T. O’Halloran

发表

Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins

A. Wernimont, D. Huffman, A. Lamb, 2000, Nature Structural Biology.

Activation of superoxide dismutases: putting the metal to the pedal.

T. O’Halloran, Mei Yang, V. Culotta, 2006, Biochimica et biophysica acta.

Evidence for retention of biological activity of a non-heme iron enzyme adsorbed on a silver colloid: a surface-enhanced resonance Raman scattering study.

M. Natan, R. V. Van Duyne, T. O’Halloran, 1993, Biochemistry.

3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.

Radhakrishnan Nagarajan, Pallavi Sethi, Meenakshi Upreti, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Coencapsulation of arsenic- and platinum-based drugs for targeted cancer treatment.

T. O’Halloran, Samuel Pazicni, N. Krett, 2009, Angewandte Chemie.

Amyotrophic Lateral Sclerosis Mutations Have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation*

T. O’Halloran, Y. Furukawa, 2005, Journal of Biological Chemistry.

Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice.

T. Siddique, T. O’Halloran, Y. Furukawa, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Transition metals in control of gene expression.

Thomas V. O'Halloran, T. O’Halloran, Thomas V. O'Halloran, 1993, Science.

DNA distortion accompanies transcriptional activation by the metal-responsive gene-regulatory protein MerR.

B. Frantz, T. O’Halloran, T V O'Halloran, 1990, Biochemistry.

Heterodimer formation between superoxide dismutase and its copper chaperone.

A. Lamb, T. O’Halloran, A. Rosenzweig, 2000, Biochemistry.

The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex

C. Fahrni, T. O’Halloran, D. Suhy, 1999, JBIC Journal of Biological Inorganic Chemistry.

Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples

B. Grzybowski, S. Soh, T. O’Halloran, 2011, Applied magnetic resonance.

A physical sciences network characterization of non-tumorigenic and metastatic cells

Christopher S. Poultney, Casey M. Kraning-Rush, Shannon M. Mumenthaler, 2013, Scientific Reports.

Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity

T. O’Halloran, T. Woodruff, Aaron C. Sue, 2022, Journal of Assisted Reproduction and Genetics.

Overproduction, purification, and characterization of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance.

T. O’Halloran, J. Broderick, Joan B. Broderick, 1991, Biochemistry.

Mercury-199 NMR of the metal receptor site in MerR and its protein-DNA complex.

J. Bryson, T. O’Halloran, L. Utschig, 1995, Science.

9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma

M. Hendrix, T. O’Halloran, S. Navarro, 2018, Anti-cancer drugs.

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models12

C. James, T. O’Halloran, A. Mazar, 2017, Translational oncology.

Macrogenomic engineering via modulation of the scaling of chromatin packing density

V. Backman, T. O’Halloran, L. Cherkezyan, 2017, Nature Biomedical Engineering.

Role of CTR4 in the Virulence of Cryptococcus neoformans

D. Hammoud, T. O’Halloran, J. Qiu, 2012, mBio.

Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.

T. O’Halloran, S. Vogt, T. Woodruff, 2011, ACS chemical biology.

A Zinc-Dependent Mechanism Regulates Meiotic Progression in Mammalian Oocytes1

T. O’Halloran, T. Woodruff, B. Kong, 2012, Biology of reproduction.

The zinc spark is an inorganic signature of human egg activation

T. O’Halloran, N. Zhang, T. Woodruff, 2016, Scientific Reports.

A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli

T. O’Halloran, A. Valledor, Estibaliz Glaría, 2018, Scientific Reports.

Structural and Mechanistic Basis of Zinc Regulation Across the E. coli Zur Regulon

A. Mondragón, T. O’Halloran, E. Swindell, 2014, PLoS biology.

High-Throughput Screen for Identifying Small Molecules That Target Fungal Zinc Homeostasis

C. Luan, T. O’Halloran, E. Weiss, 2011, PloS one.

Metal-responsive gene regulation and the zinc metalloregulatory model.

T. O’Halloran, D. Suhy, 1996, Metal ions in biological systems.

Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.

S. Nguyen, T. O’Halloran, Sai Archana Krovi, 2012, Journal of materials chemistry.

Accumulation of cadmium in insulin-producing β cells

M. Urbanek, T. O’Halloran, K. Macrenaris, 2012, Islets.

Multiple heavy-atom reagents for macromolecular X-ray structure determination. Application to the nucleosome core particle.

A Klug, A. Klug, T. Richmond, 1987, Journal of molecular biology.

Correlation between metal-metal distances and optical spectroscopy in the platinum blues: synthesis, crystal structure, and electronic spectrum of ethylenediamine platinum .alpha.-pyridone blue

S. Lippard, T. O’Halloran, M. Roberts, 1984 .

Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase.

T. O’Halloran, A. S. Torres, P. Doan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An Emerging Role for Allosteric Modulation of DNA Structure in Transcription

A. Ansari, T. O’Halloran, 1994 .

Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release.

T. O’Halloran, N. Krett, S. Rosen, 2006, Journal of the American Chemical Society.

A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118).

I. Bertini, T. O’Halloran, L. Banci, 2002, Journal of molecular biology.

Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors1

T. O’Halloran, A. Mazar, Jian-jun Wei, 2015, Neoplasia.

Quantitative imaging approaches to understanding biological processing of metal ions.

T. O’Halloran, K. Macrenaris, Keith W Macrenaris, 2022, Current opinion in chemical biology.

Zinc as a Key Meiotic Cell-Cycle Regulator in the Mammalian Oocyte

T. O’Halloran, R. Ya, T. Woodruff, 2014 .

Development and modeling of arsenic-trioxide–loaded thermosensitive liposomes for anticancer drug delivery

Ryan J. Murphy, G. Schatz, T. O’Halloran, 2011, Journal of liposome research.

Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity

T. O’Halloran, T. Woodruff, Aaron C. Sue, 2022, Journal of Assisted Reproduction and Genetics.

Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans

T. O’Halloran, S. Vogt, T. Woodruff, 2022, Biology of Reproduction.

Zinc availability during germline development impacts embryo viability in Caenorhabditis elegans.

T. O’Halloran, T. Woodruff, S. M. Wignall, 2017, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.

E. Bigio, W. Hung, T. Siddique, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Metallochaperone protein, CCS, has sulfhydryl oxidase activity: Post-translational modification of superoxide dismutase

T. O’Halloran, Y. Furukawa, N. M. Brown, 2003 .

Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity

T. O’Halloran, A. Mazar, R. Bergan, 2018, Clinical Cancer Research.

Cancer Biology and Signal Transduction Direct Binding of Arsenic Trioxide to Ampk and Generation of Inhibitory Effects on Acute Myeloid Leukemia Precursors

B. Viollet, L. Platanias, T. O’Halloran, 2022 .

A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.

T. O’Halloran, J. Qiu, P. Williamson, 2013, Metallomics : integrated biometal science.

Oxygen‐induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS

T. O’Halloran, Y. Furukawa, A. S. Torres, 2004, The EMBO journal.

Urokinase Plasminogen Activator System Targeted Delivery of Nanobins as a Novel Ovarian Cancer Therapeutics

T. O’Halloran, A. Mazar, Yilin Zhang, 2013 .

Multiple Protein Domains Contribute to the Action of the Copper Chaperone for Superoxide Dismutase*

T. O’Halloran, V. Culotta, R. A. Pufahl, 1999, The Journal of Biological Chemistry.

Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer

T. O’Halloran, A. Mazar, A. Kozikowski, 2017, Clinical Cancer Research.

STABILIZATION OF HIGH-VALENT TERMINAL-OXO COMPLEXES : INTERPLAY OF D-ORBITAL OCCUPANCY AND COORDINATION GEOMETRY

T. O’Halloran, Song-Yao Zhang, Nathanael L. P. Fackler, 1996 .

Air Oxidation of a Five-Coordinate Mn(III) Dimer to a High-Valent Oxomanganese(V) Complex

T. O’Halloran, C. Stern, F. MacDonnell, 1994 .

The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex

B. Frantz, T. O’Halloran, M. Shin, 1989, Cell.

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation

M. Wolfner, T. O’Halloran, T. Woodruff, 2020, iScience.

Mechanisms of Copper Chaperone Proteins

T. O’Halloran, R. A. Pufahl, 1999 .

Biochemical and spectroscopic probes of mercury(II) coordination environments in proteins.

T. O’Halloran, L. Utschig, J. Wright, 1993, Methods in enzymology.

A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client

T. O’Halloran, Yu-Ying Chen, 2022, Cell.

Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes.

T. O’Halloran, E. Swindell, Haimei Chen, 2013, Inorganic chemistry.

An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein.

T. O’Halloran, J. Penner‐Hahn, Kui Chen, 2003, Journal of the American Chemical Society.

Zur and zinc increase expression of E. coli ribosomal protein L31 through RNA-mediated repression of the repressor L31p

Y. Goo, T. O’Halloran, Byoung-Kyu Cho, 2022, bioRxiv.

Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic.

T. O’Halloran, A. Mazar, Richard W. Ahn, 2011, Current pharmaceutical design.

Chemical and Genetic Studies of Copper Resistance in E. coli

N. Brown, J. Bryson, T. O’Halloran, 1993 .

XAS of the MerR metalloregulatory protein

T. O’Halloran, J. Penner‐Hahn, Jeffrey G. Wright, 1989 .

Coordination chemistry of the Hg-MerR metalloregulatory protein: evidence for a novel tridentate Hg-cysteine receptor site

T. O’Halloran, J. Penner‐Hahn, Jeffrey G. Wright, 1990 .

Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation.

T. O’Halloran, S. Vogt, T. Woodruff, 2019, Theriogenology.

The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development

T. O’Halloran, N. Zhang, T. Woodruff, 2016, Scientific reports.

Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks

Stefan Vogt, Teresa K. Woodruff, T. O’Halloran, 2014, Nature chemistry.

Metal Ion Fluxes Controlling Amphibian Fertilization

B. Lai, T. O’Halloran, Ajay Sharma, 2021, Nature Chemistry.

X-ray fluorescence microscopy scanning of Drosophila oocytes and eggs

M. Wolfner, T. O’Halloran, O. Antipova, 2020, STAR protocols.

Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs.

T. O’Halloran, T. Woodruff, F. Duncan, 2020, Molecular human reproduction.

Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4.

G. Schatz, T. O’Halloran, T. Woodruff, 2019, Journal of the American Chemical Society.

Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.

Eric W. Roth, T. O’Halloran, S. Vogt, 2017, Integrative biology : quantitative biosciences from nano to macro.

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.

T. O’Halloran, T. Woodruff, B. Kong, 2014, Molecular human reproduction.

Zinc Maintains Prophase I Arrest in Mouse Oocytes Through Regulation of the MOS-MAPK Pathway1

T. O’Halloran, T. Woodruff, B. Kong, 2012, Biology of reproduction.

Zinc Requirement During Meiosis I–Meiosis II Transition in Mouse Oocytes Is Independent of the MOS-MAPK Pathway1

T. O’Halloran, T. Woodruff, A. Kim, 2010, Biology of reproduction.

Zinc Availability Regulates Exit from Meiosis in Maturing Mammalian Oocytes

T. O’Halloran, S. Vogt, T. Woodruff, 2010, Nature chemical biology.

Zinc dynamics regulate early ovarian follicle development

T. O’Halloran, Kiwon Ok, T. Woodruff, 2022, The Journal of biological chemistry.

Journal Pre-proof Zinc dynamics regulate early ovarian follicle development

T. O’Halloran, Kiwon Ok, T. Woodruff, 2022 .

The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions

Stefan Vogt, T. O’Halloran, S. Vogt, 2015, Developmental dynamics : an official publication of the American Association of Anatomists.

A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer

T. O’Halloran, V. Cryns, M. Raja, 2010, Clinical Cancer Research.

Function, structure, and mechanism of intracellular copper trafficking proteins.

D. Huffman, T. O’Halloran, D L Huffman, 2001, Annual review of biochemistry.

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

T. O’Halloran, V. Culotta, T V O'Halloran, 1999, Science.

Isomerization of binuclear amidate-bridged platinum(II) amine complexes: A 195Pt NMR investigation

S. Lippard, T. O’Halloran, 1989 .

Mercury(II)-thiolate chemistry and the mechanism of the heavy metal biosensor MerR

M. Natan, T. O’Halloran, F. MacDonnell, 2007 .

Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes.

T. O’Halloran, E. Swindell, Haimei Chen, 2013, Inorganic chemistry.

Metal ion chaperone function of the soluble Cu(I) receptor Atx1.

Shin Lin, C. Fahrni, T. O’Halloran, 1997, Science.

The Chemistry of Platinum in the +3 Oxidation State

S. Lippard, T. O’Halloran, 1985 .

Cis-bis(dimethylsulfoxide)tetraamminecobalt(III) and related complex ions[1]

T. O’Halloran, J. M. Malin, 1979 .

Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

Thomas V. O'Halloran, T. O’Halloran, L. Finney, 2003, Science.

Synthesis, structure determination, and electronic structure characterization of two mixed-Valence tetranuclear platinum blues with bridging α-pyridonate or 1-methyluracilate ligands

Ian D. Williams, S. Lippard, T. O’Halloran, 1987 .

Synthesis, structure, and 195Pt NMR solution studies of a reactive binuclear platinum(III) complex: [Pt2(en)2(C5H4NO) 2(NO2)(NO3)](NO3) 2·0.5H2O

S. Lippard, T. O’Halloran, M. Roberts, 1986 .

Probing Copper-Thioether Coordination Chemistry in Rusticyanin and Azurin by 2D (1)H-(199)Hg NMR.

T. O’Halloran, T. Baynard, L. Utschig, 1997, Inorganic chemistry.

Thermal and light-induced electron transfer between iron(II) and cobalt(III) mediated by bridging pyrazines

T. O’Halloran, D. Ryan, J. M. Malin, 1978 .

Trigonal mercuric complex of an aliphatic thiolate: a spectroscopic and structural model for the receptor site in the Hg(II) biosensor MerR

J. Bryson, T. O’Halloran, M. Sabat, 1990 .

Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes.

T. O’Halloran, A. Mazar, C. Stern, 2013, Angewandte Chemie.

Electronic Structure and Optical Spectrum of cis-Diammineplatinum α-Pyridone Blue: Metal-Metal Bonding and Charge Transfer in a Four-Atom Pt(2.25) Chain

A. P. Ginsberg, S. Lippard, T. O’Halloran, 1984 .

The 199Hg Chemical Shift as a Probe of Coordination Environments in Blue Copper Proteins

T. O’Halloran, V. Pecoraro, G. Dieckmann, 1995 .

Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy.

T. O’Halloran, M. Taki, J. Wolford, 2004, Journal of the American Chemical Society.

A place for thioether chemistry in cellular copper ion recognition and trafficking.

T. O’Halloran, A. Davis, 2008, Nature chemical biology.

Aqueous Coordination Chemistry of Quinoline-Based Fluorescence Probes for the Biological Chemistry of Zinc

C. Fahrni, T. O’Halloran, 1999 .

Platinum-195 NMR investigation of the head-to-head to head-to-tail isomerization of .alpha.-pyridonate-bridged ethylenediamineplatinum(II) dimer

S. Lippard, T. O’Halloran, 1983 .

Metallochaperones, an Intracellular Shuttle Service for Metal Ions*

Thomas V. O'Halloran, T. O’Halloran, V. Culotta, 2000, The Journal of Biological Chemistry.

Cu(I) recognition via cation-pi and methionine interactions in CusF.

T. O’Halloran, P. Focia, T. Spiro, 2008, Nature chemical biology.

The Independent cue and cusSystems Confer Copper Tolerance during Aerobic and Anaerobic Growth inEscherichia coli *

Thomas V. O'Halloran, D. Huffman, T. O’Halloran, 2001, The Journal of Biological Chemistry.

Solid-state mercury-199 nuclear magnetic resonance as a probe of coordination number and geometry in Hg(II) complexes

M. Natan, T. O’Halloran, Jeffrey G. Wright, 1990 .

Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum.

K. Haldar, T. O’Halloran, J. Penner‐Hahn, 2012, Chemistry & biology.

The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription

T. O’Halloran, M. Zhong, Xiaojin Shi, 2020, Nature Communications.

CueR activates transcription through a DNA distortion mechanism

T. O’Halloran, Yu Zhang, Yu Feng, 2020, Nature Chemical Biology.

Allosteric transcriptional regulation via changes in the overall topology of the core promoter

Ilyas Yildirim, A. Mondragón, G. Schatz, 2015, Science.

Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR

A. Mondragón, T. O’Halloran, C. Outten, 2003, Science.

Metallothionein Is Part of a Zinc-scavenging Mechanism for Cell Survival under Conditions of Extreme Zinc Deprivation*

T. O’Halloran, D. Linzer, D. Suhy, 1999, The Journal of Biological Chemistry.

Transcriptional Activation of an Escherichia coliCopper Efflux Regulon by the Chromosomal MerR Homologue, CueR*

T. O’Halloran, F. W. Outten, C. Outten, 2000, The Journal of Biological Chemistry.

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Thomas V. O'Halloran, T. O’Halloran, F. W. Outten, 2000, Journal of bacteriology.

Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures.

I. Bertini, D. Huffman, T. O’Halloran, 2002, Genome research.

A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport*

T. O’Halloran, V. Culotta, A. Dancis, 1997, The Journal of Biological Chemistry.

Iron Metabolism in Eukaryotes—Mars and Venus at It Again

T. O’Halloran, J. Kaplan, J Kaplan, 1996, Science.

Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution.

A. Wernimont, D. Huffman, T. O’Halloran, 1999, Structure.

Beyond Cisplatin: Combination Therapy with Arsenic Trioxide.

T. O’Halloran, E. Swindell, Zohra Sattar Waxali, 2019, Inorganica chimica acta.

Characterization of the Binding Interface between the Copper Chaperone Atx1 and the First Cytosolic Domain of Ccc2 ATPase* 210

I. Bertini, D. Huffman, T. O’Halloran, 2001, The Journal of Biological Chemistry.

Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer

H. Weiss, T. O’Halloran, Pallavi Sethi, 2016, Oncotarget.

Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.

S. Nguyen, T. O’Halloran, Sang-Min Lee, 2010, Journal of the American Chemical Society.

Iodide Analogs of Arsenoplatins—Potential Drug Candidates for Triple Negative Breast Cancers

T. O’Halloran, W. Qiang, V. Vitnik, 2021, Molecules.

Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis*

T. O’Halloran, N. Nukina, K. Yamanaka, 2008, Journal of Biological Chemistry.

Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.

T. O’Halloran, Y. Furukawa, 2006, Antioxidants & redox signaling.

Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer

T. Taxter, T. O’Halloran, V. Cryns, 2018, Oncology letters.

Abstract 2699: Targeting GSK-3: a novel approach to enhance glioblastoma chemosensitivity

C. James, J. Raizer, T. O’Halloran, 2015 .

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.

L. Billings, T. O’Halloran, W. Lowe, 2010, The Journal of endocrinology.

Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)

T. O’Halloran, A. Mazar, Liqing Chen, 2014, PloS one.

The Many Spaces of uPAR: Delivery of Theranostic Agents and Nanobins to Multiple Tumor Compartments through a Single Target

T. O’Halloran, A. Mazar, E. Swindell, 2013, Theranostics.

Alignment of low-dose X-ray fluorescence tomography images using differential phase contrast.

Stefan Vogt, Sophie-Charlotte Gleber, Young Pyo Hong, 2014, Journal of synchrotron radiation.

DNA-bend modulation in a repressor-to-activator switching mechanism

J. Bradner, A. Ansari, T. O’Halloran, 1995, Nature.

Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide

D. Thompson, T. O’Halloran, Haimei Chen, 2009, Molecular Cancer Therapeutics.

Crystal structure of the copper chaperone for superoxide dismutase

A. Wernimont, A. Lamb, T. O’Halloran, 1999, Nature Structural Biology.

Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy.

S. Nguyen, T. O’Halloran, V. Cryns, 2010, ACS nano.

Structure and chemistry of the copper chaperone proteins.

T. O’Halloran, A. Rosenzweig, Amy C. Rosenzweig, 2000, Current opinion in chemical biology.

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone

A. Lamb, T. O’Halloran, A. Rosenzweig, 2001, Nature Structural Biology.

Mechanism of Cu,Zn-Superoxide Dismutase Activation by the Human Metallochaperone hCCS *

T. O’Halloran, R. A. Pufahl, A. S. Torres, 2001, The Journal of Biological Chemistry.

Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria

A. Rokas, T. O’Halloran, J. Slot, 2016, Genome biology and evolution.

Urokinase Plasminogen Activator System–Targeted Delivery of Nanobins as a Novel Ovarian Cancer Therapy

E. Lengyel, T. O’Halloran, A. Mazar, 2013, Molecular Cancer Therapeutics.

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

K. White, T. O’Halloran, V. Cryns, 2016, Cancer letters.

Polymer-caged lipsomes: a pH-responsive delivery system with high stability.

S. Nguyen, T. O’Halloran, Haimei Chen, 2007, Journal of the American Chemical Society.

Allosteric underwinding of DNA is a critical step in positive control of transcription by Hg-MerR

A. Ansari, T. O’Halloran, Mark L. Chael, 1992, Nature.

DNA Distortion Mechanism for Transcriptional Activation by ZntR, a Zn(II)-responsive MerR Homologue in Escherichia coli *

T. O’Halloran, F. W. Outten, C. Outten, 1999, The Journal of Biological Chemistry.

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

A. Mondragón, T. O’Halloran, J. Penner‐Hahn, 2010, Science.

Factors Controlling the Uptake of Yeast Copper/Zinc Superoxide Dismutase into Mitochondria*

T. O’Halloran, V. Culotta, Y. Furukawa, 2003, Journal of Biological Chemistry.

"Clickable" polymer-caged nanobins as a modular drug delivery platform.

S. Nguyen, T. O’Halloran, Haimei Chen, 2009, Journal of the American Chemical Society.

Energetics of Copper Trafficking between the Atx1 Metallochaperone and the Intracellular Copper Transporter, Ccc2*

D. Huffman, T. O’Halloran, 2000, The Journal of Biological Chemistry.

Characterization of the metal receptor sites in Escherichia coli Zur, an ultrasensitive zinc(II) metalloregulatory protein.

T. O’Halloran, J. Penner‐Hahn, C. Outten, 2001, Biochemistry.

Copper Stabilizes a Heterodimer of the yCCS Metallochaperone and Its Target Superoxide Dismutase*

T. O’Halloran, A. S. Torres, T. Rae, 2001, The Journal of Biological Chemistry.

Crystal structure of the second domain of the human copper chaperone for superoxide dismutase.

A. Wernimont, A. Lamb, T. O’Halloran, 2000, Biochemistry.

De Novo Design of Mercury-Binding Two- and Three-Helical Bundles

Thomas V. O'Halloran, James E. Penner-Hahn, W. DeGrado, 1997 .

Metalloregulatory Systems at the Interface Between Bacterial Metal Homeostasis and Resistance

T. O’Halloran, F. W. Outten, C. Outten, 2000 .

The Unusually Stable Quaternary Structure of Human Cu,Zn-Superoxide Dismutase 1 Is Controlled by Both Metal Occupancy and Disulfide Status*

I. Bertini, T. O’Halloran, L. Banci, 2004, Journal of Biological Chemistry.

Imaging and elemental mapping of biological specimens with a dual-EDS dedicated scanning transmission electron microscope.

T. O’Halloran, V. Dravid, T. Woodruff, 2013, Ultramicroscopy.

Spectroscopy of Cu(II)-PcoC and the multicopper oxidase function of PcoA, two essential components of Escherichia coli pco copper resistance operon.

D. Huffman, T. O’Halloran, B. Hoffman, 2002, Biochemistry.

Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR.

T. O’Halloran, Y. Hitomi, C. Outten, 2001, Journal of the American Chemical Society.

Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction.

T. O’Halloran, D. Ralston, 1990, Advances in inorganic biochemistry.

Metalloregulatory Proteins: Metal Responsive Molecular Switches Governing Gene Expression

T. O’Halloran, 1989 .

Mercury-responsive gene regulation and mercury-199 as a probe of protein structure.

D. Huffman, T. O’Halloran, L. Utschig, 1997, Metal ions in biological systems.

Zinc, insulin, and the liver: a ménage à trois.

A. Attie, T. O’Halloran, M. Kebede, 2013, The Journal of clinical investigation.

Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release.

Ying Song, Bong Jin Hong, Thomas J Meade, 2010, Angewandte Chemie.

The PcoC copper resistance protein coordinates Cu(I) via novel S-methionine interactions.

D. Huffman, T. O’Halloran, J. Penner‐Hahn, 2003, Journal of the American Chemical Society.

Crystal structure and dimerization equilibria of PcoC, a methionine-rich copper resistance protein from Escherichia coli

A. Wernimont, D. Huffman, T. O’Halloran, 2002, JBIC Journal of Biological Inorganic Chemistry.

Metals in Cells: Control of Cellular Metal Concentration

T. O’Halloran, B. A. Gilston, 2013 .

Solution structure of the Cu(I) and apo forms of the yeast metallochaperone, Atx1.

I. Bertini, D. Huffman, T. O’Halloran, 2001, Biochemistry.

Glutathione depletion enhances arsenic trioxide‐induced apoptosis in lymphoma cells through mitochondrial‐independent mechanisms

L. Gordon, J. Winter, L. Platanias, 2010, British journal of haematology.

Mechanisms Controlling the Cellular Metal Economy

T. O’Halloran, B. A. Gilston, 2013 .

Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.

T. O’Halloran, A. Mazar, G. Ferraro, 2019, Journal of the American Chemical Society.

Structure-Function Analyses of the ATX1 Metallochaperone*

M. Portnoy, D. Huffman, T. O’Halloran, 1999, The Journal of Biological Chemistry.

Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the Apo and Cu(I)-loaded States*

I. Bertini, D. Huffman, T. O’Halloran, 2001, The Journal of Biological Chemistry.

Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo

L. Gordon, J. Winter, T. O’Halloran, 2013, PloS one.

Ultrasensitivity and heavy-metal selectivity of the allosterically modulated MerR transcription complex.

T. O’Halloran, D. Ralston, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

V. Backman, J. Marko, T. O’Halloran, 2019, Molecular biology of the cell.

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

V. Backman, J. Marko, T. O’Halloran, 2018, bioRxiv.

ATPS-91GSK-3 INHIBITOR 9-ING-41 ENHANCES GENOTOXIC THERAPY OF GBM LEADING TO CURE FROM INTRACRANIAL BRAIN TUMOR.

C. James, J. Raizer, T. O’Halloran, 2015 .

The ferric uptake regulation (Fur) repressor is a zinc metalloprotein.

T. O’Halloran, T V O'Halloran, C. Outten, 1999, Biochemistry.

Triggered release of pharmacophores from [Ni(HAsO₃)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combined experimental and theoretical study.

S. Nguyen, G. Schatz, T. O’Halloran, 2011, ACS nano.

A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli

T. O’Halloran, A. Valledor, Estibaliz Glaría, 2018, Scientific Reports.

Rapid and Accurate Analysis of an X-Ray Fluorescence Microscopy Data Set through Gaussian Mixture-Based Soft Clustering Methods

C. Jacobsen, T. O’Halloran, S. Vogt, 2013, Microscopy and Microanalysis.

Size control of arsenic trioxide nanocrystals grown in nanowells.

T. Odom, T. O’Halloran, M. Raja, 2009, Journal of the American Chemical Society.

Inorganic Reagents as Probes for the Mechanism of a Metal-Responsive Genetic Switch

B. Frantz, T. O’Halloran, 1989 .

Assessment of unsupervised clustering of label-free x-ray fluorescence microscopy data

R. Kettimuthu, T. O’Halloran, M. Chowdhury, 2022, Optical Engineering + Applications.

Construction and characterization of a mercury‐independent MerR activator (MerRAC): transcriptional activation in the absence of Hg(II) is accompanied by DNA distortion.

N. Brown, J. Parkhill, A. Ansari, 1993, The EMBO journal.

Coordination chemistry and the molecular basis of heavy metal recognition in the metalloregulatory protein, MerR.

T. O’Halloran, Shannon L. Johnson, L. Utschig, 1991 .

pH‐Responsive Theranostic Polymer‐Caged Nanobins: Enhanced Cytotoxicity and T1 MRI Contrast by Her2 Targeting

Bong Jin Hong, S. Nguyen, T. Meade, 2013, Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems.

Activation of superoxide dismutases: putting the metal to the pedal.

T. O’Halloran, Mei Yang, V. Culotta, 2006, Biochimica et biophysica acta.

A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.

T. O’Halloran, J. Qiu, P. Williamson, 2013, Metallomics : integrated biometal science.

Mechanism of Cu,Zn-Superoxide Dismutase Activation by the Human Metallochaperone hCCS *

T. O’Halloran, R. A. Pufahl, A. S. Torres, 2001, The Journal of Biological Chemistry.

Metallochaperones, an Intracellular Shuttle Service for Metal Ions*

T. O’Halloran, V. Culotta, 2000, The Journal of Biological Chemistry.

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.

L. Billings, T. O’Halloran, W. Lowe, 2010, The Journal of endocrinology.

"Clickable" polymer-caged nanobins as a modular drug delivery platform.

S. Nguyen, T. O’Halloran, Haimei Chen, 2009, Journal of the American Chemical Society.

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

K. White, T. O’Halloran, V. Cryns, 2016, Cancer letters.

Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.

S. Nguyen, T. O’Halloran, Sang-Min Lee, 2010, Journal of the American Chemical Society.

Iron drives anabolic metabolism through active histone demethylation and mTORC1

Bong Jin Hong, A. Shilatifard, J. Bergelson, 2023, Nature Cell Biology.