P. Hart

发表

Uclacyanins, stellacyanins, and plantacyanins are distinct subfamilies of phytocyanins: Plant‐specific mononuclear blue copper proteins

M. Hill, A. Nersissian, J. Valentine, 1998, Protein science : a publication of the Protein Society.

Crystal structure of the human TβR2 ectodomain–TGF-β3 complex

Shashank Deep, P. John Hart, A. Hinck, 2002, Nature Structural Biology.

CRYSTAL STRUCTURE OF THE HUMAN TBR2 ECTODOMAIN-TGF-B3 COMPLEX

A. Hinck, P. Hart, S. Deep, 2002 .

Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

P. Hart, Alexander B. Taylor, P. F. Fitzpatrick, 2016, Proceedings of the National Academy of Sciences.

Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme.

M. Sekine, P. Hart, M. Damha, 2015, The Journal of organic chemistry.

Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies

P. Hart, Alexander B. Taylor, J. A. Garza, 2017, Front. Immunol..

Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.

P. Hart, Alexander B. Taylor, P. F. Fitzpatrick, 2012, Biochemistry.

Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

S. Goff, P. Hart, Alexander B. Taylor, 2012, Proceedings of the National Academy of Sciences.

Shall we dance? How a multicopper oxidase chooses its electron transfer partner.

D. Kosman, P. Hart, Alexander B. Taylor, 2007, Accounts of chemical research.

Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface.

Y. Ishikawa-Brush, P. Hart, Alexander B. Taylor, 2003, Biochemistry.

Paratope Duality and Gullying are Among the Atypical Recognition Mechanisms Used by a Trio of Nanobodies to Differentiate Ebolavirus Nucleoproteins

P. Hart, Alexander B. Taylor, L. Sherwood, 2019, Journal of molecular biology.

Crystallization of community-acquired respiratory distress syndrome toxin from Mycoplasma pneumoniae.

O. Pakhomova, P. Hart, Alexander B. Taylor, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain

P. Hart, Alexander B. Taylor, B. S. Rothberg, 2011, Proceedings of the National Academy of Sciences.

Structure of the Hsp110:Hsc70 nucleotide exchange machine.

Borries Demeler, Jorge Cuellar, Oscar Llorca, 2008, Molecular cell.

N-terminal Residues of the Vibrio cholerae Virulence Regulatory Protein ToxT Involved in Dimerization and Modulation by Fatty Acids*

P. Hart, K. Klose, Brandon M. Childers, 2011, The Journal of Biological Chemistry.

Characterization of Pgp3, a Chlamydia trachomatis Plasmid-Encoded Immunodominant Antigen

Ding Chen, G. Zhong, P. Hart, 2010, Journal of bacteriology.

Copper-zinc superoxide dismutase and ALS.

J. Valentine, P. Hart, E. B. Gralla, 1999, Advances in experimental medicine and biology.

Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

A. Hinck, P. Hart, S. Deep, 2002, Nature structural biology.

Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine

P. Hart, Alexander B. Taylor, S. Dhandayuthapani, 2003, Journal of bacteriology.

Insights into the Role of the Unusual Disulfide Bond in Copper-Zinc Superoxide Dismutase*

Bryan F. Shaw, J. Valentine, P. Hart, 2014, The Journal of Biological Chemistry.

Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.

J. Valentine, P. Hart, Alexander B. Taylor, 2010, Biochemistry.

KDM 2 B Recruitment of th e Polycomb Group Complex , PRC 1 . 1 , Requires Cooperation between PCGF 1 and BCORL 1 Highlights

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2016 .

KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2016, Structure.

Molecular recognition of insulin by a synthetic receptor.

Adam R. Urbach, Lisa M. Ryno, P. Hart, 2011, Journal of the American Chemical Society.

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Jacob I. Ayers, D. Borchelt, J. Glass, 2016, Acta Neuropathologica.

Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q.

D. Borchelt, P. Hart, V. Culotta, 2009, Biochemistry.

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

D. Borchelt, P. Andersen, P. Hart, 2009, Human molecular genetics.

Disease-associated Mutations at Copper Ligand Histidine Residues of Superoxide Dismutase 1 Diminish the Binding of Copper and Compromise Dimer Stability*

D. Borchelt, P. Hart, J. Gitlin, 2007, Journal of Biological Chemistry.

A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase.

S. T. Thomas, J. Valentine, P. Hart, 2021, Biochemistry.

Copper–Zinc Superoxide Dismutase, Its Copper Chaperone, and Familial Amyotrophic Lateral Sclerosis

D. Borchelt, Celeste M. Karch, P. Hart, 2010 .

Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates.

P. Hart, M. Damha, A. Katolik, 2014, The Journal of organic chemistry.

Activation of Cu,Zn-Superoxide Dismutase in the Absence of Oxygen and the Copper Chaperone CCS*

P. Hart, L. T. Jensen, V. Culotta, 2009, The Journal of Biological Chemistry.

Pathogenic superoxide dismutase structure, folding, aggregation and turnover.

P. Hart, 2006, Current opinion in chemical biology.

Post-translational modification of Cu/Zn superoxide dismutase under anaerobic conditions.

P. Hart, V. Culotta, Xiaohang Cao, 2012, Biochemistry.

Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.

P. Hart, G. Oliveira, Winka Le Clec’h, 2016, International journal for parasitology.

Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3

A. Hinck, P. Hart, S. Deep, 2002 .

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Jacob I. Ayers, D. Borchelt, J. Troncoso, 2014, Acta Neuropathologica Communications.

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Jacob I. Ayers, D. Borchelt, P. Hart, 2019, G3: Genes, Genomes, Genetics.

Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.

P. Hart, M. Damha, N. Clark, 2017, ACS chemical biology.

Do Posttranslational Modifications of CuZnSOD Lead to Lateral Sporadic Amyotrophic

L. Ellerby, D. Bredesen, J. Valentine, 1997 .

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense

P. Hart, Alexander B. Taylor, V. Culotta, 2014, Proceedings of the National Academy of Sciences.

Functional mapping of community‐acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP‐ribosyltransferase, vacuolating and receptor‐binding activities

O. Pakhomova, P. Hart, J. Baseman, 2014, Molecular microbiology.

Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents.

P. Hart, Alexander B. Taylor, Frédéric D. Chevalier, 2018, ACS medicinal chemistry letters.

Copper Proteins with Type 1 SitesBased in part on the article Copper Proteins with Type 1 Sites by Edward N. Baker which appeared in the Encyclopedia of Inorganic Chemistry, First Edition.

A. Nersissian, P. Hart, S. George, 2006 .

Mechanistic and structural analyses of the role of His67 in the yeast polyamine oxidase Fms1.

P. Hart, Alexander B. Taylor, M. Adachi, 2012, Biochemistry.

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

P. Hart, Alexander B. Taylor, G. Fields, 2017, Journal of medicinal chemistry.

The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases*

P. Hart, Alexander B. Taylor, V. Culotta, 2016, The Journal of Biological Chemistry.

A missing link in cupredoxins: Crystal structure of cucumber stellacyanin at 1.6 Å resolution

David Eisenberg, D. Eisenberg, A. Nersissian, 1996, Protein science : a publication of the Protein Society.

Cloning, expression, and spectroscopic characterization of Cucumis sativus stellacyanin in its nonglycosylated form

A. Nersissian, J. Valentine, P. Hart, 1996, Protein science : a publication of the Protein Society.

An Alternative Mechanism of Bicarbonate-mediated Peroxidation by Copper-Zinc Superoxide Dismutase

J. Valentine, P. Hart, L. Hayward, 2003, Journal of Biological Chemistry.

The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p

D. Kosman, P. Hart, Alexander B. Taylor, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Misfolded CuZnSOD and amyotrophic lateral sclerosis

J. Valentine, P. Hart, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A structure-based mechanism for copper-zinc superoxide dismutase.

D. Eisenberg, M. Balbirnie, M. Weiss, 1999, Biochemistry.

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site

D. Winge, P. Hart, J. Wohlschlegel, 2017, The Journal of Biological Chemistry.

Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.

Adam R. Urbach, P. Hart, Alexander B. Taylor, 2006, Journal of the American Chemical Society.

Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites

M. Berriman, P. Hart, Isheng. J. Tsai, 2013, Science.

The Schizosaccharomyces pombe Pccs Protein Functions in Both Copper Trafficking and Metal Detoxification Pathways*

P. Hart, S. Holloway, J. Beaudoin, 2004, Journal of Biological Chemistry.

Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae

O. Pakhomova, P. Hart, Alexander B. Taylor, 2015, Proceedings of the National Academy of Sciences.

Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity

P. Hart, Alexander B. Taylor, J. Baseman, 2018, mBio.

Disulfide bond of Mycoplasma pneumoniae community‐acquired respiratory distress syndrome toxin is essential to maintain the ADP‐ribosylating and vacuolating activities

P. Hart, Alexander B. Taylor, J. Baseman, 2019, Cellular microbiology.

Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase .

Zheng You, Xiaohang Cao, P. Hart, 2010, Biochemistry.

Structure of the flavoprotein tryptophan 2-monooxygenase, a key enzyme in the formation of galls in plants.

P. Hart, Alexander B. Taylor, Helena M Gaweska, 2013, Biochemistry.

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

P. Hart, Alexander B. Taylor, Frédéric D. Chevalier, 2020, International journal for parasitology. Drugs and drug resistance.

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

E. L. Guenther, Michael R. Sawaya, Lisa M. Johnson, 2013, Proceedings of the National Academy of Sciences.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

D. Rollinson, J. Webster, P. Hart, 2019, bioRxiv.

Polycomb group targeting through different binding partners of RING1B C-terminal domain.

A. Hinck, P. Hart, Alexander B. Taylor, 2010, Structure.

The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

K. Entian, P. Kötter, J. Wöhnert, 2008, Nucleic acids research.

Multiple polymer architectures of human polyhomeotic homolog 3 sterile alpha motif

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2014, Proteins.

Amino Acid Changes in Elongation Factor Tu of Mycoplasma pneumoniae and Mycoplasma genitalium Influence Fibronectin Binding

P. Hart, J. Baseman, T. R. Kannan, 2009, Infection and Immunity.

Identifying catalytic residues in CPAF, a Chlamydia-secreted protease.

J. Chai, Ding Chen, G. Zhong, 2009, Archives of biochemistry and biophysics.

Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1.

P. Hart, C. Outten, Caryn E. Outten, 2012, The Biochemical journal.

Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis*

Osman Bilsel, C. Matthews, O. Bilsel, 2009, The Journal of Biological Chemistry.

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg

S. Antonyuk, R. Strange, J. Valentine, 2005, Protein science : a publication of the Protein Society.

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

Jennifer Stine Elam, Todd O Yeates, T. Yeates, 2003, Nature Structural Biology.

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.

Michael A Hough, S. Antonyuk, R. Strange, 2003, Journal of molecular biology.

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

Allison J. Taggart, J. Casanova, J. Boeke, 2018, Cell.

Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

P. Hart, Alexander B. Taylor, M. Damha, 2014, Nucleic acids research.

Structure of the Flavoprotein Tryptophan-2-Monooxygenase

P. Hart, Alexander B. Taylor, Helena M Gaweska, 2013 .

An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

A. Hinck, T. Sulea, P. Hart, 2017, The Journal of Biological Chemistry.

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy

P. Hart, Alexander B. Taylor, N. Clark, 2017, The Journal of Biological Chemistry.

Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.

P. Hart, Alexander B. Taylor, Chongwoo A. Kim, 2013, Structure.

Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3*

Ding Chen, G. Zhong, P. Hart, 2013, The Journal of Biological Chemistry.

RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.

Rory Johnson, P. Hart, Alexander B. Taylor, 2015, Cell reports.

Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

D. Borchelt, P. Hart, S. Holloway, 2009, Experimental biology and medicine.

Dissociation of Human Copper-Zinc Superoxide Dismutase Dimers Using Chaotrope and Reductant

Borries Demeler, Xiaohang Cao, P. John Hart, 2004, Journal of Biological Chemistry.

Potassium and the K + / H + Exchanger Kha 1 p Promote Binding of Copper to ApoFet 3 p Multi-copper

D. Kosman, P. Hart, E. Cera, 2017 .

Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase*

D. Kosman, E. Di Cera, P. Hart, 2016, The Journal of Biological Chemistry.

Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis*

S. Antonyuk, R. Strange, S. Hasnain, 2008, Journal of Biological Chemistry.

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Jacob I. Ayers, P. Hart, B. Giasson, 2018, Journal of Virology.

Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.

P. Hart, A. Srivastava, T. Igumenova, 2017, Biochemistry.

Cd2+ as a Ca2+ surrogate in protein-membrane interactions: isostructural but not isofunctional.

P. Hart, T. Igumenova, Alexander B. Taylor, 2013, Journal of the American Chemical Society.

Copper Proteins with Type 1 Sites

A. Nersissian, P. Hart, S. George, 2006 .

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

J Günter Grossmann, Michael A Hough, S. Antonyuk, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Stellacyanin, A Member of the Phytocyanin Family of Plant Proteins

A. Nersissian, J. Valentine, P. Hart, 2011 .

Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase*

P. Hart, Alexander B. Taylor, L. McAlister-Henn, 2008, Journal of Biological Chemistry.

A Manganese-rich Environment Supports Superoxide Dismutase Activity in a Lyme Disease Pathogen, Borrelia burgdorferi*

M. Saito, M. McIlvin, P. Hart, 2013, The Journal of Biological Chemistry.

Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase.

P. Hart, Alexander B. Taylor, S. Daubner, 2010, Biochemistry.

Histidine ligand variants of a flavo-diiron protein: effects on structure and activities

P. Hart, Alexander B. Taylor, J. Caranto, 2012, JBIC Journal of Biological Inorganic Chemistry.

Subunit asymmetry in the three‐dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

Matteo Pellegrini, David Eisenberg, D. Eisenberg, 1998, Protein science : a publication of the Protein Society.

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

D. Borchelt, P. Hart, M. Prudencio, 2009, Proceedings of the National Academy of Sciences.

The Effects of Glutaredoxin and Copper Activation Pathways on the Disulfide and Stability of Cu,Zn Superoxide Dismutase*

W. Watson, P. Hart, L. T. Jensen, 2006, Journal of Biological Chemistry.

Proteasomal Degradation of Mutant Superoxide Dismutases Linked to Amyotrophic Lateral Sclerosis*

P. Hart, R. Levine, Xiaohang Cao, 2005, Journal of Biological Chemistry.

Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine

P. Hart, Alexander B. Taylor, T. Anderson, 2015, PLoS neglected tropical diseases.

Crystal structure of the yeast nicotinamidase Pnc1p.

P. Hart, Alexander B. Taylor, L. McAlister-Henn, 2007, Archives of biochemistry and biophysics.

Crystallization and preliminary X-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase.

P. Hart, Alexander B. Taylor, L. McAlister-Henn, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Shall We Dance? How a Multicopper Oxidase Chooses Its Electron Transfer Partner

D. Kosman, P. Hart, Alexander B. Taylor, 2007 .

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

T. Spicer, P. Hart, Alexander B. Taylor, 2014, Journal of medicinal chemistry.

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

D. Borchelt, J. Troncoso, P. Hart, 2014, Acta neuropathologica communications.

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.

S. Antonyuk, R. Strange, S. Hasnain, 2009, Archives of biochemistry and biophysics.

X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery.

L. T. Hall, H. Zhu, T. Lyons, 2000, Biochemistry.

Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.

D. Eisenberg, J. Tainer, M. Weiss, 1996, Biochemistry.

Structures of mouse SOD1 and human/mouse SOD1 chimeras.

P. Hart, Alexander B. Taylor, S. Holloway, 2010, Archives of biochemistry and biophysics.

Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism.

H. Zhu, J. Valentine, P. Hart, 2000, Biochemistry.

Crystal structure of an endochitinase from Hordeum vulgare L. seeds.

P. Hart, A. Monzingo, J. Robertus, 1993, Journal of molecular biology.

Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine

P. Hart, Alexander B. Taylor, S. Dhandayuthapani, 2003, Journal of bacteriology.

Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies

P. Hart, Alexander B. Taylor, J. A. Garza, 2017, Front. Immunol..

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.

P. Hart, J. Pascal, J. Robertus, 2002, Journal of molecular biology.

Supporting Information Title: Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

E. L. Guenther, D. Eisenberg, Stuart A. Sievers, 2013 .

Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.

Adam R. Urbach, P. Hart, Lisa M. Heitmann, 2006, Journal of the American Chemical Society.

Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.

W. Fairbrother, P. Hart, Alexander B. Taylor, 2022, Biochemistry.

Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain

W. Fairbrother, P. Hart, M. Damha, 2023, The Journal of biological chemistry.