V. M. Holers

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The Central Role of the Alternative Complement Pathway in Human Disease1

J. Thurman, V. M. Holers, V. Holers, 2006, The Journal of Immunology.

Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis

P. Gregersen, J. Norris, L. Criswell, 2010, Genes and Immunity.

Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells.

V. M. Holers, Robert M. Roman, J. Craft, 2010, Arthritis and rheumatism.

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis.

M. Weinblatt, N. Shadick, D. Solomon, 2010, Arthritis and rheumatism.

Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.

V. M. Holers, D. Simberg, S. Moghimi, 2015, ACS nano.

Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.

V. M. Holers, G. Tsokos, C. Atkinson, 2005, The Journal of clinical investigation.

CD4+ T Cells and Complement Independently Mediate Graft Ischemia in the Rejection of Mouse Orthotopic Tracheal Transplants

V. M. Holers, M. Nicolls, C. Atkinson, 2011, Circulation research.

IgM contributes to glomerular injury in FSGS.

J. Thurman, V. M. Holers, D. Strassheim, 2013, Journal of the American Society of Nephrology : JASN.

Association of Systemic Inflammatory Factors with Progression to Advanced Age-related Macular Degeneration

V. M. Holers, A. Palestine, A. Lynch, 2021, Ophthalmic epidemiology.

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.

E. Groman, V. M. Holers, D. Simberg, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Complement Component C3 Is Not Required for Full Expression of Immune Complex Glomerulonephritis in MRL/lpr Mice

V. M. Holers, H. Sekine, G. Gilkeson, 2001, The Journal of Immunology.

Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells.

S. Adler, V. M. Holers, R. Quigg, 1995, Kidney international.

Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells.

D. Karp, V. M. Holers, S. Boackle, 1998, Journal of immunology.

B Cell Subsets Contribute to Renal Injury and Renal Protection after Ischemia/Reperfusion

J. Thurman, V. M. Holers, M. Glogowska, 2010, The Journal of Immunology.

The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.

Ivana V. Yang, Adrianne L. Stefanski, D. Lynch, 2018, American journal of physiology. Lung cellular and molecular physiology.

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

Alastair D G Lawson, Andrew G. Watts, S. Crennell, 2021, Frontiers in Immunology.

In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms

V. M. Holers, D. Simberg, S. Moghimi, 2017, Front. Immunol..

Studies of Filipino patients with systemic lupus erythematosus: Autoantibody profile of first-degree relatives

V. M. Holers, V. Holers, S. Navarra, 2011, Lupus.

Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus

P. Gaffney, J. Norris, C. Langefeld, 2022, Frontiers in Immunology.

Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion.

J. Thurman, V. M. Holers, B. Rohrer, 2010, Advances in experimental medicine and biology.

The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation

M. Pangburn, E. Gelfand, J. Thurman, 2012, The Journal of Immunology.

The spectrum of complement alternative pathway‐mediated diseases

V. M. Holers, V. Holers, 2008, Immunological reviews.

γ‐glutamyl transpeptidase, an ecto‐enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes

D. Karp, V. M. Holers, J. Guthridge, 1998, European journal of immunology.

A Potential New Mouse Model of Axial Spondyloarthritis Involving the Complement System

V. M. Holers, N. Banda, F. L. La Rosa, 2021, Immune network.

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice

V. M. Holers, M. Glogowska, T. Merkel, 2012, The Journal of Immunology.

This information is current as Collagen Antibody-Induced Arthritis in Mice Complement Protein C 6 Deficiency in Role of C 3 a Receptors , C 5 a Receptors , and Wetsel

V. M. Holers, M. Glogowska, T. Merkel, 2011 .

in Cerebral Injury Following Ischemic Stroke Pathogenic Natural Antibodies Propagate

V. M. Holers, M. Kindy, Jin Yu, 2013 .

Pathogenic Natural Antibodies Propagate Cerebral Injury Following Ischemic Stroke in Mice

V. M. Holers, M. Kindy, Jin Yu, 2012, The Journal of Immunology.

Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury1

V. M. Holers, R. Quigg, C. Moratz, 2009, The Journal of Immunology.

Mouse Complement Receptor-Related Gene y/p65-Neutralized Tumor Vaccine Induces Antitumor Activity In Vivo 1

V. M. Holers, H. Okada, M. Imai, 2004, The Journal of Immunology.

Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function.

D. Karp, V. M. Holers, S. Henson, 2001, Journal of immunological methods.

Natural Antibody and Complement Activation Characterize Patients with Idiopathic Nephrotic Syndrome.

B. Rovin, J. Thurman, V. M. Holers, 2021, American journal of physiology. Renal physiology.

Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM

J. Klawitter, U. Christians, J. Thurman, 2018, European journal of immunology.

IgM exacerbates glomerular disease progression in complement induced glomerulopathy

J. Thurman, V. M. Holers, W. Zhong, 2015, Kidney international.

Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion Injury

M. Goddard, V. M. Holers, C. Atkinson, 2015, Circulation.

Murine Complement Inhibitor Glomerulonephritis with Crry-Ig , a Soluble Blockade of Antibody-Induced Kremmer and

E. Kremmer, D. Salant, V. M. Holers, 1998 .

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.

John D Lambris, J. Lambris, E. Gelfand, 2004, American journal of respiratory and critical care medicine.

Inhibition of complement activation decreases airway inflammation and hyperresponsiveness.

E. Gelfand, V. M. Holers, A. Joetham, 2003, American journal of respiratory and critical care medicine.

Expression and function of membrane regulators of complement on rat astrocytes in culture

P. Gasque, V. M. Holers, B. Morgan, 1996, Immunology.

Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.

W. Robinson, V. M. Holers, D. Riches, 2013, Arthritis and rheumatism.

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

V. M. Holers, Hong Zhu, C. Atkinson, 2017, Journal of Neuroinflammation.

Epstein-Barr Virus Promotes Interferon- α Production by Plasmacytoid Dendritic Cells

V. M. Holers, Robert M. Roman, J. Craft, 2010 .

Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.

C. Alpers, V. M. Holers, R. Quigg, 2004, Kidney international.

Complement deficient mice as model systems for kidney diseases

J. Thurman, V. M. Holers, V. Holers, 2006 .

Deficiency of complement receptors CR2/CR1 in Cr2-/-mice reduces the extent of secondary brain damage after closed head injury

V. M. Holers, P. Stahel, M. Flierl, 2014, Journal of Neuroinflammation.

A Complement C3 Inhibitor Specifically Targeted to Sites of Complement Activation Effectively Ameliorates Collagen-Induced Arthritis in DBA/1J Mice1

V. M. Holers, C. Atkinson, S. Tomlinson, 2007, The Journal of Immunology.

Cutting Edge: Complement (C3d)-Linked Antigens Break B Cell Anergy

V. M. Holers, J. D. Dal Porto, J. Cambier, 2007, The Journal of Immunology.

Complement Pathway Factor B Mice Genetically Deficient in the Alternative lpr Modulation of Renal Disease in MRL/

H. Colten, V. M. Holers, G. Gilkeson, 1999 .

Inhibiting the complement system does not reduce injury in renal ischemia reperfusion.

V. M. Holers, J. Alexander, R. Quigg, 2001, Journal of the American Society of Nephrology : JASN.

Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis.

V. M. Holers, R. Quigg, B. Morgan, 1995, Journal of immunology.

Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis.

V. M. Holers, J. Alexander, R. Quigg, 2003, Biochimica et biophysica acta.

Expression of the murine complement regulatory protein Crry by glial cells and neurons

N. Davoust, S. Barnum, V. M. Holers, 1999, Glia.

Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y1

V. M. Holers, W. Arend, A. Bendele, 2003, The Journal of Immunology.

Gene / Protein y Inhibitor Complement Receptor 1-Related Mice Transgenic for the Complement Prevention of Collagen-Induced Arthritis in

V. M. Holers, W. Arend, A. Bendele, 2003 .

Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.

E. Gelfand, J. Thurman, V. M. Holers, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure.

V. M. Holers, J. Alexander, R. Quigg, 2000, Kidney international.

Complement Inhibitor, Complement Receptor 1-Related Gene/Protein y-Ig Attenuates Intestinal Damage After the Onset of Mesenteric Ischemia/Reperfusion Injury in Mice1

V. M. Holers, J. Guthridge, S. Fleming, 2001, The Journal of Immunology.

Mice Mesenteric Ischemia / Reperfusion Injury in Intestinal Damage After the Onset of 1-Related Gene / Protein yIg Attenuates Complement Inhibitor , Complement Receptor

V. M. Holers, J. Guthridge, S. Fleming, 2001 .

This information is current as 2/Complement Receptor 1-Deficient Mice Injury in Complement Receptor Mesenteric Ischemia/Reperfusion-Induced Anti-Phospholipid Antibodies Restore

V. M. Holers, Ryan P. Egan, G. Tsokos, 2013 .

2 / Complement Receptor 1-Deficient Mice Injury in Complement Receptor Mesenteric Ischemia / Reperfusion-Induced AntiPhospholipid Antibodies

V. M. Holers, Ryan P. Egan, S. Fleming, 2004 .

Role for CD21 in the Establishment of an Extracellular HIV Reservoir in Lymphoid Tissues1

T. Chun, A. Fauci, V. M. Holers, 2007, The Journal of Immunology.

A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease.

V. M. Holers, S. Tomlinson, L. Kulik, 2015, Molecular immunology.

Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.

V. M. Holers, P. Stahel, M. Flierl, 2012, Journal of neurotrauma.

Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists.

V. M. Holers, B. Huber, Kuan-Ru Chen, 2011, Molecular immunology.

This information is current as Signaling Pathway without Engagement of an Inhibitory Using Its Natural Ligand C 3 dg : Activation Complement Receptor Type 2 ( CR 2 / CD 21 ) Coligation of the B Cell Receptor with

V. M. Holers, V. Holers, J. Cambier, 2005 .

Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice.

V. M. Holers, R. Quigg, Y. Kozono, 1997, Journal of immunology.

Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes.

V. M. Holers, Lezlie A. Derber, T. Lyubchenko, 2013, Journal of autoimmunity.

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

W. Robinson, Yuan Luo, V. M. Holers, 2011, The Journal of Immunology.

Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus

J. Thurman, V. M. Holers, Zhiying You, 2019, The Journal of Immunology.

Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3.

V. M. Holers, Andreas M. Rossbach, J. Twohig, 2007, Molecular immunology.

Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury

J. Thurman, V. M. Holers, Wade R. Smith, 2006, Experimental Neurology.

Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop

V. M. Holers, V. Holers, 2022, Immunological reviews.

Cell Subsets Contribute to Renal Injury and Renal Protection after Ischemia / Reperfusion

J. Thurman, V. M. Holers, M. Glogowska, 2010 .

Splenic B Cells Both B7-1 and B7-2 Expression on Murine Cross-Linking CD21/CD35 or CD19 Increases

V. M. Holers, R. Abe, Y. Kozono, 1998 .

Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2.

V. M. Holers, S. Perkins, V. Holers, 2008, Journal of molecular biology.

A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA

V. M. Holers, R. Scheinman, N. Banda, 2015, The Journal of Immunology.

Interfering RNA an Anti-C5aR1 Antibody and C5 Small Arthritis in Mice with a Novel Conjugate of A New Approach for the Treatment of

V. M. Holers, R. Scheinman, G. Mehta, 2015 .

Co‐ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI‐231 cells from anti‐surface IgM‐induced apoptosis

V. M. Holers, Y. Kozono, R. Duke, 1995, European journal of immunology.

This information is current as Resting Peripheral Blood B Cells Presentation of Immune Complexes by Complement Opsonization Is Required for and

D. Karp, V. M. Holers, S. Boackle, 1998 .

J. Thurman, V. M. Holers, J. Hannan, 2022, Kidney international.

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

S. Violette, J. Thurman, V. M. Holers, 2022, Frontiers in Immunology.

Edinburgh Research Explorer A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

D. Ricklin, J. Lambris, V. M. Holers, 2010 .

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor

D. Ricklin, J. Lambris, V. M. Holers, 2009 .

Therapeutic Interventions in the Complement System

John D Lambris, J. Lambris, V. M. Holers, 2000, Contemporary Immunology.

Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

M. Pangburn, V. M. Holers, V. Ferreira, 2013, The Journal of Immunology.

Review: The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

J. Thurman, V. M. Holers, A. Frazer-Abel, 2017, Arthritis & rheumatology.

The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation

M. Pangburn, E. Gelfand, J. Thurman, 2012, The Journal of Immunology.

Complement Pathway in Human Disease The Central Role of the Alternative

J. Thurman, V. M. Holers, V. Holers, 2006 .

Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications.

Clive G. Wilson, P. Campochiaro, H. Grossniklaus, 2010, Investigative ophthalmology & visual science.

Marginal zone B cells acquire dendritic cell functions by trogocytosis

J. Thurman, V. M. Holers, L. Beattie, 2022, Science.

Antitumor Activity In Vivo y/p65-Neutralized Tumor Vaccine Induces Mouse Complement Receptor-Related Gene

Tomlinson, V. M. Holers, M. Imai, 2004 .