disease in patients with recurrent breast cancer.

R. Paridaens, R. Sylvester, G. Leclercq, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Accumulation of a non-binding form of estrogen receptor in MCF-7 cells under hydroxytamoxifen treatment

M. Piccart, G. Leclercq, N. Legros, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Effect of estrogenic and antiestrogenic triphenylethylene derivatives on progesterone and estrogen receptors levels of MCF-7 cells.

G. Leclercq, R. Mccague, N. Legros, 1991, Biochemical pharmacology.

Tamoxifen-induced estrogen receptor up-regulation in mammary tumor cells is not related to growth inhibition

L. Jin, G. Leclercq, N. Legros, 1997, Cancer Chemotherapy and Pharmacology.

Modification of the basic side chain in tamoxifen: effects on microsomal metabolism and in vitro biological activity.

G. Leclercq, R. Mccague, A. B. Foster, 1986, Anti-cancer drug design.

Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor α

G. Leclercq, Y. Jacquot, G. Laurent, 2007, Molecular and Cellular Endocrinology.

Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones

G. Leclercq, Y. Jacquot, A. Xicluna, 2013, Medicinal Chemistry Research.

Biophysical studies of the interaction between calmodulin and the R²⁸⁷-T³¹¹ region of human estrogen receptor α reveals an atypical binding process.

G. Leclercq, M. Desmadril, L. Carlier, 2012, Biochemical and biophysical research communications.

Biophysical studies of the interaction between calmodulin and the R 287-T 311 region of human estrogen receptor a reveals an atypical binding process

G. Leclercq, M. Desmadril, L. Carlier, 2012 .

ERα17p, a peptide reproducing the hinge region of the estrogen receptor α associates to biological membranes: A biophysical approach

M. Kampa, E. Castanas, G. Leclercq, 2012, Steroids.

Calmodulin association with the synthetic ERα17p peptide investigated by mass spectrometry

G. Leclercq, Y. Jacquot, J. Tabet, 2011 .

In vitro testing of cytotoxic compounds in hormone-dependent and -independent breast cancer cell lines.

G. Leclercq, N. Devleeschouwer, J. Heuson, 1984, Cancer treatment reviews.

Relationship between receptors for epidermal growth factor and steroid hormones in normal, dysplastic and neoplastic canine mammary tissues.

G. Leclercq, I. Donnay, N. Devleeschouwer, 1996, Research in veterinary science.

Psychosocial correlates of oestrogen and progesterone receptors in breast cancer

P. Houtte, R. Paridaens, D. Razavi, 1990, The Lancet.

Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain

G. Leclercq, Y. Jacquot, G. Laurent, 2007 .

Estrogen receptor alpha—Identification by a modeling approach of a potential polyproline II recognizing domain within the AF-2 region of the receptor that would play a role of prime importance in its mechanism of action

G. Leclercq, Y. Jacquot, D. Gallo, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Expression of c-erbB2, TGF-beta 1 and pS2 genes in primary human breast cancers.

M. Piccart, J. Hustin, G. Leclercq, 1992, European Journal of Cancer.

Comparison of estrogen and progesterone receptor expression in normal and tumor mammary tissues from dogs.

G. Leclercq, I. Donnay, N. Devleeschouwer, 1995, American journal of veterinary research.

Effect of castration and 17 beta-estradiol pulse on cell proliferation in the uterus and the MXT mouse mammary tumor.

R. Kiss, R. Paridaens, G. Leclercq, 1985, Journal of the National Cancer Institute.

Molecular characterization of breast cancer cell lines by a low-density microarray.

Guy Leclercq, Vincent Bertholet, Nathalie Zammatteo, 2005, International journal of oncology.

Effect of fluorination on the pharmacological profile of 11beta isomers of fulvestrant in breast carcinoma cells.

G. Leclercq, G. Laurent, D. Nonclercq, 2009, Journal of medicinal chemistry.

Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERα coactivator interactions.

V. Pelekanou, E. Castanas, G. Leclercq, 2013, Chirality.

Growth factor-like activity of phenol red preparations in the MCF-7 breast cancer cell line.

G. Leclercq, J. Body, I. Donnay, 1992, Anticancer research.

Estrogen receptor of primary breast cancers: evidence for intracellular proteolysis

D. Larsimont, M. Lacroix, G. Leclercq, 2000, Breast Cancer Research.

ERα17p, an ERα P295‐T311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements

M. Kampa, E. Castanas, G. Leclercq, 2011, Journal of cellular biochemistry.

Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells

G. Leclercq, Y. Jacquot, G. Laurent, 2008, Molecular and Cellular Endocrinology.

Evolution towards hormone independence of the MXT mouse mammary tumor is associated with a gradual change in its estrogen receptor molecular polymorphism.

M. Piccart, G. Leclercq, A. Debbaudt, 1998, Cancer biochemistry biophysics.

Major molecular weight heterogeneity of estrogen receptor from breast cancer is not related to neoplasia.

G. Leclercq, Y. Maaroufi, S. Trivedi, 1995, Cancer biochemistry biophysics.

Comparison of tritiated estradiol and tamoxifen aziridine for measurement of estrogen receptors in human breast cancer cytosols.

C. Bosman, M. Piccart, G. Leclercq, 1991, Journal of the National Cancer Institute.

G. Leclercq, Y. Jacquot, G. Laurent, 2010, Biochemical pharmacology.

Trophic effect in MCF-7 cells of ERα17p, a peptide corresponding to a platform regulatory motif of the estrogen receptor α—Underlying mechanisms

G. Leclercq, Y. Jacquot, G. Laurent, 2008, The Journal of Steroid Biochemistry and Molecular Biology.