Jerson L. Silva

发表

DNA Converts Cellular Prion Protein into the β-Sheet Conformation and Inhibits Prion Peptide Aggregation*

Y. Cordeiro, Filipe A. Machado, L. Juliano, 2001, The Journal of Biological Chemistry.

Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds

Jerson L. Silva, E. Cino, I. N. Soares, 2016, Scientific Reports.

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

Yraima Cordeiro, Y. Cordeiro, Jerson L. Silva, 2013, Bioscience reports.

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

Y. Cordeiro, Jerson L. Silva, Guilherme A. P. de Oliveira, 2012, The Journal of Biological Chemistry.

The Status of p53 Oligomeric and Aggregation States in Cancer

Jerson L. Silva, E. Cino, M. Pedrote, 2020, Biomolecules.

The Structural Dynamics of the Flavivirus Fusion Peptide–Membrane Interaction

Pedro G. Pascutti, Rafael C. Bernardi, P. Pascutti, 2012, PloS one.

On the entry of an emerging arbovirus into host cells: Mayaro virus takes the highway to the cytoplasm through fusion with early endosomes and caveolae-derived vesicles

Jerson L. Silva, A. M. Gomes, Andréa C. Oliveira, 2017, PeerJ.

Pressure-Inactivated Virus: A Promising Alternative for Vaccine Production.

Jerson L. Silva, Y. Mendes, A. M. Gomes, 2015, Sub-cellular biochemistry.

Mutations in the hydrophobic core and in the protein-RNA interface affect the packing and stability of icosahedral viruses.

Jerson L. Silva, S. Lima, D. Peabody, 2003, European journal of biochemistry.

Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation.

Marcos da Silva Freire, Luciane P. Gaspar, Jerson L. Silva, 2009, Vaccine.

High pressure studies on the misfolding and aggregation of p53 in cancer and of α-synuclein in Parkinson’s disease

Jerson L. Silva, M. Pedrote, Guilherme A. P. de Oliveira, 2019, High Pressure Research.

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer

E. Gratton, Jerson L. Silva, E. Cino, 2018, The Journal of Biological Chemistry.

Title Aggregation-primed molten globule conformers of the p 53 core domain provide potential tools for studying p 53 C aggregation in cancer

E. Gratton, Jerson L. Silva, E. Cino, 2018 .

Intranasal Immunization with Pressure Inactivated Avian Influenza Elicits Cellular and Humoral Responses in Mice

D. Ferreira, Jerson L. Silva, F. Bozza, 2015, PloS one.

VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN.

T. Smith, Jerson L. Silva, Y. Mendes, 2007, Journal of molecular biology.

Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues

Jerson L. Silva, Giulia D. S. Ferretti, Luciana Pereira Rangel, 2020, Molecules.

Liquid‐liquid phase separation and fibrillation of the prion protein modulated by a high‐affinity DNA aptamer

V. Uversky, M. Almeida, Y. Cordeiro, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Process intensification for the production of yellow fever virus‐like particles as potential recombinant vaccine antigen

Jerson L. Silva, Guilherme A. P. de Oliveira, L. Castilho, 2021, Biotechnology and bioengineering.

Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane*♦

Y. Cordeiro, Jerson L. Silva, Guilherme A. P. de Oliveira, 2013, The Journal of Biological Chemistry.

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

Jerson L. Silva, Luciana Pereira Rangel, E. Fialho, 2020, Molecules.

Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin.

J. Kelly, Y. Cordeiro, D. Foguel, 2006, Biophysical journal.

Synergistic effect of curcumin, piperine and resveratrol in MCF-7 and MDA MB-231 breast cancer cells.

Jerson L. Silva, E. Fialho, C. Ferreira, 2020 .

Charge neutralization as the major factor for the assembly of nucleocapsid-like particles from C-terminal truncated hepatitis C virus core protein

D. Ferreira, Jerson L. Silva, M. L. Bianconi, 2016, PeerJ.

Mice Vaccination with High Hydrostatic Pressure-Inactivated H3N8 Virus Protects Against Experimental Avian Flu

Jerson L. Silva, Andréa C. Oliveira, S. P. C. Barroso, 2012 .

Yellow fever vaccine protects mice against Zika virus infection

Jerson L. Silva, A. M. Gomes, Andréa C. Oliveira, 2021, PLoS neglected tropical diseases.

Yellow Fever Vaccine Protects Resistant and Susceptible Mice Against Zika Virus Infection

Jerson L. Silva, A. M. Gomes, Andréa C. Oliveira, 2019, bioRxiv.

Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells

Jerson L. Silva, M. Sorgine, G. Atella, 2019, Scientific Reports.

p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

Jerson L. Silva, Giulia D. S. Ferretti, L. P. Rangel, 2019, The Journal of Biological Chemistry.

Backbone resonance assignments of the human p73 DNA binding domain

Jerson L. Silva, E. Cino, I. N. Soares, 2016, Biomolecular NMR assignments.

Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2022, Frontiers in Molecular Biosciences.

Inhibition of Mayaro virus infection by bovine lactoferrin.

Jerson L. Silva, A. M. Gomes, I. Sousa, 2014, Virology.

SARS-CoV-2 spike protein induces long-term TLR4-mediated synapse and cognitive loss recapitulating Post-COVID syndrome

Jerson L. Silva, G. F. Passos, S. Alves-Leon, 2022, bioRxiv.

Free-energy linkage between folding and calcium binding in EF-hand proteins.

D. Foguel, Jerson L. Silva, M. Sorenson, 2008, Biophysical Journal.

Volume and free energy of folding for troponin C C-domain: linkage to ion binding and N-domain interaction.

D. Foguel, Jerson L. Silva, M. Sorenson, 2008, Biochemistry.

Structure and Stability of Wildtype and F29W Mutant Forms of the N-Domain of Avian Troponin C Subjected to High Pressures

A. Jonas, D. Foguel, Jerson L. Silva, 1999 .

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex*

Fabiana A. Caetano, D. Westaway, Jerson L. Silva, 2016, The Journal of Biological Chemistry.

Effects of Naturally Occurring Polyols and Urea on Mitochondrial F0F1ATPase

Jerson L. Silva, J. Meyer-Fernandes, C. E. Peres-Sampaio, 2000, Zeitschrift fur Naturforschung. C, Journal of biosciences.

A Contribution of the Mitochondrial Adenosinetriphosphatase Inhibitor Protein to the Thermal Stability of the F0F1-ATPase Complex

Jerson L. Silva, J. Meyer-Fernandes, J. Saad-Nehme, 1997, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Pressure studies on protein folding, misfolding, protein-DNA interactions and amyloidogenesis

D. Foguel, Jerson L. Silva, L. Lima, 2002 .

Exploring the polymorphism, conformational dynamics and function of amyloidogenic peptides and proteins by temperature and pressure modulation.

Jerson L. Silva, Guilherme A. P. de Oliveira, R. Winter, 2020, Biophysical chemistry.

Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice

Jerson L. Silva, A. M. Gomes, Carlos H. Dumard, 2022, Vaccines.

Envelope Lipid-packing as a Critical Factor for the Biological Activity and Stability of Alphavirus Particles Isolated from Mammalian and Mosquito Cells*

D. Ferreira, Jerson L. Silva, A. M. Gomes, 2010, The Journal of Biological Chemistry.

Role of hydration in the closed-to-open transition involved in Ca2+ binding by troponin C.

D. Foguel, Jerson L. Silva, L. Lima, 2003, Biochemistry.

Stability of different influenza subtypes: How can high hydrostatic pressure be a useful tool for vaccine development?

Jerson L. Silva, N. S. Alves, A. M. Gomes, 2017, Biophysical chemistry.

Pressure-inactivated yellow fever 17DD virus: implications for vaccine development.

Jerson L. Silva, Y. Mendes, Andréa C. Oliveira, 2008, Journal of virological methods.

Pressure-induced fusogenic conformation of vesicular stomatitis virus glycoprotein.

Jerson L. Silva, A. M. Gomes, C. Bonafe, 2003, Biochemistry.

Reversible aggregation plays a crucial role on the folding landscape of p53 core domain.

Jerson L. Silva, A. A. Ano Bom, L. Lima, 2004, Biophysical journal.

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament.

D. Foguel, Jerson L. Silva, C. Braga, 2006, The international journal of biochemistry & cell biology.

Backbone resonance assignments of the human p73 DNA binding domain

Jerson L. Silva, E. Cino, I. N. Soares, 2015, Biomolecular NMR Assignments.

Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands†

Y. Cordeiro, Jerson L. Silva, M. Pedrote, 2021, Chemical science.

Conformational stability of SARS-CoV-2 glycoprotein spike variants

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2022, iScience.

Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids

Y. Cordeiro, Jerson L. Silva, L. P. Rangel, 2014, JBIC Journal of Biological Inorganic Chemistry.

Recent Synthetic Approaches towards Small Molecule Reactivators of p53

Jerson L. Silva, Giulia D. S. Ferretti, L. P. Rangel, 2020, Biomolecules.

Aminoquinolones and Their Benzoquinone Dimer Hybrids as Modulators of Prion Protein Conversion

Jerson L. Silva, L. P. Rangel, M. D. de Moraes, 2022, Molecules.

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2017, Scientific Reports.

Different urea stoichiometries between the dissociation and denaturation of tobacco mosaic virus as probed by hydrostatic pressure.

R. Aparício, Jerson L. Silva, I. Joekes, 2008, Biophysical chemistry.

Tetramerization of the LexA repressor in solution: implications for gene regulation of the E.coli SOS system at acidic pH.

C. L. Oliveira, D. Foguel, Jerson L. Silva, 2006, Journal of molecular biology.

Positive Contribution of Hydration on DNA Binding by E2c Protein from Papillomavirus*

Jerson L. Silva, L. Lima, 2004, Journal of Biological Chemistry.

Biophysical characterization of p53 core domain aggregates.

Jerson L. Silva, E. Cino, Guilherme A. P. de Oliveira, 2019, The Biochemical journal.

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

A. Tanuri, Jerson L. Silva, A. M. Gomes, 2021, bioRxiv.

Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target

Jerson L. Silva, E. Fialho, Danielly C. Ferraz da Costa, 2017, Molecules.

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

Jerson L. Silva, Guilherme A. P. de Oliveira, M. A. Marques, 2017, Scientific Reports.

The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation

P. Chase, Jerson L. Silva, Guilherme A. P. de Oliveira, 2019, The Journal of Biological Chemistry.

Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases.

Y. Cordeiro, Jerson L. Silva, Guilherme A. P. de Oliveira, 2019, Advances in protein chemistry and structural biology.

Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

Jerson L. Silva, E. Cino, I. N. Soares, 2016, Cold Spring Harbor perspectives in biology.

Prion-like aggregation of mutant p53 in cancer.

Jerson L. Silva, L. P. Rangel, C. V. de Moura Gallo, 2014, Trends in biochemical sciences.

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy

P. Chase, Jerson L. Silva, E. Cino, 2021, Chemical science.

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion*

Jerson L. Silva, M. Pedrote, Guilherme A. P. de Oliveira, 2017, The Journal of Biological Chemistry.

Insights into the intramolecular coupling between the N- and C-domains of troponin C derived from high-pressure, fluorescence, nuclear magnetic resonance, and small-angle X-ray scattering studies.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2013, Biochemistry.

Fine modulation of the respiratory syncytial virus M2-1 protein quaternary structure by reversible zinc removal from its Cys(3)-His(1) motif.

Jerson L. Silva, Guilherme A. P. de Oliveira, G. de Prat-Gay, 2013, Biochemistry.

Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer.

Jerson L. Silva, E. Cino, I. N. Soares, 2018, Accounts of chemical research.

Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI.

P. Pascutti, Jerson L. Silva, Daniel Sanches, 2010, Biophysical chemistry.

Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer

Jerson L. Silva, Guilherme A. P. de Oliveira, L. P. Rangel, 2015, Front. Oncol..

High-pressure chemical biology and biotechnology.

D. Foguel, Jerson L. Silva, Guilherme A. P. de Oliveira, 2014, Chemical reviews.

LexA Repressor Forms Stable Dimers in Solution

D. Foguel, Jerson L. Silva, R. Mohana-Borges, 2000, The Journal of Biological Chemistry.

APPROACH FOR THE STUDY OF OLIGOmRIC PROTEINS

Jerson L. Silva, G. Weber, A. Paladini, 1989 .

Slab Gel Electrophoresis Performed at High Hydrostatic Pressure: A New Approach for the Study of Oligomeric Proteins

Jerson L. Silva, G. Weber, A. Paladini, 1989 .

Structural insights into the stabilization of the human immunodeficiency virus type 1 capsid protein by the cyclophilin-binding domain and implications on the virus cycle.

P. Prevelige, Jerson L. Silva, R. Mohana-Borges, 2015, Biochimica et biophysica acta.

Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson’s disease

Jerson L. Silva, Guilherme A. P. de Oliveira, 2019, Communications Biology.

Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2013, Biophysical chemistry.

Conformational changes in bovine lactoferrin induced by slow or fast temperature increases

Jerson L. Silva, Andréa C. Oliveira, R. B. Gonçalves, 2008, Biological chemistry.

Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency

Carolina Q. Sacramento, A. Tanuri, Jerson L. Silva, 2021, iScience.

RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction

Y. Cordeiro, Jerson L. Silva, S. Sanyal, 2019, Scientific Reports.

Pressure-inactivated FMDV: a potential vaccine.

Jerson L. Silva, D. Ishimaru, D. Sá-Carvalho, 2004, Vaccine.

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

Y. Cordeiro, Jerson L. Silva, C. V. de Moura Gallo, 2009, Biochemistry.

The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation.

Roland Winter, Yraima Cordeiro, Y. Cordeiro, 2005, Biophysical journal.

The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins*

Y. Cordeiro, Jerson L. Silva, 2016, The Journal of Biological Chemistry.

Science and technology to combat dengue virus.

Jerson L. Silva, Andréa C. Oliveira, 2009, Anais da Academia Brasileira de Ciencias.

Second-Generation RT-QuIC Assay for the Diagnosis of Creutzfeldt-Jakob Disease Patients in Brazil

R. Nitrini, Jerson L. Silva, Tuane C. Vieira, 2020, Frontiers in Bioengineering and Biotechnology.

Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion.

Y. Cordeiro, Jerson L. Silva, L. P. Rangel, 2011, Methods.

Liquid-liquid phase separation and aggregation of the prion protein globular domain modulated by a high-affinity DNA aptamer

M. Almeida, Y. Cordeiro, Jerson L. Silva, 2019, bioRxiv.

Heparin binding confers prion stability and impairs its aggregation

B. Caughey, Y. Cordeiro, Jerson L. Silva, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis and anti-prion activity evaluation of aminoquinoline analogues.

T. Egan, Y. Cordeiro, Jerson L. Silva, 2010, European journal of medicinal chemistry.

PrP interactions with nucleic acids and glycosaminoglycans in function and disease.

Y. Cordeiro, Jerson L. Silva, Tuane C. Vieira, 2010, Frontiers in bioscience.

Enhanced prion protein stability coupled to DNA recognition and milieu acidification.

Y. Cordeiro, Jerson L. Silva, L. Lima, 2009, Biophysical chemistry.

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

M. Almeida, Y. Cordeiro, Jerson L. Silva, 2008, Journal of Biological Chemistry.

The peculiar interaction between mammalian prion protein and RNA

Y. Cordeiro, Jerson L. Silva, Mariana P. B. Gomes, 2008, Prion.

Intriguing nucleic-acid-binding features of mammalian prion protein.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2008, Trends in biochemical sciences.

The aggregation of mutant p53 produces prion-like properties in cancer

Jerson L. Silva, L. P. Rangel, Tuane C. Vieira, 2014, Prion.

Modulation of Prion Protein Oligomerization, Aggregation, and β-sheet Conversion by 4,4′-Dianilino-1,1′-binaphthyl-5,5′-sulfonate (bis-ANS)*

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2004, Journal of Biological Chemistry.

The role of RNA in mammalian prion protein conversion

Y. Cordeiro, Jerson L. Silva, Tuane C. Vieira, 2012, Wiley interdisciplinary reviews. RNA.

Cryo-EM to visualize the structural organization of viruses

Jerson L. Silva, Guilherme A. P. de Oliveira, 2021, Current Opinion in Virology.

Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability

Jerson L. Silva, Andréa C. Oliveira, D. Peabody, 2006, The FEBS journal.

Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2016, Scientific Reports.

Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications

Y. Cordeiro, Jerson L. Silva, Guilherme A. P. de Oliveira, 2012, PloS one.

The fusogenic state of mayaro virus induced by low pH and by hydrostatic pressure

Jerson L. Silva, A. T. Poian, O. Barth, 2007, Cell Biochemistry and Biophysics.

Potent neutralizing equine antibodies raised against recombinant SARS-CoV-2 spike protein for COVID-19 passive immunization therapy

Carolina Q. Sacramento, A. Tanuri, Jerson L. Silva, 2020, bioRxiv.

Equine hyperimmune globulin raised against the SARS-CoV-2 spike glycoprotein has extremely high neutralizing titers

Carolina Q. Sacramento, A. Tanuri, Jerson L. Silva, 2020 .

Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STIl

R. Linden, Y. Cordeiro, D. Foguel, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Metastable State of Nucleocapsids of Enveloped Viruses as Probed by High Hydrostatic Pressure*

D. Foguel, Jerson L. Silva, A. Pinheiro, 2001, The Journal of Biological Chemistry.

Characterization of a Partially Folded Monomer of the DNA-binding Domain of Human Papillomavirus E2 Protein Obtained at High Pressure*

D. Foguel, Jerson L. Silva, G. de Prat-Gay, 1998, The Journal of Biological Chemistry.

Full Inactivation of Human Influenza Virus by High Hydrostatic Pressure Preserves Virus Structure and Membrane Fusion While Conferring Protection to Mice against Infection

D. Ferreira, Jerson L. Silva, Guilherme A. P. de Oliveira, 2013, PloS one.

Protein-RNA Interactions and Virus Stability as Probed by the Dynamics of Tryptophan Side Chains*

John E. Johnson, Jerson L. Silva, A. D. da Poian, 2002, The Journal of Biological Chemistry.

The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species.

H. Lashuel, D. Foguel, Jerson L. Silva, 2011, Journal of molecular biology.

Structure of the Ebola Fusion Peptide in a Membrane-mimetic Environment and the Interaction with Lipid Rafts*

M. Almeida, Jerson L. Silva, L. Degrève, 2007, Journal of Biological Chemistry.

Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.

L. Juliano, D. Foguel, Jerson L. Silva, 2005, The Journal of biological chemistry.

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Jerson L. Silva, G. F. Passos, C. Figueiredo, 2023, Frontiers in Immunology.

Structure of a Membrane-binding Domain from a Non-enveloped Animal Virus

John E. Johnson, Jerson L. Silva, F. Almeida, 2006, Journal of Biological Chemistry.

Pressure Studies on Protein-Dna Interactions

R. Clegg, Jerson L. Silva, M. Villas-Bôas, 1993 .

Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases

Y. Cordeiro, Jerson L. Silva, Bruno Macedo, 2014, Biophysical Reviews.

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2009, Accounts of chemical research.

Pressure induces folding intermediates that are crucial for protein-DNA recognition and virus assembly.

D. Foguel, Jerson L. Silva, R. Mohana-Borges, 2002, Biochimica et biophysica acta.

Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2004, The Journal of biological chemistry.

Dissociation of amyloid fibrils of α-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

P. Lansbury, J. Kelly, H. Lashuel, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Effects of Hydrostatic Pressure on Viruses

Jerson L. Silva, A. M. Gomes, Andréa C. Oliveira, 2008 .

High-pressure applications in medicine and pharmacology

D. Foguel, Jerson L. Silva, A. M. Gomes, 2004 .

Carbohydrates Protect Mitochondrial F0F1-ATPase Complex against Thermal Inactivation

Jerson L. Silva, J. Meyer-Fernandes, J. Saad-Nehme, 2000 .

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant.

Jerson L. Silva, F. Almeida, A. Valente, 2003, Journal of molecular biology.

Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells

Jerson L. Silva, E. Fialho, C. Ferreira, 2020, International journal of molecular sciences.

The p53 Core Domain Is a Molten Globule at Low pH

Y. Cordeiro, Jerson L. Silva, A. A. Ano Bom, 2009, The Journal of Biological Chemistry.

Transient Transfection of a Wild-Type p53 Gene Triggers Resveratrol-Induced Apoptosis in Cancer Cells

Jerson L. Silva, Daniel Sanches, E. Fialho, 2012, PloS one.

Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases

Y. Cordeiro, Jerson L. Silva, Bruno Macedo, 2014, Biophysical Reviews.

A hypothesis to reconcile the physical and chemical unfolding of proteins

Jerson L. Silva, Guilherme A. P. de Oliveira, 2015, Proceedings of the National Academy of Sciences.

Hydration, cavities and volume in protein folding, aggregation and amyloid assembly

D. Foguel, Jerson L. Silva, 2009, Physical biology.

Protein folding and aggregation: two sides of the same coin in the condensation of proteins revealed by pressure studies.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2006, Biochimica et biophysica acta.

New insights into the mechanisms of protein misfolding and aggregation in amyloidogenic diseases derived from pressure studies.

D. Foguel, Jerson L. Silva, 2004, Biochemistry.

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease.

J. Kelly, H. Lashuel, D. Foguel, 2003, Journal of molecular biology.

Water Leakage Pathway Leads to Internal Hydration of the p53 Core Domain.

Jerson L. Silva, E. Cino, M. Pedrote, 2022, Biochemistry.

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers

E. Gratton, Jerson L. Silva, M. Pedrote, 2020, iScience.

Resveratrol prevents p53 aggregation in vitro and in breast cancer cells

Jerson L. Silva, L. P. Rangel, C. Ramos, 2018, Oncotarget.

Fibrillar aggregates of the tumor suppressor p53 core domain.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2003, Biochemistry.

Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition

Jerson L. Silva, E. Fialho, T. El-Bacha, 2021, Nutrition and cancer.

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors.

Y. Cordeiro, Jerson L. Silva, A. A. Ano Bom, 2011, The international journal of biochemistry & cell biology.

Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants

Jerson L. Silva, Guilherme A. P. de Oliveira, L. Castilho, 2022, bioRxiv.

Green Tea (Camellia sinensis) Extract Induces p53-Mediated Cytotoxicity and Inhibits Migration of Breast Cancer Cells

Jerson L. Silva, M. Monteiro, E. Fialho, 2021, Foods.

Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein.

P. Lansbury, H. Lashuel, D. Foguel, 2007, Biochemistry.

The push-and-pull hypothesis in protein unfolding, misfolding and aggregation.

Jerson L. Silva, Guilherme A. P. de Oliveira, 2017, Biophysical chemistry.

Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation.

Y. Cordeiro, Jerson L. Silva, Guilherme A. P. de Oliveira, 2022, Current opinion in structural biology.

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells

Jerson L. Silva, M. Pedrote, Guilherme A. P. de Oliveira, 2019, The Journal of Biological Chemistry.

Modulation of p53 and prion protein aggregation by RNA.

Y. Cordeiro, Jerson L. Silva, S. Sanyal, 2019, Biochimica et biophysica acta. Proteins and proteomics.

In Vitro Prion Amplification Methodology for Inhibitor Screening.

Jerson L. Silva, Tuane C. Vieira, Tuane C. R. G. Vieira, 2018, Methods in molecular biology.

Resveratrol Modifies Lipid Composition of Two Cancer Cell Lines

Jerson L. Silva, G. Atella, E. Fialho, 2020, BioMed research international.

Measuring the Strength of Interaction between the Ebola Fusion Peptide and Lipid Rafts: Implications for Membrane Fusion and Virus Infection

C. Vilani, C. Achete, Jerson L. Silva, 2011, PloS one.

The interplay between a GC-rich oligonucleotide and copper ions on prion protein conformational and phase transitions.

Y. Cordeiro, Jerson L. Silva, Yulli M. Passos, 2021, International journal of biological macromolecules.

Evolutionary Role of Water-Accessible Cavities in Src Homology 2 (SH2) Domains.

Jerson L. Silva, Guilherme A. P. de Oliveira, G. D. de Andrade, 2022, The journal of physical chemistry. B.

Targeting Biomolecular Condensation and Protein Aggregation against Cancer.

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2023, Chemical reviews.

Hydration and Packing Effects on Prion Folding and β-Sheet Conversion

Y. Cordeiro, D. Foguel, Jerson L. Silva, 2004, Journal of Biological Chemistry.

Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain

K. Edwards, Y. Cordeiro, Jerson L. Silva, 2017, The Journal of Biological Chemistry.

Heparin binding by murine recombinant prion protein leads to transient aggregation and formation of RNA-resistant species.

M. Almeida, Y. Cordeiro, Jerson L. Silva, 2011, Journal of the American Chemical Society.

Nonspecific prion protein-nucleic acid interactions lead to different aggregates and cytotoxic species.

Y. Cordeiro, Jerson L. Silva, C. Braga, 2012, Biochemistry.

Structural insights into the interaction between prion protein and nucleic acid.

Gildon Choi, Yraima Cordeiro, B. Caughey, 2006, Biochemistry.

Pressure provides new insights into protein folding, dynamics and structure.

C A Royer, D. Foguel, Jerson L. Silva, 2001, Trends in biochemical sciences.

Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson’s disease

Jerson L. Silva, Guilherme A. P. de Oliveira, 2019, Communications Biology.

Pressure stability of proteins.

Jerson L. Silva, G. Weber, J. Silva, 1993, Annual review of physical chemistry.

Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors

Y. Cordeiro, Jerson L. Silva, Tuane C. Vieira, 2021, Frontiers in Neuroscience.

Partially folded states of the capsid protein of cowpea severe mosaic virus in the disassembly pathway.

John E. Johnson, Jerson L. Silva, J. Johnson, 1997, Journal of molecular biology.

Role of entropic interactions in viral capsids: single amino acid substitutions in P22 bacteriophage coat protein resulting in loss of capsid stability.

P. Prevelige, C. Teschke, D. Foguel, 1995, Biochemistry.

Hydrostatic Pressure Induces the Fusion-active State of Enveloped Viruses*

D. Foguel, Jerson L. Silva, A. A. Ano Bom, 2002, The Journal of Biological Chemistry.

Virus Maturation Targets the Protein Capsid to Concerted Disassembly and Unfolding*

John E. Johnson, Jerson L. Silva, R. Mohana-Borges, 2000, The Journal of Biological Chemistry.

Hydrostatic pressure rescues native protein from aggregates.

D. Foguel, Jerson L. Silva, A. Robinson, 1999, Biotechnology and bioengineering.

Controlling (cid:1) -Amyloid Oligomerization by the Use of Naphthalene Sulfonates TRAPPING LOW MOLECULAR WEIGHT OLIGOMERIC SPECIES *

L. Juliano, D. Foguel, Jerson L. Silva, 2005 .