M. Paine

发表

Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases.

N. Scrutton, A. Gutiérrez, C. Wolf, 2000, Biochemistry.

Cloning and Characterization of a Novel Human Dual Flavin Reductase*

C. Wolf, M. Paine, A. P. Garner, 2000, The Journal of Biological Chemistry.

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

N. Scrutton, A. Gutiérrez, C. Wolf, 2002, Biochemistry.

Rainbow tags: a visual tag system for recombinant protein expression and purification.

Robert D Finn, Mark J I Paine, R. Finn, 2005, BioTechniques.

Engineering of a functional human NADH-dependent cytochrome P450 system.

C. Wolf, G. Roberts, M. Paine, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

M. Sutcliffe, C. Wolf, G. Roberts, 2003, The Biochemical journal.

Role of conserved Asp 293 of cytochrome P 450 2 C 9 in substrate recognition and catalytic activity

M. Sutcliffe, C. Wolf, G. Roberts, 2022 .

Mass Drug Administration and beyond: how can we strengthen health systems to deliver complex interventions to eliminate neglected tropical diseases?

T. Hollingsworth, M. Paine, S. Torr, 2015, BMC Proceedings.

CHAPTER 39 – PRIMARY MYELOPATHIES (DEGENERATIVE, INFECTIVE, METABOLIC)

M. Paine, 2007 .

Structural studies on FMN domain of cytochrome P450 reductase.

C. Wolf, L. Lian, G. Roberts, 1995, Biochemical Society transactions.

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

C. Wolf, M. Paine, D. Kostrzewa-Nowak, 2012, Anti-cancer drugs.

IN SILICO AND IN VITRO SCREENING FOR INHIBITION OF CYTOCHROME P450 CYP3A4 BY COMEDICATIONS COMMONLY USED BY PATIENTS WITH CANCER

Gordon C K Roberts, Simon J Brown, C Roland Wolf, 2006, Drug Metabolism and Disposition.

Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite

M. Paine, J. Crampton, M. Paine, 1996, European journal of immunology.

Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian "armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin.

M. Paine, J. Crampton, R. Theakston, 1993, The Journal of biological chemistry.

Reviewing the evidence for and against selection of specific pyrethroids for programmatic purposes

M. Paine, D. Weetman, P. McCall, 2020 .

Gene expression in Echis carinatus (carpet viper) venom glands following milking.

M. Paine, J. Crampton, R. Theakston, 1992, Toxicon : official journal of the International Society on Toxinology.

cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom.

M. Paine, S. Kawabata, S. Iwanaga, 1995, Biochemistry.

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6‐drug interactions

M. Sutcliffe, Jean‐Didier Maréchal, C. Wolf, 2008, British journal of pharmacology.

Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?

M. Sutcliffe, Jean‐Didier Maréchal, C. Wolf, 2005, Journal of Biological Chemistry.

Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility

J. Hemingway, M. Paine, G. Lycett, 2006, Insect molecular biology.

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

R. Poulsom, C. Wolf, G. Roberts, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.

W U Primrose, M. Sutcliffe, C. Wolf, 1996, Biochemistry.

Assessing cross-resistance within the pyrethroids in terms of their interactions with key cytochrome P450 enzymes and resistance in vector populations

C. Moyes, P. Hancock, M. Paine, 2021, Parasites & vectors.

Electron Transfer Partners of Cytochrome P450

N. Scrutton, A. Gutiérrez, A. Munro, 2005 .

Chapter 240 – Ecarin

M. Paine, G. Laing, 2013 .

Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.

M. Paine, J. Crampton, M. Paine, 1992, The Journal of biological chemistry.

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

C. Wolf, G. Roberts, M. Paine, 1996, Archives of Biochemistry and Biophysics.

Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.

C. Wolf, M. Paine, D. Kostrzewa-Nowak, 2007, Cancer letters.

Contribution of Lstm to the Control of Neglected Tropical Diseases

T. Hollingsworth, M. Paine, S. Torr, 2022 .

Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu

T. Russell, J. Morgan, J. Hemingway, 2014, Malaria Journal.

Fit for purpose: do we have the right tools to sustain NTD elimination?

T. Hollingsworth, M. Paine, H. Ranson, 2015, BMC Proceedings.

IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE

Gordon C K Roberts, Simon J Brown, Jean-Didier Maréchal, 2006, Drug Metabolism and Disposition.

In Silico Prediction of Drug Binding to Cytochrome P450 2D6: Identification of a new Metabolite of Metoclopramide

Simon J Brown, M. Sutcliffe, Jean‐Didier Maréchal, 2006 .

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

P. Ortiz de Montellano, C. Wolf, M. Paine, 1999, Cancer research.

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells.

C. Wolf, M. Paine, D. Kostrzewa-Nowak, 2012, European journal of pharmacology.

The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines

C. Wolf, M. Paine, D. Kostrzewa-Nowak, 2005, British Journal of Cancer.

Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.

C. Wolf, M. Paine, E. Borowski, 2003, Oncology research.

The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: Evolution of venom group II phospholipase A2's may imply gene duplications

M. Paine, J. Crampton, A. Moura-da-Silva, 1995, Journal of Molecular Evolution.

Cloning of Metalloprotease Genes in the Carpet Viper (Echis pyramidurm leakeyi)

M. Paine, J. Crampton, A. Moura-da-Silva, 1994 .

Crystal structure of the FMN‐binding domain of human cytochrome P450 reductase at 1.93 Å resolution

P. McDonagh, Qiang Zhao, C. Wolf, 1999, Protein science : a publication of the Protein Society.

Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.

C. Wolf, L. Lian, G. Roberts, 2001, Biochemistry.

Processing of pro-tumour necrosis factor-α by venom metalloproteinases: a hypothesis towards explaining local tissue damage following snakebite

M. Paine, J. Crampton, A. Moura-da-Silva, 1997 .

Electron transfer in human cytochrome P450 reductase.

N. Scrutton, A. Gutiérrez, A. Munro, 2001, Biochemical Society transactions.

Improving the performance of spray operators through monitoring and evaluation of insecticide concentrations of pirimiphos-methyl during indoor residual spraying for malaria control on Bioko Island

M. Paine, T. Weppelmann, G. García, 2020, Malaria journal.

Specific identification of western Atlantic Ocean scombrids using mitochondrial DNA cytochrome C oxidase subunit I (COI) gene region sequences

J. Graves, M. Paine, J. McDowell, 2007 .

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.

C. Wolf, M. Paine, S. Clarke, 2001, Archives of biochemistry and biophysics.

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450

C. Wolf, L. Lian, G. Roberts, 1997, Journal of biomolecular NMR.

Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase.

H P Driessen, L Y Lian, G C Roberts, 1996, Journal of structural biology.

Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.

R. Finn, N. Scrutton, A. Munro, 2003, European journal of biochemistry.

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Gordon C K Roberts, Jean-Didier Maréchal, C Roland Wolf, 2004, The Biochemical journal.

Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6*

Gordon C K Roberts, C Roland Wolf, Mark J I Paine, 2003, The Journal of Biological Chemistry.

Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1

R. Finn, Gillian Smith, M. Wilkie, 2005, Pharmacogenetics and genomics.

Cycling and Bioreductive Anticancer Agents Nitric Oxide Synthases Catalyze the Activation of Redox Updated

C. Wolf, M. Paine, E. Chinje, 1999 .

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

M. Sutcliffe, Jean‐Didier Maréchal, C. Wolf, 2008, Drug Metabolism and Disposition.