S. Clarke

发表

Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae.

H. Cai, D. Dumlao, J. Katz, 2001, Biochemistry.

Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice.

S. Clarke, B. Karger, Shujia Dai, 2013, Analytical chemistry.

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

S. Clarke, T. Geiger, S Clarke, 1987, The Journal of biological chemistry.

Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase.

S. Clarke, Z. Jia, T. V. Brennan, 1994, The Journal of biological chemistry.

A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis

G. Giaever, C. Nislow, A. Baryshnikova, 2011, PLoS genetics.

Protein arginine methylation in mammals: who, what, and why.

S. Clarke, M. Bedford, 2009, Molecular cell.

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

S. Clarke, R. Stephenson, 1990, The Journal of biological chemistry.

Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro.

S. Clarke, C. Hrycyna, 1992, The Journal of biological chemistry.

Exceptional seed longevity and robust growth: ancient Sacred Lotus from China

S. Clarke, R. Berger, J. Shen-Miller, 1995 .

In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits.

S. Clarke, B. K. Fung, P. O'Brien, 1992, The Journal of biological chemistry.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity.

David Eisenberg, Cameron Mura, Jonathan E Katz, 2003, Journal of molecular biology.

Multiple Motif Scanning to Identify Methyltransferases from the Yeast Proteome*

S. Clarke, T. Petrossian, Tanya C Petrossian, 2009, Molecular & Cellular Proteomics.

Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes.

R. Kagan, S. Clarke, 1994, Archives of biochemistry and biophysics.

PRMT 3, a Type I Protein Arginine N-Methyltransferase That Differs from PRMT1 in Its Oligomerization, Subcellular Localization, Substrate Specificity, and Regulation*

J. Tang, S. Clarke, H. Herschman, 1998, The Journal of Biological Chemistry.

PRMT7 Is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity*

T. Miranda, S. Clarke, A. Frankel, 2004, Journal of Biological Chemistry.

A Type III Protein Arginine Methyltransferase from the Protozoan Parasite Trypanosoma brucei*

S. Clarke, Vladimir Presnyak, S. Menon, 2009, Journal of Biological Chemistry.

7 Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase

S. Young, S. Clarke, P. Ambroziak, 2001 .

Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.

S. Clarke, P. N. Mcfadden, P. N. McFadden, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10.

M. Mehrabian, S. Clarke, D. C. Maclaren, 1992, Genomics.

Age-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes.

S. Clarke, L. S. Brunauer, 1986, The Journal of biological chemistry.

Proteomic Identification of Novel Substrates of a Protein Isoaspartyl Methyltransferase Repair Enzyme*

D. Ray, S. Clarke, W. Carter, 2006, Journal of Biological Chemistry.

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

L. Wen, K. Herold, S. Clarke, 2021, bioRxiv.

Protein-arginine Methyltransferase 1 (PRMT1) Methylates Ash2L, a Shared Component of Mammalian Histone H3K4 Methyltransferase Complexes*

Sharon Y. R. Dent, S. Clarke, M. Bedford, 2011, The Journal of Biological Chemistry.

Uncovering the Human Methyltransferasome * □ S

S. Clarke, T. Petrossian, 2010 .

A Novel SET Domain Methyltransferase in Yeast

S. Clarke, J. Whitelegge, Tanya R. Porras-Yakushi, 2006, Journal of Biological Chemistry.

Perspectives on the biological function and enzymology of protein carboxyl methylation reactions in eucaryotic and procaryotic cells.

S. Clarke, 1988, Advances in experimental medicine and biology.

Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes.

S. Clarke, J. Momand, 1987, Biochemistry.

Protein Repair Methyltransferase from the Hyperthermophilic Archaeon Pyrococcus furiosus

T. Yeates, S. Clarke, N. Thapar, 2002, The Journal of Biological Chemistry.

Crystal Structure of Human l-Isoaspartyl Methyltransferase*

T. Yeates, M. Sawaya, S. Clarke, 2002, The Journal of Biological Chemistry.

Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins.

Eric Z. Pang, S. Clarke, J. Lowenson, 2022, Biochemistry.

RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases.

S. Clarke, A. Frankel, 1999, Biochemical and biophysical research communications.

Protein methylation.

S. Clarke, S Clarke, Steven Clarke, 1993, Current opinion in cell biology.

Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC.

S. Clarke, A. Vashisht, J. Wohlschlegel, 2016, Journal of proteome research.

Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin.

I. Ota, S. Clarke, 1989, Biochemistry.

Neighboring side chain effects on asparaginyl and aspartyl degradation: an ab initio study of the relationship between peptide conformation and backbone NH acidity.

K N Houk, K. Houk, S. Clarke, 2001, Journal of the American Chemical Society.

Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens.

S. Clarke, E. Mansilla, Rebeccah A Warmack, 2016, Rejuvenation research.

Isoaspartyl Dipeptidase (IadA)

S. Clarke, A. Patananan, 2013 .

Translational Roles of Elongation Factor 2 Protein Lysine Methylation*

K. Travaglini, S. Clarke, G. Chanfreau, 2014, The Journal of Biological Chemistry.

Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: Effects of the solvent dielectric

S. Clarke, T. V. Brennan, T. Brennan, 1993, Protein science : a publication of the Protein Society.

Chemical modifications of deposited amyloid-beta peptides.

S. Clarke, A. Roher, J. Lowenson, 1999, Methods in enzymology.

Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase. Detection of a new site of methylation at isomerized L-aspartyl residues.

S. Clarke, E. D. Murray, 1984, The Journal of biological chemistry.

Protein carboxyl methyltransferase and methyl acceptor proteins in aging and cataractous tissue of the human eye lens

S. Clarke, P. N. Mcfadden, P. N. McFadden, 1986, Mechanisms of Ageing and Development.

Metabolism of a synthetic L-isoaspartyl-containing hexapeptide in erythrocyte extracts. Enzymatic methyl esterification is followed by nonenzymatic succinimide formation.

S. Clarke, E. D. Murray, 1986, The Journal of biological chemistry.

Enzymatic methylation of L-isoaspartyl residues derived from aspartyl residues in affinity-purified calmodulin. The role of conformational flexibility in spontaneous isoaspartyl formation.

I. Ota, S. Clarke, 1989, The Journal of biological chemistry.

Structural elements affecting the recognition of L-isoaspartyl residues by the L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis.

S. Clarke, J. Lowenson, 1991, The Journal of biological chemistry.

Expression and purification of a human recombinant methyltransferase that repairs damaged proteins.

S. Clarke, D. C. Maclaren, 1995, Protein expression and purification.

Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues*

Troy E. Sandberg, S. Clarke, Ryan T. Kelly, 2012, The Journal of Biological Chemistry.

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

S. Richard, S. Clarke, A. Guo, 2013, Scientific Reports.

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

R. Deschenes, J. Stock, S. Clarke, 1988, Proceedings of the National Academy of Sciences of the United States of America.

DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo

I. Newsham, D. Gutmann, T. Miranda, 2004, Oncogene.

Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: purification, cloning, and sequence analysis of the wheat germ enzyme.

S. Clarke, M. B. Mudgett, 1993, Biochemistry.

An Arabidopsis ATP-Dependent, DEAD-Box RNA Helicase Loses Activity upon IsoAsp Formation but Is Restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE[C][W]

S. Clarke, S. E. Perry, P. Limbach, 2013, Plant Cell.

Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif.

S. Clarke, R. Stephenson, 1992, The Journal of biological chemistry.

Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain*

S. Clarke, Kristofor J. Webb, M. Bedford, 2007, Journal of Biological Chemistry.

An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A.

S. Clarke, H. Xie, 1994, Biochemical and biophysical research communications.

Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction.

S. Clarke, H. Xie, 1993, The Journal of biological chemistry.

Autophagy and Insulin/TOR Signaling in Caenorhabditis elegans pcm-1 Protein Repair Mutants

S. Clarke, T. Gomez, 2007, Autophagy.

Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins.

S. Clarke, P. N. Mcfadden, P. N. McFadden, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt 1 2 / 2 Mice

S. Clarke, J. Lowenson, K. B. MacKay, 2012 .

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice

S. Clarke, J. Lowenson, K. B. MacKay, 2012, PloS one.

Chapter 12 Why are proteins methylated

S. Clarke, 1995 .

A distinctly regulated protein repair L-isoaspartylmethyltransferase from Arabidopsis thaliana

S. Clarke, M. B. Mudgett, 1996, Plant Molecular Biology.

Protein L-isoaspartyl methyltransferase from the nematode Caenorhabditis elegans: genomic structure and substrate specificity.

R. Kagan, S. Clarke, 1995, Biochemistry.

Lupus autoimmunity altered by cellular methylation metabolism

S. Clarke, M. Mamula, Shilpi Khare, 2013, Autoimmunity.

An acidic loop within the human soluble CD23 protein may direct the interaction between sCD23 and the αXβ2 integrin.

S. Clarke, V. Oosthuizen, E. Prinsloo, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Deuteration protects asparagine residues against racemization

M. Shchepinov, S. Clarke, J. Lowenson, 2016, Amino Acids.

D-aspartate content of erythrocyte membrane proteins is decreased in uremia: implications for the repair of damaged proteins.

S. Clarke, J. Lowenson, A. D’Aniello, 1997, Journal of the American Society of Nephrology : JASN.

Human erythrocyte D-aspartyl/L-isoaspartyl methyltransferases: enzymes that recognize age-damaged proteins.

S. Clarke, D. Ingrosso, 1991, Advances in experimental medicine and biology.

The stereospecificity of protein kinases.

S. Clarke, K. Drickamer, L. Lou, 1987, Archives of biochemistry and biophysics.

Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus.

M. Gelb, S. Clarke, H. Yamane, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A major polypeptide component of rat liver mitochondria: carbamyl phosphate synthetase.

S. Clarke, 1976, The Journal of biological chemistry.

Chemical conversion of aspartyl peptides to isoaspartyl peptides. A method for generating new methyl-accepting substrates for the erythrocyte D-aspartyl/L-isoaspartyl protein methyltransferase.

S. Clarke, P. N. Mcfadden, P. N. McFadden, 1986, The Journal of biological chemistry.

HIV protease inhibitors and nuclear lamin processing: Getting the right bells and whistles

S. Clarke, 2007, Proceedings of the National Academy of Sciences.

Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II.

R. Kagan, S. Clarke, D. C. Maclaren, 1992, Biochemical and biophysical research communications.

3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase.

D. Dumlao, J. Katz, S. Clarke, 2004, Biochemistry.

Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A.

T. Miranda, J. Katz, S. Clarke, 2006, The Biochemical journal.

Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.

S. Clarke, Joyce Sayegh, 2008, Biochemical and biophysical research communications.

Yeast Hsl 7 ( histone synthetic lethal 7 ) catalyses the in vitro formation of ω-NG-monomethylarginine in calf thymus histone H 2 A

T. Miranda, J. Katz, S. Clarke, 2006 .

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.

S. Clarke, C. Hrycyna, 1990, Molecular and cellular biology.

RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus.

J. Broach, R. Deschenes, J. Stock, 1989, The Journal of biological chemistry.

The graphite deposit at Borrowdale (UK): a catastrophic mineralizing event associated with Ordovician magmatism

S. Clarke, M. Rodas, O. Beyssac, 2010 .

The methylator meets the terminator

S. Clarke, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The l-Isoaspartyl Protein Repair Methyltransferase Enhances Survival of Aging Escherichia coli Subjected to Secondary Environmental Stresses

S. Clarke, H. Cai, J. E. Visick, 1998, Journal of bacteriology.

Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli.

J. Fu, S. Clarke, L. Ding, 1991, The Journal of biological chemistry.

Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides.

S. Clarke, T. V. Brennan, Steven Clarke, 2009, International journal of peptide and protein research.

l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

Carole L. Linster, S. Clarke, M. L. Cordero-Maldonado, 2021, Frontiers in Genetics.

Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp.

S. Ceman, S. Clarke, Xing Zhang, 2006, Human molecular genetics.

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a.

R. Reeves, T. Miranda, S. Clarke, 2005, Biochemical and biophysical research communications.

Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus.

S. Pestka, T. Miranda, S. Clarke, 2004, Biochemical and biophysical research communications.

Ornithine transcarbamylase from Neurospora crassa: purification and properties.

S. Clarke, R. L. Weiss, M. Bates, 1985, Archives of biochemistry and biophysics.

The polypeptides of rat liver mitochondria: identification of a 36,000 dalton polypeptide as the subunit of ornithine transcarbamylase.

S. Clarke, 1976, Biochemical and biophysical research communications.

Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping.

S. Clarke, B. Karger, Shujia Dai, 2008, Analytical chemistry.

Two major isozymes of the protein D-aspartyl/L-isoaspartyl methyltransferase from human erythrocytes.

I. Ota, S. Clarke, J. M. Gilbert, 1988, Biochemical and biophysical research communications.

Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?

S. Clarke, Chris R. Vinci, 2010, Rejuvenation research.

Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase.

R. Kagan, S. Clarke, D. Ingrosso, 1991, Biochemical and biophysical research communications.

The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence

I. Endo, S. Clarke, M. Bouvet, 2020, bioRxiv.

Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins.

S. Clarke, 2009, International journal of peptide and protein research.

Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants?

S. Clarke, A. Niewmierzycka, 1999, Archives of biochemistry and biophysics.

Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor.

J. Kuo, S. Clarke, J. Lowenson, 1990, Biochemistry.

Multiple sites of methyl esterification of calmodulin in intact human erythrocytes.

I. Ota, S. Clarke, 1990, Archives of biochemistry and biophysics.

Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase.

I. Ota, S. Clarke, L. Ding, 1987, The Journal of biological chemistry.

Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides.

D. Aswad, S. Clarke, B. A. Johnson, 1987, The Journal of biological chemistry.

Protein Methylation at Abnormal Aspartyl Residues

S. Clarke, 1986 .

Demethylation of protein carboxyl methyl esters: a nonenzymatic process in human erythrocytes?

S. Clarke, J. Barber, 1985, Biochemistry.

Carboxyl methylation of cytosolic proteins in intact human erythrocytes. Identification of numerous methyl-accepting proteins including hemoglobin and carbonic anhydrase.

S. Clarke, C. O'connor, C. O’Connor, 1984, The Journal of biological chemistry.

Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair.

S. Clarke, W. Tsai, 1994, Biochemical and biophysical research communications.

Mechanism of cleavage at Asn 148 during the maturation of jack bean concanavalin A.

S. Clarke, T. V. Brennan, 1993, Biochemical and biophysical research communications.

Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases.

H. Cai, D. Dumlao, S. Clarke, 2001, Biochemistry.

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues.

S. Clarke, S Clarke, 1992, Annual review of biochemistry.

16 Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary same?

S. Clarke, 2006, The Enzymes.

Reversible methylation of cytoskeletal and membrane proteins in intact human erythrocytes.

S. Clarke, C. Freitag, 1981, The Journal of biological chemistry.

PRMT3 Is a Distinct Member of the Protein Arginine N-Methyltransferase Family

S. Clarke, A. Frankel, 2000, The Journal of Biological Chemistry.

PRMT7 as a unique member of the protein arginine methyltransferase family: A review.

S. Clarke, Kanishk Jain, 2019, Archives of biochemistry and biophysics.

Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities.

S. Clarke, Andrea Hadjikyriacou, 2017, Biochemistry.

Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures*

E. Debler, S. Clarke, Rebeccah A Warmack, 2016, The Journal of Biological Chemistry.

PRMT 9 is a Type II methyltransferase that methylates the splicing factor SAP 145

S. Clarke, Zheng Xia, Wei Li, 2015 .

Substrate Specificity of Human Protein Arginine Methyltransferase 7 (PRMT7)

S. Clarke, You Feng, Andrea Hadjikyriacou, 2014, The Journal of Biological Chemistry.

The hydrophobic effect: Formation of micelles and biological membranes, 2nd edition (Tanford, Charles)

S. Clarke, 1981 .

Size and shape of membrane protein-detergent complexes: hydrodynamic studies.

S. Clarke, M. Smigel, 1989, Methods in enzymology.

The interaction of Triton X-100 with soluble proteins: possible implications for the transport of proteins across membranes.

S. Clarke, 1977, Biochemical and biophysical research communications.

Histidine methylation of yeast ribosomal protein Rpl 3 p is 1 required for proper 60 S subunit assembly 2 3

S. Clarke, G. Chanfreau, William H. Munroe, 2014 .

TbPRMT6 Is a Type I Protein Arginine Methyltransferase That Contributes to Cytokinesis in Trypanosoma brucei

S. Clarke, L. Read, John C. Fisk, 2010, Eukaryotic Cell.

Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways.

S. Clarke, C. Hrycyna, M. C. Yang, 1994, Biochemistry.

Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation.

S. Clarke, J. Lowenson, 1991, Gerontology.

Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase.

S. Clarke, J. Lowenson, 1990, The Journal of biological chemistry.

Specificity of endoproteinase Asp-N (Pseudomonas fragi): cleavage at glutamyl residues in two proteins.

S. Clarke, J. Bleibaum, D. Ingrosso, 1989, Biochemical and biophysical research communications.

Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.

S. Clarke, J. Lowenson, 1988, Blood cells.

Carboxyl methylation of human erythrocyte band 3 in intact cells. Relation to anion transport activity.

S. Clarke, L. Lou, 1986, The Biochemical journal.

Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates.

D. Aswad, S. Clarke, C. O'connor, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Membrane protein carboxyl methylation does not appear to be involved in the response of erythrocytes to cytoskeletal stress.

S. Clarke, J. Barber, 1984, Biochemical and biophysical research communications.

Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.

S. Clarke, J. Barber, 1984, The Journal of biological chemistry.

Methylation of erythrocyte membrane proteins at extracellular and intracellular D-aspartyl sites in vitro. Saturation of intracellular sites in vivo.

S. Clarke, C. O'connor, C. O’Connor, 1983, The Journal of biological chemistry.

S-Adenosylmethionine-dependent Protein Methylation in Mammalian Cytosol via Tyrphostin Modification by Catechol-O-methyltransferase*

S. Clarke, Rebecca S. Lipson, 2007, Journal of Biological Chemistry.

[31] Isolation of d-aspartic acid β-methyl ester from erythrocyte carboxyl methylated proteins

S. Clarke, L. Lou, P. N. Mcfadden, 1984 .

Identification of aspartic acid as a site of methylation in human erythrocyte membrane proteins.

C. Janson, S. Clarke, 1980, The Journal of biological chemistry.

A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

K. Travaglini, S. Clarke, J. Loo, 2014, Biochemical and biophysical research communications.

A Novel Post-translational Modification of Yeast Elongation Factor 1A

S. Clarke, P. Zobel-Thropp, Melody C. Yang, 2000, The Journal of Biological Chemistry.

Lipoprotein with Unusual Amino Acid Repeat Sequences

J. Ichikawa, S. Clarke, FU June, 2022 .

Hormonal and environmental responsiveness of a developmentally regulated protein repair L-isoaspartyl methyltransferase in wheat.

S. Clarke, M. B. Mudgett, 1994, The Journal of biological chemistry.

Protein Repair L-Isoaspartyl Methyltransferase in Plants (Phylogenetic Distribution and the Accumulation of Substrate Proteins in Aged Barley Seeds)

S. Clarke, J. Lowenson, M. B. Mudgett, 1997, Plant physiology.

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

M J Ball, M. Ball, S. Clarke, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Recognition of Age-damaged (R,S)-Adenosyl-L-methionine by Two Methyltransferases in the Yeast Saccharomyces cerevisiae*

S. Clarke, Steven G Clarke, Chris R Vinci, 2007, Journal of Biological Chemistry.

The Predominant Protein-arginine Methyltransferase from Saccharomyces cerevisiae(*)

S. Clarke, H. Herschman, Wey-Jinq Lin, 1996, The Journal of Biological Chemistry.

RNA and protein interactions modulated by protein arginine methylation.

S. Clarke, S Clarke, J D Gary, 1998, Progress in nucleic acid research and molecular biology.

L-Ascorbate biosynthesis in higher plants: the role of VTC2.

Carole L. Linster, S. Clarke, 2008, Trends in plant science.

Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans

Carole L. Linster, S. Clarke, Shilpi Khare, 2009, Mechanisms of Ageing and Development.

Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures.

S. Clarke, Qilong Xu, A. Downie, 2006, Physiologia plantarum.

A Novel Methyltransferase Catalyzes the Methyl Esterification of trans-Aconitate in Escherichia coli *

S. Clarke, H. Cai, 1999, The Journal of Biological Chemistry.

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

M J Ball, M. Ball, I. Reardon, 1993, The Journal of biological chemistry.

Arabidopsis VTC2 Encodes a GDP-l-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants*♦

C. Brenner, Carole L. Linster, S. Clarke, 2007, Journal of Biological Chemistry.

Secreted 3-isopropylmalate methyl ester signals invasive growth during amino acid starvation in Saccharomyces cerevisiae.

D. Dumlao, S. Clarke, Nicholas T. Hertz, 2008, Biochemistry.

Thermal-Stable Proteins of Fruit of Long-Living Sacred Lotus Nelumbo nucifera Gaertn var. China Antique

S. Clarke, J. Loo, Yongming Xie, 2013, Tropical Plant Biology.

A Second GDP-l-galactose Phosphorylase in Arabidopsis en Route to Vitamin C

C. Brenner, Carole L. Linster, S. Clarke, 2008, Journal of Biological Chemistry.

Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a GDP-l-galactose Phosphorylase*

M. Pellegrini, Carole L. Linster, S. Clarke, 2012, The Journal of Biological Chemistry.

Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a

M. Pellegrini, Carole L. Linster, S. Clarke, 2012 .

l-galactose Phosphorylase Gene Encoding a VTC 2 Regulation of the via Chlamydomonas Biosynthesis in Impact of Oxidative Stress on Ascorbate Plant Biology :

M. Pellegrini, Carole L. Linster, S. Clarke, 2012 .

The invertebrate Caenorhabditis elegans biosynthesizes ascorbate

S. Clarke, A. Patananan, E. Torres, 2015, Archives of biochemistry and biophysics.

Enzymatic methylation of band 3 anion transporter in intact human erythrocytes.

S. Clarke, L. Lou, S Clarke, 1987, Biochemistry.

The size and detergent binding of membrane proteins.

S. Clarke, 1975, The Journal of biological chemistry.

Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions*

S. Clarke, A. Clark, J. Masson, 2013, The Journal of Biological Chemistry.

Uncovering the Human Methyltransferasome*

S. Clarke, T. Petrossian, Tanya C Petrossian, 2010, Molecular & Cellular Proteomics.

The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity*

S. Clarke, A. Frankel, M. Bedford, 2002, The Journal of Biological Chemistry.

Arginine Methylation Inhibits the Binding of Proline-rich Ligands to Src Homology 3, but Not WW, Domains*

Michael B. Yaffe, Steven Clarke, P. Leder, 2000, The Journal of Biological Chemistry.

The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine N-Methyltransferase*

S. Clarke, H. Herschman, Wey-Jinq Lin, 1996, The Journal of Biological Chemistry.

Altered Levels of S-Adenosylmethionine and S-Adenosylhomocysteine in the Brains ofl-Isoaspartyl (d-Aspartyl)O-Methyltransferase-deficient Mice*

S. Clarke, Christine E Farrar, 2002, The Journal of Biological Chemistry.

The membrane binding domain of rod cGMP phosphodiesterase is posttranslationally modified by methyl esterification at a C-terminal cysteine.

I. Ota, S. Clarke, B. K. Fung, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Homocysteine Methyltransferases Mht1 and Sam4 Prevent the Accumulation of Age-damaged (R,S)-AdoMet in the Yeast Saccharomyces cerevisiae*

S. Clarke, Chris R. Vinci, 2010, The Journal of Biological Chemistry.

Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.

S. Clarke, R. Stephenson, S Clarke, 1989, The Journal of biological chemistry.

Protein carboxyl methyltransferase from cow eye lens.

S. Clarke, J. Horwitz, P. N. Mcfadden, 1983, Biochemical and biophysical research communications.

The γ subunit of brain G‐proteins is methyl esterified at a C‐terminal cysteine

I. Ota, S. Clarke, H. Yamane, 1990 .

10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins.

S. Young, S. Clarke, L. Fong, 2006, The Enzymes.

A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA.

S. Clarke, H. Kalhor, Mahmud Penjwini, 2005, Biochemical and biophysical research communications.

Automated Identification of Putative Methyltransferases from Genomic Open Reading Frames*S

Jonathan E Katz, Steven Clarke, J. Katz, 2003, Molecular & Cellular Proteomics.

Novel Methyltransferase for Modified Uridine Residues at the Wobble Position of tRNA

S. Clarke, H. Kalhor, 2003, Molecular and Cellular Biology.

Non-repair Pathways for Minimizing Protein Isoaspartyl Damage in the Yeast Saccharomyces cerevisiae*

S. Clarke, J. Whitelegge, A. Patananan, 2014, The Journal of Biological Chemistry.

Saccharomyces cerevisiae Protein Isoaspartyl Damage in the Yeast Non-Repair Pathways for Minimizing Protein Synthesis and Degradation :

S. Clarke, A. Patananan, Joseph R. Capri, 2014 .

Increased cell proliferation and granule cell number in the dentate gyrus of protein repair‐deficient mice

C. Houser, S. Clarke, Christine E Farrar, 2005, The Journal of comparative neurology.

Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport

S. Clarke, A. E. McBride, Shannon E Elf, 2007, Eukaryotic Cell.

PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells*

H R Herschman, K. Williams, S. Clarke, 2000, The Journal of Biological Chemistry.

A novel small molecule methyltransferase is important for virulence in Candida albicans.

G. Giaever, C. Nislow, M. Del Poeta, 2013, ACS chemical biology.

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

T. Graeber, T. Cloughesy, H. Christofk, 2015, Cell metabolism.

Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity

S. Clarke, G. Chanfreau, Kevin Roy, 2016, RNA.

Oxidative Modifications in Tissue Pathology and Autoimmune Disease.

K. Herold, S. Clarke, H. Doyle, 2017, Antioxidants & redox signaling.

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

Steven Clarke, Michael R. Stallcup, Yali Dou, 2004, Science.

Molecular phylogenetics of a protein repair methyltransferase.

R. Kagan, S. Clarke, P. N. Mcfadden, 1997, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insulin Signaling

S. Young, S. Clarke, Yiping Tu, 2013, PloS one.

Limited Accumulation of Damaged Proteins inl-Isoaspartyl (d-Aspartyl)O-Methyltransferase-deficient Mice*

Stephen G. Young, Steven Clarke, S. Young, 2001, The Journal of Biological Chemistry.

ACCELERATED RACEMIZATION OF ASPARTIC ACID AND ASPARAGINE RESIDUES VIA SUCCINIMIDE INTERMEDIATES : AN AB INITIO THEORETICAL EXPLORATION OF MECHANISM

Hendrik Zipse, Kendall N. Houk, Steven Clarke, 1996 .

Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.

S. Young, S. Clarke, J. Lowenson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Purification and Characterization of an Isoaspartyl Dipeptidase from Escherichia coli(*)

S. Clarke, J. Gary, 1995, The Journal of Biological Chemistry.

Phenotypic Analysis of Seizure-prone Mice Lacking l-Isoaspartate (d-Aspartate)O-Methyltransferase*

S. Young, S. Clarke, J. Lowenson, 1999, The Journal of Biological Chemistry.

Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair‐deficient mice

C. Houser, S. Clarke, Christine E Farrar, 2005, Aging cell.

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

G. Blobel, E. Debler, S. Clarke, 2016, Proceedings of the National Academy of Sciences.

Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

S. Clarke, J. Bleibaum, D. Ingrosso, 1989, The Journal of biological chemistry.

Modification of eukaryotic signaling proteins by C-terminal methylation reactions.

S. Clarke, C. Hrycyna, 1993, Pharmacology & therapeutics.

Analysis of prenylated carboxyl-terminal cysteine methyl esters in proteins

S. Clarke, H. Yamane, B. K. Fung, 1990 .

Protein methylation at the surface and buried deep: thinking outside the histone box.

S. Clarke, 2013, Trends in biochemical sciences.

Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants.

S. Clarke, N. Thapar, A. K. Kim, 2001, Plant physiology.

Expression, purification, and characterization of the protein repair l-isoaspartyl methyltransferase from Arabidopsis thaliana.

S. Clarke, N. Thapar, Steven Clarke, 2000, Protein expression and purification.

The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.

S. Clarke, T. Gomez, Kelley L. Banfield, 2007, Developmental biology.

A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase*

S. Clarke, J. Whitelegge, Kristofor J. Webb, 2010, The Journal of Biological Chemistry.

The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis.

D. Koshland, J. Stock, S. Clarke, 1984, Methods in enzymology.

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C‐terminal methylation of a‐factor and RAS proteins.

S. Clarke, S. Michaelis, C. Hrycyna, 1991, The EMBO journal.

Protein methylation and translation: Role of lysine modification on the function of yeast elongation factor 1A.

S. Clarke, G. Chanfreau, Charles Wang, 2019, Biochemistry.

Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface

Tamir Gonen, Duilio Cascio, Michael R Sawaya, 2019, Nature Communications.

APP/Aβ structural diversity and Alzheimer's disease pathogenesis

Steven G. Clarke, Thomas G. Beach, T. Beach, 2017, Neurochemistry International.

A b structural diversity and Alzheimer ' s disease pathogenesis

T. Beach, G. Serrano, S. Clarke, 2017 .

Methylation of chicken fibroblast heat shock proteins at lysyl and arginyl residues.

E. Lazarides, S. Clarke, C. Wang, 1982, The Journal of biological chemistry.

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

Ailan Guo, Wei Li, Zheng Xia, 2015, Nature Communications.

Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.

S. Clarke, Kristofor J. Webb, Brian D. Young, 2012, Biochemistry.

Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.

S. Clarke, Kristofor J. Webb, Rebecca S. Lipson, 2010, Biochemical and biophysical research communications.

Rmt1 catalyzes zinc-finger independent arginine methylation of the small ribosomal protein Rps2 in Saccharomyces cerevisiae

S. Clarke, Kristofor J. Webb, Rebecca S. Lipson, 2010 .

Rmt 1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps 2 in Saccharomyces cerevisiae

S. Clarke, Kristofor J. Webb, Rebecca S. Lipson, 2010 .

Identification of Two SET Domain Proteins Required for Methylation of Lysine Residues in Yeast Ribosomal Protein Rpl42ab*

S. Clarke, J. Whitelegge, Kristofor J. Webb, 2008, Journal of Biological Chemistry.

A Novel SET Domain Methyltransferase Modifies Ribosomal Protein Rpl23ab in Yeast*

T. Miranda, S. Clarke, J. Whitelegge, 2005, Journal of Biological Chemistry.

A new type of protein methylation activated by tyrphostin A25 and vanadate

T. Miranda, S. Clarke, Jonathan D. Lowenson, 2004, FEBS Letters.

δ-N-Methylarginine Is a Novel Posttranslational Modification of Arginine Residues in Yeast Proteins*

S. Clarke, J. Gary, P. Zobel-Thropp, 1998, The Journal of Biological Chemistry.

Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.

S. Clarke, Kristofor J. Webb, Rebecca S. Lipson, 2010, Archives of biochemistry and biophysics.

Identification of protein N-terminal methyltransferases in yeast and humans.

S. Clarke, J. Whitelegge, Kristofor J. Webb, 2010, Biochemistry.

Ellagic Acid and Urolithin A Improve Insulin Sensitivity in Diet-Induced Insulin Resistant Mice and Reduce Detrimental Effects of Palmitate Administration in Differentiated C2C12 Myotubes

Zhaoping Li, S. Clarke, C. Clarke, 2018 .

S-Adenosylmethionine-dependent Methylation in Saccharomyces cerevisiae

S. Clarke, A. Niewmierzycka, 1999, The Journal of Biological Chemistry.

Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair

Steven Clarke, S. Clarke, 2003, Ageing Research Reviews.

PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins*

Steven Clarke, S. Pestka, S. Clarke, 2001, The Journal of Biological Chemistry.

Analysis of erythrocyte protein methyl esters by two-dimensional gel electrophoresis under acidic separating conditions.

S. Clarke, C. O’Connor, C. M. O’Connor, 1985, Analytical biochemistry.

2-Hydroxyglutarate Inhibit s ATP Synthase andmTOR Signaling Graphical

T. Graeber, T. Cloughesy, H. Christofk, 2015 .

Systems and Trans-System Level Analysis Identifies Conserved Iron Deficiency Responses in the Plant Lineage[W][OA]

Scott I. Hsieh, M. Pellegrini, Crysten E. Blaby-Haas, 2012, Plant Cell.

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

M. Gelb, S. Clarke, H. Yamane, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Protein aging Extracellular amyloid formation and intracellular repair.

S. Clarke, A. Roher, J. Lowenson, 1994, Trends in cardiovascular medicine.

The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex*

E. Debler, S. Clarke, L. Read, 2016, The Journal of Biological Chemistry.

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2*

S. Clarke, M. Bedford, Yanzhong Yang, 2015, The Journal of Biological Chemistry.

PRMT8, a New Membrane-bound Tissue-specific Member of the Protein Arginine Methyltransferase Family*

Steven Clarke, Mark T Bedford, S. Clarke, 2005, Journal of Biological Chemistry.

A Second Protein l-Isoaspartyl Methyltransferase Gene in Arabidopsis Produces Two Transcripts Whose Products Are Sequestered in the Nucleus1[w]

S. Clarke, Qilong Xu, R. Dinkins, 2004, Plant Physiology.

Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1.

S. Clarke, Heather L. Rust, P. Thompson, 2011, Biochemistry.

A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylation.

S. Clarke, Kristofor J. Webb, Yinsheng Wang, 2007, Biochemistry.

A highly conserved 3-methylhistidine modification is absent in yeast actin.

S. Clarke, K. Faull, P. Rubenstein, 1999, Archives of biochemistry and biophysics.

Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.

S. Richard, P. Lasko, T. Miranda, 2004, The Biochemical journal.

S-adenosylmethionine synthetase in cultured normal and oncogenically-transformed human and rat cells.

S. Clarke, R. Hoffman, K. Carson, 1983, Biochimica et biophysica acta.

S-adenosyl-L-methionine synthetase from human erythrocytes: role in the regulation of cellular S-adenosylmethionine levels.

S. Clarke, K L Oden, S Clarke, 1983, Biochemistry.

Do eukaryotic carboxyl methyltransferase regulate protein function

S. Clarke, C. O’Connor, 1983 .

Evolutionarily Divergent Type II Protein Arginine Methyltransferase in Trypanosoma brucei

S. Clarke, L. Read, Deborah A. Pasternack, 2007, Eukaryotic Cell.

Membrane protein carboxyl methylation increases with human erythrocyte age. Evidence for an increase in the number of methylatable sites.

S. Clarke, J. Barber, 1983, The Journal of biological chemistry.

In vitro methylation of bacterial chemotaxis proteins: characterization of protein methyltransferase activity in crude extracts of Salmonella typhimurium.

D. Koshland, S. Clarke, K. Sparrow, 1980, Journal of supramolecular structure.

Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes.

S. Clarke, J. Bleibaum, A. Fowler, 1988, Biochemistry.

Membrane receptors for aspartate and serine in bacterial chemotaxis.

D E Koshland, D. Koshland, S. Clarke, 1979, The Journal of biological chemistry.

Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction

S. Clarke, M. Bouvet, R. Hoffman, 2021, Cancer Genomics & Proteomics.

Yeast Ribosomal/Cytochrome c SET Domain Methyltransferase Subfamily

S. Clarke, J. Whitelegge, Tanya R. Porras-Yakushi, 2007, Journal of Biological Chemistry.

N‐terminal methylation of proteins: Structure, function and specificity

J. Stock, Ann M Stock, S. Clarke, 1987, FEBS letters.

Diet-dependent survival of protein repair-deficient mice.

S. Clarke, Christine E Farrar, 2005, The Journal of nutritional biochemistry.

Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase

S. Clarke, R. Vitali, 2004, Behavioural Brain Research.

Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice.

R. Zubarev, S. Clarke, Hongqian Yang, 2013, Journal of proteome research.

The protein l-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response

S. Clarke, T. Gomez, Kelley L. Banfield, 2008, Mechanisms of Ageing and Development.

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

S. Clarke, Cyrus Y. Jin, Kanishk Jain, 2017, Proceedings of the National Academy of Sciences.

The Ribosomal L1 Protuberance in Yeast Is Methylated on a Lysine Residue Catalyzed by a Seven-β-strand Methyltransferase*

S. Clarke, Kristofor J. Webb, Brian D. Young, 2011, The Journal of Biological Chemistry.

Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.

Hui Chen, José M Mato, Steven Clarke, 2007, Gastroenterology.

ole of Methionine Adenosyltransferase 2 A and S-adenosylmethionine in itogen-Induced Growth of Human Colon Cancer Cells

P. Laird, H. Lenz, S. Clarke, 2007 .

Methylation of calmodulin at carboxylic acid residues in erythrocytes. A non-regulatory covalent modification?

S. Clarke, L. S. Brunauer, 1986, The Biochemical journal.

Recognition of D-aspartyl residues in polypeptides by the erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis.

S. Clarke, J. Lowenson, S Clarke, 1992, The Journal of biological chemistry.

Protein carboxyl methyltransferases: two distinct classes of enzymes.

S. Clarke, S Clarke, 1985, Annual review of biochemistry.

Caenorhabditis elegans Battling Starvation Stress: Low Levels of Ethanol Prolong Lifespan in L1 Larvae

Paola Castro, S. Clarke, Brian D. Young, 2012, PloS one.

Role of ERAB/l-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Aβ-induced Cytotoxicity*

Steven G. Clarke, David M. Stern, Futwan Al-Mohanna, 1999, The Journal of Biological Chemistry.

Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein.

R. Deschenes, J. Stock, S. Clarke, 1990, Biochemistry.

Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae.

S. Clarke, C. Hrycyna, 1993, Biochemistry.

Systems and Trans-System Level Analysis Identi fi es Conserved Iron

Scott I. Hsieh, M. Pellegrini, Crysten E. Blaby-Haas, 2013 .

Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress.

M. Frosch, E. Connolly, S. Clarke, 2000, The Journal of biological chemistry.

A Novel Automethylation Reaction in the Aspergillus nidulans LaeA Protein Generates S-Methylmethionine*

S. Clarke, A. Patananan, J. Palmer, 2013, The Journal of Biological Chemistry.

Approaches to measuring the activities of protein arginine N-methyltransferases.

Ted M. Lakowski, S. Clarke, A. Frankel, 2010, Analytical biochemistry.

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

D. James, D. Vance, J. Ho, 2021, Redox biology.

Histidine Methylation of Yeast Ribosomal Protein Rpl3p Is Required for Proper 60S Subunit Assembly

S. Clarke, G. Chanfreau, William H. Munroe, 2014, Molecular and Cellular Biology.

Bioinformatic Identification of Novel Methyltransferases.

Tanya Petrossian, Steven Clarke, S. Clarke, 2009, Epigenomics.

Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases

S. Clarke, Kelley L. Banfield, 2002 .

Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.

T. Yeates, M. Sawaya, D. Boutz, 2001, Journal of molecular biology.

Metabolism of S-adenosyl-L-methionine in intact human erythrocytes.

B H Morimoto, S. Clarke, S Clarke, 1986, Biochimica et Biophysica Acta.

A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima.

J. Ichikawa, S. Clarke, Steven Clarke, 1998, Archives of biochemistry and biophysics.

Intracellular protein modification associated with altered T cell functions in autoimmunity

D. Aswad, S. Clarke, J. Lowenson, 2006, The Journal of Immunology.

The ribosome: A hot spot for the identification of new types of protein methyltransferases

S. Clarke, 2018, The Journal of Biological Chemistry.

Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast.

S. Clarke, S Clarke, H R Kalhor, 2001, Archives of biochemistry and biophysics.

Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

S. Clarke, H. Xie, 1994, The Journal of biological chemistry.

A PROTEIN CARBOXYL METHYLTRANSFERASE THAT RECOGNIZES AGE-DAMAGED PEPTIDES AND PROTEINS AND PARTICIPATES IN THEIR REPAIR

S. Clarke, 1999 .

Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning*

S. Clarke, S. E. Perry, T. Rejtar, 2010, The Journal of Biological Chemistry.

Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme

J. Bowie, S. Clarke, T. Korman, 2016, Scientific Reports.

Fighting cancer by disrupting C-terminal methylation of signaling proteins.

F. Tamanoi, S. Clarke, 2004, The Journal of clinical investigation.

Adenine ribo- and deoxyribonucleotide metabolism in human erythrocytes, B- and T-lymphocyte cell lines, and monocyte-macrophages.

S. Clarke, W. Valentine, D. Paglia, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Deuteration protects asparagine residues against racemization

M. Shchepinov, S. Clarke, J. Lowenson, 2016, Amino Acids.

Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation.

S. Clarke, Qais Al-Hadid, J. White, 2016, Biochemical and biophysical research communications.

The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans

Carole L. Linster, S. Clarke, Shilpi Khare, 2011, PloS one.

Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins

S. Clarke, Christopher G DeVry, C. G. DeVry, 1999, Journal of Human Genetics.

Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.

R. Kagan, S. Clarke, A. Niewmierzycka, 1997, Archives of biochemistry and biophysics.

Methylation of membrane proteins in human erythrocytes. Identification and characterization of polypeptides methylated in lysed cells.

T. Terwilliger, S. Clarke, 1981, The Journal of biological chemistry.

Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans

S. Clarke, A. Patananan, A. Eskin, 2015, Experimental Gerontology.

Computational methods to identify novel methyltransferases

Steven G. Clarke, Tanya C. Petrossian, S. Clarke, 2009, BMC Bioinformatics.

A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at the N terminus. VOLUME 281 (2006) PAGES 35835-35845

S. Clarke, J. Whitelegge, Tanya R. Porras-Yakushi, 2008 .

Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity1

D. Aswad, S. Clarke, J. Lowenson, 2006, The Journal of Immunology.

A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS: tools for the visualization of matched datasets

Jonathan E Katz, Steven Clarke, D. Dumlao, 2004, Journal of the American Society for Mass Spectrometry.

The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites

S. Clarke, Troy L. Lowe, T. Bondoc, 2023, PloS one.

Expression , Purification , and Characterization of the Protein Repair L-Isoaspartyl Methyltransferase rom Arabidopsis thaliana

S. Clarke, N. Thapar, 2000 .

Deamidation and Isoaspartate Formation in Model Synthetic Peptides: The Effects of Sequence and Solution Environment

S. Clarke, T. V. Brennan, 1995 .

Specific recognition of altered polypeptides by widely distributed methyltransferases.

S. Clarke, C. O’Connor, C. M. O’Connor, 1985, Biochemical and biophysical research communications.

Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.

S. Clarke, J. Perry, J. Lowenson, 2020, Journal of structural biology.

Early responses of PC‐12 cells to NGF and EGF: Effect of K252a and 5′‐methylthioadenosine on gene expression and membrane protein methylation

S. Clarke, R. Law, H. Herschman, 1993, Journal of neuroscience research.

Direct renaturation of the dodecyl sulfate complexes of proteins with Triton X-100.

S. Clarke, 1981, Biochimica et biophysica acta.

RpoS- and OxyR-independent induction of HPI catalase at stationary phase in Escherichia coli and identification of rpoS mutations in common laboratory strains

S. Clarke, J. E. Visick, S. Clarke, 1997, Journal of bacteriology.

The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation

S. Clarke, J. Loo, J. Horwitz, 2019, The Journal of Biological Chemistry.

Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans.

S. Clarke, P. L. Larsen, T. Gomez, 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

A Novel GDP-d-glucose Phosphorylase Involved in Quality Control of the Nucleoside Diphosphate Sugar Pool in Caenorhabditis elegans and Mammals*

Carole L. Linster, S. Clarke, T. Gomez, 2011, The Journal of Biological Chemistry.

Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability.

R. Weinshilboum, D. Aswad, S. Clarke, 1997, Archives of biochemistry and biophysics.

Translational Roles of Elongation Factor 2 Protein Lysine Methylation*

K. Travaglini, S. Clarke, G. Chanfreau, 2014, The Journal of Biological Chemistry.

Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.

A. Joachimiak, C. Arrowsmith, J. Katz, 2001, Structure.

Membrane-binding domain of the small G protein G 25 K contains an S-( all-trans-geranylgeranyl ) cysteine methyl ester at its carboxyl terminus ( prenylation / carboxyl methylation / signal transduction )

M. Gelb, S. Clarke, H. Yamane, 2022 .

Membrane receptors for aspartate and serine in bacterial chemotaxis.

D. Koshland, S. Clarke, 1979, The Journal of biological chemistry.

Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.

S. Clarke, Kristofor J. Webb, Rebecca S. Lipson, 2010, Archives of biochemistry and biophysics.

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

S. Clarke, Cyrus Y. Jin, Kanishk Jain, 2017, Proceedings of the National Academy of Sciences.