J. Huizinga

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Relaxation oscillator and core conductor models are needed for understanding of GI electrical activities.

B. Bardakjian, N. Diamant, E. Daniel, 1994, The American journal of physiology.

Statistical Assessment of Change Point Detectors for Single Molecule Kinetic Analysis

J. Huizinga, S. Parsons, 2013, The Journal of Membrane Biology.

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system.

J. Huizinga, R. Riddell, S. Collins, 2001, Gastroenterology.

Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management

J. Huizinga, J. Malagelada, F. Mearin, 2003, Gut.

Ion channels in interstitial cells of Cajal as targets for neurotransmitter action

J. Huizinga, Yaohui Zhu, C. M. Golden, 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.

G. Farrugia, J. Huizinga, N. Zárate, 2009, Gastroenterology.

Role of interstitial cells of Cajal in the generation and modulation of motor activity induced by cholinergic neurotransmission in the stomach

J. Huizinga, X-Y Wang, R-X Zhang, 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.

K. Chorneyko, J. Huizinga, R. Riddell, 1999, The American journal of surgical pathology.

Robust and fast heart rate variability analysis of long and noisy electrocardiograms using neural networks and images

J. Huizinga, S. Parsons, 2019, 1902.06151.

Measurement of intracellular chloride ion concentration in ICC in situ and in explant culture

J. Huizinga, S. Parsons, Y. Zhu, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Non-invasive, Multimodal Functional Imaging of the Intestine with Frozen Micellar Naphthalocyanines

Mukund Seshadri, Chulhong Kim, Hao Hong, 2014, Nature nanotechnology.

Spatial Noise in Coupling Strength and Natural Frequency within a Pacemaker Network; Consequences for Development of Intestinal Motor Patterns According to a Weakly Coupled Phase Oscillator Model

J. Huizinga, S. Parsons, 2016, Front. Neurosci..

IV. Pathophysiology of GI motility related to interstitial cells of Cajal.

J. Huizinga, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Action potentials in gastrointestinal smooth muscle.

J. Huizinga, 1991, Canadian journal of physiology and pharmacology.

Pacemaker activity in the proximal lower oesophageal sphincter of the dog.

J. Huizinga, P. D. Walton, J D Huizinga, 1989, The Journal of physiology.

Test of Normality for Integrated Change Point Detection and Mixture Modeling

J. Huizinga, S. Parsons, 2012, The Journal of Membrane Biology.

Theory and applications of geometric scaling of localized calcium release events.

J. Huizinga, S. Parsons, M. Harhun, 2010, American journal of physiology. Cell physiology.

Transient outward potassium current in ICC.

J. Huizinga, S. Parsons, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli.

J. Huizinga, J. Bienenstock, Xuelian Ma, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Electrophysiologic control of motility in the human colon.

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1985, Gastroenterology.

Interstitial cells of Cajal and human colon motility in health and disease.

J. Huizinga, Amer Hussain, Ji-Hong Chen, 2021, American journal of physiology. Gastrointestinal and liver physiology.

Gastric pacing as a treatment for intractable gastroparesis: shocking news?

J. Huizinga, G. Tougas, 1998, Gastroenterology.

Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut

J. Huizinga, S. Parsons, 2018, The Journal of physiology.

Effects of gap junction inhibition on

J. Huizinga, S. Parsons, 2014 .

Interstitial cell of Cajal loss correlates with the degree of inflammation in the human appendix and reverses after inflammation.

W. Staines, J. Huizinga, Xuan-Yu Wang, 2012, Journal of pediatric surgery.

Interstitial Cells of Cajal: Pathology, injury and repair.

J. Huizinga, D. Al‐Sajee, 2012, Sultan Qaboos University medical journal.

Neurotransmission in lower esophageal sphincter of W/Wv mutant mice.

J. Huizinga, W. Paterson, X. Y. Wang, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small

J. Huizinga, G. Donnelly, A. Safdar, 2009 .

Ultrastructural injury to interstitial cells of Cajal and communication with mast cells in Crohn's disease

L. W. Liu, Louis W C Liu, J. Huizinga, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Ava[l-Pro9,N-MeLeu10] Substance P(7-11) (GR 73632) and Sar9, Met(O2)11 Increase Distention-Induced Peristalsis through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal

J. Huizinga, Florentine Nieuwmeyer, Jing Ye, 2006, Journal of Pharmacology and Experimental Therapeutics.

IL-9 enhances growth of ICC, maintains network structure and strengthens rhythmicity of contraction in culture

J. Huizinga, W. Khan, J. Snick, 2006, Journal of cellular and molecular medicine.

Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistry.

J. Huizinga, H. Mikkelsen, S. Collins, 2002, The American journal of pathology.

Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal.

K. Chorneyko, J. Huizinga, R. Riddell, 2000, The American journal of pathology.

Short Communication Gastrointestinal Stromal Tumors May Originate from a Subset of CD34-Positive Interstitial Cells of Cajal

K. Chorneyko, J. Huizinga, R. Riddell, 2000 .

Interstitial cells of cajal and inflammation-induced motor dysfunction in the mouse small intestine.

J. Huizinga, S. Collins, P. Bercik, 2000, Gastroenterology.

Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal.

J. Huizinga, I. Berezin, Jonathan C F Lee, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Searching for intrinsic properties and functions of interstitial cells of Cajal.

J. Huizinga, J. Malysz, 1999, Current opinion in gastroenterology.

Development of pacemaker activity and interstitial cells of cajal in the neonatal mouse small intestine

L. W. Liu, Louis W C Liu, J. Huizinga, 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

Interstitial cells of Cajal: pacemaker cells?

K. Chorneyko, J. Huizinga, R. Riddell, 1998, The American journal of pathology.

Developmental origin and kit‐dependent development of the interstitial cells of cajal in the mammalian small intestine

M. Klüppel, J. Huizinga, A. Bernstein, 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal.

S. Sarna, J. Huizinga, I. Berezin, 1997, The American journal of physiology.

Interstitial cells of cajal in the canine colon: A special communication network at the inner border of the circular muscle

E. Daniel, J. Huizinga, I. Berezin, 1988, The Journal of comparative neurology.

Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves.

L. W. Liu, Louis W C Liu, J. Huizinga, 1994, The American journal of physiology.

Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP

J. Huizinga, S. Parsons, Xuan-Yu Wang, 2013, Pflügers Archiv - European Journal of Physiology.

The Sphincter of O’Beirne—Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia

J. Huizinga, S. Collins, M. Pervez, 2021, Digestive Diseases and Sciences.

Vagal Fibers Form Associations With Interstitial Cells of Cajal During Fetal Development

J. Huizinga, Xuan-Yu Wang, E. Ratcliffe, 2015, Anatomical record.

The phase response and state space of slow wave contractions in the small intestine

J. Huizinga, S. Parsons, 2017, Experimental physiology.

Modulation of contractions in the small intestine indicate desynchronization via supercritical Andronov–Hopf bifurcation

J. Huizinga, S. Parsons, 2020, Scientific Reports.

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication

B. Berger, D. Moine, J. Huizinga, 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Cancer pain and neuropathic pain are associated with Aβ sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord

J. Huizinga, J. Kwiecien, W. Dąbrowski, 2018, Molecular pain.

Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo

J. Huizinga, Natalie J. Zacal, J. Henry, 2017, Pain reports.

Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain

J. Huizinga, Natalie J. Zacal, J. Henry, 2016, Molecular pain.

Slow wave contraction frequency plateaux in the small intestine are composed of discrete waves of interval increase associated with dislocations

J. Huizinga, S. Parsons, 2018, Experimental physiology.

Slow-wave activity in colon: role of network of submucosal interstitial cells of Cajal.

E. Daniel, J. Huizinga, I. Berezin, 1991, The American journal of physiology.

Interstitial cells of Cajal in health and disease. Part I: Normal ICC structure and function with associated motility disorders

J. Huizinga, R. Riddell, D. Driman, 2007, Histopathology.

Pacemaker activity recorded in interstitial cells of Cajal of the gastrointestinal tract.

E. Daniel, J. Huizinga, I. Berezin, 1989, The American journal of physiology.

Characterization of the outward rectifying potassium channel in a novel mouse intestinal smooth muscle cell preparation.

J. Huizinga, A. Molleman, L. Thuneberg, 1993, The Journal of physiology.

Inwardly rectifying chloride channel activity in intestinal pacemaker cells.

J. Huizinga, Yaohui Zhu, A. Mucci, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine.

J. Huizinga, J. Malysz, G. Donnelly, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Myogenic electrical control activity in longitudinal muscle of human and dog colon.

J. Huizinga, E. Chow, 1987, The Journal of physiology.

currents regulate pacemaker activity in ICC

J. Huizinga, Yaohui Zhu, Xuan-Yu Wang, 2003 .

ERG K+ currents regulate pacemaker activity in ICC.

J. Huizinga, Yaohui Zhu, Xuan-Yu Wang, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Loss of CD117 (c-kit)- and CD34-Positive ICC and Associated CD34-Positive Fibroblasts Defines a Subpopulation of Chronic Intestinal Pseudo-obstruction

C. Streutker, J. Huizinga, R. Riddell, 2003, The American journal of surgical pathology.

Mast cell ionic channels: significance for stimulus-secretion coupling.

J. Huizinga, M. Blennerhassett, J. Janiszewski, 1992, Canadian journal of physiology and pharmacology.

Intramuscular interstitial cells of Cajal associated with mast cells survive nitrergic nerves in achalasia

M. Anvari, J. Huizinga, J. Malagelada, 2006, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Electrophysiologic the Human Colon Control of Motility in

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1985 .

Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal.

J. Huizinga, J. Foster, E. White, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus.

Louis W C Liu, J. Huizinga, Xuan-Yu Wang, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Gating of maxi channels observed from pseudo-phase portraits.

J. Huizinga, S. Parsons, 2013, American journal of physiology. Cell physiology.

Altered small intestinal smooth muscle function in Crohn's disease.

J. Huizinga, R. Riddell, S. Collins, 1993, Gastroenterology.

Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture

J. Huizinga, Xuan-Yu Wang, C. Barajas-López, 2014, Cellular & Molecular Biology Letters.

Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation

J. Huizinga, Ji-Hong Chen, N. Milkova, 2022, Scientific Reports.

Maxi-channels recorded in situ from ICC and pericytes associated with the mouse myenteric plexus.

J. Huizinga, S. Parsons, W. Kunze, 2012, American journal of physiology. Cell physiology.

Modulation of the autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction

J. Huizinga, Ji-Hong Chen, N. Milkova, 2022, Frontiers in Neuroscience.

Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine

J. Huizinga, S. Parsons, Xuan-Yu Wang, 2014, Pflügers Archiv - European Journal of Physiology.

Bifidobacterium longum NCC3001 inhibits AH neuron excitability

J. Huizinga, W. Kunze, A. Khoshdel, 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Volume-activated chloride currents in interstitial cells of Cajal.

J. Huizinga, Yaohui Zhu, Sung Jin Park, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Inhibitory innervation of colonic smooth muscle cells and interstitial cells of Cajal.

E. Daniel, J. Huizinga, I. Berezin, 1990, Canadian journal of physiology and pharmacology.

Ionized calcium‐binding adaptor molecule 1 positive macrophages and HO‐1 up‐regulation in intestinal muscularis resident macrophages

J. Larsen, J. Huizinga, S. Kirkeby, 2017, Anatomical record.

Determinants of Occurrence and Volume of Transpyloric Flow During Gastric Emptying of Liquids in Dogs

M. Anvari, J. Huizinga, C. A. Paterson, 2000, Digestive Diseases and Sciences.

Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin.

J. Huizinga, W. Khan, S. Parsons, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin‐induced diabetes

L. W. Liu, J. Huizinga, X-Y Wang, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Interstitial Cells of Cajal: Update on Basic and Clinical Science

J. Huizinga, Ji-Hong Chen, 2014, Current Gastroenterology Reports.

Interstitial cells of Cajal: mediators of communication between circular and longitudinal muscle layers of canine colon

Louis W C Liu, J. Huizinga, I. Berezin, 1998, Cell and Tissue Research.

On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle.

J. Huizinga, D. Richardson, K. Alibhai, 1992, Pharmacology & toxicology.

Intercellular metabolic coupling in canine colon musculature.

J. Huizinga, A. Ball, L. Farraway, 1995, American Journal of Physiology.

Substance P activates a non‐selective cation channel in murine pacemaker ICC

J. Huizinga, C. D'Antonio, C. Mckay, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Progenitor cells of interstitial cells of Cajal: on the road to tissue repair.

J. Huizinga, Elizabeth J. White, 2008, Gastroenterology.

Neurogenic and Myogenic Properties of Pan-Colonic Motor Patterns and Their Spatiotemporal Organization in Rats

J. Huizinga, Ji-Hong Chen, H. Liao, 2013, PloS one.

Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract

K. Sanders, J. Huizinga, P. Cann, 1995 .

Intestinal microbiota influence the early postnatal development of the enteric nervous system

J. Huizinga, E. Ratcliffe, R. Borojevic, 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium‐dependent potassium channel opening

Paul Forsythe, John Bienenstock, Bingxian Wang, 2009, Journal of cellular and molecular medicine.

Pharmacology of drugs acting on gastrointestinal motility

E. Daniel, J. Huizinga, S. Collins, 2011 .

Innervation of interstitial cells of Cajal by vasoactive intestinal polypeptide containing nerves in canine colon.

E. Daniel, J. Huizinga, I. Berezin, 1990, Canadian journal of physiology and pharmacology.

Dual action of high energy adenine nucleotides in comparison with responses evoked by other adenine derivatives and intramural nerve stimulation on smooth muscle.

J. Huizinga, A. den Hertog, J. Pielkenrood, 1981, European journal of pharmacology.

Habitual rapid food intake and ineffective esophageal motility.

J. Huizinga, Ji-Hong Chen, Shawn Vadakepeedika, 2013, World journal of gastroenterology.

Haustral boundary contractions in the proximal 3-taeniated rabbit colon.

J. Huizinga, Ji-Hong Chen, Yuanjie Yu, 2016, American journal of physiology. Gastrointestinal and liver physiology.

On the origin of rhythmic contractile activity of the esophagus in early achalasia, a clinical case study

Louis W C Liu, J. Huizinga, Ji-Hong Chen, 2013, Front. Neurosci..

Assessment of gastric emptying using a low fat meal: establishment of international control values

J. Huizinga, T. Abell, K. Koch, 2000, American Journal of Gastroenterology.

Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon

J. Huizinga, Ji-Hong Chen, Wei Tan, 2020, Frontiers in Physiology.

Cell‐specific effects of nitric oxide on the efficiency and frequency of long distance contractions in murine colon

J. Huizinga, S. Parsons, A. Friebe, 2019, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon

J. Huizinga, S. Parsons, Ji-Hong Chen, 2019, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Intraluminal prucalopride increases propulsive motor activities via luminal 5‐HT4 receptors in the rabbit colon

J. Huizinga, Ji-Hong Chen, M. Shokrollahi, 2019, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

J. Huizinga, Ji-Hong Chen, Yuanjie Yu, 2017, Scientific Reports.

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

J. Huizinga, Ji-Hong Chen, Yuanjie Yu, 2016, Journal of neurogastroenterology and motility.

Involvement of 5‐HT3 and 5‐HT4 receptors in colonic motor patterns in rats

J. Huizinga, J. Shi, L. Jiang, 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal

J. Huizinga, I. Berezin, J. Lee, 1999 .

Gut peristalsis is governed by a multitude of cooperating mechanisms.

W. Lammers, J. Huizinga, Jan D Huizinga, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Gastrointestinal peristalsis: Joint action of enteric nerves, smooth muscle, and interstitial cells of Cajal

J. Huizinga, Jan D. Huizinga, 1999, Microscopy research and technique.

Two Independent Networks of Interstitial Cells of Cajal Work Cooperatively with the Enteric Nervous System to Create Colonic Motor Patterns

J. Huizinga, S. Parsons, M. Jimenez, 2011, Front. Neurosci..

Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation.

Louis W C Liu, J. Huizinga, N. Zárate, 2008, American journal of physiology. Gastrointestinal and liver physiology.

About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract

J. Huizinga, M. Faussone‐Pellegrini, Jan D. Huizinga, 2005, Journal of cellular and molecular medicine.

Interstitial cells of Cajal and adaptive relaxation in the mouse stomach.

Louis W C Liu, J. Huizinga, D. Boreham, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Editorial: Irritable Bowel Syndrome and the Elusive Mast Cells

J. Huizinga, S. Asadi, T. Theoharides, 2012, The American Journal of Gastroenterology.

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

R. Spiller, P. Dinning, C. Di Lorenzo, 2019, Nature Reviews Gastroenterology & Hepatology.

Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit

J. Huizinga, Ji-Hong Chen, Xiaojing Quan, 2017, Scientific Reports.

Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry

P. Moayyedi, D. Armstrong, J. Huizinga, 2018, Front. Physiol..

Pharmacology of neuroendocrine peptides

E. Daniel, J. Huizinga, S. Collins, 2011 .

Inhibition of fundic strips from guinea-pig stomach: the effect of theophylline on responses to adenosine, ATP and intramural nerve stimulation.

J. Huizinga, A. den Hertog, 1980, European journal of pharmacology.

Inhibition of fundic strips from guinea-pig stomach: the effect of theophylline on the membrane potential, muscle contraction and ion fluxes.

J. Huizinga, A. den Hertog, 1979, European Journal of Pharmacology.

The effect of enkephalins on the intramural inhibitory non-adrenergic nerve responses of smooth muscle.

J. Huizinga, A. den Hertog, 1979, European journal of pharmacology.

Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine

J. Huizinga, S. Parsons, W. Kunze, 2014, Pflügers Archiv - European Journal of Physiology.

A Personal Perspective on the Development of Our Understanding of the Myogenic Control Mechanisms of Gut Motor Function.

J. Huizinga, 2016, Advances in experimental medicine and biology.

The myogenic and neurogenic components of the rhythmic segmentation motor patterns of the intestine

J. Huizinga, Ji-Hong Chen, 2014, Front. Neurosci..

The many facets of intestinal peristalsis.

J. Huizinga, C. Mckay, E. J. White, 2006, American journal of physiology. Gastrointestinal and liver physiology.

The effects of cholecystokinin-octapeptide and pentagastrin on electrical and motor activities of canine colonic circular muscle.

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1984, Canadian journal of physiology and pharmacology.

Ultrastructure of interstitial cells of Cajal in the canine distal esophagus.

E. Daniel, J. Huizinga, I. Berezin, 1994, Canadian journal of physiology and pharmacology.

Circular muscle lamellae of canine colon are electrically isolated functional units.

L. W. Liu, J. Huizinga, R. Ruo, 1997, Canadian journal of physiology and pharmacology.

Generation of slow‐wave‐type action potentials in canine colon smooth muscle involves a non‐L‐type Ca2+ conductance.

J. Huizinga, A. den Hertog, L. Farraway, 1991, The Journal of physiology.

Ionic basis of pacemaker generation in dog colonic smooth muscle.

J. Huizinga, C. Barajas-López, A. den Hertog, 1989, The Journal of physiology.

Role of the sodium pump in pacemaker generation in dog colonic smooth muscle.

J. Huizinga, C. Barajas-López, A. den Hertog, 1989, The Journal of physiology.

The cyclic motor patterns in the human colon

J. Huizinga, S. Parsons, M. Pervez, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats.

J. Huizinga, M. Jimenez, X. Y. Wang, 2007, American journal of physiology. Gastrointestinal and liver physiology.

The effect of amino acids on intestinal smooth muscle related to their content in blood and tissue.

J. Huizinga, 1980, European journal of pharmacology.

Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/W(V) mice.

J. Huizinga, S. Collins, B. Vallance, 2001, American journal of physiology. Gastrointestinal and liver physiology.

A myogenic motor pattern in mice lacking myenteric interstitial cells of Cajal explained by a second coupled oscillator network.

J. Huizinga, S. Parsons, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Muscarinic activation of transient inward current and contraction in canine colon circular smooth muscle cells.

L. W. Liu, J. Huizinga, A. Molleman, 2001, Canadian journal of physiology and pharmacology.

Intercellular communication in smooth muscle

L. W. Liu, J. Huizinga, M. Blennerhassett, 1992, Experientia.

Effect of voltage and cyclic AMP on frequency of slow‐wave‐type action potentials in canine colon smooth muscle.

J. Huizinga, A. den Hertog, L. Farraway, 1991, The Journal of physiology.

Electrophysiological basis of excitation of canine colonic circular muscle by cholinergic agents and substance P.

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1984, The Journal of pharmacology and experimental therapeutics.

Interstitial cells of Cajal in health and disease. Part II: ICC and gastrointestinal stromal tumours

J. Huizinga, R. Riddell, D. Driman, 2007, Histopathology.

Interstitial cells of Cajal generate a rhythmic pacemaker current

David W. Andrews, Jan D. Huizinga, D. Andrews, 1998, Nature Medicine.

Cholinergic and nitrergic innervation of ICC‐DMP and ICC‐IM in the human small intestine

J. Huizinga, X-Y Wang, C. Paterson, 2003, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Involvement of nitric oxide in nerve-mediated inhibition and action of vasoactive intestinal peptide in colonic smooth muscle.

J. Huizinga, J. Tomlinson, J. Pintin-Quezada, 1992, The Journal of pharmacology and experimental therapeutics.

On the nature of high-amplitude propagating pressure waves in the human colon

J. Huizinga, S. Parsons, E. Ratcliffe, 2020, American journal of physiology. Gastrointestinal and liver physiology.

Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction

J. Huizinga, 2020, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Distal Colon Motor Coordination: The Role of the Coloanal Reflex and the Rectoanal Inhibitory Reflex in Sampling, Flatulence, and Defecation

J. Huizinga, Ji-Hong Chen, Lijun Liu, 2021, Frontiers in Medicine.

Jejunal circular muscle motility is decreased in nematode-infected rat.

J. Huizinga, J. Fox, A. Crosthwaite, 1990, Gastroenterology.

Changes in interstitial cells of Cajal at the deep muscular plexus are associated with loss of distention-induced burst-type muscle activity in mice infected by Trichinella spiralis.

J. Huizinga, M. Vannucchi, Florentine Nieuwmeyer, 2005, The American journal of pathology.

Neural injury, repair, and adaptation in the GI tract. IV. Pathophysiology of GI motility related to interstitial cells of Cajal.

J. Huizinga, 1998, The American journal of physiology.

Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators

J. Huizinga, S. Parsons, Ruihan Wei, 2016, Experimental physiology.

Electrotonic current spread in colonic smooth muscle.

J. Huizinga, E. Chow, 1988, The American journal of physiology.

Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine.

W. Lammers, J. Huizinga, P. Bercik, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Pinaverium acts as L-type calcium channel blocker on smooth muscle of colon

J. Huizinga, J. Malysz, M. Christen, 1997 .

On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine.

J. Huizinga, Bobbi-Jo Lowie, Xuan‐yu Wang, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Origin of Rhythmic Calcium Transients in the ICC-MP of the Mouse Small Intestine

J. Huizinga, Bobbi-Jo Lowie, Bobbi‐Jo Lowie, 2011 .

ICC-MP of the mouse small intestine On the origin of rhythmic calcium transients in the

J. Huizinga, Bobbi-Jo Lowie, Xuan‐yu Wang, 2011 .

Interstitial cells of cajal direct normal propulsive contractile activity in the mouse small intestine.

J. Huizinga, J. Malysz, T. Der-Silaphet, 1998, Gastroenterology.

Abnormal response to cholinergic stimulation in the circular muscle layer of the human colon in diverticular disease.

J. Huizinga, W. Waterfall, H. Stern, 1999, Scandinavian journal of gastroenterology.

Optimizing Autonomic Function Analysis via Heart Rate Variability Associated With Motor Activity of the Human Colon

J. Huizinga, Ji-Hong Chen, Lijun Liu, 2021, Frontiers in Physiology.

Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. II. Gastric motility: lessons from mutant mice on slow waves and innervation.

J D Huizinga, J. Huizinga, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders.

J. Huizinga, J. Rumessen, J. Vanderwinden, 1997, Trends in pharmacological sciences.

Cyclopiazonic acid, inhibiting the endoplasmic reticulum calcium pump, reduces the canine colonic pacemaker frequency.

L. W. Liu, J. Huizinga, L. Thuneberg, 1995, The Journal of pharmacology and experimental therapeutics.

Generation of slow wave type action potentials in the mouse small intestine involves a non-L-type calcium channel.

J. Huizinga, J. Malysz, M. Christen, 1995, Canadian journal of physiology and pharmacology.

Action potential generation in the small intestine of W mutant mice that lack interstitial cells of Cajal.

J. Huizinga, H. Mikkelsen, J. Malysz, 1996, The American journal of physiology.

Electrical coupling of circular muscle to longitudinal muscle and interstitial cells of Cajal in canine colon.

L. W. Liu, J. Huizinga, L. W. Liu, 1993, The Journal of physiology.

Different mechanisms of contraction generation in circular muscle of canine colon.

J. Huizinga, C. Barajas-López, 1989, The American journal of physiology.

Expression of P2X3 and P2X5 Myenteric Receptors Varies During the Intestinal Postnatal Development in the Guinea Pig

J. Huizinga, C. Barajas-López, R. Espinosa-Luna, 2014, Cellular and Molecular Neurobiology.

Unique distribution of interstitial cells of Cajal in the feline pylorus

N. Diamant, Louis W C Liu, J. Huizinga, 2007, Cell and Tissue Research.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Jordi Villà-Freixa, Peter Sandner, Bernd J. Pichler, 2017, BMC Pharmacology and Toxicology.

Noninvasive measurements to evaluate the effects of military training on the human autonomic nervous system

J. Huizinga, Cuizhen Zhang, Ji-Hong Chen, 2014 .

Interstitial cells of Cajal, from structure to function

J. Huizinga, S. Parsons, H. Mikkelsen, 2013, Front. Neurosci..

Gastric Electrical Stimulation in Intractable Symptomatic Gastroparesis

E. Van Cutsem, J. Galmiche, J. Huizinga, 2003, Digestion.

Structural characterization of interstitial cells of Cajal in myenteric plexus and muscle layers of canine colon.

E. Daniel, J. Huizinga, I. Berezin, 1990, Canadian journal of physiology and pharmacology.

Stimulus-dependent pacemaker activity in the distal canine lower esophageal sphincter.

J. Huizinga, P. D. Walton, 1989, Canadian journal of physiology and pharmacology.

Pinaverium acts as L-type calcium channel blocker on smooth muscle of colon.

J. Huizinga, J. Malysz, M. Christen, 1997, Canadian journal of physiology and pharmacology.

THE ORIGIN OF SEGMENTATION MOTOR ACTIVITY IN THE INTESTINE

B. Bardakjian, J. Huizinga, S. Parsons, 2014, Nature Communications.

Survival dependency of intramuscular ICC on vagal afferent nerves in the cat esophagus.

N. Diamant, Louis W C Liu, J. Huizinga, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Intercellular coupling mediated by potassium accumulation in peg-and-socket junctions

Berj L. Bardakjian, Edward J. Vigmond, Lars Thuneberg, 2000, IEEE Transactions on Biomedical Engineering.

Electrical correlate of circumferential contractions in human colonic circular muscle.

J. Huizinga, W. Waterfall, 1988, Gut.

Lactobacillus reuteri ingestion and IKCa channel blockade have similar effects on rat colon motility and myenteric neurones

J. Huizinga, J. Bienenstock, C. Diorio, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Coordination of electrical activities in muscle layers of the pig colon.

N. Diamant, J. Huizinga, E. Chow, 1987, The American journal of physiology.

Electrophysiology of human colon motility in health and disease.

J. Huizinga, 1986, Clinics in gastroenterology.

Electrical basis of excitation and inhibition of human colonic smooth muscle.

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1986, Gastroenterology.

Electrical basis of contractions in the muscle layers of the pig colon.

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1983, The American journal of physiology.

THEORY AND APPLICATIONS OF GEOMETRICAL

J. Huizinga, S. Parsons, M. Harhun, 2010 .

The myogenic component in distention-induced peristalsis in the guinea pig small intestine.

J. Huizinga, G. Donnelly, A. Safdar, 2001, American journal of physiology. Gastrointestinal and liver physiology.

The Pressure’s on: Finding the Cause of Diverticula Formation

J. Huizinga, Ji-Hong Chen, 2020, Digestive Diseases and Sciences.

High-conductance chloride channels generate pacemaker currents in interstitial cells of Cajal.

J. Huizinga, Yaohui Zhu, Jan D Huizinga, 2002, Gastroenterology.

In situ recording from gut pacemaker cells

Jan D. Huizinga, Bingxian Wang, J. Huizinga, 2008, Pflügers Archiv - European Journal of Physiology.

Selective accumulation of methylene blue by interstitial cells of Cajal in canine colon.

L. W. Liu, E. Daniel, J. Huizinga, 1993, The American journal of physiology.

Potassium channel activation by cromakalim affects the slow wave type action potential of colonic smooth muscle.

J. Huizinga, L. Farraway, 1991, The Journal of pharmacology and experimental therapeutics.

The Gastric Conduction System in Health and Disease: A Translational Review.

J. Huizinga, G. O’Grady, P. Du, 2021, American journal of physiology. Gastrointestinal and liver physiology.

Electrical Basis of Excitation Inhibition of Human Colonic Muscle and Smooth

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1986 .

Myoelectric correlates of colonic motor complexes and contractile activity.

J. Huizinga, 1986, The American journal of physiology.

Control of human colonic motor function

E. Daniel, J. Huizinga, Jan D. Huizinga, 1986, Digestive Diseases and Sciences.

Intrinsic inhibitory innervation of the stomach

J. Huizinga, N. Zárate, Devika Dixit, 2005, British journal of pharmacology.

Ultrastructural evidence for communication between intramuscular vagal mechanoreceptors and interstitial cells of Cajal in the rat fundus

L. W. Liu, J. Huizinga, E. Fox, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Co‐operation between neural and myogenic mechanisms in the control of distension‐induced peristalsis in the mouse small intestine

J. Huizinga, K. Ambrous, Jan D. Huizinga, 1998, The Journal of physiology.

Motor patterns of the small intestine explained by phase-amplitude coupling of two pacemaker activities: the critical importance of propagation velocity.

J. Huizinga, S. Parsons, Y. Zhu, 2015, American journal of physiology. Cell physiology.

Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle.

J. Huizinga, A. Pawelka, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.

J. Huizinga, S. Parsons, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Pacemaker network properties determine intestinal motor pattern behaviour

J. Huizinga, S. Parsons, 2019, Experimental Physiology.

Trans-illumination intestine projection imaging of intestinal motility in mice

J. Xia, J. Huizinga, Lidai Wang, 2021, Nature Communications.

Nitric Oxide Is Essential for Generating the Minute Rhythm Contraction Pattern in the Small Intestine, Likely via ICC-DMP

J. Huizinga, S. Parsons, 2021, Frontiers in Neuroscience.

Muscarinic Regulation of Ether-a-go-go-Related Gene K+ Currents in Interstitial Cells of Cajal

J. Huizinga, C. Mckay, 2006, Journal of Pharmacology and Experimental Therapeutics.

Clotrimazole-sensitive K+ currents regulate pacemaker activity in interstitial cells of Cajal.

J. Huizinga, Yaohui Zhu, Jing Ye, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal.

S. Sarna, J. Huizinga, I. Berezin, 1997, American journal of physiology. Gastrointestinal and liver physiology.

Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture

J. Huizinga, C. Barajas-López, G. Wright, 2014, Cellular & Molecular Biology Letters.

Discrepancies between c‐Kit positive and Ano1 positive ICC‐SMP in the W/Wv and wild‐type mouse colon; relationships with motor patterns and calcium transients

J. Huizinga, Y. Zhu, Ji-Hong Chen, 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

New transmitters and new targets in the autonomic nervous system

J. Huizinga, Carlos Barajas-López, JanD Huizinga, 1993, Current Opinion in Neurobiology.

Role of Calcium Channels in Pharmacological Modulation of Gastrointestinal Motility

Louis W C Liu, J. Huizinga, 1993 .

Modulation of the Pacemaker Activity in Circular Muscle of the Canine Colon

T. Y. El-Sharkawy, N. Diamant, J. Huizinga, 1984 .

Test of Normality for Integrated Change Point Detection and Mixture Modeling

J. Huizinga, S. Parsons, Jan D. Huizinga, 2012, The Journal of Membrane Biology.

Statistical Assessment of Change Point Detectors for Single Molecule Kinetic Analysis

J. Huizinga, S. Parsons, 2013, The Journal of Membrane Biology.

conduction system Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric

Louis W C Liu, W. Lammers, J. Huizinga, 2009 .

P2x‐purinoceptors of myenteric neurones from the guinea‐pig ileum and their unusual pharmacological properties

J. Huizinga, S. Collins, C. Barajas-López, 1996, British journal of pharmacology.

Nitric oxide decreases the excitability of interstitial cells of Cajal through activation of the BK channel

J. Huizinga, Yaohui Zhu, 2008, Journal of cellular and molecular medicine.

Characterization of depolarization‐evoked ERG K+ currents in interstitial cells of Cajal

J. Huizinga, C. Mckay, J. Ye, 2006, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Commentary: Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm

Jan D. Huizinga, J. Huizinga, 2017, Front. Neurosci..

Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP

J. Huizinga, S. Parsons, C. Barajas-López, 2014, Pflügers Archiv - European Journal of Physiology.

Ava[ L -Pro 9 , N -MeLeu10] Substance P(7-11) (GR 73632) and Sar 9 , Met(O 2 ) 11 Increase Distention-Induced Peristalsis through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal

J. Huizinga, Florentine Nieuwmeyer, Jing Ye, 2006 .

Canine colonic circular muscle generates action potentials without the pacemaker component.

L. W. Liu, J. Huizinga, L. W. Liu, 1994, Canadian journal of physiology and pharmacology.

Electrical coupling and pacemaker activity in colonic smooth muscle.

J. Huizinga, E. Chow, A. Shin, 1988, The American journal of physiology.

The powerful advantages of extracellular electrical recording

J. Huizinga, 2017, Nature Reviews Gastroenterology &Hepatology.

Pacemaker Activity and Intercellular Communication

J. Huizinga, 1995 .

The Sphincter of O’Beirne – Part 1: Study of 18 Normal Subjects

J. Huizinga, M. Pervez, Ji-Hong Chen, 2021, Digestive Diseases and Sciences.

Autism Spectrum Disorder in Children Is Not Associated With Abnormal Autonomic Nervous System Function: Hypothesis and Theory

J. Huizinga, Ji-Hong Chen, Ashley Barbier, 2022, Frontiers in Psychiatry.

Toward a Concept of Stretch Coupling in Smooth Muscle: A Thesis by Lars Thuneberg on Contractile Activity in Neonatal Interstitial Cells of Cajal

W. Lammers, J. Huizinga, H. Mikkelsen, 2010, Anatomical record.

Quinidine and quinine effects on the slow wave activity of colonic circular muscle.

J. Huizinga, C. Barajas-López, 1989, European journal of pharmacology.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

James C. Campbell, Dong I. Lee, M. Zaccolo, 2017, BMC Pharmacology and Toxicology.

Interstitial Cells of Cajal: Pacemaker Cells of the Pancreatic Duct?

N. Diamant, J. Huizinga, Xuan‐yu Wang, 2011, Pancreas.

Maxi-channels recorded in situ from ICC and pericytes associated with the mouse myenteric plexus.

J. Huizinga, S. Parsons, W. Kunze, 2012, American journal of physiology. Cell physiology.

Associations Between Colonic Motor Patterns and Autonomic Nervous System Activity Assessed by High-Resolution Manometry and Concurrent Heart Rate Variability

L. Schmidt, Yuhong Yuan, K. Mathewson, 2020, Frontiers in Neuroscience.

Intraluminal Prucalopride Increases Propulsive Motor Activitiesin the Human Colon

J. Huizinga, Ji-Hong Chen, Xuan‐yu Wang, 2020, medRxiv.

Interstitial Cells of Cajal: Pathology, injury and repair.

J. Huizinga, D. Al‐Sajee, 2012, Sultan Qaboos University medical journal.

Gastric Electrical Stimulation in Intractable Symptomatic Gastroparesis

J. Galmiche, J. Huizinga, B. Familoni, 2003, Digestion.

Characterization of haustral activity in the human colon.

J. Huizinga, M. Pervez, Ji-Hong Chen, 2021, American journal of physiology. Gastrointestinal and liver physiology.

Ouabain-induced excitation of colonic smooth muscle due to block of K+ conductance by intracellular Na+ ions.

J. Huizinga, C. Barajas-López, 1992, European journal of pharmacology.

Immunohistochemical localization of a gap junction protein (connexin43) in the muscularis externa of murine, canine, and human intestine

J. Huizinga, J. Rumessen, H. Mikkelsen, 1993, Cell and Tissue Research.

Heterogeneity in spontaneous and tetraethylammonium induced intracellular electrical activity in colonic circular muscle

J. Huizinga, C. Barajas-López, 1988, Pflügers Archiv.

Expression of P2X3 and P2X5 Myenteric Receptors Varies During the Intestinal Postnatal Development in the Guinea Pig

J. Huizinga, C. Barajas-López, L. Montaño, 2014, Cellular and Molecular Neurobiology.

Interstitial Cells of Cajal: Pacemaker Cells of the Pancreatic Duct?

N. Diamant, J. Huizinga, Xuan‐yu Wang, 2011, Pancreas.