H. Nar

A. Schnapp, H. Nar, P. Garin‐Chesa, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Hit and Lead Generation Strategies

R. Schnitzer, P. Ettmayer, A. Bergner, 2017 .

Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

J. King, H. Nar, M. Bauer, 2020, Proceedings of the National Academy of Sciences.

Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.

H. Nar, M. Bauer, H Dollinger, 2001, Journal of molecular biology.

Structural characterization of three crystalline modifications of telmisartan by single crystal and high-resolution X-ray powder diffraction.

K. Shankland, W. David, H. Nar, 2000, Journal of pharmaceutical sciences.

Active site topology and reaction mechanism of GTP cyclohydrolase I.

R. Huber, A. Bacher, A. Bracher, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.

R. Cheng, A. Pautsch, C. Tautermann, 2019, Structure.

Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.

A. Pautsch, H. Ahorn, H. Nar, 2001, Structure.

In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A

R. Cheng, M. Hennig, H. Nar, 2020, The FEBS journal.

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

A. Sharff, H. Nar, J. Yon, 2007, Acta crystallographica. Section D, Biological crystallography.

Crystal structure and receptor-interacting residues of MYDGF — a protein mediating ischemic tissue repair

H. Nar, L. Frego, K. Wollert, 2019, Nature Communications.

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.

A. Gils, H. Nar, P. Declerck, 2000, Journal of molecular biology.

A specific antidote for dabigatran: functional and structural characterization.

H. Nar, J. van Ryn, J. Park, 2013, Blood.

Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.

H. Nar, B. Kistler, M. Hafner, 2012, The Biochemical journal.

Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.

H. Nar, G. Auerbach, B. Thöny, 1999, Journal of molecular biology.

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I

H. Nar, M. Bauer, M. Zeeb, 2020, Proceedings of the National Academy of Sciences.

High-Throughput Crystallography and Its Applications in Drug Discovery

Alexander Pautsch, Herbert Nar, D. Fiegen, 2017 .

Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist

T. Zichner, S. Carotta, H. Nar, 2020 .

Complete sequential 1H and 15N nuclear magnetic resonance assignments and solution secondary structure of the blue copper protein azurin from Pseudomonas aeruginosa.

R. Huber, S. Wijmenga, C. Hilbers, 1992, Biochemistry.

Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.

J. King, H. Nar, M. Bauer, 2021, Journal of medicinal chemistry.

Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.

P. Bonneau, D. Lamarre, H. Nar, 2003, Angewandte Chemie.

Characterization and Comparative Evaluation of a Novel PAI-1 Inhibitor

A. Gils, H. Nar, P. Declerck, 2002, Thrombosis and Haemostasis.

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate.

R. Huber, A. Bacher, A. Bracher, 2002, Journal of molecular biology.

Structural and Functional Consequences of Mutations in 6-Pyruvoyltetrahydropterin Synthase Causing Hyperphenylalaninemia in Humans

C. Heizmann, H. Nar, N. Blau, 1995, The Journal of Biological Chemistry.

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.

Andreas Bracher, Robert Huber, Markus Fischer, 2003, Journal of molecular biology.

Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.

H. Nar, A. Heckel, Stefan Hoerer, 2004, Journal of molecular biology.

Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

H. Nar, Zhixin Chen, Lei Chen, 2021, Nature.

Structure and mechanism of GTP cyclohydrolase I of Escherichia coli.

R. Huber, A. Bacher, A. Bracher, 1996, Biochemical Society transactions.

Studies on GTP cyclohydrolase I of Escherichia coli.

T. Werner, H. Nar, W. Meining, 1993, Advances in experimental medicine and biology.

Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.

W. Bode, H. Nar, F. Gomis-Rüth, 1994, The Journal of biological chemistry.

GTP Cyclohydrolase I

H. Nar, 1996 .

Three‐dimensional structure of 6‐pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis.

C. Heizmann, H. Nar, B. Thöny, 1994, The EMBO journal.

Development and Characterization of a Cocrystal as a Viable Solid Form for an Active Pharmaceutical Ingredient

Jinhua J. Song, H. Nar, C. Senanayake, 2013 .

Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.

H. Nar, G. Schnapp, R. Bakker, 2016, Journal of medicinal chemistry.

Dabigatran Reversal Agent

H. Nar, F. Schiele, 2016 .

Sequential Backbone Assignment of Peroxisome Proliferator-Activated Receptor-γ Ligand Binding Domain

H. Kalbitzer, H. Nar, S. Kauschke, 2005, Journal of biomolecular NMR.

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

H. Nar, T. Weiser, M. Grauert, 2002, Journal of medicinal chemistry.

Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.

H. Nar, R. Ebenhoch, F. Schiele, 2023, ImmunoHorizons.

Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

H. Nar, Zhixin Chen, Lei Chen, 2021, Nature.

Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.

H. Nar, S. LaPlante, A. Jakalian, 2014, Journal of medicinal chemistry.

6-Pyruvoyl-Tetrahydropterin Synthase

H. Nar, 1996 .

Structure of the azurin mutant nickel-Trp48Met from Pseudomonas aeruginosa at 2.2 A resolution.

H. Nar, N. Bonander, V. Langer, 1995, Acta crystallographica. Section D, Biological crystallography.

An antibody against the C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo.

H. Nar, J. Park, G. Luippold, 2013, Journal of molecular biology.

A hybrid screening approach for very small fragments - X-ray and Computational Screening on FKBP51.

H. Nar, M. Bauer, M. Zeeb, 2020, Journal of medicinal chemistry.

Synthesis of cyclic dipeptide templates, their incorporation into peptides and studies on their conformational and biological properties.

H. Briem, H. Nar, P. Schiller, 2009, The journal of peptide research : official journal of the American Peptide Society.

A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein

H. Nar, P. Schreiner, G. Schnapp, 2020, ChemMedChem.

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.

R. Gregg, Suresh B. Singh, H. Nar, 2010, Bioorganic & medicinal chemistry letters.

A W-Band Electron Spin Echo Envelope Modulation Study of a Single Crystal of Azurin

H. Nar, O. Poluektov, A. Messerschmidt, 1997 .

Electron self-exchange in azurin: calculation of the superexchange electron tunneling rate.

K. Mikkelsen, H. Nar, L. Skov, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the azurin mutant Phe114Ala from Pseudomonas aeruginosa at 2.6 A resolution.

H. Nar, V. Langer, T. Pascher, 1995, Acta crystallographica. Section D, Biological crystallography.

Solution structure and synaptic analyses reveal molecular mechanisms of bispecific T cell engagers

D. Klenerman, H. Nar, Edward Jenkins, 2023, bioRxiv.

meso-(1,1,4,7,10,10-Hexaphenyl-1,4,7,10-tetraphosphadecane-P,P',P'',P''')platinum(II) bis(tetraphenylborate)

H. Nar, A. Messerschmidt, P. Brüggeller, 1992 .

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

J. Prestle, H. Nar, François Debaene, 2020, Communications Chemistry.

High‐Resolution Crystal Structure of a Lasso Peptide

H. Nar, O. Potterat, C. Puder, 2010, ChemMedChem.

Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments.

H. Nar, D. Reinert, S. Hörer, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer.

S. Carotta, H. Nar, A. Grube, 2023, Journal of medicinal chemistry.

Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611.

J. Wiedenmann, G. Nienhaus, K. Nienhaus, 2008, Journal of the American Chemical Society.