G. Adams

发表

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

A. Harris, A. Patterson, H. Barham, 1995, British Journal of Cancer.

Reactivity of the Hydroxyl Radical in Aqueous Solutions.

G. Adams, L. M. Dorfman, Leon M Dorfman, 1973 .

Manipulation and exploitation of the tumour environment for therapeutic benefit.

G. Adams, I. Stratford, P. Wood, 1994, International journal of radiation biology.

Hypoxia‐mediated druGS FOR RADIATION AND CHEMOTHERAPY

G. Adams, 1981 .

In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts: effects of blood flow modification.

G. Radda, J. Dunn, G. Adams, 1991, British Journal of Cancer.

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo.

G. Adams, I. Stratford, M. Jaffar, 1997, Journal of medicinal chemistry.

Hypoxia-mediated drugs for radiation and chemotherapy.

G. Adams, 1981, Cancer.

Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

G. Adams, I. Stratford, 1977, British Journal of Cancer.

HYPOXIC CELL SENSITISERS IN RADIOTHERAPY

J. Fowler, G. Adams, S. Dische, 1976, The Lancet.

Chemical radiosensitization of hypoxic cells.

G. Adams, 1973, British Medical Bulletin.

Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.

G. Adams, M. Watts, K. Patel, 1974, Radiation research.

Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria.

G. Adams, M. Cooke, 1969, International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine.

Electron affinic sensitization. II. Para-nitroacetophenone: a radiosensitizer for anoxic bacterial and mammalian cells.

G. Adams, R. Willson, B. Michael, 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Radical oxidation mechanisms in cellular radiosensitisation: electron transfer in the pulse radiolysis of aqueous nucleotide solutions.

G. Adams, R. Willson, J. V. van Hemmen, 1972, Radiation Research.

Combination of photodynamic therapy (PDT) and melphalan in experimental tumors.

J. K. Bradley, G. Adams, I. Stratford, 1994, International journal of radiation oncology, biology, physics.

Redox, Radiation, and Reductive Bioactivation

G. Adams, 1992 .

BIOREDUCTIVE DRUGS - DUAL FUNCTION AGENTS AND RELATED COMPOUNDS

G. Adams, I. Stratford, P. Wood, 1992 .

Fused pyrazine mono-n-oxides as bioreductive drugs. II Cytotoxicity in human cells and oncogenicity in a rodent transformation assay.

S. X. Liu, E. Hall, G. Adams, 1996, International journal of radiation oncology, biology, physics.

The measurement of radiosensitizer-induced changes in mouse tumor metabolism by 31P magnetic resonance spectroscopy.

G. Adams, M. Horsman, P. Wood, 1991, International journal of radiation oncology, biology, physics.

The olivine — clinopyroxene geobarometer: experimental results in the CaO-FeO-MgO-SiO2 system

G. Adams, F. C. Bishop, 1986 .

The Klaas Breur Lecture. Radiation, hypoxia and genetic stimulation: implications for future therapies.

G. Adams, M. Joiner, N. Hasan, 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo.

G. Adams, I. Stratford, P. Sheldon, 1984, International journal of radiation oncology, biology, physics.

Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo.

G. Adams, I. Stratford, P. Sheldon, 1984, British Journal of Cancer.

The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31P magnetic resonance spectroscopy.

G. Adams, I. Stratford, P. Wood, 1992, International journal of radiation oncology, biology, physics.

Selective free radical reactions with proteins and enzymes: reactions of inorganic radical anions with amino acids.

J. Aldrich, G. Adams, J. Redpath, 1972, Radiation research.

A posteffect of oxygen in irradiated bacteria: a submillisecond fast mixing study.

G. Adams, B. Michael, M. Watts, 1973, Radiation research.

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.

C. Thiemermann, G. Adams, I. Stratford, 1994, Cancer research.

Radiation and cancer: a two-edged sword.

G. Adams, 1987, The British journal of cancer. Supplement.

The clinical relevance of tumour hypoxia.

G. Adams, 1990, European journal of cancer.

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo.

G. Adams, I. Stratford, J. Godden, 1989, International journal of radiation biology.

Does initial haemoglobin level modify the efficacy of radiosensitizers? An analysis of the MRC misonidazole studies in head and neck cancer and cervix cancer.

N. Bleehen, G. Adams, S. Dische, 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

The biological basis of radiotherapy. Second edition

A. Horwich, G. Adams, G. Steel, 1989 .

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential.

G. Adams, I. Stratford, P. Wardman, 1980, Journal of the National Cancer Institute.

Mammalian cell toxicity of nitro compounds : dependence upon reduction potential.

E. Clarke, G. Adams, I. Stratford, 1976, Biochemical and biophysical research communications.

RADIATION CHEMICAL MECHANISMS IN RADIATION BIOLOGY.

G. Adams, 1972 .

Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.

G. Adams, S. Dische, M. Saunders, 1977, British Journal of Cancer.

Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations.

G. Adams, S. Dische, I. Flockhart, 1976, Clinical radiology.

Radiation Sensitizers and Related Compounds: New Approaches to Modification of Radiation Response

G. Adams, I. Stratford, 1988 .

Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069.

G. Adams, I. Stratford, J. Walling, 1988, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Lethality from acute and protracted radiation exposure in man. An account of a forum organized by the Medical Research Council's Committee on Effects of Ionising Radiation, 17 November 1983. Abstracts.

G. Adams, 1984, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Induction of tumour hypoxia by a vasoactive agent A combined NMR and radiobiological study

S. Frostick, G. Adams, G. Radda, 1989, FEBS letters.

Radiosensitizers of hypoxic cells in solid tumors.

J. Fowler, G. Adams, J. Denekamp, 1976, Cancer treatment reviews.

Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine.

G. Adams, I. Stratford, J. Nolan, 1988, British Journal of Cancer.

Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.

G. Adams, I. Stratford, E. Smith, 1980, British Journal of Cancer.

Hypoxic cell sensitizers for radiotherapy.

G. Adams, 1978, International journal of radiation oncology, biology, physics.

Energy Migration in DNA Irradiated in the Solid State

G. Adams, E. Fielden, P. O'Neill, 1990 .

Potentiation of cyclophosphamide cytotoxicity in vivo: a study with misonidazole and fifteen other 1-substituted 2-nitroimidazoles.

G. Adams, D. Chaplin, P. Sheldon, 1984, International journal of radiation oncology, biology, physics.

HYDRATED ELECTRONS AND RADIOBIOLOGICAL SENSITISATION.

G. Adams, D. L. Dewey, D. Dewey, 1963, Biochemical and biophysical research communications.

Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents.

G. Adams, I. Stratford, J. Godden, 1989, International journal of radiation oncology, biology, physics.

Magnetic resonance spectroscopy studies on experimental murine and human tumors: comparison of changes in phosphorus metabolism with induced changes in vascular volume.

G. Adams, I. Stratford, P. Wood, 1992, International journal of radiation oncology, biology, physics.

Bioreductive drugs and the selective induction of tumour hypoxia.

G. Adams, I. Stratford, J. C. Bremner, 1990, British Journal of Cancer.

Radiosensitization in vivo: a study with an homologous series of 2-nitroimidazoles.

G. Adams, I. Stratford, D. Chaplin, 1983, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Potentiation of melphalan activity against a murine tumour by nitroimidazole compounds.

G. Adams, P. Sheldon, E. Batten, 1982, British Journal of Cancer.

On the mechanism of the radiation-induced inactivation of ribonuclease in dilute aqueous solution.

G. Adams, R. Willson, R. Cundall, 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Identification of Essential Residues in Lysozyme: a Pulse Radiolysis Method

J. Aldrich, G. Adams, R. Willson, 1969, Nature.

Radiation-induced luminescence in DNA: evidence for long-range electron migration.

G. Adams, M. Naylor, E. Fielden, 1994, Radiation research.

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.

G. Adams, I. Stratford, P. Wardman, 1976, Radiation research.

Magnetic resonance spectroscopic studies on 'real-time' changes in RIF-1 tumour metabolism and blood flow during and after photodynamic therapy.

J. K. Bradley, G. Adams, I. Stratford, 1994, British Journal of Cancer.

NATIONAL BUREAU OF STANDARDS The National Bureau of Standards

G. Adams, L. M. Dorfman, Leon M. Dorfman, 2022 .

Selective free radical reactions with proteins and enzymes: the inactivation of alpha-chymotrypsin.

G. Adams, J. Redpath, K. Baverstock, 1974, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Radiation effects on -chymotrypsin in aqueous solution: pulse radiolysis and inactivation studies.

G. Adams, J. Redpath, K. Baverstock, 1973, Radiation research.

Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.

G. Adams, I. Stratford, M. Stratford, 1998, Journal of medicinal chemistry.

Nitroimidazoles : chemistry, pharmacology, and clinical application

G. Adams, B. Cavalleri, A. Breccia, 1982 .

Electron-affinic sensitization. VI. A pulse radiolysis and ESR comparison of some 2- and 5-nitroimidazoles.

G. Adams, D. Whillans, 1975, Radiation Research.

Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.

G. Adams, I. Stratford, 1986, Biochemical pharmacology.

Free radical reactions with proteins and enzymes: the inactivation of pepsin.

G. Adams, R. Cundall, R. Bisby, 1979, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Critical residues in D-amino acid oxidase. A pulse-radiolysis and inactivation study.

G. Adams, K. Patel, R. Anderson, 1977, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Mechanism of tryptophan oxidation by some inorganic radical-anions: a pulse radiolysis study

G. Adams, P. Wardman, R. Cundall, 1976 .

Selective free-radical reactions with proteins and enzymes: pulse radiolysis and inactivation studies on papain.

G. Adams, J. Redpath, 1974, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Selective free radical reactions with proteins and enzymes. The inactivation of subtilisin Carlsberg and subtilisin Novo

G. Adams, J. Redpath, R. Cundall, 1974 .

Selective free radical reactions with proteins and enzymes. Reactions of inorganic radical anions with trypsin

G. Adams, J. Redpath, R. Cundall, 1973 .

Abnormal radiosensitizing and cytotoxic properties of ortho-substituted nitroimidazoles.

G. Adams, I. Stratford, C. Hardy, 1983, International journal of radiation biology and related studies in physics, chemistry, and medicine.

The Assessment of Bioreductive Drug Toxicity in vitro and in Experimental Tumours in vivo

G. Adams, I. Stratford, S. Cole, 1990 .

Electron-Affinic SensitizationVII. A Correlation between Structures, One-Electron Reduction Potentials, and Efficiencies of Nitroimidazoles as Hypoxic Cell Radiosensitizers

G. Adams, I. Stratford, P. Wardman, 2012 .

Free radicals in biology: the pulse radiolysis approach

G. Adams, P. Wardman, 1977 .

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.

G. Adams, I. Stratford, M. Jaffar, 1998, Anti-cancer drug design.

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia.

G. Adams, I. Stratford, N. Robertson, 1994, European Journal of Cancer.

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

G. Adams, I. Stratford, J. Carmichael, 1992, Biochemical pharmacology.

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins.

G. Adams, I. Stratford, M. Threadgill, 1990, Journal of medicinal chemistry.

Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage.

G. Adams, I. Stratford, T. C. Jenkins, 1987, Anti-cancer drug design.

Bioreductive drugs for cancer therapy: the search for tumor specificity.

G. Adams, I. Stratford, Gerald E. Adams, 1994, International journal of radiation oncology, biology, physics.

ROLE OF HYDRATION IN INFLUENCING RADIATION-INDUCED DAMAGE OF DNA AT EARLY TIMES

G. Adams, E. Fielden, P. O'Neill, 1992 .

Radiolysis and Photolysis of Aqueous Formic Acid. Carbon Monoxide Formation

G. Adams, E. Hart, 1962 .

Redical and Molecular Yields in the y-Irradiation of Liquid Methanol

G. Adams, J. Baxendale, 1958 .

Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins.

P. Webb, G. Adams, I. Stratford, 1991, Journal of medicinal chemistry.

Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.

G. Adams, I. Stratford, M. Threadgill, 1990, Journal of medicinal chemistry.

On the mechanism of BUdR sensitization: a pulse radiolysis study of one electron transfer in nucleic-acid derivatives.

G. Adams, R. Willson, 1972, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Radiation-induced energy migration within solid DNA: the role of misonidazole as an electron trap.

G. Adams, E. Fielden, P. O'Neill, 1990, Radiation research.

Some Radical and Molecular Yields in the γ-Irradiation of Some Organic liquids

G. Adams, R. Sedgwick, J. Baxendale, 1959 .

Rapid-Mixing Studies on the Time-Scale of Radiation Damage in Cells1

G. Adams, B. Michael, M. Watts, 1975 .

Reactions of nucleic acid radicals with radiation modifiers

G. Adams, B. Michael, C. Greenstock, 1975 .

MOLECULAR MECHANISMS OF CELLULAR RADIOSENSITIZATION AND PROTECTION.

G. Adams, 1970 .

One-electron reduction reactions with enzymes in solution. A pulse radiolysis study

G. Adams, J. Redpath, R. Cundall, 1976 .

Selective free radical reactions with proteins and enzymes: the inactivation of ribonuclease.

G. Adams, J. Redpath, R. Willson, 1972, Radiation research.

On the mechanism of the radiation-induced inactivation of lysozyme in dilute aqueous solution.

J. Aldrich, G. Adams, R. Willson, 1969, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.

G. Adams, I. Stratford, C. Williamson, 1980, British Journal of Cancer.

The standardization of hydroxyl radical rate data from radiation chemistry

G. Adams, R. Willson, C. Greenstock, 1971 .

Time-resolved oxygen effects in irradiated bacteria and mammalian cells: a rapid-mix study.

G. Adams, M. Watts, M. Shenoy, 1975, Radiation research.

One-electron oxidation of 5,6-dihydroxy-2,3-dihydroindole: the influence of Zn2+

G. Adams, R. Cundall, P. O'Neill, 1996 .

Direct observation of the reaction of the quinone-methide from 5,6-dihydroxyindole with the nucleophilic azide ion

G. Adams, R. Cundall, P. O'Neill, 1992 .

One-electron oxidation of methoxylated and hydroxylated indoles by azide. 1. Characterization of the primary indolic radicals

G. Adams, R. Cundall, P. O'Neill, 1990 .

Reactions of indolic radicals produced upon one-electron oxidation of 5,6-dihydroxyindole and its N(1)-methylated analogue

G. Adams, R. Cundall, P. O'Neill, 1991 .

Characterisation of the intermediates produced upon one-electron oxidation of 4-, 5-, 6- and 7-hydroxyindoles by the azide radical

G. Adams, R. Cundall, P. O'Neill, 1992 .

One-Electron Oxidation of Methoxylated and Hydroxylated Indoles by N· 3. Part 1. Characterization of the Primary Indolic Radicals.

G. Adams, R. Cundall, P. O'Neill, 1990 .

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation.

G. Adams, I. Stratford, A. Keohane, 1990, British Journal of Cancer.

Structure-activity relationships in the development of hypoxic cell radiosensitizers. II. Cytotoxicity and therapeutic ratio.

E. Clarke, G. Adams, I. Stratford, 1979, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Ketyl radicals in aqueous solution pulse radiolysis study

G. Adams, R. Willson, 1973 .

Structure-activity relationships in the development of hypoxic cell radiosensitizers. I. Sensitization efficiency.

E. Clarke, G. Adams, I. Stratford, 1979, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Studies of the mechanisms of radiosensitization of bacterial and mammalian cells by Diamide.

G. Adams, M. Watts, D. Whillans, 1975, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Respiratory effects and ascorbate reactions with misonidazole and other recently developed drugs.

G. Adams, E. Fielden, J. Biaglow, 1980, Cancer clinical trials.

Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.

G. Adams, I. Stratford, E. Smith, 1982, British Journal of Cancer.

Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo.

G. Adams, I. Stratford, T. C. Jenkins, 1986, International journal of radiation oncology, biology, physics.

Advanced Topics on Radiosensitizers of Hypoxic Cells

G. Adams, A. Breccia, C. Rimondi, 1982, NATO Advanced Study Institutes Series.

Radiosensitization by the 2,4-dinitro-5-aziridinyl benzamide CB 1954: a structure/activity study.

G. Adams, I. Stratford, J. Walling, 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues.

G. Adams, I. Stratford, T. C. Jenkins, 1986, International journal of radiation oncology, biology, physics.

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.

G. Adams, I. Stratford, A. Silver, 1986, Biochemical pharmacology.

Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs.

G. Adams, I. Stratford, M. Naylor, 1992, International journal of radiation oncology, biology, physics.

Structure-activity relationships in the development of hypoxic cell radiosensitizers. III. Effects of basic substituents in nitroimidazole sidechains.

E. Clarke, G. Adams, I. Stratford, 1980, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Radiosensitizing and cytotoxicity studies with CB 1954 (2,4-dinitro-5-aziridinylbenzamide).

G. Adams, I. Stratford, C. Williamson, 1981, Radiation research.

Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles.

G. Adams, I. Stratford, E. Fielden, 1981, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Nitro derivatives of bi- and tri-cyclic heterocycles as potential radio-sensitizers

G. Adams, I. Stratford, J. Parrick, 1989 .

Protection of pig epidermis against radiation-induced damage by the infusion of BW12C.

J. Hopewell, G. Adams, I. Stratford, 1991, International journal of radiation biology.

Experimental investigation of CaMg exchange between olivine, orthopyroxene, and clinopyroxene: potential for geobarometry

G. Adams, F. C. Bishop, 1982 .

Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice.

G. Adams, I. Stratford, E. Wright, 1991, International journal of radiation oncology, biology, physics.

The perfluorocarbon emulsion PFOB: potential indicator of change in blood volume using fluorine-19 NMR spectroscopy.

G. Adams, P. Wood, J. Sansom, 1992, EXS.

Relative change in blood volume following administration of hydralazine as monitored by 19F NMR spectroscopy.

G. Adams, P. Wood, C. Counsell, 1991, International journal of radiation biology.

Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status.

K. Brindle, P. Thelwall, G. Adams, 1998, British Journal of Cancer.

Biological Basis of Radiosensitization by Hypoxic-Cell Radiosensitizers

G. Adams, J. Denekamp, J. Fowler, 1976 .

Selective Activation of Drugs by Redox Processes

G. Adams, P. Wardman, E. Fielden, 1990, NATO ASI Series.

Induction of hypoxia in normal and malignant tissues by changing the oxygen affinity of hemoglobin--implications for therapy.

J. Hopewell, G. Adams, I. Stratford, 1986, International journal of radiation oncology, biology, physics.

The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.

G. Adams, M. Horsman, I. Stratford, 1980, Cancer clinical trials.

Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship.

G. Adams, I. Stratford, C. Clarke, 1982, British Journal of Cancer.

The Biological Basis of Radiotherapy

Alan Horwich, A. Horwich, G. Adams, 1989 .

Hypoxic cell sensitisers in radiotherapy.

J. Fowler, G. Adams, S. Dische, 1978, International journal of radiation oncology, biology, physics.

Heterocyclic mono-N-oxides with potential applications as bioreductive anti-tumour drugs: Part 1. 8-Alkylamino-substituted phenylimidazo [1,2-a] quinoxalines.

G. Adams, I. Stratford, M. Naylor, 1993, Anti-cancer drug design.

Pharmacokinetics, metabolism and distribution of 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-A] pyrido [3,2-E] pyrazine-5-oxide in C3H mice.

G. Adams, I. Stratford, M. Naylor, 1994, International Journal of Radiation Oncology, Biology, Physics.

Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity.

G. Adams, I. Stratford, M. Naylor, 1994, International Journal of Radiation Oncology, Biology, Physics.

Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo.

G. Adams, I. Stratford, P. O'Neill, 1984, International journal of radiation biology and related studies in physics, chemistry, and medicine.

31P MRS to monitor the induction of tumor hypoxia by the modification of the oxygen affinity of hemoglobin using BW 589C.

G. Adams, I. Stratford, P. Wood, 1994, International journal of radiation oncology, biology, physics.

Preincubation with electron affinic radiosensitizers followed by hyperthermia or X rays.

G. Adams, I. Stratford, S. Rajaratnam, 1982, International journal of radiation oncology, biology, physics.

Radiosensitizers: a conference preview.

G. Adams, 1984, International journal of radiation oncology, biology, physics.

Monitoring metabolic responses after induction of hypoxia in the KHT tumour using 31P NMR spectroscopy.

G. Adams, I. Stratford, C. Counsell, 1991, International journal of radiation biology.

Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin.

G. Adams, I. Stratford, R. D. White, 1989, International journal of radiation oncology, biology, physics.

Radiosensitization of hypoxic cells in vitro: a water-soluble derivative of paranitroacetophenone.

G. Adams, M. Watts, J. C. Asquith, 1972, Nature: New biology.

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.

G. Adams, I. Stratford, S. Cole, 1992, International journal of radiation oncology, biology, physics.

Care with radiosensitizers.

G. Adams, S. Dische, 1979, The British journal of radiology.

Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas.

G. Adams, I. Stratford, T. C. Jenkins, 1990, Radiation research.

A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour.

C. Streffer, J. Overgaard, G. Adams, 1996, Acta oncologica.

Effect of hydralazine in spontaneous tumours assessed by oxygen electrodes and 31P-magnetic resonance spectroscopy.

R. Maxwell, J. Overgaard, G. Adams, 1996, The British journal of cancer. Supplement.

Effect ofhydralazine inspontaneous tumours assessed byoxygenelectrodes and31P-magnetic resonancespectroscopy

G. Adams, M. Nordsmark, 1996 .

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine.

C. Thiemermann, J. Vane, G. Adams, 1994, International journal of radiation oncology, biology, physics.

PULSE RADIOLYSIS STUDIES OF DEAERATED AQUEOUS SALICYLATE SOLUTIONS.

G. Adams, B. Michael, C. Amphlett, 1968 .

The development of some nitroimidazoles as hypoxic cell sensitizers.

G. Adams, I. Stratford, E. Fielden, 1980, Cancer clinical trials.

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.

J. Sebolt-Leopold, G. Adams, I. Stratford, 1992, International journal of radiation oncology, biology, physics.

Effect of serum starvation on expression and phosphorylation of PKC‐α and p53 in V79 cells: Implications for cell death

G. Adams, Nael M Hasan, M. Joiner, 1999, International journal of cancer.

Phosphomonoester is associated with proliferation in human breast cancer: a 31P MRS study.

A. Harris, G. Radda, P. Styles, 1993, British Journal of Cancer.

Technetium-99m HMPAO and SPECT in the assessment of blood flow in human lung tumours.

V. R. McCready, A. Horwich, D. Tait, 1989, British Journal of Cancer.

Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT).

J. K. Bradley, G. Adams, I. Stratford, 1994, International journal of radiation oncology, biology, physics.

Use of fluorine-19 nuclear magnetic resonance spectroscopy and hydralazine for measuring dynamic changes in blood perfusion volume in tumors in mice.

G. Adams, P. Wood, C. Counsell, 1992, Journal of the National Cancer Institute.

Nitroimidazoles as Hypoxia-Mediated Drugs in Cancer Chemotherapy

G. Adams, I. Stratford, 1982 .

Manipulation of radiobiological hypoxia in a human melanoma xenograft to exploit the bioreductive cytotoxicity of RSU-1069.

G. Adams, I. Stratford, S. Cole, 1989, International journal of radiation biology.

Hypoxia-mediated radiation and chemo-sensitizing drugs.

G. Adams, 1984, British Journal of Cancer.

Evaluation of novel radiation sensitizers in vitro and in vivo.

G. Adams, I. Stratford, P. Sheldon, 1982, International journal of radiation oncology, biology, physics.

The toxicity of the radiosensitizer misonidazole towards hypoxic cells in vitro: a model for mouse and man.

G. Adams, I. Stratford, 1978, The British journal of radiology.

Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase.

G. Adams, I. Stratford, P. Wood, 1997, British Journal of Cancer.

Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.

C. Thiemermann, J. Vane, G. Adams, 1993, Biochemical and biophysical research communications.

Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs.

G. Adams, E. Fielden, S. Cole, 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Failla Memorial Lecture. Redox, radiation, and reductive bioactivation.

G. Adams, 1992, Radiation Research.

Induction of Differential Hypoxia in Tissues and its Implications for Therapy

G. Adams, I. Stratford, 1987 .

Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1.

C. Thiemermann, J. Vane, G. Adams, 1996, The British journal of cancer. Supplement.

31P-nuclear-magnetic-resonance spectra of tumours and muscle in the anaesthetized mouse

J. Griffiths, G. Adams, R. E. Gordon, 1982 .

2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives.

P. Webb, G. Adams, I. Stratford, 1992, Journal of medicinal chemistry.

Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145.

G. Adams, I. Stratford, D. Phillips, 1992, British Journal of Cancer.

31P magnetic resonance spectroscopy as a predictor of efficacy in photodynamic therapy using differently charged zinc phthalocyanines

J. K. Bradley, G. Adams, S. Brown, 1999, British Journal of Cancer.

Radiation-induced luminescence from "dry" and hydrated DNA and related macromolecules

G. Adams, E. Fielden, P. O'Neill, 1988 .

Selective Free Radical Reactions with Proteins and Enzymes: A Reversible Equilibrium in the Reaction of with Lysozyme

G. Adams, P. Wardman, R. Cundall, 1982 .

Sensitization of ultraviolet radiation damage in bacteria and mammalian cells.

G. Adams, M. Watts, K. Patel, 1978, The British journal of cancer. Supplement.

Comments on the estimated distance over which electrons can migrate in solid DNA before being trapped by misonidazole.

G. Adams, E. Fielden, P. O'Neill, 1991, Radiation research.

An experimental investigation of thermodynamic mixing properties and unit-cell parameters of forsterite-monticellite solid solution

G. Adams, F. C. Bishop, 1985 .

Thermotolerance in chinese hamster cells under oxic conditions after chronic culture under hypoxia.

G. Adams, I. Stratford, E. Smith, 1981, British Journal of Cancer.

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

A. Harris, A. Patterson, G. Adams, 1994, International journal of radiation oncology, biology, physics.