D. Tew

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Cloning and Characterization of a Novel Human Dual Flavin Reductase*

C. Wolf, M. Paine, A. P. Garner, 2000, The Journal of Biological Chemistry.

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors.

Mehul M. Patel, S. Thrall, D. Tew, 2008, Bioorganic & medicinal chemistry letters.

Off-colony screening of biosynthetic libraries by rapid laser-enabled mass spectrometry.

Tom Ellis, Marcelo Kern, T. Ellis, 2019, ACS synthetic biology.

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

C. Southan, F. Walsh, T. Smith, 1999, Molecular and cellular neurosciences.

A versatile biosynthetic approach to amide bond formation

D. Tew, P. Thomas, S. Lovelock, 2018 .

The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin.

P. Ortiz de Montellano, D. Tew, 1988, The Journal of biological chemistry.

An opsonised microelectrode

D. Tew, H. Hill, N. Walton, 1985, FEBS letters.

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

David G. Tew, C. Southan, F. Walsh, 1999, Molecular and Cellular Neuroscience.

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

D. Tew, H. Boyd, D. Dhanak, 1999, The Biochemical journal.

Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

D. Harrison, C. Wolf, D. Tew, 1993, The Lancet.

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

C. Southan, P. Murdock, F. Walsh, 2000, Molecular and cellular neurosciences.

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

D. Tew, H. Boyd, A. Shaw, 1998, The Biochemical journal.

Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism.

D. Tew, B. Clarke, E. Sternberg, 1999, Bioorganic & medicinal chemistry letters.

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones.

D. Tew, P. Lavery, R. L. Jarvest, 1999, Bioorganic & medicinal chemistry letters.

Lipoprotein-associated PLA2 inhibition--a novel, non-lipid lowering strategy for atherosclerosis therapy.

D. Tew, Stephen A. Smith, S. Smith, 2001, Farmaco.

The rate of oxygen consumption and superoxide anion formation by stimulated human neutrophils The effect of particle concentration and size

D. Tew, H. Hill, M. Green, 1987, FEBS letters.

An opsonised electrode

D. Tew, H. Hill, N. Walton, 1984, FEBS letters.

Structure-based design of non-peptide, carbohydrazide-based cathepsin K inhibitors.

R. DesJarlais, D. Veber, D. Tew, 1999, Bioorganic & medicinal chemistry.

Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor.

C. Southan, D. Tew, S. Rice, 1998, The Biochemical journal.

Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2).

M. Doyle, D. Tew, D. Casper, 2001, Biochemistry.

Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Cheryl A. Janson, C. Janson, D. Tew, 2002, Antimicrobial Agents and Chemotherapy.

Nitrogen-15 NMR studies of nitrosyl (bent and linear), nitro, and nitrito ligands in 4-, 5-, and 6-coordinate complexes of the platinum metals

D. Tew, D. Mingos, J. Mason, 1983 .

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

Guang Yang, Keith W Ward, D. Veber, 2005, Journal of medicinal chemistry.

Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease.

G. Burton, D. Tew, D. Dhanak, 1998, Bioorganic & medicinal chemistry letters.

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

D. Tew, H. Boyd, I. Stansfield, 2000, Bioorganic & medicinal chemistry letters.

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.

D. Tew, H. Boyd, I. Stansfield, 2000, Bioorganic & medicinal chemistry letters.

The nitrogen-15 n.m.r. criterion of bond angle in nitrosyl complexes

D. Tew, D. Mingos, J. Mason, 1983 .

Determination of phosphate in nanomolar range by an enzyme-coupling fluorescent method.

D. Tew, Beatriz Rodríguez, M. Vázquez, 2003, Analytical biochemistry.

Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.

D. Tew, 1993, Biochemistry.

Azepanone-based inhibitors of human and rat cathepsin K.

Y. Ru, D. Veber, K. Ward, 2001, Journal of medicinal chemistry.

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Keizo Yamashita, Guang Yang, D. Veber, 2007, Journal of medicinal chemistry.

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase.

D. Tew, O. Jones, B. O’Donnell, 1993, The Biochemical journal.

Cyclic ketone inhibitors of the cysteine protease cathepsin K.

Y. Ru, D. Veber, M. Hemling, 2001, Journal of medicinal chemistry.

Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm.

D. Tew, S. Gul, F. Flett, 2009, The Biochemical journal.

ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

C. Southan, P. Murdock, F. Walsh, 2000, Molecular and Cellular Neuroscience.

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

P. Ortiz de Montellano, C. Wolf, M. Paine, 1999, Cancer research.

The kinetic model of the shikimate pathway as a tool to optimize enzyme assays for high‐throughput screening

Joshua West, Frank Tobin, Oleg Demin, 2006, Biotechnology and bioengineering.

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

Andy Neely, J. G. Bartlett, Chris Abell, 2022, Scientific Reports.

An iteratively optimised process for improving the e ciency and effectiveness of an industrial SARS- CoV-2 diagnostic facility

Christopher A. Brown, Emma L. Koppe, Melanie V. Leveridge, 2021 .

Decorating Self-Assembled Peptide Cages with Proteins.

R. Sessions, D. Woolfson, Jordan M Fletcher, 2017, ACS nano.

Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX.

P. Ortiz de Montellano, D. Tew, P. R. Montellano, 1988, Biochemistry.

Crystal structure of the FMN‐binding domain of human cytochrome P450 reductase at 1.93 Å resolution

P. McDonagh, Qiang Zhao, C. Wolf, 1999, Protein science : a publication of the Protein Society.

Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.

C. Wolf, D. Tew, G. Smith, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L.

D. Veber, D. Tew, D. Yamashita, 1999, Journal of combinatorial chemistry.

Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.

T. Häkkinen, D. Tew, S. Ylä-Herttuala, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Synthetic biology and healthcare.

David G. Tew, D. Tew, 2019, Emerging topics in life sciences.

Napsins: new human aspartic proteinases

J. Kay, T. Smith, D. Tew, 1998, FEBS letters.

Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins.

C. Southan, D. Tew, S. Rice, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Anti-atherosclerotic effect of SB-244323, a lipoprotein associated phospholipase A2 inhibitor, in WHHL rabbits

D. Tew, H. Boyd, K. Suckling, 2000 .

Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry.

D. Tew, H. Boyd, C. Leach, 1998, Biochemistry.

ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.

D. Tew, H. Boyd, A. Shaw, 1998, Journal of medicinal chemistry.

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.

D. Tew, A. Shaw, P. Groot, 1996, Journal of medicinal chemistry.

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

R. DesJarlais, D. Veber, S. Abdel-Meguid, 1998, Journal of medicinal chemistry.

Kinetic and chemical mechanisms of the fabG-encoded Streptococcus pneumoniae beta-ketoacyl-ACP reductase.

S. Thrall, D. Tew, T. Meek, 2005, Biochemistry.

Utilization of Substrate-Induced Quenching for Screening Targets Promoting NADH and NADPH Consumption

D. Tew, A. Bardera, F. Ramon, 2006, Journal of biomolecular screening.

Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase.

H P Driessen, L Y Lian, G C Roberts, 1996, Journal of structural biology.

Improved betulinic acid biosynthesis using synthetic yeast chromosome recombination and semi-automated rapid LC-MS screening

T. Ellis, D. Tew, M. Kern, 2020, Nature Communications.

Improved betulinic acid biosynthesis using synthetic yeast chromosome recombination and semi-automated rapid LC-MS screening

T. Ellis, D. Tew, G.-O. F. Gowers, 2020, Nature Communications.

Applications of spin-trapping to biological systems.

D. Tew, H. Hill, M. Green, 1985, Biochemical Society transactions.