S. Bell

发表

Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam.

S. Bell, Xuehui Chen, R. Sowden, 2002, Journal of the American Chemical Society.

Control of Structure Topology and Spatial Distribution of Biomacromolecules in Protein@ZIF-8 Biocomposites

S. Bell, Weibin Liang, C. Doonan, 2018 .

Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.

I. Schlichting, S. Bell, M. Cryle, 2010, Biochemistry.

P450(BM3) (CYP102A1): connecting the dots.

S. Bell, L. Wong, Christopher J. C. Whitehouse, 2012, Chemical Society reviews.

Examination of Selectivity in the Oxidation of ortho‐ and meta‐Disubstituted Benzenes by CYP102A1 (P450 Bm3) Variants

S. Bell, Samuel D. Munday, Shaghayegh Dezvarei, 2017 .

Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options.

R. J. Kenny, S. Bell, L. Wong, 2008, Chemical communications.

A Structural Model of a P450-Ferredoxin Complex from Orientation-Selective Double Electron-Electron Resonance Spectroscopy.

S. Bell, L. Wong, Weihong Zhou, 2017, Journal of the American Chemical Society.

The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum.

S. Bell, J. Bruning, S. A. Child, 2019, Biochimica et biophysica acta. General subjects.

The dynamics of camphor in the cytochrome P450 CYP101D2

P. Biggin, S. Bell, L. Wong, 2013, Protein science : a publication of the Protein Society.

Chain length-dependent cooperativity in fatty acid binding and oxidation by cytochrome P450BM3 (CYP102A1)

S. Bell, L. Wong, Christopher J. C. Whitehouse, 2011, Protein & Cell.

Rearrangement-Free Hydroxylation of Methylcubanes by a Cytochrome P450: The Case for Dynamical Coupling of C-H Abstraction and Rebound.

S. Bell, E. Krenske, Craig M. Williams, 2019, Journal of the American Chemical Society.

Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes

S. Bell, J. Bruning, T. Coleman, 2020, JBIC Journal of Biological Inorganic Chemistry.

Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal-Organic Frameworks.

S. Bell, H. Amenitsch, F. Carraro, 2019, Journal of the American Chemical Society.

Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1.

S. Bell, O. Shoji, Shaghayegh Dezvarei, 2018, Journal of inorganic biochemistry.

Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2.

S. Bell, L. Wong, Eachan O. Johnson, 2009, Molecular bioSystems.

P450BM3 (CYP102A1): Connecting the Dots

S. Bell, L. Wong, Christopher J. C. Whitehouse, 2012 .

Dearomatisation of o-xylene by P450BM3 (CYP102A1).

S. Bell, L. Wong, N. Rees, 2011, Chemistry.

Different Geometric Requirements for Cytochrome P450-Catalyzed Aliphatic Versus Aromatic Hydroxylation Results in Chemoselective Oxidation

S. Bell, J. Bruning, E. Krenske, 2022, ACS Catalysis.

Desaturation of alkylbenzenes by cytochrome P450(BM3) (CYP102A1).

S. Bell, L. Wong, Christopher J. C. Whitehouse, 2008, Chemistry.

Increasing the Activity and Efficiency of Stereoselective Oxidations by using Decoy Molecules in Combination with Rate‐Enhancing Variants of P450Bm3

S. Bell, Samuel D. Munday, Shaghayegh Dezvarei, 2016 .

The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis.

S. Bell, L. Wong, Weihong Zhou, 2015, Molecular bioSystems.

The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4

S. Bell, J. J. Voss, Rebecca R. Chao, 2016 .

An Altered Heme Environment in an Engineered Cytochrome P450 Enzyme Enables the Switch from Monooxygenase to Peroxygenase Activity

S. Bell, J. Bruning, P. Bernhardt, 2022, ACS Catalysis.

Aliphatic vs. aromatric C–H bond activation of phenylcyclohexane catalysed by cytochrome P450cam

S. Bell, L. Wong, S. Flitsch, 1996 .

Molecular Recognition in (+)-a-Pinene Oxidation by Cytochrome P450 cam

S. Bell, Xuehui Chen, R. Sowden, 2003 .

The effect of decoy molecules on the activity of the P450Bm3 holoenzyme and a heme domain peroxygenase variant

S. Bell, O. Shoji, Shaghayegh Dezvarei, 2019, Catalysis Communications.

Crystallization and preliminary X-ray diffraction studies of a ferredoxin reductase from Rhodopseudomonas palustris CGA009.

S. Bell, Feng Xu, L. Wong, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

CW and Pulse EPR of Cytochrome P450 to Determine Structure and Function

Jeanette E. Stok, S. Bell, J. J. Voss, 2017 .

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes.

S. Bell, F. Whelan, K. Shearwin, 2022, Chemical communications.

Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes

S. Bell, J. Bruning, T. Coleman, 2020, JBIC Journal of Biological Inorganic Chemistry.

Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

S. Bell, R. Sowden, L. Wong, 2005, Organic & biomolecular chemistry.

Improving the Monooxygenase Activity and the Regio- and Stereoselectivity of Terpenoid Hydroxylation Using Ester Directing Groups

S. Bell, Samuel D. Munday, Joel H. Z. Lee, 2016 .

Selective aliphatic carbon-hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes.

S. Bell, L. Wong, J. George, 2014, Organic & biomolecular chemistry.

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

S. Bell, C. Doherty, A. Hill, 2015, Nature Communications.

Structural information from orientationally selective DEER spectroscopy.

S. Bell, L. Wong, J. Dilworth, 2009, Physical chemistry chemical physics : PCCP.

Conjugate addition of organocopper reagents to gamma-alkoxybutenolides and application to the synthesis of non-racemic alkyl cyclopentenones.

S. Bell, J. Robertson, R. Ford, 2004, Organic & biomolecular chemistry.

Complementary and selective oxidation of hydrocarbon derivatives by two cytochrome P450 enzymes of the same family

S. Bell, Md. Raihan Sarkar, 2020 .

The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1

S. Bell, Joel H. Z. Lee, Md. Raihan Sarkar, 2017, Chembiochem : a European journal of chemical biology.

Enzyme Encapsulation in a Porous Hydrogen-Bonded Organic Framework.

S. Bell, H. Amenitsch, F. Carraro, 2019, Journal of the American Chemical Society.

Separation of electron-transfer and coupled chemical reaction components of biocatalytic processes using Fourier transform ac voltammetry.

A. Bond, S. Bell, L. Wong, 2005, Analytical chemistry.

Influence of the Synthesis and Storage Conditions on the Activity of Candida antarctica Lipase B ZIF-8 Biocomposites.

S. Bell, C. Doonan, P. Falcaro, 2021, ACS applied materials & interfaces.

Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00825f

S. Bell, C. Doonan, P. Falcaro, 2018, Chemical science.

Enzyme encapsulation in zeolitic imidazolate frameworks: a comparison between controlled co-precipitation and biomimetic mineralisation.

S. Bell, C. Doonan, P. Falcaro, 2016, Chemical communications.

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand–Protein Binding Affinities

C. Supuran, S. Bell, W. Donald, 2019, ACS central science.

P450 catalysed dehydrogenation

S. Bell, J. D. De Voss, S. Wong, 2017 .

Iron: Heme Proteins, Mono- & Dioxygenases

S. Bell, L. Wong, 2006 .

Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants.

Jeanette E. Stok, S. Bell, J. Clegg, 2019, Archives of biochemistry and biophysics.

In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1

Jeanette E. Stok, S. Bell, J. J. Voss, 2016 .

The efficient and selective biocatalytic oxidation of norisoprenoid and aromatic substrates by CYP101B1 from Novosphingobium aromaticivorans DSM12444

S. Bell, Emma A. Hall, 2015 .

Modification of an Enzyme Biocatalyst for the Efficient and Selective Oxidative Demethylation of para‐Substituted Benzene Derivatives

S. Bell, Ian C.‐K. Lau, Rebecca R. Chao, 2016 .

Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions.

S. Bell, J. Bruning, T. Coleman, 2019, Journal of inorganic biochemistry.

Stereoselective hydroxylation of isophorone by variants of the cytochromes P450 CYP102A1 and CYP101A1.

S. Bell, Shaghayegh Dezvarei, Joel H. Z. Lee, 2018, Enzyme and microbial technology.

CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives

S. Bell, J. Bruning, T. Coleman, 2015 .

A phthalate family oxygenase reductase supports terpene alcohol oxidation by CYP238A1 from Pseudomonas putida KT2440

S. Bell, L. Wong, G. Preston, 2013, Biotechnology and applied biochemistry.

Improving the affinity and activity of CYP101D2 for hydrophobic substrates

S. Bell, L. Wong, Weihong Zhou, 2013, Applied Microbiology and Biotechnology.

Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering.

S. Bell, L. Wong, Weihong Zhou, 2012, Chemistry.

Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity.

S. Bell, L. Wong, Eachan O. Johnson, 2012, Chemical communications.

Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzyme.

S. Bell, L. Wong, M. Bartlam, 2012, Acta crystallographica. Section D, Biological crystallography.

The structure of CYP101D2 unveils a potential path for substrate entry into the active site.

S. Bell, L. Wong, Z. Rao, 2011, The Biochemical journal.

Molecular Characterization of a Class I P450 Electron Transfer System from Novosphingobium aromaticivorans DSM12444*

S. Bell, L. Wong, Z. Rao, 2010, The Journal of Biological Chemistry.

A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans

S. Bell, L. Wong, N. Rees, 2010, Applied Microbiology and Biotechnology.

Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris.

S. Bell, Feng Xu, L. Wong, 2006, Biochemical and biophysical research communications.

The heme monooxygenase cytochrome P450cam can be engineered to oxidize ethane to ethanol.

S. Bell, Feng Xu, L. Wong, 2005, Angewandte Chemie.

The Metallothionein/Thionein System: An Oxidoreductive Metabolic Zinc Link

S. Bell, B. Vallee, B. Vallée, 2009, Chembiochem : a European journal of chemical biology.

Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris.

S. Bell, Feng Xu, L. Wong, 2008, Journal of molecular biology.

Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation

S. Bell, J. Bruning, T. Coleman, 2018 .

The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2.

S. Bell, T. Coleman, J. D. De Voss, 2016, Biochimica et biophysica acta.

Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris

S. Bell, Feng Xu, L. Wong, 2009, Proteins.

Cymredoxin, a [2Fe-2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12.

S. Bell, J. D. De Voss, J. E. Stok, 2023, Archives of biochemistry and biophysics.

Analysis and preliminary characterisation of the cytochrome P450 monooxygenases from Frankia sp. EuI1c (Frankia inefficax sp.).

D. Nelson, S. Bell, R. Feyereisen, 2019, Archives of biochemistry and biophysics.

Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria† †Electronic supplementary information (ESI) available: Details of M. marinum CYPome, experimental methods and additional data tables and figures. See DOI: 10.1039/c8sc01286e

S. Bell, T. Pukala, N. L. Le Brun, 2018, Chemical science.

A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis.

S. Bell, J. Bruning, S. A. Child, 2020, Journal of inorganic biochemistry.

Selective ϖ-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum.

S. Bell, S. A. Child, Vanessa P Rossi, 2019, Biochimica et biophysica acta. General subjects.

Characterisation of two self-sufficient CYP102 family monooxygenases from Ktedonobacter racemifer DSM44963 which have new fatty acid alcohol product profiles.

R. J. Young, S. Bell, Natasha K Maddigan, 2016, Biochimica et biophysica acta.

Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum.

S. Bell, J. Bruning, S. A. Child, 2018, The Biochemical journal.

The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum.

S. Bell, J. Bruning, J. D. De Voss, 2022, ACS infectious diseases.

d-Alanine–d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations

S. Bell, J. Bruning, J. L. Pederick, 2020, The Journal of Biological Chemistry.

Engineering the CYP101 system for in vivo oxidation of unnatural substrates.

S. Bell, L. Wong, C. F. Harford-Cross, 2001, Protein engineering.

Iron: Heme Proteins, Mono‐ & DioxygenasesBased in part on the article Iron: Heme Proteins, Mono‐ & Dioxygenases by Masanori Sono & John H. Dawson which appeared in the Encyclopedia of Inorganic Chemistry, First Edition.

S. Bell, L. Wong, 2006 .

Engineering cytochrome P450cam into an alkane hydroxylase

S. Bell, L. Wong, H. Boyd, 2003 .

Crystal Structure of the F87W/Y96F/V247L Mutant of Cytochrome P-450cam with 1,3,5-Trichlorobenzene Bound and Further Protein Engineering for the Oxidation of Pentachlorobenzene and Hexachlorobenzene* 210

S. Bell, Xuehui Chen, Feng Xu, 2002, The Journal of Biological Chemistry.

The electrochemistry of a heme-containing enzyme, CYP199A2, adsorbed directly onto a pyrolytic graphite electrode

A. Bond, S. Bell, L. Wong, 2007 .

Protein recognition in ferredoxin–P450 electron transfer in the class I CYP199A2 system from Rhodopseudomonas palustris

S. Bell, Feng Xu, L. Wong, 2010, JBIC Journal of Biological Inorganic Chemistry.

Purification , crystallization and preliminary crystallographic analysis of cytochrome P 450 203 A 1 from Rhodopseudomonas palustris

S. Bell, Feng Xu, X. Pang, 2007 .

The structure of a novel electron-transfer ferredoxin from Rhodopseudomonas palustris HaA2 which contains a histidine residue in its iron-sulfur cluster-binding motif.

S. Bell, L. Wong, Weihong Zhou, 2014, Acta crystallographica. Section D, Biological crystallography.

The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site.

S. Bell, L. Wong, Weihong Zhou, 2012, Dalton transactions.

Structural Basis for the Properties of Two Single‐Site Proline Mutants of CYP102A1 (P450BM3)

S. Bell, L. Wong, M. Bartlam, 2010, Chembiochem : a European journal of chemical biology.

A Highly Active Single‐Mutation Variant of P450BM3 (CYP102A1)

S. Bell, L. Wong, Z. Rao, 2009, Chembiochem : a European journal of chemical biology.

Redox properties of cytochrome p450BM3 measured by direct methods.

V. Urlacher, S. Bell, L. Wong, 2003, European journal of biochemistry.

The binding of nitrogen-donor ligands to the ferric and ferrous forms of cytochrome P450 enzymes.

S. Bell, Amna Ghith, H. Mohamed, 2023, Journal of inorganic biochemistry.

To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme.

C. R. Wang, S. Bell, J. Bruning, 2021, Inorganic chemistry.

Biophysical techniques to distinguish ligand binding modes in cytochrome P450 monooxygenases.

S. Bell, L. Wong, J. Bruning, 2020, Biochemistry.

Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant.

S. Bell, L. Wong, Z. Rao, 2011, Dalton transactions.

Biomimetic and Biocatalytic Synthesis of Bruceol.

S. Bell, C. Sumby, J. George, 2018, Angewandte Chemie.

The electrochemistry and scanning tunnelling microscopy of the flavoprotein putidaredoxin reductase on alkanethiol-modified gold

S. Bell, L. Wong, H. Hill, 2003 .

The selective oxidation of substituted aromatic hydrocarbons and the observation of uncoupling via redox cycling during naphthalene oxidation by the CYP101B1 system

S. Bell, Emma A. Hall, Raihan Sarkar, 2017 .

In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals

S. Bell, L. Wong, J. Dilworth, 2009, Physics in medicine and biology.

Influence of nanoscale structuralisation on the catalytic performance of ZIF-8: a cautionary surface catalysis study

S. Bell, K. Sumida, C. Doonan, 2018 .

Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates.

S. Bell, S. Pyke, S. Dasgupta, 2019, Chemical communications.

Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase.

S. Bell, Tegan P. Stockdale, J. D. De Voss, 2023, Journal of inorganic biochemistry.

The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum

S. Bell, J. Bruning, Amna Ghith, 2023, The Journal of Steroid Biochemistry and Molecular Biology.

The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.

S. Bell, J. Bruning, Amna Ghith, 2023, Archives of biochemistry and biophysics.

Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.

S. Sligar, S. Bell, M. Schuler, 2023, Journal of the American Chemical Society.

Understanding the Mechanistic Requirements for Efficient and Stereoselective Alkene Epoxidation by a Cytochrome P450 Enzyme

S. Bell, J. Bruning, E. Krenske, 2021 .

A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis

S. Bell, J. Bruning, S. A. Child, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

S. Bell, J. Bruning, E. Krenske, 2022, Chemistry.

Butane and propane oxidation by engineered cytochrome P450cam.

S. Bell, L. Wong, H. Boyd, 2002, Chemical communications.

Cytochrome P450-catalyzed oxidation of halogen-containing substrates.

S. Bell, J. Bruning, T. Coleman, 2023, Journal of inorganic biochemistry.

The use of directing groups enables the selective and efficient biocatalytic oxidation of unactivated adamantyl C-H bonds

S. Bell, S. Dasgupta, Emma A. Hall, 2016 .

P450 enzymes from the bacterium Novosphingobium aromaticivorans.

S. Bell, L. Wong, 2007, Biochemical and biophysical research communications.

Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules.

S. Bell, L. Wong, O. Shoji, 2016, Chemical communications.

The self-sufficient CYP102 family enzyme, Krac9955, from Ktedonobacter racemifer DSM44963 acts as an alkyl- and alkyloxy-benzoic acid hydroxylase.

S. Bell, Natasha K Maddigan, 2017, Archives of biochemistry and biophysics.