D. Sherman

发表

Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst

Alison R. H. Narayan, K. Houk, M. M. Gilbert, 2017, ACS central science.

Production of a polyhydroxyalkanoate biopolymer in insect cells with a modified eucaryotic fatty acid synthase

D. Sherman, M. Williams, J. A. Rahn, 1996, Applied and environmental microbiology.

Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis.

D. Sherman, Michael M. Schofield, 2013, Current opinion in biotechnology.

Structural basis for macrolactonization by the pikromycin thioesterase

Janet L. Smith, D. Sherman, D. Akey, 2006, Nature chemical biology.

Minimum Information about a Biosynthetic Gene cluster.

Carla S. Jones, M. Smanski, Jan Claesen, 2015, Nature chemical biology.

Microscale Adaptation of In Vitro Transcription/Translation for High‐Throughput Screening of Natural Product Extract Libraries

D. Sherman, M. Larsen, A. N. Lowell, 2015, Chemical biology & drug design.

Functional Analysis of MycE and MycF, Two O‐Methyltransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibiotics

D. Sherman, Shengying Li, Y. Anzai, 2009, Chembiochem : a European journal of chemical biology.

Uncovering Genes with Divergent mRNA-Protein Dynamics in Streptomyces coelicolor

Wei-Shou Hu, Timothy J. Griffin, David H. Sherman, 2008, PloS one.

Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins

M. Bibb, C. Khosla, D. Sherman, 1993, Journal of bacteriology.

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

W. Gerwick, Janet L. Smith, D. Sherman, 2016, ACS chemical biology.

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria.

Pieter C Dorrestein, Lena Gerwick, David H Sherman, 2015, Journal of natural products.

Biosynthesis of an engineered tautomycetin analogue via disruption of tmcK-encoding terminal decarboxylase in Streptomyces CK4412

D. Sherman, H. Shin, Sisun Choi, 2012 .

An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains

D. Sherman, Y. Anzai, Yohei Iizaka, 2021, Applied Microbiology and Biotechnology.

Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida

A. Bashan, A. Yonath, L. Valinsky, 2021, Nucleic acids research.

Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform.

Aravind Srinivasan, David H Sherman, Jonathan S Dordick, 2004, Biotechnology and bioengineering.

The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis.

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2009, Bioorganic & medicinal chemistry.

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998, Chemistry & biology.

Natural Diels-Alderases: Elusive and Irresistable.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2015, The Journal of organic chemistry.

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

W. Gerwick, Janet L. Smith, D. Sherman, 2017, ACS chemical biology.

Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts.

Dafna M. Abelson, Zachary Q. Beck, Richard E. Moore, 2006, ACS chemical biology.

Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.

D. Sherman, Sisun Choi, Eung-Soo Kim, 2007, Microbiology.

Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis

W. Gerwick, Janet L. Smith, D. Sherman, 2010, Proceedings of the National Academy of Sciences.

Characterization of the Bafilomycin Biosynthetic Gene Cluster from Streptomyces lohii

D. Sherman, Jinyong Yan, Shengying Li, 2013, Chembiochem : a European journal of chemical biology.

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Samuel T. Slocum, M. Demars, D. Sherman, 2017, Journal of the American Chemical Society.

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity.

W. Gerwick, D. Sherman, L. Gerwick, 2016, Natural product reports.

An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases.

David H Sherman, K. Reynolds, D. Sherman, 2004, Protein engineering, design & selection : PEDS.

bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina.

M. Hildebrand, D. Sherman, S. Sudek, 2004, Chemistry & biology.

Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases.

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2009, Journal of the American Chemical Society.

Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species

D. Sherman, E. Kim, K. D. Cramer, 1995, Journal of bacteriology.

Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation.

M. Bibb, D. Sherman, D. Hopwood, 1995, Biochimica et biophysica acta.

Multi-component microscale biosynthesis of unnatural cyanobacterial indole alkaloids.

D. Sherman, A. N. Lowell, Y. Khatri, 2020, ACS synthetic biology.

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.

Ashootosh Tripathi, David H Sherman, M. O'Neil-Johnson, 2015, Journal of the American Chemical Society.

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.

D. Sherman, A. N. Lowell, Joseph A. Chemler, 2020, Angewandte Chemie.

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Gavin J. Williams, D. Sherman, A. N. Lowell, 2020, Nature Communications.

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases

D. Sherman, A. N. Lowell, Joseph A. Chemler, 2020, Angewandte Chemie.

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

K. Houk, D. Sherman, G. Jiménez‐Osés, 2017, Journal of the American Chemical Society.

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

D. Sherman, Douglas A. Hansen, Aaron A. Koch, 2017, Journal of the American Chemical Society.

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae.

K. Reynolds, D. Sherman, Y. Yoon, 2002, Chemistry & biology.

Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae

Won Seok Jung, C. Choi, D. Sherman, 2006, Applied Microbiology and Biotechnology.

Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.

Alison R. H. Narayan, D. Sherman, Y. Yoon, 2013, Journal of the American Chemical Society.

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.

David H Sherman, Christian Kasey, Gavin J. Williams, 2017, ACS chemical biology.

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

K. Reynolds, D. Sherman, K. Håkansson, 2011, Chemistry & biology.

A global positive regulator afsR2 stimulates tautomycetin production via pathway-specific regulatory gene over-expression in Streptomyces sp. CK4412

D. Sherman, Sisun Choi, Eung-Soo Kim, 2009 .

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria.

W. Gerwick, D. Sherman, Adam C. Jones, 2009, Current opinion in chemical biology.

The Unique Mechanistic Transformations Involved in the Biosynthesis of Modular Natural Products from Marine Cyanobacteria

W. Gerwick, D. Sherman, L. Gerwick, 2010 .

Molecular Analysis of the Rebeccamycin l-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243

D. Sherman, C. Aldrich, T. Nishizawa, 2005, Journal of bacteriology.

Enzymatic assembly of the bis-indole core of rebeccamycin.

D. Sherman, D. E. Jayamaha, Chizuko Nishizawa-Harada, 2006, Journal of the American Chemical Society.

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

D. Sherman, T. Pochapsky, D. Tietz, 2017, Biochemistry.

Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne

D. Sherman, A. Tripathi, Yael M. Plotnick, 2018 .

Re-Engineering Nature's Catalysts

Alison R. H. Narayan, D. Sherman, 2013, Science.

Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.

Wei Zhang, G. Chlipala, D. Sherman, 2016, Tetrahedron letters.

A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Janet L. Smith, D. Sherman, S. Bernard, 2011, Journal of molecular biology.

Halogenase engineering and its utility in medicinal chemistry.

D. Sherman, A. Fraley, 2018, Bioorganic & medicinal chemistry letters.

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

D. Klepacki, A. Mankin, N. Vázquez-Laslop, 2017, Nucleic acids research.

Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450

D. Sherman, M. Ito, Y. Anzai, 2021, Journal of industrial microbiology & biotechnology.

Complementary Cell-Based High-Throughput Screens Identify Novel Modulators of the Unfolded Protein Response

R. Neubig, R. Kaufman, D. Sherman, 2011, Journal of biomolecular screening.

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

D. Sherman, D. Kranz, H. Eisen, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Chemoenzymatic Synthesis of Glycosylated Macrolactam Analogues of the Macrolide Antibiotic YC‐17

D. Sherman, D. G. Lee, Y. Yoon, 2015 .

OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.

Robert M. Williams, D. Sherman, F. Yu, 2016, Journal of the American Chemical Society.

Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes

D. Sherman, K. Håkansson, Haichuan Liu, 2007, Journal of the American Society for Mass Spectrometry.

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

K. Houk, Robert M. Williams, J. N. Sanders, 2018, Nature Chemical Biology.

Structural and functional analysis of AsbF: Origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis

Brian F. Pfleger, N. Bergman, A. Joachimiak, 2008, Proceedings of the National Academy of Sciences.

High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864

D. Sherman, F. Yu, Sujay Paul, 2017, Standards in Genomic Sciences.

Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.

K. Houk, D. Sherman, M. Garcia‐Borràs, 2020, ACS catalysis.

The role of HTS in drug discovery at the University of Michigan.

D. Sherman, A. Mapp, J. Grembecka, 2014, Combinatorial chemistry & high throughput screening.

DANSing with Caenorhabditis elegans

D. Sherman, Patrick J. Hu, 2009, Proceedings of the National Academy of Sciences.

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.

D. Sherman, Shengying Li, L. Podust, 2007, Journal of the American Chemical Society.

Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone*

D. Sherman, A. Sartorelli, M. Belcourt, 2001, The Journal of Biological Chemistry.

Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.

D. Sherman, S. Rockwell, A. Sartorelli, 2001, Cancer research.

Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.

D. Sherman, S. Rockwell, A. Sartorelli, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria.

W. Gerwick, D. Sherman, L. Gerwick, 2010, Natural product reports.

Chemoenzymatic synthesis of fluorinated polyketides

D. Sherman, Alexander Rittner, M. Grininger, 2022, Nature Chemistry.

Directed biosynthesis of fluorinated polyketides

D. Sherman, Alexander Rittner, M. Grininger, 2021, bioRxiv.

Synthesis of Triketide δ-Lactones

D. Sherman, Han-young Kang, Sang-Jung Kim, 2001 .

Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs.

D. Sherman, J. Montgomery, Abdur-Rafay Shareef, 2012, Chemical science.

Function of Cytochrome P450 Enzymes MycCI and MycG in Micromonospora griseorubida, a Producer of the Macrolide Antibiotic Mycinamicin

D. Sherman, Shengying Li, Y. Anzai, 2012, Antimicrobial Agents and Chemotherapy.

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

Jessica K. Gagnon, Chinmay Y. Majmudar, C. Brooks, 2012, Angewandte Chemie.

Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor.

R. Flavell, D. Sherman, P. Kincade, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.

G. Skiniotis, Janet L. Smith, D. Sherman, 2015, Current opinion in structural biology.

Identification of Protein Kinase C Activation as a Novel Mechanism for RGS2 Protein Upregulation through Phenotypic Screening of Natural Product Extracts

R. Neubig, J. Clardy, D. Sherman, 2014, Molecular Pharmacology.

Identification of PKC activation as a novel mechanism for RGS 2 protein up-regulation through phenotypic screening of natural product extracts

R. Neubig, J. Clardy, D. Sherman, 2014 .

Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

R. Kaufman, D. Sherman, G. Yoo, 2015, ACS medicinal chemistry letters.

Regulation of Petrobactin and Bacillibactin Biosynthesis in Bacillus anthracis under Iron and Oxygen Variation

Karla D. Passalacqua, D. Sherman, P. Hanna, 2011, PloS one.

An Enzyme Assembly Line

Janet L. Smith, D. Sherman, 2008, Science.

Structure and Function of NzeB, a Versatile C-C and C-N Bond Forming Diketopiperazine Dimerase.

K. Houk, J. N. Sanders, D. Sherman, 2020, Journal of the American Chemical Society.

Genetic analysis of petrobactin transport in Bacillus anthracis

D. Sherman, Shandee D. Dixon, B. Janes, 2010, Molecular microbiology.

Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

D. Sherman, H. Mobley, G. Tamayo-Castillo, 2017, Chemical communications.

The Phormidolide Biosynthetic Gene Cluster: A trans‐AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

W. Gerwick, D. Sherman, L. Gerwick, 2016, Chembiochem : a European journal of chemical biology.

Biochemical Evidence for an Editing Role of Thioesterase II in the Biosynthesis of the Polyketide Pikromycin*

K. Reynolds, D. Sherman, B. Kim, 2002, The Journal of Biological Chemistry.

Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.

Young Ji Yoo, W. Gerwick, D. Sherman, 2012, Organic letters.

Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Samuel T. Slocum, Janet L. Smith, D. Sherman, 2018, Methods in enzymology.

Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase.

D. Sherman, W. Seufert, J. D. Kittendorf, 2007, Chemistry & biology.

Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice

R. Flavell, D. Sherman, B. Huber, 1987, Molecular and cellular biology.

Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice

R. Flavell, D. Sherman, G. Waneck, 1987, The Journal of experimental medicine.

Characterization of the β‐Methylaspartate‐α‐decarboxylase (CrpG) from the Cryptophycin Biosynthetic Pathway

D. Sherman, Z. Beck, Douglas A. Burr, 2007 .

Molecular genetic analysis reveals a putative bifunctional polyketide cyclase/dehydrase gene from Streptomycea coelicolor and Streptomyces violoceoruber, and a cyclase/O-methyltransferase from Streptomyces glaucescens.

D. Sherman, D. Hopwood, T. J. Simpson, 1991 .

Expression of structurally diverse Qa-2-encoded molecules on the surface of cloned cytotoxic T lymphocytes

D. Sherman, D. Kranz, H. Eisen, 1984, The Journal of experimental medicine.

Expression of Microcystis Biosynthetic Gene Clusters in Natural Populations Suggests Temporally Dynamic Synthesis of Novel and Known Secondary Metabolites in Western Lake Erie

D. Sherman, G. Dick, F. Yu, 2022, bioRxiv.

Computational-based Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-membered Macrolide Antibiotics

Song Yang, J. Grandner, D. Sherman, 2020 .

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.

W. Gerwick, D. Sherman, K. Håkansson, 2006, Journal of the American Chemical Society.

Iterative chain elongation by a pikromycin monomodular polyketide synthase.

K. Reynolds, D. Sherman, C. Aldrich, 2003, Journal of the American Chemical Society.

Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis*

Brian F. Pfleger, G. Challis, A. Joachimiak, 2012, The Journal of Biological Chemistry.

Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway

D. Sherman, Hong-Se Oh, Han-young Kang, 2007 .

Modular Polyketide Synthases

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2012 .

Polyketide Biosynthesis: Modular Polyketide Synthases

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2008 .

Chemoenzymatic synthesis of cryptophycin/arenastatin natural products.

D. Sherman, G. Georg, N. Magarvey, 2005, Biochemistry.

Molecular Analysis of a 4-Dimethylallyltryptophan Synthase from Malbranchea aurantiaca*

Robert M. Williams, D. Sherman, Yousong Ding, 2008, Journal of Biological Chemistry.

Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products

D. Sherman, Jennifer J. Schmidt, M. L. Adrover-Castellano, 2021, ChemCatChem.

Production of a Polyhydroxyalkanoate Biopolymer in Insect Cells with a Modified Eucaryotic Fatty Acid Synthase

D. Sherman, Mark D. Williams, J. A. Rahn, 1996, Applied and Environmental Microbiology.

Expression and analysis of a bacterial poly(hydroxyalkanoate) synthase in insect cells using a baculovirus system.

D. Sherman, M. Williams, R. Grant, 1996, Protein expression and purification.

Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety [6]

D. Sherman, J. Thorson, Hung‐wen Liu, 1999 .

Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1999, Organic letters.

Mechanistic studies of desosamine biosynthesis: C-4 deoxygenation precedes C-3 transamination [18]

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Biosynthesis of Desosamine: Construction of a New Methymycin/Neomethymycin Analogue by Deletion of a Desosamine Biosynthetic Gene

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides

D. Sherman, S. Tsukamoto, H. Kato, 2019, Chembiochem : a European journal of chemical biology.

Structural Basis of Polyketide Synthase O-Methylation.

P. Wipf, W. Gerwick, Janet L. Smith, 2018, ACS chemical biology.

Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides.

D. Sherman, D. Wilson, Y. Xue, 2000, Gene.

Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.

G. Chlipala, D. Sherman, G. Tamayo-Castillo, 2014, Journal of the American Chemical Society.

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

W. Gerwick, Janet L. Smith, D. Sherman, 2018, ACS chemical biology.

Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids.

Robert M. Williams, D. Sherman, Shengying Li, 2012, Journal of the American Chemical Society.

Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique

D. Sherman, Pamela J. Schultz, P. Price, 2021, Marine drugs.

Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).

J. Frisvad, Robert M. Williams, D. Sherman, 2016, Angewandte Chemie.

Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii

Wei Zhang, D. Sherman, Yuanyuan Jiang, 2017, The Journal of Biological Chemistry.

Control of stereoselectivity in diverse hapalindole metabolites is mediated by cofactor induced combinatorial pairing of Stig cyclases.

Robert M. Williams, Jiachen Zi, D. Sherman, 2019, Angewandte Chemie.

Chemoenzymatic synthesis of fluorinated polyketides

D. Sherman, Alexander Rittner, M. Grininger, 2022, Nature Chemistry.

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase.

K. Reynolds, D. Sherman, C. Aldrich, 2003, Journal of the American Chemical Society.

Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae.

D. Sherman, Q. Zhang, 2001, Journal of natural products.

Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp.

Kenneth A. Miller, Robert M. Williams, D. Sherman, 2010, Journal of the American Chemical Society.

Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity.

D. Sherman, Robert M. Hohlman, 2021, Natural product reports.

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

Robert M. Williams, D. Sherman, F. Yu, 2017, Nature chemical biology.

Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae

K. Reynolds, D. Sherman, Daniel J. Wilson, 2001 .

Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest.

D. Sherman, F. Yu, Sujay Paul, 2017, Journal of Biotechnology.

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica

Z. Deng, L. Bai, D. Sherman, 2012, Applied Microbiology and Biotechnology.

Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica

D. Sherman, Eung-Soo Kim, Miyoung Lee, 2009, Journal of Industrial Microbiology & Biotechnology.

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

K. Houk, Robert M. Williams, J. N. Sanders, 2019, Nature Chemistry.

An NmrA-like enzyme-catalysed redox-mediated Diels–Alder cycloaddition with anti-selectivity

Mitchell D. Miller, G. Phillips, J. N. Sanders, 2023, Nature Chemistry.

Recent Developments in the Production of Novel Polyketides by Combinatorial Biosynthesis

K. Reynolds, D. Sherman, Y. Yoon, 2002, Biotechnology & genetic engineering reviews.

Genetic Localization and Molecular Characterization of Two Key Genes (mitAB) Required for Biosynthesis of the Antitumor Antibiotic Mitomycin C

D. Sherman, M. Varoglu, Yingqing Mao, 1999, Journal of bacteriology.

Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.

P. Güntert, C. Walsh, V. Dötsch, 2012, ACS chemical biology.

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis

Peter Wipf, David H Sherman, William H Gerwick, 2011, The Journal of Biological Chemistry.

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Janet L. Smith, D. Sherman, D. Akey, 2010, Angewandte Chemie.

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

David H Sherman, William H Gerwick, W. Gerwick, 2010, Structure.

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

David H Sherman, K. Reynolds, Janet L. Smith, 2009, ACS chemical biology.

Automated genome mining for natural products

Peter Man-Un Ung, Sylvie Garneau-Tsodikova, David H. Sherman, 2009, BMC Bioinformatics.

Clearing the skies over modular polyketide synthases.

Janet L. Smith, D. Sherman, 2006, ACS chemical biology.

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.

David H Sherman, William H Gerwick, W. Gerwick, 2004, Journal of natural products.

Efficient de novo construction of the indanepropionic acid precursor of 11-oxo steroids. An improved internal Diels-Alder sequence

D. Sherman, G. Stork, 1982 .

Diversity of P450 enzymes in the biosynthesis of natural products.

D. Sherman, L. Podust, 2012, Natural product reports.

Enantiomeric natural products: occurrence and biogenesis.

Robert M. Williams, D. Sherman, Jennifer M. Finefield, 2012, Angewandte Chemie.

Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis.

K. Houk, J. N. Sanders, D. Sherman, 2021, ACS catalysis.

Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.

Robert M. Williams, D. Sherman, F. Yu, 2015, Journal of the American Chemical Society.

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

P. Zimmerman, D. Sherman, Jia-Hui Tay, 2017, Journal of the American Chemical Society.

Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein.

D. Sherman, M. He, P. Sheldon, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery.

D. Sherman, N. Magarvey, C. Salomon, 2004, Natural product reports.

Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi.

J. Frisvad, Robert M. Williams, D. Sherman, 2018, Natural product reports.

Formal total synthesis of the polyketide macrolactone narbonolide.

D. Sherman, C. Aldrich, R. Fecik, 2005, The Journal of organic chemistry.

Stereoselective Synthesis of Baulamycin A.

Robert M. Williams, D. Sherman, Jonathan R. Thielman, 2020, The Journal of organic chemistry.

Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin A and incorporation into notoamide B and sclerotiamide.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2011, Organic letters.

Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.

J. Frisvad, Robert M. Williams, D. Sherman, 2012, Journal of natural products.

Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum.

Robert M. Williams, D. Sherman, James D. Sunderhaus, 2011, Israel journal of chemistry.

Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

G. Dodge, Janet L. Smith, D. Sherman, 2016, Journal of the American Chemical Society.

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Janet L. Smith, G. Chlipala, D. Sherman, 2012, Journal of the American Chemical Society.

Efficient, divergent synthesis of cryptophycin unit A analogues.

D. Sherman, S. Larsen, Kyle L. Bolduc, 2012, Chemical communications.

NRPS/PKS hybrid enzymes and their natural products

D. Sherman, J. D. Kittendorf, Jeffrey D. Kittendorf, 2010 .

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.

Mark Hildebrand, David H Sherman, M. Hildebrand, 2007, Journal of natural products.

Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide.

D. Sherman, C. Aldrich, R. Fecik, 2005, Journal of the American Chemical Society.

Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications.

J. Frisvad, Robert M. Williams, D. Sherman, 2015, Organic letters.

Fungal-derived brevianamide assembly by a stereoselective semipinacolase

Robert M. Williams, D. Sherman, A. Minami, 2020, Nature Catalysis.

Cofactor-Independent Pinacolase Directs Non-Diels-Alderase Biogenesis of the Brevianamides

Robert M. Williams, D. Sherman, A. Minami, 2019 .

Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A.

Janet L. Smith, D. Sherman, S. Tsukamoto, 2022, Journal of the American Chemical Society.

Structural and Data Science-Driven Analysis to Assess Substrate Specificity of Diketopiperazine Reverse Prenyltransferase NotF: Cascade Biocatalytic Synthesis of (–)-Eurotiumin A

Janet L. Smith, D. Sherman, S. Tsukamoto, 2021 .

Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway.

K. Houk, Robert M. Williams, Janet L. Smith, 2019, Journal of the American Chemical Society.

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs.

D. Sherman, F. Valeriote, Y. Khatri, 2020, ACS chemical biology.

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.

K. Houk, Song Yang, J. Grandner, 2020, Journal of the American Chemical Society.

Enzyme evolution in fungal indole alkaloid biosynthesis

D. Sherman, A. Fraley, 2020, The FEBS journal.

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

R. Sarpong, Robert M. Williams, Janet L. Smith, 2017, Journal of the American Chemical Society.

Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.

Robert M. Williams, D. Sherman, F. Yu, 2012, MedChemComm.

Biomimetic total synthesis of malbrancheamide and malbrancheamide B.

Kenneth A. Miller, Robert M. Williams, D. Sherman, 2008, The Journal of organic chemistry.

The Biosynthesis of Epoxides

D. Sherman, S. Grüschow, 2006 .

Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support.

D. Sherman, W. Seufert, Z. Beck, 2007, Angewandte Chemie.

Isolation and Characterization of Novel Marine-Derived Actinomycete Taxa Rich in Bioactive Metabolites

M. Dworkin, D. Sherman, N. Magarvey, 2004, Applied and Environmental Microbiology.

Structural characterization of the mitomycin 7‐O‐methyltransferase

G. Phillips, D. Sherman, J. Thorson, 2011, Proteins.

Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp. 307‐9

D. Sherman, Shengying Li, Y. Anzai, 2010, Chembiochem : a European journal of chemical biology.

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria

David J. Miller, D. Sherman, A. Tai, 2013, PloS one.

Structure of a modular polyketide synthase

Georgios Skiniotis, David H. Sherman, Alison R. H. Narayan, 2014, Nature.

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica

Z. Deng, L. Bai, D. Sherman, 2012, Applied Microbiology and Biotechnology.

Biochemistry: Enzyme's black box cracked open

D. Sherman, 2009, Nature.

Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway

M. Bibb, D. Sherman, D. Hopwood, 1992, Journal of bacteriology.

Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450

K. Houk, J. N. Sanders, Song Yang, 2019, The Journal of Biological Chemistry.

Bioconversion of 6-epi-Notoamide T Produces Metabolites of Unprecedented Structures in a Marine-derived Aspergillus sp.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2015, Tetrahedron letters.

Isolation of amoenamide A and five antipodal prenylated alkaloids from Aspergillus amoenus NRRL 35600.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2017, Tetrahedron letters.

Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications.

Robert M. Williams, D. Sherman, Yousong Ding, 2008, Journal of natural products.

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.

D. Sherman, D. Hopwood, 1990, Annual review of genetics.

Utilizing the Power of Microbial Genetics to Bridge the Gap Between the Promise and the Application of Marine Natural Products

D. Sherman, J. Fortman, 2005, Chembiochem : a European journal of chemical biology.

Substrate Controlled Divergence in Polyketide Synthase Catalysis

D. Sherman, Douglas A. Hansen, Aaron A. Koch, 2015, Journal of the American Chemical Society.

Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

Raghunath O. Ramabhadran, Alison R. H. Narayan, K. Houk, 2015, Nature Chemistry.

Precursor and Cofactor as a Check Valve for Cephamycin Biosynthesis in Streptomycesclavuligerus

D. Sherman, L. Malmberg, Y. Kyung, 1999, Biotechnology progress.

Crystal Structures of Acyl Carrier Protein in Complex with Two Catalytic Partners Show a Dynamic Role in Cellular Metabolism

D. Sherman, Sean A. Newmister, 2014, Chembiochem : a European journal of chemical biology.

Structural rearrangements of a polyketide synthase module during its catalytic cycle

Georgios Skiniotis, David H. Sherman, Alison R. H. Narayan, 2014, Nature.

Mechanisms of molecular recognition in the pikromycin polyketide synthase.

K. Reynolds, D. Sherman, S. Chen, 2000, Chemistry & biology.

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

S. Douthwaite, A. Mankin, N. Vázquez-Laslop, 2015, Proceedings of the National Academy of Sciences.

Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates.

David H Sherman, Courtney C Aldrich, D. Sherman, 2005, Journal of the American Chemical Society.

Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.

Renju T. Jacob, R. Kaufman, D. Sherman, 2015, ACS medicinal chemistry letters.

The Combined Use of Alphavirus Replicons and Pseudoinfectious Particles for the Discovery of Antivirals Derived from Natural Products

David J. Miller, D. Sherman, G. Tamayo-Castillo, 2015, Journal of biomolecular screening.

MScreen: an integrated compound management and high-throughput screening data storage and analysis system.

David H Sherman, Renju T. Jacob, Renju T Jacob, 2012, Journal of biomolecular screening.

Molecular biology of the H-2 histocompatibility complex.

R. Flavell, D. Sherman, L. Burkly, 1986, Science.

Metagenomic and Metatranscriptomic Insights into Population Diversity of Microcystis Blooms: Spatial and Temporal Dynamics of mcy Genotypes, Including a Partial Operon That Can Be Abundant and Expressed

S. Ruberg, K. Goodwin, D. Sherman, 2022, Applied and environmental microbiology.

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.

D. Sherman, K. Håkansson, Yousong Ding, 2011, Journal of the American Chemical Society.

Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae

K. Reynolds, D. Sherman, Daniel J. Wilson, 2001, Journal of bacteriology.

Biosynthesis of desosamine: Molecular evidence suggesting β- glucosylation as a self-resistance mechanism in methymycin/neomethymycin producing strain, Streptomyces venezuelae [7]

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways

S. Kelly, D. Lamb, M. Waterman, 2004, Protein science : a publication of the Protein Society.

The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1

Benjamin A. Neely, S. Kelly, D. Lamb, 2003, The Journal of Biological Chemistry.

Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.

Robert M. Williams, D. Sherman, Stephen Chamberland, 2009, Organic letters.

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.

J. Otlewski, Z. Dauter, D. Sherman, 2002, Structure.

Analysis of a Parallel Branch in the Mitomycin Biosynthetic Pathway Involving the mitN-Encoded Aziridine N-Methyltransferase*

D. Sherman, Yingqing Mao, N. Lopanik, 2007, Journal of Biological Chemistry.

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564.

D. Sherman, Y. Mao, M. Varoglu, 1999, Chemistry & biology.

Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation

Alison R. H. Narayan, D. Sherman, J. Montgomery, 2014, Journal of the American Chemical Society.

Total synthesis of narbonolide and biotransformation to pikromycin.

D. Sherman, C. Salomon, R. Fecik, 2006, The Journal of organic chemistry.

Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae.

Won Seok Jung, Ji Won Kim, C. Choi, 2006, Journal of natural products.

The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*

Youngchang Kim, David H Sherman, M. Waterman, 2006, Journal of Biological Chemistry.

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

D. Sherman, A. N. Lowell, Sung Ryeol Park, 2016, ACS chemical biology.

Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae

D. Sherman, D. Johnson, P. August, 1997, Journal of bacteriology.

Frontiers and opportunities in chemoenzymatic synthesis.

D. Sherman, Jonathan D Mortison, 2010, The Journal of organic chemistry.

Time‐lapsed confocal microscopy reveals temporal and spatial expression of the lysine ɛ‐aminotransferase gene in Streptomyces clavuligerus

D. Sherman, A. Khetan, D. H. Sherman, 1999, Molecular microbiology.

A genomic catalog of Earth’s microbiomes

Vincent J. Denef, Natalia N. Ivanova, Paramvir S. Dehal, 2020, Nature Biotechnology.

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

B. Walker, J. Hurley, D. Sherman, 2020, Proceedings of the National Academy of Sciences.

Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis

John A. Robinson, D. Sherman, D. Hopwood, 1992, Molecular and General Genetics MGG.

Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.

S Omura, M. Bibb, S. Ōmura, 1994, Gene.

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.

G. Skiniotis, W. Gerwick, D. Sherman, 2011, Angewandte Chemie.

Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillusanthracis

Brian F. Pfleger, Karla D. Passalacqua, N. Bergman, 2006, Journal of bacteriology.

Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412

Eung-Soo Kim, Ashootosh Tripathi, David H. Sherman, 2016, Journal of Industrial Microbiology & Biotechnology.

Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2)

Sarika Mehra, S. Charaniya, D. Sherman, 2008, BMC Genomics.

Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412

Y. Chang, D. Sherman, Y. Kim, 2009, Journal of Industrial Microbiology & Biotechnology.

Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans

D. Sherman, Karthik P. Jayapal, Wei-wei Lian, 2007, BMC Genomics.

Structural diversification of macrolactones by substrate-flexible cytochrome P450 monooxygenases

Won Seok Jung, C. Choi, D. Sherman, 2005 .

Site-Directed Mutagenesis on Putative Macrolactone Ring Size Determinant in the Hybrid Pikromycin-Tylosin Polyketide Synthase

Won Seok Jung, C. Choi, D. Sherman, 2003 .

Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae.

D. Sherman, Y. Xue, 2001, Metabolic engineering.

Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase.

D. Sherman, Y. Mao, M. Varoglu, 2001, Journal of the American Chemical Society.

Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein

D. Sherman, Y. Kyung, Wei-Shou Hu, 2001, Molecular microbiology.

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.

W. Gerwick, D. Sherman, P. Flatt, 2002, Gene.

Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways

Eric E. Allen, Alla Lapidus, Lena Gerwick, 2014, PloS one.

Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.

P. Wipf, W. Gerwick, Janet L. Smith, 2012, ACS chemical biology.

Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.

M. Bibb, D. Sherman, D. Hopwood, 1994, Gene.

The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide.

K. Reynolds, D. Sherman, S. Chen, 2001, Gene.

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes

D. Sherman, Shengying Li, Y. Anzai, 2011, Nature chemistry.

Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae

D. Sherman, P. August, M. Flickinger, 1994, Journal of bacteriology.

Biosynthetic principles in marine natural product systems

D. Sherman, J. D. Kittendorf, Jonathan D Mortison, 2012 .

The Role of Synthesis and Biosynthetic Logic

D. Sherman, Yousong Ding, 2010 .

A framework to analyze multiple time series data: A case study with Streptomyces coelicolor

Wei-Shou Hu, Sarika Mehra, David H. Sherman, 2006, Journal of Industrial Microbiology and Biotechnology.

High‐Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity

D. Sherman, J. Gestwicki, Pamela J. Schultz, 2014, Chemical biology & drug design.

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.

P. Dorrestein, W. Gerwick, D. Sherman, 2017, Journal of natural products.

Qa-2 antigen encoded by Q7b is biochemically indistinguishable from Qa-2 expressed on the surface of C57BL/10 mouse spleen cells.

R. Flavell, D. Sherman, G. Waneck, 1988, Journal of immunology.

Publications Committee Editorial Board Executive Editor Assistant Executive Editor

D. Sherman, J. Devlin, E. Weiss, 2012 .

Evolution and expression of the transplantation antigen gene family.

R. Flavell, D. Sherman, G. Widera, 1985, Federation proceedings.

Uncovering the Cultivable Microbial Diversity of Costa Rican Beetles and Its Ability to Break Down Plant Cell Wall Components

D. Sherman, G. Tamayo-Castillo, B. Rivera, 2014, PloS one.

Selective oxidation of carbolide C–H bonds by an engineered macrolide P450 mono-oxygenase

D. Sherman, J. Montgomery, Shengying Li, 2009, Proceedings of the National Academy of Sciences.

New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners

L. Yao, D. Sherman, Jinyong Yan, 2014, Journal of the American Chemical Society.

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae *

D. Sherman, Shengying Li, L. Podust, 2009, Journal of Biological Chemistry.

Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne

D. Sherman, P. Hanna, A. Tripathi, 2018, mBio.

Environmental Pseudomonads Inhibit Cystic Fibrosis Patient-Derived Pseudomonas aeruginosa

Fengan Yu, David H. Sherman, Daniel D. Wiegmann, 2016, Applied and Environmental Microbiology.

Chip‐Based Polyketide Biosynthesis and Functionalization

A. Srinivasan, J. Dordick, D. Sherman, 2006, Biotechnology progress.

Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows

Pieter C. Dorrestein, Lena Gerwick, William H. Gerwick, 2015, PloS one.

Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.

D. Sherman, J. Montgomery, Shengying Li, 2008, Chemistry & biology.

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743.

D. Sherman, G. Dick, Sunit Jain, 2015, Environmental microbiology.

Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases.

Zachary Q. Beck, D. Sherman, Z. Beck, 2006, Analytical biochemistry.

The Global Transcriptional Responses of Bacillus anthracis Sterne (34F2) and a ΔsodA1 Mutant to Paraquat Reveal Metal Ion Homeostasis Imbalances during Endogenous Superoxide Stress

Karla D. Passalacqua, N. Bergman, D. Sherman, 2007, Journal of bacteriology.

Role of Molecular Recognition in Determination of Macrolactone Ring Formation by the Pikromycin PKS

D. Sherman, 2006 .

Co-cultivation of microbial sub-communities in microfluidic droplets facilitates high-resolution genomic dissection of microbial 'dark matter'.

M. Burns, X. Lin, D. Sherman, 2020, Integrative biology : quantitative biosciences from nano to macro.

In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin.

D. Sherman, B. Hwang, Jung Yeop Lee, 2008, Pest management science.

Mitomycin Resistance in Streptomyces lavendulae Includes a Novel Drug-Binding-Protein-Dependent Export System

D. Sherman, M. He, P. Sheldon, 1999, Journal of bacteriology.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

David H Sherman, Kristina Håkansson, Christopher M Thomas, 2008, Chemistry & biology.

High-throughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction.

J. Dordick, D. Sherman, S. Kwon, 2007, ACS chemical biology.

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis.

David H Sherman, K. Reynolds, D. Sherman, 2002, Biochemistry.

Metamorphic enzyme assembly in polyketide diversification

P. Wipf, W. Gerwick, Janet L. Smith, 2009, Nature.

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.

James Inglese, David H Sherman, Min Shen, 2011, Chemistry & biology.

Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2011, The Journal of organic chemistry.

Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2011, Tetrahedron letters.

Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Hye Kyong Kweon, Robert M. Williams, D. Sherman, 2011, ACS chemical biology.

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

Bo Wang, Lena Gerwick, William H. Gerwick, 2009, Journal of the American Chemical Society.

Isolation of a new indoxyl alkaloid, Amoenamide B, from Aspergillus amoenus NRRL 35600: biosynthetic implications and correction of the structure of Speramide B.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2018, Tetrahedron letters.

Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca.

Kenneth A. Miller, Robert M. Williams, D. Sherman, 2008, Organic letters.

Engineered production of hapalindole alkaloids in the cyanobacterium Synechococcus sp. UTEX 2973.

D. Sherman, H. Pakrasi, Y. Khatri, 2019, ACS synthetic biology.

Molecular Analysis of the Role of Tyrosine 224 in the Active Site of Streptomyces coelicolor RppA, a Bacterial Type III Polyketide Synthase*

J. Dordick, D. Sherman, Shengying Li, 2007, Journal of Biological Chemistry.

New enzymes for “warheads”

D. Sherman, 2002, Nature Biotechnology.

Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation.

A. Srinivasan, J. Dordick, D. Sherman, 2005, Journal of the American Chemical Society.

Substrate Profile Analysis and ACP‐Mediated Acyl Transfer in Streptomyces coelicolor Type III Polyketide Synthases

J. Dordick, D. Sherman, W. Seufert, 2007, Chembiochem : a European journal of chemical biology.

GNAT-Like Strategy for Polyketide Chain Initiation

W. Gerwick, Janet L. Smith, D. Sherman, 2007, Science.

Phylogenetic and Chemical Diversity of Three Chemotypes of Bloom-Forming Lyngbya Species (Cyanobacteria: Oscillatoriales) from Reefs of Southeastern Florida

S. Matthew, D. Sherman, V. Paul, 2009, Applied and Environmental Microbiology.

Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2013, Organic letters.

STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2010, Heterocycles.

Characterization of the initial enzymatic steps of barbamide biosynthesis.

W. Gerwick, D. Sherman, P. Flatt, 2006, Journal of natural products.

Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.

D. Sherman, Sisun Choi, Eung-Soo Kim, 2008, Microbiology.

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

Robert M. Williams, W. Koch, D. Sherman, 2019, Proceedings of the National Academy of Sciences.

Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway

D. Sherman, G. Tamayo-Castillo, F. Yu, 2016, Nature Communications.

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase.

K. Reynolds, D. Sherman, Y. Yoon, 2002, Chemistry & biology.

Alternative modular polyketide synthase expression controls macrolactone structure

David H. Sherman, D. Sherman, Yongquan Xue, 2000, Nature.

Proteobactin and a yersiniabactin‐related siderophore mediate iron acquisition in Proteus mirabilis

D. Sherman, H. Mobley, Melanie M. Pearson, 2010, Molecular microbiology.

A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster

S. Gruber, J. Barton, D. Sherman, 2018, Nature Chemistry.

Simultaneous Analysis of Spatio‐Temporal Gene Expression for Cephamycin Biosynthesis in Streptomycesclavuligerus

D. Sherman, Y. Kyung, Wei-Shou Hu, 2001, Biotechnology progress.

Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity.

D. Sherman, W. Seufert, Yousong Ding, 2008, Journal of the American Chemical Society.

The Lego-ization of polyketide biosynthesis

David H Sherman, D. Sherman, 2005, Nature Biotechnology.

Functional Dissection of a Multimodular Polypeptide of the Pikromycin Polyketide Synthase into Monomodules by Using a Matched Pair of Heterologous Docking Domains

David H Sherman, Shuchi Gupta, K. Reynolds, 2009, Chembiochem : a European journal of chemical biology.

DDAP: docking domain affinity and biosynthetic pathway prediction tool for type I polyketide synthases

Tingyang Li, Ashootosh Tripathi, Fengan Yu, 2019, bioRxiv.

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.

W. Gerwick, Janet L. Smith, D. Sherman, 2015, Structure.

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.

W. Gerwick, Janet L. Smith, D. Sherman, 2019, Structure.

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

W. Gerwick, Janet L. Smith, D. Sherman, 2016, Proceedings of the National Academy of Sciences.

Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.

X. Su, R. Guha, J. Clardy, 2015, Journal of Natural Products.

Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.

Robert M. Williams, Janet L. Smith, D. Sherman, 2018, Organic & biomolecular chemistry.

Crystal Structure of the ECH2 Catalytic Domain of CurF from Lyngbya majuscula

W. Gerwick, Janet L. Smith, D. Sherman, 2007, Journal of Biological Chemistry.

Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis.

Brian F. Pfleger, D. Sherman, C. Aldrich, 2007, Biochemistry.

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

David H Sherman, William H Gerwick, W. Gerwick, 2013, Chemistry & biology.

Analysis of Rate‐limiting Reactions in Cephalosporin Biosynthesis a

D. Sherman, L. Malmberg, D. H. Sherman, 1992, Annals of the New York Academy of Sciences.

Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

D. Sherman, K. Håkansson, C. Rath, 2010, Chemistry & biology.

SSHSH O ATKS TEACP module 6 end PikAIV SHSH OH ATKS TEACP module 6 end PikAIV SSH OH ATKS TEACP module 6 end PikAIV OH ATKS TEACP module 6 end PikAIV

K. Reynolds, D. Sherman, K. Håkansson, 2011 .

Enzymatic Release and Macrolactonization of Cryptophycins from a Safety-Catch Solid Support This project was generously funded by the Swiss National Science Foundation (PBBS2-113008 to W.S.) and NIH CA076477 (to D.H.S.)

David H. Sherman, Wolfgang Seufert, Zachary Q. Beck, 2007 .

Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases.

K. Houk, J. N. Sanders, D. Sherman, 2023, Angewandte Chemie.

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels

Janet L. Smith, D. Sherman, D. Akey, 2006, Nature chemical biology.

The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle

Alison R. H. Narayan, G. Skiniotis, Janet L. Smith, 2013 .

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

Gavin J. Williams, D. Sherman, A. N. Lowell, 2019, Journal of the American Chemical Society.

Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.

Janet L. Smith, D. Sherman, S. Bernard, 2015, ACS chemical biology.

Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412

D. Sherman, H. Shin, Sisun Choi, 2012, Journal of Industrial Microbiology & Biotechnology.

Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site.

D. Sherman, Shengying Li, Y. Anzai, 2010, FEMS microbiology letters.

Gene targeting forO-methyltransferase genes,mycEandmycF,on the chromosomeofMicromonosporagriseorubida producing mycinamicinwithadisruption cassette containing the bacteriophage/C31attB attachment site

D. Sherman, Shengying Li, Y. Anzai, 2010 .

Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX

D. Sherman, P. Hanna, A. Tripathi, 2017, mBio.

Siderophore Pathway from Bacillus anthracis

Brian F. Pfleger, Karla D. Passalacqua, N. Bergman, 2006 .

Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions*

D. Sherman, Shengying Li, Y. Anzai, 2012, The Journal of Biological Chemistry.

Natural Diels-Alderases: Elusive and Irresistable

Robert M. Williams, D. Sherman, S. Tsukamoto, 2016 .

Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics

K. Houk, D. Sherman, M. Garcia‐Borràs, 2021, ACS Catalysis.

Investigating Metabolic Trends in the Oral Cavity to Identify Novel Metabolites

D. Sherman, W. Giannobile, J. Kinney, 2023, bioRxiv.

Developing tools for engineering hybrid polyketide synthetic pathways.

David H Sherman, D. Sherman, J. D. Kittendorf, 2006, Current opinion in biotechnology.

Structural basis for the antibacterial activity of the 12-membered-ring mono-sugar macrolide methymycin

A. Bashan, A. Yonath, H. Rozenberg, 2010 .

Structure and activity of DmmA, a marine haloalkane dehalogenase

W. Gerwick, Janet L. Smith, D. Sherman, 2012, Protein science : a publication of the Protein Society.

High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864

D. Sherman, F. Yu, Sujay Paul, 2017, Standards in genomic sciences.

Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.

D. Sherman, Shengying Li, Jacob C. Carlson, 2009, Journal of natural products.

Characterization of Two Type I Polyketide Sythases Methyltransferase Domains from the Curacin A Biosynthetic Pathway

Janet L. Smith, D. Sherman, S. Bernard, 2015 .

Epoxidation and late-stage C-H functionalization by P450 TamI is mediated by variant heme-iron oxidizing species

K. Houk, D. Sherman, Y. Khatri, 2021, ACS Catalysis.

Automated genome mining for natural products

D. Sherman, P. Ung, S. Garneau‐Tsodikova, 2009, BMC Bioinform..

Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis.

D. Sherman, G. Tamayo-Castillo, Pamela J. Schultz, 2020, Tetrahedron letters.

Erratum: Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in staphylococcus aureus and bacillus anthracis (Journal of the American Chemical Society (2014) 136 (1579-1586)) DOI:10.1021/ja4115924)

G. Chlipala, D. Sherman, G. Tamayo-Castillo, 2014 .

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic Engineering of Cephalosporin Biosynthesis in Streptomyces clavuligerus a

W. S. Hu, D. Sherman, A. Khetan, 1996, Annals of the New York Academy of Sciences.

Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter.

D. Sherman, A. Khetan, Anurag Khetan, 2000, Microbiology.

Structure of a modular polyketide synthase reducing region.

Janet L. Smith, D. Sherman, D. Akey, 2023, Structure.

Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae.

D. Sherman, P. August, J. A. Rahn, 1996, Gene.

Enantiomeric natural products: occurrence and biogenesis.

Robert M. Williams, D. Sherman, Jennifer M. Finefield, 2012, Angewandte Chemie.

Minimum Information about a Biosynthetic Gene cluster.

M. Smanski, Jan Claesen, B. Shen, 2015, Nature chemical biology.

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

Christopher M Thomas, D. Sherman, K. Håkansson, 2008, Chemistry & biology.

Molecular Analysis of a 4-Dimethylallyltryptophan Synthase from Malbranchea aurantiaca*

Robert M. Williams, D. Sherman, Yousong Ding, 2008, Journal of Biological Chemistry.

Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants

D. Sherman, D. Hopwood, E. Kim, 1994, Journal of bacteriology.

Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity.

Zachary Q. Beck, D. Sherman, W. Seufert, 2008, Journal of the American Chemical Society.

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

Jessica K. Gagnon, Chinmay Y. Majmudar, C. Brooks, 2012, Angewandte Chemie.

Functional Dissection of a Multimodular Polypeptide of the Pikromycin Polyketide Synthase into Monomodules by Using a Matched Pair of Heterologous Docking Domains

K. Reynolds, Shuchi Gupta, D. Sherman, 2009, Chembiochem : a European journal of chemical biology.

MScreen

Renju T. Jacob, R. Neubig, D. Sherman, 2012, Journal of biomolecular screening.